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The Effects of 5 Weeks of Leg-Drive Training on Bench Press Performance in Recreationally-Trained,College-Age men

Journal of Science in Sport and Exercise 2022年第3期4卷 231-236页

作者： Jacob K.Gardner Justin T.Chia Brent m.Peterson kelsey L.miller Department of Kinesiology and Health Science Biola University13800 Biola AveLa MiradaCA 90639USA Department of Health and Human Development Western Washington University516 High StreetBellinghamWA 98225USA

Introduction The bench press is commonly used to measure upper-body *** much emphasis has been placed on the upper-body,little is known about how the lower-body can play a role in bench press ***-drive is a technique that includes flexing the knee so the feet line up posterior to the knee joint,while simultaneously contracting the knee extensors isometrically during the *** purpose of this study was to compare strength characteristics of lifters in a standard bench press versus a leg-drive bench press over the course of 5-weeks of *** Twenty-three recreationally active males(age:22.4±2.1 years,height:175.0±5.9 cm,mass:78.4±9.5 kg)were randomized into a standard bench or leg-drive bench press *** performed four sets to failure,two times per week for five *** of interests were training volume and 1-repetition maximum(1Rm)*** training volume,a 2×5(group×week)repeated measures analysis of variance(RmANOVA)was *** the 1Rm’s,a 2×2×2(group×press type×time)RmANOVA was used.A priori alpha levels were set to *** Over time,both groups showed an approximate 6%increase in 1Rm *** volume for week 4 was 5.6%less than week 5,but was not different from weeks 1 through *** between-group differences were observed for 1Rm strength or training *** This results of this work indicates that 5 weeks of leg-drive training is effective in increasing 1Rm strength,but was not more effective than standard bench press ***,lifters should choose either lifting style based on personal preference.

关键词： Chest press Lower-body Weight lifting Isometric contraction

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FOXP3 protects conventional human T cells from premature restimulation-induced cell death

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Cellular & molecular Immunology 2021年第1期18卷 194-205页

作者： kelsey Voss Camille Lake Christopher R.Luthers Nathaniel m.Lott Batsukh Dorjbal Swadhinya Arjunaraja Bradly m.Bauman Anthony R.Soltis Gauthaman Sukumar Clifton LDalgard Andrew L.Snow Department of Pharmacology&molecular Therapeutics Uniformed Services University of the Health SciencesBethesdaMD 20817USA The American Genome Center(TAGC) Collaborative Health Initiative Research ProgramUniformed Services University of the Health SciencesBethesdaMDUSA Department of Anatomy Physiology&GeneticsUniformed Services University of the Health SciencesBethesdaMDUSA

The adaptive immune response relies on specific apoptotic programs to maintain *** effector T cell(Tcon)expansion is constrained by both forkhead box P3(FOXP3)^(+)-regulatory T cells(Tregs)and restimulation-induced cell death(RICD),a proprlocidal apoptosis pathway triggered by repeated stimulation through the T-cell receptor(TCR).Constitutive FOXP3 expression protects Tregs from RICD by suppressing SLAm-associated protein(SAP),a key adaptor protein that amplifies TCR signaling *** role of transient FOXP3 induction in activated human CD4 and CD8 Tcons remains unresolved,but its expression is inversely correlated with acquired RICD ***,we describe a novel role for FOXP3 In protecting human Tcons from premature RICD during *** FOXP3-mediated protection from RICD in Tregs,FOXP3 protects Tcons through a distinct mechanism requiring de novo transcription that does not require SAP *** profiling and functional analyses of expanding Tcons revealed that FOXP3 enhances expression of the SLAm family receptor CD48,which in turn sustains basal autophagy and suppresses pro-apoptotic p53 *** CD48 and FOXP3 expression reduced p53 accumulation upon TCR ***,silencing FOXP3 expression or blocking CD48 decreased the mitochondrial membrane potential in expanding Tcons with a concomitant reduction in basal *** findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression.

