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Pedosphere 2009年第5期19卷 631-641页

作者： m.j.khan D.L.jONES Department of Soil and Environmental Sciences NWFP Agricultural UniversityPeshawar(Pakistan) School of Agricultural and Forest Sciences University of WalesBangorGwynedd LL57 2UW(UK)

Soil samples from a historic copper mine tailing site at the Parys mountain,North Wales(UK) were amended with green waste compost(GC),GC+30% sewage sludge(GCS),lime and diammonium phosphate(DAP),to determine the effect of amendments on DTPA-and Ca(NO3)2-extractable metals in the mine tailing and on the phytoavailability of heavy metals by a lettuce(Lactuca sativa L.).Both compost were added at the rate of 10% by weight,lime was added as calcium carbonate equivalent(pH = 7) and DAP at a 2300 mg kg-1 soil *** experiment was arranged in randomised complete design with three replicates in pots under control *** of lime resulted in the largest reduction in metal extractability with DTPA and Ca(NO3)2 and phytoavailability of Cu,Fe and Zn while DAP was effective in lowering Pb extractability and *** exception of Zn,all other metals extracted decreased with time after amendment *** distribution of heavy metals between and within the four procedures of potentially bioavailable sequential extraction(PBASE) varied significantly(P metals extracted with PBASE SE1 and Cu,Pb(P me is sufficient to restore the vegetative cover to a high metal mine waste while DAP is good for stabilizing Pb,but its detrimental role on plant growth and the risk associated with presence of N in DAP(through N leaching) may restrict its chances for remediation of contaminated sites.

关键词： lettuce metal uptake potentially bioavailable sequential extraction

Effect of Organic manure and Chemical Amendments on Soil Properties and Crop Yield on a Salt Affected Entisol

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Pedosphere 2005年第1期15卷 46-51页

作者： A.U.BHATTI Q.khan A.H.GURmANI m.j.khan DepartmentofSoilandEnvironmentalSciences NWFPAgriculturalUniversityPeshawarPakistan AridZoneResearchInstitute DeralsmailKhanNWFPPakistan

A field experiment was conducted for two consecutive years in a farmer's field at Haji mora Village, Dera Ismail khan (D.I. khan) in the Northwest Frontier Province (NWPP) of Pakistan to compare various management practices, such as the effect of various organic manures and gypsum in a rice-wheat cropping system on a saline-sodic Entisol (Zindani soil series). The treatments consisted of 1) a control (rice-wheat), 2) gypsum, 3) farmyard manure (FYm), 4) berseem (Trifolium alexzndrinum L.) as green manure (Gm), and 5) dhancha (Sesbania sp.) as Gm. All treatments increased yields of both rice and wheat significantly (P manure treatments proving more economical than the others; while they decreased pH, electrical conductivity (EC), and sodium adsorption ratio (SAR) of the soil. Saturation percentage and available water of the soil were raised for all treatments due to an increase in organic matter content of the soil.

关键词： berseem dhancha farm yard manure gypsum saline-sodic Entisol

Compatibility of salinomycin and tiamulin while dietary long-term co-administration in broiler along with chlortetracycline

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Compatibility of salinomycin and tiamulin while dietary long...

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

The 15th World Veterinary Poultry Congress

作者： K.m.S.Islam S.Afrin m.Valks P.m.Das m.m.Hassan m.j.khan Department of Animal Nutrition Bangladesh Agricultural UniversityMymensingh-2202Bangladesh. Department of Animal Nutrition Bangladesh Agricultural UniversityMymensingh-2202Bangladesh. International Brand manager（Poultry） Novartis Animal HealthPO Box 4002 BaselSwitzerland. Department of Pathology Bangladesh Agricultural UniversityMymensingh-2202Bangladesh Novartis Animal Health（Bangladesh）Limited House 50Road 2ADhanmondi R.A.Dhaka 1209Bangladesh. Department of Animal Nutrition Bangladesh Agricultural UniversityMymensingh-2202Bangladesh.

＜正＞The pleuromutilin antibiotic tiamulin（TIA）is known to produce negative interaction in broiler when ad- ministered in combination with several ionophore anticoccidials like salinomycin（SAL）.Chlortetracycline ...

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来源： cnki会议评论

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest miller School of medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Transient flow of magnetized maxwell nanofluid: Buongiorno model perspective of Cattaneo-Christov theory

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Applied mathematics and mechanics(English Edition) 2020年第4期41卷 655-666页

作者： m.khan A.AHmED j.AHmED Department of mathematics Quaid-i-Azam UniversityIslamabad 44000Pakistan Department of Basic Sciences University of Engineering and TechnologyTaxila 47050Pakistan

The present research article is devoted to studying the characteristics of Cattaneo-Christov heat and mass fluxes in the maxwell nanofluid flow caused by a stretching sheet with the magnetic field *** maxwell nanofluid is investigated with the impact of the Lorentz force to examine the consequence of a magnetic field on the flow characteristics and the transport of *** heat and mass transport mechanisms in the current physical model are analyzed with the modified versions of Fourier’s and Fick’s laws,***,the well-known Buongiorno model for the nanofluids is first introduced together with the Cattaneo-Christov heat and mass fluxes during the transient motion of the maxwell *** governing partial differential equations(PDEs)for the flow and energy transport phenomena are obtained by using the maxwell model and the Cattaneo-Christov theory in addition to the laws of *** transformations are used to convert the PDEs into a system of nonlinear ordinary differential equations(ODEs).The homotopic solution methodology is applied to the nonlinear differential system for an analytic *** results for the time relaxation parameter in the flow,thermal energy,and mass transport equations are discussed *** is noted that higher values of the thermal and solutal relaxation time parameters in the Cattaneo-Christov heat and mass fluxes decline the thermal and concentration fields of the ***,larger values of the thermophoretic force enhance the heat and mass transport in the ***,the Brownian motion of the nanoparticles declines the concentration field and increases the temperature *** validation of the results is assured with the help of numerical tabular data for the surface velocity gradient.

