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High Power Laser Science and Engineering 2019年第1期7卷 10-16页

作者： J.Jarrett m.King R.J.Gray N.Neumann L.Dhl C.D.Baird T.Ebert m.hesse A.Tebartz D.R.Rusby N.C.Woolsey D.Neely m.Roth P.mcKenna Department of Physics SUPA University of Strathclyde Institut f¨ur Kernphysik Technische Universit?t Darmstadt York Plasma Institute University of York STFC-Rutherford Appleton Laboratory Institut fur Kernphysik Technische Universit?t Darmstadt

The spatial-intensity profile of light reflected during the interaction of an intense laser pulse with a microstructured target is investigated experimentally and the potential to apply this as a diagnostic of the interaction physics is explored numerically. Diffraction and speckle patterns are measured in the specularly reflected light in the cases of targets with regular groove and needle-like structures, respectively, highlighting the potential to use this as a diagnostic of the evolving plasma surface. It is shown, via ray-tracing and numerical modelling, that for a laser focal spot diameter smaller than the periodicity of the target structure, the reflected light patterns can potentially be used to diagnose the degree of plasma expansion, and by extension the local plasma temperature, at the focus of the intense laser light. The reflected patterns could also be used to diagnose the size of the laser focal spot during a high-intensity interaction when using a regular structure with known spacing.

关键词： high power laser laser-solid interactions plasma temperature diagnosis

Hydrochemistry, Origin and Evolution of Sedimentary Subsurface Fluids:——Ⅱ. Early diagenetic pore-water evolution in high sedimentation-rate offshore basins

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Acta Geochimica 1987年第1期6卷 1-18页

作者： REINHARD hesse Department of Geological Sciences mcGill University montreal Quebec H3A 2A7 Canada

High sedimentation-rate basins are characteristic of the continental margins, where sedimentation ratesup to 500m/ma and more are no exception. The sediments are rich in organic matter and undergo awell-established sequence of bacterial oxidation reactions, starting at the sediment/water interface with:（1）the oxidation zone （absent in euxinic basins）, which is followed downwards by （2） the nitrate reduction zone,（3） the sulfate reduction zone, （4） the carbonate reduction zone, （5） the fermentation zone and （6） thedecarboxylation zone, which marks the onset of thermocatalytic reactions characteristic of the intermediatestage （and deeper stages） of diagenesis. This sequence of bacterially mediated organic-matter decomposition reactions in rapidly depositedsediments on the continental margins is well reflected in the vertical trends of pore-water chemistry. Carbonisotopic fractionation permits to distinguish between zones （1） to （3） with negative δ;C values for the CO;generated, and between zones （4） and （5） with increasingly heavier carbon-isotopes in CO;(up to + 15 to+ 25‰δ;C). The formation of gas-hydrates causes characteristic chemical and isotopic signatures in porewaters retrieved from hydrate-beating sediments. After hydrate decomposition （in the sampling process orat the base of hydrate zones） marked chlorimity decreases accompanied by increases in heavy oxygenisotopes are observed. These are distinctly different from the effects of meteoric water influx, which are notaccompanied by positive δ;O values. The opposite trend of increasing salinity at shallow burial depths,rather than pore-waters freshening, is observed in the vicinity of evaporites.

关键词： Origin and Evolution of Sedimentary Subsurface Fluids Early diagenetic pore-water evolution in high sedimentation-rate offshore basins Hydrochemistry rate high

Analysis on variety and characteristics of maghemite

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Science China Earth Sciences 2010年第8期53卷 1153-1162页

作者： SHAW John BLOEmENDAL Jan hesse Paul ROLPH Tim Department of Earth Sciences University of Liverpool Department of Geography University of Liverpool Department of Environment and Geography Macquarie University Department of Geology University of Newcastle

maghemite (γ-Fe2O3) is a very common mineral at the earth’s surface and also an important material for making music and video tapes. maghemite is usually synthesized from magnetite under oxidizing conditions after a few hours or a few days below a temperature of 300°C. The magnetic property of thermal instability and the chemical action after heating is an important character for maghemite. That is, it will become hematite in certain proportion after being heated above 250°C. maghemite is therefore actually unable to have its Curie temperature measured. But late using synthetic sample, maghemite was further found partially thermal stable with a measurable Curie temperature ~645°C. During our thermally magnetic experiments for a set of synthetic magnetite, we found that extra fined grain size (pseudo single domain (PSD) and small multi-domain (mD), mainly 1-10 μm) magnetite was formed to a completely thermally stable maghemite. This maghemite can also be produced by heating the same powder up to 700°C in an oven and keeping this temperature for 10 min, then cooling it down. When the generated maghemite by these two ways is heated from room temperature to 700°C, it shows almost fully reversible, or thermally stable. We used X-ray powder diffraction and mssbauer spectroscopy to confirm the identity of this maghemite and compared its magnetic hysteresis, high temperature magnetization, low temperature thermal demagnetization, and low temperature susceptibility with those of the original preheated magnetite. Such quickly oxidized maghemite by heating to high temperature implies some types of maghemite formed in certain natural condition can carry a thermal remnant magnetization (TRm). Four types of maghemite were characterized and discussed according to their thermal stability. Among them, partially stable and fully thermally stable maghemite after heating should possess capability of carrying TRm. There is possibly a compensation of synthetizing maghemite between heatin

关键词： maghemite paleomagnetism environmental magnetism magnetic mineral thermal stability TRm

Synchrotron microtomography reveals insights into the degradation kinetics of bio-degradable coronary magnesium scaffolds

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Bioactive materials 2024年第2期32卷 1-11页

作者： Roman menze Bernhard hesse maciej Kusmierczuk Duote Chen Timm Weitkamp Stephanie Bettink Bruno Scheller meKo manufacturing e.K. Im Kirchenfelde 12-1431157SarstedtGermany Xploraytion GmbH Bismarckstr.10-1210625BerlinGermany Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190Saint-AubinFrance InnoRa GmbH Robert-Koch-Platz 410115BerlinGermany Universität des Saarlandes Campus Homburg66421HomburgGermany

Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis,especially for young *** to the degradation of these scaffolds(<1 year),long-term device-related clinical events c... 详细信息

Bioresorbable magnesium scaffolds are a promising future treatment option for coronary artery stenosis,especially for young *** to the degradation of these scaffolds(m device-related clinical events could be reduced compared to treatments with conventional drug eluting *** clinical trials indicate a return of vasomotion after one year,which may be associated with improved long-term clinical ***,even after decades of development,the degradation process,ideal degradation time and biological response in vivo are still not fully *** present study investigates the in vivo degradation of magnesium scaffolds in the coronary arteries of pigs influenced by different strut thicknesses and the presence of antiproliferative *** to high 3D image contrast of synchrotron-based micro-CT with phase contrast(SR-μCT),a qualitative and quantitative evaluation of the degradation morphology of magnesium scaffolds was *** the segmentation of theμCT images a convolutional network architecture(U-net)was exploited,demonstrating the huge potential of merging high resolution SR-μCT with deep learning(DL)supported data *** total,30 scaffolds,made of the rare earth alloy Resoloy^(®),with different strut designs were implanted into the coronary arteries of 10 domestic pigs for 28 days using drug-coated or uncoated angioplasty balloons for *** degradation morphology was analyzed using scanning electron microscopy,energy dispersive x-ray spectroscopy and SR-μ*** data from these methods were then related to data from angiography,optical coherence tomography and histology.A thinner strut size(95 vs.130μm)and the presence of paclitaxel indicated a slower degradation rate at 28 d in vivo,which positively influences the late lumen loss(0.5 and 0.6 mm vs.1.0 and 1.1 mm)and recoil values(0 and 1.7%vs.6.1 and 22%).

