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Neurocircuit regeneration by extracellular matrix reprogramming

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Neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian N.Levasseur Kimberly m.Alonge Department of medicinal Chemistry University of WashingtonSeattleWAUSA Department of Chemistry University of WashingtonSeattleWAUSA Department of medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(ECm),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECm regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(miyata et al.,2012),cation buffering(moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECm indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

Experimental study on fly ash capture mercury in flue gas

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Science China(Technological Sciences) 2010年第4期53卷 976-983页

作者： mercedes Díaz-SOmOANO Patricia ABAD-VALLE m.Rosa mARTíNEZ-TARazONA Instituto Nacional del Carbón(CSIC)

Systematic experiments were conducted on a fixed-bed reactor to investigate the interaction between fly ash and mercury,the results implied that fly ash can capture mercury *** different fly ashes,the unburned carbon in the FA2 and FA3 fly ashes has the highest mercury capture capacity,up to 10.3 and 9.36 μg/g,respectively,which is close to that of commercial activated *** is no obvious relationship between mercury content and carbon content or BET surface area of fly *** classification standard was applied to distinguish fly ash carbon *** content is not the only variable that controls mercury capture on fly ash,there are likely significant differences in the mercury capture capacities of the various carbon *** capture capacity mainly depends on the content of anisotropy carbon particles with porous network structure.

关键词： mercury fly ash unburned carbon petrography adsorption

Stability analysis and soliton solutions of the(1+1)-dimensional nonlinear chiral Schrodinger equation in nuclear physics

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Communications in Theoretical Physics 2024年第9期76卷 1-15页

作者： Fazal Badshah Kalim U Tariq Ahmet Bekir S m Raza Kazmi Emad az-Zo'bi School of Electrical and Information Engineering Hubei University of Automotive TechnologyShiyan 442002China Department of mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey Department of mathematics and Statistics Faculty of ScienceMutah UniversityAlKarak 61710Jordan

The nonlinear Schrodinger equation equation is one of the most important physical models used in optical fiber theory to explain the transmission of an optical *** field of chiral soliton propagation in nuclear physics is very interesting because of its numerous applications in communications and ultra-fast signal routing ***(1+1)-dimensional chiral dynamical structure that describes the soliton behaviour in data transmission is dealt with in this work using a variety of in-depth analytical *** work has applications in particle physics,ionised science,nuclear physics,optics,and other applied mathematical *** are able to develop a variety of solutions to demonstrate the behaviour of solitary wave structures,periodic soliton solutions,chiral soliton solutions,and bell-shaped soliton solutions with the use of applied ***,in order to verify the scientific calculations,the stability analysis for the observed solutions of the governing model is taken into *** addition,the3-dimensional,contour,and 2-dimensional visuals are supplied for a better understanding of the behaviour of the *** employed strategies are dependable,uncomplicated,and effective;yet have not been utilised with the governing model in the literature that is now *** resulting outcomes have impressive applications across a large number of study areas and computational physics phenomena representing real-world *** methods applied in this model are not utilized on the given models in previous literature so we can say that these describe the novelty of the work.

关键词： solitons the nonlinear Schrodinger equation stability analysis chiral solitons exact solutions

modeling of Heat Transfer and Steam Condensation Inside a Horizontal Flattened Tube

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Fluid Dynamics & materials Processing 2022年第4期18卷 985-998页

作者： m.Gh.mohammed Kamil m.S.Kassim R.A.mahmood L.az mahdi mechanical Engineering Department Faculty of EngineeringMustansiriyah UniversityBaghdad10052Iraq School of mechanical and Electrical Engineering University of Southern QueenslandQueensland4350Australia Engineering Collage University of ZakhoZakho42002Iraq Energy and Renewable Energies Technology Center University of TechnologyBaghdad10066Iraq

This work investigates the steam condensation phenomena in an air-cooled *** considered horizontal flattened tube has a 30 mm hydraulic diameter,and its length is a function of the steam quality with a limit value between 0.95 and *** mass flow rate ranges from 4 to 40 kg/m^(2).s with a saturated temperature spanning an interval from 40°C to 80°C.A special approach has been implemented using the Engineering Equation Solver(EES)to solve a series of equations for the two-phase flow pattern and the related heat transfer coefficients.A wavy-stratified structure of the two-phase flow has been found when the mass rate was between 4 and 24 kg/m^(2).*** contrast,an initially annular flow is gradually converted into a wavy stratified flow(due to the condensation process taking place inside the flattened tube)when the considered range ranges from 32 to 40 kg/m^(2).s.