关键词： transient flow Cattaneo-Christov theory maxwell nanofluid Buongiorno model homotopy analysis method (HAm) solution

Thermal analysis in swirl motion of maxwell nanofluid over a rotating circular cylinder

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Applied mathematics and mechanics(English Edition) 2020年第9期41卷 1417-1430页

作者： A.AHmED m.khan j.AHmED Department of mathematics Quaid-i-Azam UniversityIslamabad 44000Pakistan Department of Basic Sciences University of Engineering and TechnologyTaxila 47050Pakistan

In this paper,the mechanism of thermal energy transport in swirling flow of the maxwell nanofluid induced by a stretchable rotating cylinder is *** rotation of the cylinder is kept constant in order to avoid the induced axially secondary ***,the novel features of heat generation/absorption,thermal radiation,and joule heating are studied to control the rate of heat *** effects of Brownian and thermophoretic forces exerted by the maxwell nanofluid to the transport of thermal energy are investigated by utilizing an effective model for the nanofluid proposed by *** whole physical problem of fluid flow and thermal energy transport is modelled in the form of partial differential equations(PDEs)and transformed into nonlinear ordinary differential equations(ODEs)with the help of the suitable flow *** acquired results through the technique bvp4c are reported graphically with physical *** analysis reveals that there is higher transport of heat energy in the maxwell nanoliquid for a constant wall temperature(CWT)as compared with the prescribed surface temperature(PST).Both thermophoretic and Brownian forces enhance the thermal energy transport in the flowing maxwell ***,the temperature distribution increases with increasing values of the radiation parameter and the Eckert *** is also noted that an increase in Reynolds number reduces the penetration depth,and as a result the flow and transport of energy occur only near the surface of the cylinder.

关键词： maxwell nanofluid rotating cylinder heat source/sink joule heating convective condition numerical solution

Boundary layer flow of maxwell fluid due to torsional motion of cylinder: modeling and simulation

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Applied mathematics and mechanics(English Edition) 2020年第4期41卷 667-680页

作者： m.khan A.AHmED j.AHmED Department of mathematics Quaid-i-Azam UniversityIslamabad 44000Pakistan Department of Basic Sciences University of Engineering and TechnologyTaxila 47050Pakistan

This paper investigates the boundary layer flow of the maxwell fluid around a stretchable horizontal rotating cylinder under the influence of a transverse magnetic *** constitutive flow equations for the current physical problem are modeled and analyzed for the first time in the *** torsional motion of the cylinder is considered with the constant azimuthal velocity *** partial differential equations(PDEs)governing the torsional motion of the maxwell fluid together with energy transport are simplified with the boundary layer *** current analysis is valid only for a certain range of the positive Reynolds ***,for very large Reynolds numbers,the flow becomes ***,the governing similarity equations are simplified through suitable transformations for the analysis of the large Reynolds *** numerical simulations for the flow,heat,and mass transport phenomena are carried out in view of the bvp4c scheme in *** outcomes reveal that the velocity decays exponentially faster and reduces for higher values of the Reynolds numbers and the flow penetrates shallower into the free stream *** is also noted that the phenomenon of stress relaxation,described by the Deborah number,causes to decline the flow fields and enhance the thermal and solutal energy transport during the fluid *** penetration depth decreases for the transport of heat and mass in the fluid with the higher Reynolds *** excellent validation of the numerical results is assured through tabular data with the existing literature.

关键词： torsional motion maxwell fluid magnetic field stretchable rotating cylinder bvp4c scheme

Pollution of water resources due to industrialization in arid zone of Rajasthan, India

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journal of Environmental Sciences 2001年第2期13卷 218-223页

作者： khan m A Central Arid Zone Research Institute 印度 342003

In arid zone of Rajasthan, India, nearly 21,900 hm2 area along Bandi River has been affected by industrial effluent discharge into the river bed. Analysis of groundwater samples collected from these sites revealed that area at the vicinity of the river is most affected. The effluent water in the river is the main source of contamination of ground water. Concentration of sodium and chloride has been higher with proportional increase in TDS and EC value in the area within zone A (river water), zone B (0-100 m), zone C (101-250 m), zone D (251-500 m) and zone E (501-1000 m). There is decreasing trend in ion concentration from zone A to zone E and F, reflecting reduced effect of effluents. The pollution of water resources has resulted in the degradation of other natural resources such as land, soil and vegetation. Nearly 4463 hm2 (20.38%) area has been very severely affected. EC value at places exceeds 20 dS/m. Soil and land have become hard, compact and saline. Cropping intensity has declined. In the area (3633 hm2) affected severely, the EC value of water varies from 10-20 dS/m. Irrigation with such water has created problem of salinity, sodicity in soils. Herbal biomass declined considerably. Double cropping has almost stopped. Almost 8494 hm2 area is affected moderately. EC of ground water varies from 5 to 10 dS/m. Fragile surface crust, declining trend of phosphorous and potassium in the soil, poor density of natural vegetation are significant manifestations. Apart from this, 5305 hm2 area is slightly affected.

关键词： India Pollution of water resources due to industrialization in arid zone of Rajasthan

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis