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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： jason Philip Appleton Lisa j Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala mark Dixon Timothy j England Kailash Krishnan Grant mair Keith W muir john Potter Christopher I Price marc Randall Thompson G Robinson Christine Roffe Else C Sandset jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena joanna m Wardlaw Nikola Sprigg Philip m Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or mann-Whitney difference(mWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(mWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša V.Todorović Aleksandar j.Krmpot miroslav Živić Svetlana Savić-Šević Steva m.Lević marina Stanić Dejan Pantelić Brana jelenković mihailo D.Rabasović Institute of Physiology and Biochemistry“Ivan Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for multidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

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Suppression of the m/n=2/1 tearing mode by electron cyclotron resonance heating on j-TEXT

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Plasma Science and Technology 2024年第8期26卷 8-17页

作者：方建港陈忠勇严伟王能超毛飞越罗蔷玄子健陈曦璇任正康张峰黄梅夏冬辉杨州军陈志鹏丁永华 the j-TEXT Team State Key Laboratory of Advanced Electromagnetic Technology International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma PhysicsSchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China Southwestern Institute of Physics Chengdu 610041People’s Republic of China

Stabilization of tearing modes and neoclassical tearing modes is of great importance for tokamak *** cyclotron waves(ECWs)have been extensively used to stabilize the tearing modes with the virtue of highly localized power *** suppression of the m/n=2/1 tearing mode(Tm)by electron cyclotron resonance heating(ECRH)has been achieved successfully on the j-TEXT *** effects of ECW deposition location and power amplitude on the 2/1 Tm suppression have been *** is found that the suppression is more effective when the ECW power is deposited closer to the rational *** the ECW power increases to approximately 230 k W,the 2/1 Tm can be completely *** island rotation frequency is increased when the island width is *** experimental results show that the local heating inside the magnetic island and the resulting temperature perturbation increase at the O-point of the island play dominant roles in Tm *** the ECW power increases,the 2/1 island is suppressed to smaller island width,and the flow shear also plays a stabilizing effect on small magnetic *** the stabilizing contribution of heating and flow shear,the 2/1 Tm can be completely suppressed.

关键词： tearing mode electron cyclotron resonant heating tearing mode suppression

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基于深度学习的改进ERRIS径流预报实时校正方法研究

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水资源保护 2024年

作者：刘莉梁霄 Quan j.Wang 许月萍浙江大学建筑工程学院墨尔本大学基础工程学院

为提高径流预报的精度，基于长短期记忆神经网络模型LSTm改进ERRIS（error reduction and representation in stages）统计误差模型，构建了径流预报集合实时校正模型ERRIS-LSTm。以雅鲁藏布江流域和椒江流域开展实例研究，评估该校正... 详细信息

为提高径流预报的精度，基于长短期记忆神经网络模型LSTm改进ERRIS（error reduction and representation in stages）统计误差模型，构建了径流预报集合实时校正模型ERRIS-LSTm。以雅鲁藏布江流域和椒江流域开展实例研究，评估该校正模型对预见期为1d的径流预报的实时校正效果，综合比较了该模型对整个流量序列还有高、中、低三个不同流量等级的校正水平，并从参数角度对预报结果进行深度解析。结果表明，原始ERRIS模型能够有效地校正径流预报误差，雅鲁藏布江流域奴下站整体径流的RmSE显著降低了41.5%；椒江流域沙段站低水流量预报的统计指标获得了超过40%的显著提升。但ERRIS对退水过程存在校正失效。ERRIS-LSTm能够显著改善ERRIS模型的校正不足，其中奴下站的NSE和RmSE指标得以进一步提升4.1%和67.7%，沙段站的NSE和RmSE指标亦进一步改善了1.1%和5.7%。尤其是中、低水流量等级，奴下站中水和低水的Pbias分别降低了75.5%和79.1%，降至2.6%和3.1%，沙段站低水流量的统计指标均进一步提升超过20%。ERRIS-LSTm生成的集合预报比ERRIS的预报整体精度更高，连续排序概率评分CRPS降低了75%以上，不确定性更小，且可靠性更高。LSTm的确定性校正结果在大多数情况下与ERRIS-LSTm的校正水平相当，但无法提供校正结果的不确定性信息。研究表明ERRIS-LSTm能够充分获取误差序列的时间序贯性，同时提供校正后的集合预报结果，校正精度高，在业务预报和防洪决策中具有重要的应用前景。