关键词： conventional T cells RICD FOXP3 autophagy CD48

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morbidity and mortality of coagulase-negative staphylococcal sepsis in very-low-birth-weight infants

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World Journal of Pediatrics 2018年第3期14卷 269-273页

作者： Joseph B.Cantey kelsey R.Anderson Ram R.Kalagiri Lea H.mallett Department of Pediatrics University of Texas Health Science Center San Antonio7703 Floyd Curl DriveSan AntonioTX 78229USA Texas A&m Health Science Center College of medicine BryanTXUSA Texas A&m Health Science Center Baylor/Scott&White HealthTempleTXUSA

Background Coagulase-negative staphylococci (CoNS) are the most common cause of late-onset sepsis in the neonatal intensive care unit (NICU) and usually require vancomycin treatment. Our objective was to determine whether CoNS are associated with neonatal morbidity and mortality. methods This was a retrospective cohort study of very-low-birth-weight (VLBW, ≤ 1500 g) infants from 1989 to 2015. Exclusion criteria were major congenital anomaly or death within 72 h. CoNS was considered a pathogen if recovered from ≥ 2 cultures, or 1 culture if treated for ≥ 5 days and signs of sepsis were present. Logistic regression was used to exam-ine factors associated with morbidity and mortality. Results Of 2242 VLBW infants, 285 (12.7%) had late-onset sepsis. CoNS (125, 44%),Staphylococcus aureus (52, 18%), and Escherichia coli (36, 13%) were the most commonly recovered organisms. In multivariate analysis, CoNS sepsis was not associated with mortality (OR 0.6 (95% CI 0.2-2.6)), but sepsis with other organisms was (OR 4.5 (95% CI 2.6-8.0))CoNS sepsis was associated with longer hospitalization but not risk for bronchopulmonary dysplasia, intraventricular hem-orrhage, or retinopathy of prematurity. Conclusion CoNS sepsis was not associated with mortality or morbidities other than length of stay. These findings support vancomycin-reduction strategies in the NICU.

关键词： morbidity mortality Neonate Sepsis

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Hepatic Adenoma Secondary to Long-Term Oral Contraception Use in a Young Female

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Open Journal of Internal medicine 2023年第2期13卷 104-113页

作者： kelsey m. Lamb Jessica E. Darden Suresh G. Jayatilaka Edward Via College of Osteopathic medicine in Virginia Blacksburg USA Department of Gastroenterology Southern Gastroenterology Associates St. Georges University School of Medicine St. Georges Grenada

Hepatic adenomas are a rare byproduct of oral contraceptive pill (OCP) use. Laboratory workup is often inconclusive. Diagnosis can be made via mRI;however, select cases may require further testing such as fine needle aspiration or core needle biopsy. We report a case of a 36-year-old female who was referred to gastroenterology for further evaluation of several liver lesions found incidentally on imaging. Due to risk factors, such as age, long-term oral contraceptive use and obesity, adenoma was high on the differential. Although infrequent, this case emphasizes the importance of a detailed history, including medication review, and physical examination.

关键词： Hepatic Adenoma Oral Contraceptives Liver Lesion

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Differences in metabolic Stress Using a Breathing Restrictive mask Compared to Hypobaric Hypoxia During Cycling at a matched Workload

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Journal of Science in Sport and Exercise 2022年第4期4卷 397-404页

作者： Bryanne N.Bellovary Andrew D.Wells Zachary J.Fennel Jonathan m.Houck Desmond J.millender kelsey C.Bourbeau Christine m.mermier Department of Health Exerciseand Sports SciencesUniversity of New MexicoJohnson Center B143 MSC042610AlbuquerqueNM 87131-0001USA

Purpose The Elevation Training mask(ETm)has been assessed for its impact on exercise performance using acute and training *** the ETm is widely available to consumers,little research exists for validation of the ETm mask ***,the purpose of this study was to compare physiological responses during exercise for the ETm mask settings against moderate hypobaric *** Nine participants living at moderate altitude(1600-1650 m)rested(10 min)and cycled in hypobaric hypoxia simulating 2743 m(ALT),in hypobaric hypoxia simulating 1829 m with the ETm set to 914 m(ALT+ETm),and with the ETm set to 2743 m(ETm)in a randomized *** cycled for 20 min at 60%VO_(2max)as determined by a maximal exertion test(VO_(2max))at baseline *** consumption was measured throughout each *** There were no differences between conditions at *** measures ANOVA showed the ALT condition elicited significantly greater VO_(2) compared to the ETm condition and 60%VO_(2max)at baseline altitude(Pmatched workload,the exercising VO_(2) was higher in the ALT condition than at the ETm mask setting of 2743 m and exercising VO2 during the ETm condition was similar to 60%VO_(2max)at baseline *** results of this study indicate that the ETm did not produce additional metabolic stress compared to hypobaric hypoxia during steady-state exercise in moderate-altitude living individuals.

关键词： Intermittent hypoxia Training mask Acute cycling Altitude

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Plastic Additives Decrease Agrin-Induced Acetylcholine Receptor Clusters and myotube Formation in C2C12 Skeletal muscle Cell Culture

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CellBio 2015年第1期4卷 12-22页

作者： kelsey Neufeld Kelly Ezell Wade A. Grow Department of Anatomy Arizona College of Osteopathic Medicine Midwestern University Glendale AZ USA

Common additives in plastics such as bisphenol A (BPA) or phthalates like di-(2-ethylhexyl) phthalate (DEHP) are environmental estrogens that have been shown to be endocrine disruptors in some experimental animal models. This project used the C2C12 cell culture model to examine how exposure to BPA or DEHP affects two aspects of skeletal muscle development, the fusion of myoblasts into myotubes and agrin-induced clustering of acetylcholine receptors (AChRs). During myotube formation AChRs cluster spontaneously. Treatment with motor neuron derived agrin increases the frequency of AChR clusters through an agrin signaling pathway that also clusters other postsynaptic components of the neuromuscular synapse. For this project C2C12 cells were exposed to BPA or DEHP while myoblasts fused into myotubes. After exposure to 10 μm BPA or 100 μm DEHP the frequency of agrin-induced AChR clusters decreased. In addition, myotube formation decreased as a higher percentage of nuclei remained in myoblasts. Furthermore, BPA or DEHP reduced the amount of the myogenic regulatory factor myogenin. This suggests that BPA and DEHP decrease AChR clustering by reducing myogenin. moreover, plastic additives like BPA and DEHP may pose a risk for skeletal muscle development in humans.

关键词： AChR Agrin Bisphenol A (BPA) C2C12 Di-(2-Ethylhexyl) Phthalate (DEHP) myogenin

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Gibberellic acid induced parthenocarpic‘Honeycrisp’apples(malus domestica)exhibit reduced ovary width and lower acidity

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Horticulture Research 2019年第1期6卷 1129-1141页

作者： kelsey D.Galimba Daniel G.Bullock Chris Dardick Zhongchi Liu Ann m.Callahan Appalachian Fruit Research Station Agricultural Research ServiceUnited States Department of Agriculture2217 Wiltshire RoadKearneysvilleWV 25430USA Department of Cell Biology and molecular Genetics College of Mathematics and Natural SciencesUniversity of MarylandCollege ParkMD 20742USA

Fruit set and development are dependent on auxin,gibberellin,and cytokinin,which cause parthenocarpic development in many species when applied *** sprays containing these hormones are used to improve apple fruit set,size,and shape,but have been implicated negatively in other aspects of fruit *** applied gibberellic acid(GA_(3)),synthetic auxin(NAA),and the auxin-transport inhibitor NPA to‘Honeycrisp’apple *** retention and size were quantified throughout development,and seed number and fruit quality parameters were measured at ***_(3)alone caused the development of seedless parthenocarpic *** maturity,GA_(3)-treated apples were narrower due to reduced ovary width,indicating that GA_(3)induced normal growth of the hypanthium,but not the ***_(3)-treated fruits were also less acidic than hand-pollinated controls,but had similar firmness,starch,and sugar *** further understand the regulation of parthenocarpy,we performed tissue-specific transcriptome analysis on GA_(3)-treated,NAA-treated,and control fruits,at 18 days after treatment and again at ***,transcriptome analysis showed GA_(3)-treated and hand-pollinated fruits were highly similar in RNA expression *** expression differences in putative cell division,cytokinin degradation,and cell wall modification genes in GA_(3)-treated ovaries correlated with the observed shape differences,while early expression differences in the acidity gene ma1 may be responsible for the changes in *** together,our results indicate that GA_(3)triggers the development of parthenocarpic apple fruit with morphological deviations that correlate with a number of candidate gene expression differences.

关键词： maturity width acidity

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Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice

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Life metabolism 2023年第2期2卷 23-34页

作者： Patrick J.Ferrara marisa J.Lang Jordan m.Johnson Shinya Watanabe kelsey L.mcLaughlin John Alan maschek Anthony R.P.Verkerke Piyarat Siripoksup Amandine Chaix James E.Cox kelsey H.Fisher-Wellman Katsuhiko Funai Diabetes&metabolism Research Center University of UtahSalt Lake CityUtah 84112United States Department of Nutrition&Integrative Physiology University of UtahSalt Lake CityUtah 84112United States East Carolina Diabetes&Obesity Institute East Carolina UniversityGreenvilleNorth Carolina 27834United States Department of Physiology East Carolina UniversityGreenvilleNorth Carolina 27834United States metabolomics Core Research Facility University of UtahSalt Lake CityUtah 84112United States molecular medicine Program University of UtahSalt Lake CityUtah 84112United States Department of Biochemistry University of UtahSalt Lake CityUtah 84112United States

Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight *** suggests that this energetic mismatch originates from lean *** this phenomenon is well documented,the mechanisms have remained *** hypothesized that increased mitochondrial energy efficiency in skeletal muscle is associated with reduced expenditure under weight ***(WT)male C57BL6/N mice were fed with high-fat diet for 10 weeks,followed by a subset of mice that were maintained on the obesogenic diet(OB)or switched to standard chow to promote weight loss(WL)for additional 6 *** energy efficiency was evaluated using high-resolution respirometry and *** spectrometric analyses were employed to describe the mitochondrial proteome and *** loss promoted~50%increase in the efficiency of oxidative phosphorylation(ATP produced per O_(2) consumed,or P/O)in skeletal ***,Weight loss did not appear to induce significant changes in mitochondrial proteome,nor any changes in respiratory supercomplex ***,it accelerated the remodeling of mitochondrial cardiolipin(CL)acyl-chains to increase tetralinoleoyl CL(TLCL)content,a species of lipids thought to be functionally critical for the respiratory *** further show that lowering TLCL by deleting the CL transacylase tafazzin was sufficient to reduce skeletal muscle P/O and protect mice from diet-induced weight *** findings implicate skeletal muscle mitochondrial efficiency as a novel mechanism by which weight loss reduces energy expenditure in obesity.

关键词： energy efficiency energy expenditure mitochondria oxidative phosphorylation phospholipids weight loss

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Evidence of a conservative gait strategy in athletes with a history of concussions

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Journal of Sport and Health Science 2016年第4期5卷 417-423页

作者： Thomas A.Buckley Srikant Vallabhajosula Jessie R.Oldham Barry A.munkasy kelsey m.Evans David A.Krazeise Caroline J.Ketcham Eric E.Hall Department of Kinesiology and Applied Physiology University of Delaware Department of Physical Therapy Education Elon University Department of Health and Kinesiology Georgia Southern University Department of Intercollegiate Athletics Stetson University Department of Exercise Science Elon University