关键词： Condensation flow pattern structure heat transfer rate flow in horizontal pipe flow behaviour EES modelling

New records of bats from the northern region of the Peruvian Amazon

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Zoological Research 2011年第2期32卷 168-178页

作者： m mónica Díaz PIDBA(Program of Argentine Biodiversity Research) Faculty of Natural Science and Institute Miguel LilloNational University of Tucuman-PCMA(Program of Argentine Bat Conservation) CONICET(National Council of Scientific and Technical Research)Miguel Lillo205CP.4000TucumánArgentina

The northern Amazon Basin in Peru is one of the most diverse areas for small mammals in the *** this work,I present information related to the diversity of bat species in the Amazonian region of Iquitos,Peru,where nearly 60%of the 152 bat species known to Peru *** in previous investigations in this area,bat surveys were designed to detect species living in urban and rural *** results have added a new bat species（Eumops delticus）to the Peruvian fauna,eight new species for the region around Iquitos（Peropteryx macrotis,Peropteryx pallidoptera,Anoura caudifer,Lionycteris spurrelli,Vampyrum spectrum,Thyroptera lavali,Cynomops planirostris,and molossus coibensis）,and a new species for Northeast Peru（Eumops maurus）.

关键词： Chiroptera Iquitos Amazon Checklist

Overcast sky condition prevails on and influences the biometeorology of the tropical Andean Páramos

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Journal of mountain Science 2023年第1期20卷 78-86页

作者： Paola mONTENEGRO-DÍaz Rolando CELLERIALVEAR Galo CARRILLO-ROJAS Departamento de Recursos Hídricos y Ciencias Ambientales Universidad de CuencaCuenca010207Ecuador Facultad de Ingeniería Universidad de CuencaCuenca010207Ecuador Facultad de Ciencias Químicas Universidad de CuencaCuenca010207Ecuador

Clouds play a major role in modulating the biometeorological processes. We studied the influence of cloudiness on four biometeorological variables:daily air temperature(Tair), relative humidity(RH),reference evapotranspiration(ETr),and photosynthetic active radiation(PAR), recorded at four sites of Andean Páramos in southern Ecuador during 2.5 to 5.5 years. First, we quantified both the cloud cover percentage(Cloud%) creating cloud masks over the visible bands of Landsat 7 images and the sky condition(K_(T)) using the records of solar and extraterrestrial radiation. Second, we estimated KTfrom Cloud%. Finally, we quantified T_(air), RH, ET_(r), and PAR under clear, cloudy, and overcast K_(T) and their dependence on KT. The average Cloud% ranged between 65%–76%, and KTcorroborated the prevailing overcast sky(between 55% and 72.5% of the days) over the páramos. The proposed model performed well in the sites of calibration(R^(2)= 0.80;mBE = 0.00;RmSE = 0.05) and validation(R^(2)= 0.74;mBE =-0.07;RmSE = 0.11). The overcast sky diminished T_(air)(≤ 10℃), ET_(r)(≤ 1.6 mm day-1), and PAR(4 mJ m^(-2)day^(-1)) and increased RH(≥ 88%),while the variables showed the opposite behavior during the uncommon clear sky(≤ 5.5% of the days).Thus, mostly the dynamic of RH(R^(2)≥ 0.62), ETr(R^(2)≥ 0.85), and PAR(R2≥ 0.77) depended on K_(T). Hence,the prevailing overcast sky influenced the biometeorology of the páramos.

关键词： Cloudiness indicator Clearness index Satellite imagery Tropical Andes

Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco m Jesús Fernández Aceñero Luis Ortega medina Department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA molecular

Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan Antonio López-Villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de málaga y Plataforma en Nanomedicina(IBImA Plataforma Bionand) MálagaSpain

Oligodendrocytes(OLs),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,OLs provide trophic support to neurons and ***,OL metabolism is important for OL well-being and the proper accomplishment of their functions,and OL metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin

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Journal of Environmental Sciences 2013年第7期25卷 1408-1418页

作者： Gabriela V. Aguirre-martínez Sara Buratti Elena Fabbri Angel T. DelValls m. Laura martín-Díaz Unitwin/Unesco/WiCoP Physical Chemistry Department University of Cdiz Faculty of Marine and Environmental SciencesPolígono Río San Pedro s/n 11510 Puerto Real Cdiz Spain Andalusian Center for marine Science and Technology (CACYTmAR) Campus Universitariode Puerto Real11510 Puerto Real Cdiz Spain University of Bologna Interdepartment Centre for Research in Environmental Sciences (CIRSA)via S. Alberto 16348123 Ravenna Italy

Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability （LmS） has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LmS in Ruditapes philippinarum haemolymph using the neutral red retention assay （NRRA）. Clamswere exposed in laboratory conditions to caffeine （0.1, 5, 15, 50 μg/L）, ibuprofen （0.1, 5, 10, 50 μg/L）, carbamazepine and novobiocin （both at 0.1, 1, 10, 50 μg/L） for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations （p 〈 0.05）（caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L）, compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status （retention time 〈45 min）, significantlyworse than controls （96 min）（p 〈 0.05）. The predicted no environmental effect concentration （PNEC） results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. measurement of the alteration of LmS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker.

关键词： neutral red pharmaceuticals bioassay haemolymph bivalves health status manila clam