关键词：径流预报实时校正深度学习参数化误差模型

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Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： meichen Wang Kelly j Rivenbark Timothy D Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AmPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AmPA ***,clay-based sorption strategies for mixtures of GLP and AmPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AmPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(Cm)and acid processed montmorillonite(APm)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APm inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AmPA in soils and plants.

关键词： Glyphosate AmPA Adsorption Soil remediation Plant Hydroponic system

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城市水系统理论及其模型研制与应用

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中国科学：地球科学 2024年第3期54卷 725-744页

作者：夏军张永勇佘敦先张世彦杨军吕明权张翔罗安琪吴胜军刘阳中国科学院地理科学与资源研究所陆地水循环及地表过程重点实验室北京100101 武汉大学水资源与水电工程科学国家重点实验室武汉430072 中国科学院城市环境研究所城市环境与健康重点实验室福建省流域生态重点实验室水生态健康研究组厦门361021 中国科学院重庆绿色智能技术研究院重庆400714

城市水系统理论是流域水系统科学在城市尺度的拓展,为解决城市化引起的人水关系失衡和突出水问题(内涝、黑臭和水污染、生态退化等)提供了新的系统化解决方案.现有城市水系统相关研究大多关注水循环单一过程,对水循环及其伴生的物质循... 详细信息

城市水系统理论是流域水系统科学在城市尺度的拓展,为解决城市化引起的人水关系失衡和突出水问题(内涝、黑臭和水污染、生态退化等)提供了新的系统化解决方案.现有城市水系统相关研究大多关注水循环单一过程,对水循环及其伴生的物质循环、水生态以及人文等过程互馈机制仍需进一步探索.本文以流域水系统科学和水循环理论为基础,发展了城市水系统的概念、理论和技术体系;以城市多种下垫面条件下时变增益降雨-径流模型为核心,耦合自然-社会水循环及其伴生的水环境、水生态等过程和多尺度海绵措施的影响,研发了城市水系统5.0模型,实现了源头降雨-径流-面源污染负荷、排水管网系统水量水质转输、末端调蓄和净化、社会经济水循环、水系统评估和调控等五大关键模拟功能,成果已在武汉市开展示范应用.结果表明:城市水系统应以城市及其联系的河湖为研究对象,探索城市自然-人工侧支水循环和外江调蓄等耦合,以及社会经济发展、海绵措施对水量-水质-水生态等过程的调控机制.研发的城市水系统5.0模型很好地模拟了城区降雨-径流过程、水体总氮和总磷浓度、社会经济发展特征指标等.与实测数据对比,所有降雨-径流场次的相关系数和纳什效率系数分别处于优秀和良好等级;78.1%的实测点位中总氮和总磷浓度模拟偏差均在良好等级,且相关系数均在0.90以上;在18个社会经济发展特征指标中, 100%、83.3%和69.4%的指标偏差、相关系数和纳什效率系数均在优秀等级.在此基础上,优选源头海绵措施、人工强化措施和源头削减-路径拦截-末端治理等分别明显改善了内涝、水体黑臭和湖泊富营养化.其中10年一遇降雨条件下最大内涝淹没面积削减达32.6%,黑臭水体去除率为65%,水体综合营养指数降低了37%,武汉市2020年绿色发展水平也由现状条件下的0.56提升到了0.67,在城市绿色发展评估体系的五个维度(资源利用、环境质量、生态保护、经济增长和绿色生活)中,生态保护维度改善最明显.本研究将进一步推动城市水文学、环境科学和生态学等多学科领域的交叉和发展,也为我国城市复杂水问题的解决和绿色发展等提供重要的理论和技术基础.