Background：A history of 3 or more concussions is frequently associated with numerous short-and long-term *** in postural control are a known acute consequence of concussion;however,limited evidence exists on the effects of multiple concussions on *** purpose of this study was to assess gait stepping characteristics in collegiate aged student-athletes based on concussion ***：There were 63 participants divided into 3 even groups based on concussion history：≥3 concussions,1–2 concussions,and 0 *** participants completed 10 trials of gait on a 4.9 m instrumented *** dependent variables of interest included both gait stepping characteristics（step velocity,length,and width,double support time,and the percentage of the gait cycle in stance） and coefficien of variability（CoV） measures（step length,time,and width）.The gait stepping characteristics were compared firs with a mANOVA with follow-up 1-way ANOVAs and Tukey post hoc tests as *** Co V measures were compared with 1-way ANOVAs and Tukey post hoc ***：There were main effects for group for step velocity,length,width,and double support ***,the 0 concussion group displayed typical healthy young gait parameters and performed significant y better than either concussion *** 0 concussion group had a significant y greater step length Co V,but there were no differences in the step time or width Co ***：This findin provides evidence of subtle impairments in postural control during gait among individuals with prior history of concussion which could be an early indicator of future neurological deficiencies The limited difference in the variability measures is consistent with prior static stance studies and could suggest the individuals constrain their motor systems to reduce *** together,these findi gs suggest a conservative gait strategy which is adopted by individuals with a history of concussions.

关键词： Balance Brain injury Gait performance Locomotion mild traumatic Postural control Postural stability Variability

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Peroxidase-Like Reactivity at Iron-Chelation Sites in a mesoporous Synthetic melanin

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CCS Chemistry 2021年第3期3卷 1483-1490页

作者： Yijun Xie kelsey A.Krug Kristine S.Cay mark Kalaj Naneki C.mcCallum Zofia E.Siwicka Zhao Wang Nathan C.Gianneschi michael D.Burkart Jeffrey D.Rinehart materials Science and Engineering Program University of CaliforniaSan DiegoLa JollaCA 92093 Department of Chemistry and Biochemistry University of CaliforniaSan DiegoLa JollaCA 92093 Department of Chemistry Northwestern UniversityEvanstonIL 60208 International Institute of Nanotechnology Simpson-Querrey InstituteChemistry of Life Processes InstituteNorthwestern UniversityEvanstonIL 60208 Pritzker School of molecular Engineering University of ChicagoChicagoIL 60637 Lurie Cancer Center Northwestern UniversityEvanstonIL 60208 Department of materials Sciences and Engineering Northwestern UniversityEvanstonIL 60208 Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208

High catalytic activity and substrate specificity make enzymes a rich source of inspiration for catalyst ***-opting the advantages of natural materials while tuning them to a modified form and purpose,however,is not a straightforward synthetic *** of L-3,4-dihydroxyphenylalanine(L-DOPA)results in amorphous polymer nanoparticles that are similar in many ways to natural ***,the authors introduce mesoporosity and iron ion chelation to synthesize a variant of the L-DOPA polymer with high peroxidase-like *** results indicate catalytic reaction with peroxide under mildly acidic conditions(pH 5.4 and 6)with a greater maximum reaction velocity(Vmax)than horseradish peroxidase(HRP)at optimal pH 3.5–*** between Fe(Ⅲ)and Fe(Ⅱ)loading indicates that either can be used as a starting point to trigger reactivity,though Fe(Ⅱ)loading leads to materials with twice the Vmax of the Fe(Ⅲ)-loaded *** lack of catalyst degradation despite the redox changes and presence of radical species is consistent with the robust nature and redox versatility of polydopamine-based materials and demonstrates strong potential as a versatile redox-catalysis platform.

关键词： L-DOPA mesoporosity peroxidase-like reactivity iron ion chelation catalysis

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