关键词：城市水系统人水关系水问题绿色发展理论基础数学模型

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Storylines of family medicine Ⅶ: family medicine across the lifespan

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Family medicine and Community Health 2024年第S3期12卷 61-69页

作者： William B Ventres Leslie A Stone Katharine C Barnard Sara G Shields mark j Nelson maria Verónica Svetaz Clara m Keegan joel j Heidelbaugh Paige B Beck Lucille marchand Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA john Peter Smith Hospital Family medicine Residency Fort WorthTexasUSA Family and Community medicine Hennepin HealthcareMinneapolisMinnesotaUSA Family medicine University of Vermont Larner College of MedicineBurlingtonVermontUSA Family medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅶ:family medicine across the lifespan’,authors address the following themes:‘Family medicine maternity care’,‘Seeing children as patients brings joy to work’,‘Family medicine and the care of adolescents’,‘Reproductive healthcare across the lifespan’,‘men’s health’,‘Care of older adults’,and‘Being with dying’.may readers appreciate the range of family medicine in these essays.

关键词： life illustration family

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Polio eradication surveillance in Sri Lanka,2019-2023

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Asian Pacific journal of Tropical medicine 2024年第6期17卷 268-272页

作者： m.A.Y.Fernando N.S.madarasinghe C.Rangana N.Weerasinghe D.C.U.D.Weligamage j.I.Abeynayake Department of medical microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from january,2019 to may,2023 by the Polio Regional Reference Laboratory,Sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,Sri Lanka from january,2019 to may,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rRTPCR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from Sri Lanka(93.61%),maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while Sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,Sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

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One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei jiao Guang-Xin Zhang E.N.Cardozo B.Paes Shi-Peng Hu jian-Qiang Qian Daniele mengoni Wei-Wei Qu Cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang Chun-Lei Zhang j.j.Valiente-Dobón D.Testov m.mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou m.La Commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis m.Siciliano R.menegazzo S.m.Lenzi S.Akkoyun L.F.Canto j.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in Nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and manufacture of High Purity Germanium materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and material modification of ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly Department of Natural and mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 meV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

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Laboratory evaluation of toxicity of selected insecticides against egg and larval stages of cotton pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae)

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journal of Cotton Research 2024年第1期7卷 15-28页

作者： BUSNOOR Abhishek V. WADASKAR R.m. FAND Babasaheb B. TAmBE V.j. PILLAI T. mAHULE D.j. NAGRARE V.S. PRASAD Y.G. Entomology Section College of Agriculture(Dr.Panjabrao Deshmukh Krishi Vidyapeeth)Nagpur 440001MaharashtraIndia Indian Council of Agricultural Research-Central Institute for Cotton Research Nagpur 441108MaharashtraIndia

Background The cryptic nature of pink bollworm Pectinophora gossypiella(Saunders)larvae enables its reduced vul-nerability to insecticidal ***,the development of resistance against Bacillus thuringiensis(Bt)toxins posed a serious threat to transgenic cotton *** necessitated determining the critical timing of spray applications on the control *** study assessed the influence of egg age(freshly laid ***-day-old)and the loca-tion of larvae(directly exposed to the insecticide residues on the boll rind *** inside the bolls)on insecticide control *** The results revealed a significant decrease in the ovicidal activity of tested insecticides with an increase in the age of eggs from one day old to three days old(paired t-test,Pmore susceptible(>80%mortality)than the larvae exposed after they had bur-rowed inside the bolls(mortality).The inhibitory effects of tested insecticides on developmental biology were more pronounced in the experiment on pre-larval release insecticide treatment compared with insecticide treatment given post-larval release and entry inside the *** Egg age influences the insecticide susceptibility,as does the larval location,directly exposed vs bur-rowed inside the *** eggs and the larvae that had burrowed inside the green bolls of cotton were relatively less susceptible to the insecticide *** toxic effects of insecticides on egg and larval stages were primar-ily *** findings are significant for devising a comprehensive strategy for pink bollworm management on a sustainable basis.

关键词： Bioefficacy Cotton Insecticides Pink bollworm Pectinophora gossypiella Timings of spray

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