关键词： Resoloy magnesium scaffold DCB Paclitaxel Degradation Inflammation Artificial intelligence

mrchen vom Korbstuhl

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德语学习 2008年第2期 10-15页

作者： Hermann hesse

Hermann hesse wurde a m *** 1877 in Calw/Wrttemberg als Sohn eines baltendeutschen missionars und einer wrttembergischen missionarstochter

关键词：德语学习方法阅读训练教学方法

A review of potential conservation and fisheries benefits of breaching four dams in the Lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller Charles E.Petrosky Robert L.Vadas Jr. Benjamin J.Clemens Gary Sprague Norman mercado-Silva Brett Roper michael J.Parsley Edward Bowles Robert m.Hughes Jay A.hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)Snake River Basin Pacific Lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

心脏多层CT对冠状窦与二尖瓣环和冠状动脉左旋支解剖学关系的在体分析:在经皮冠状窦二尖瓣环成形术中的应用

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 57-58页

作者： Choure A.J. Garcia m.J. hesse B. S.R.Kapadia 刘少伟 Department of Cardiovascular medicine Cleveland ClinicClevelandOHUnited States Dr.

目的:本研究旨在用心脏CT确定二尖瓣环(mA)与冠状窦(CS)以及CS与冠状动脉左旋支(LCX)之间的在体解剖学关系。背景:目前。

关键词：瓣环成形术左旋支二尖瓣环冠状窦解剖学特点二尖瓣反流二尖瓣脱垂标测后位发展阶段

WONCA研究论文摘要汇编——针灸用于剖宫产术后的疼痛控制:一项前瞻性观察试点研究

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中国全科医学 2016年第12期 1466-1466页

作者： hesse T Henkel B Zygmunt m 本刊编辑部

目的剖宫产术后患者镇痛药物的选择较为有限,而针灸有望成为术后镇痛的方法。在这一前瞻性观察试点研究中,对针灸作为剖宫产术后的附加镇痛方法的可行性与可接受性进行研究。方法根据纳入标准,纳入22例计划在脊髓麻醉下进行选择性剖宫... 详细信息

目的剖宫产术后患者镇痛药物的选择较为有限,而针灸有望成为术后镇痛的方法。在这一前瞻性观察试点研究中,对针灸作为剖宫产术后的附加镇痛方法的可行性与可接受性进行研究。方法根据纳入标准,纳入22例计划在脊髓麻醉下进行选择性剖宫产的患者。按照以往术后镇痛的验证施针方法,利用20个内在固定针,进行耳压结合体穴针刺。采用11级主诉疼痛分级法(VRS-11,0分为无疼痛,10分为最大痛感)评估疼痛强度;记录镇痛相关不良反应、剖宫产术后的移动和导尿管移除时间;运用VRS-5(1分为最佳,5分为最差)对患者的治疗依从性和满意度进行评估。结果在最终分析中,共纳入20例患者。1例患者在施针处感觉异常,其他患者的施针状态良好。术后第1天移动时的疼痛强度为(4.3±2.4)分,出院当天下降至(2.2±1.2)分。患者的满意度为(1.9±0.8)分,依从性得分为(1.5±0.5)分(由护士打分)。结论针灸作为剖宫产术后的附加镇痛方法的接受度较好。

关键词：针灸剖宫产术后 WONCA 试点研究

managing stress granule disassembly with ubiquitin and its cousin

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3377-3378页

作者： Stefan müller Institute of Biochemistry II Gustav Embden ZentrumGoethe University FrankfurtFaculty of MedicineFrankfurtGermany

Recently,maxwell et al.1 revealed a critical function of ubiquitylation in stress granule(SG)disassembly upon recovery from heat *** are continuously exposed to endogenous or environmental *** stress endangers DNA integrity,whereas proteotoxic stress causes an imbalance in protein homeostasis(proteostasis).Genotoxic insults activate DNA damage response pathways that halt the cell-cycle progression and initiate DNA *** quality control(PQC)systems in turn safeguard the integrity of the proteome and prepare for the restart of cellular activities upon stress *** genome and proteome integrity pathways are orchestrated by ubiquitin signaling and the ubiquitin-proteasome system(UPS).

关键词： stress aging integrity

2-aminoethyl Dihydrogen Phosphate as a modulator of Proliferative and Apoptotic Effects in Breast Cancer Cell Lines

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Journal of Pharmacy and Pharmacology 2021年第3期9卷 83-97页

作者： manuela Garcia Laveli da Silva Laertty Garcia de Sousa Cabral monique Gonçalves Alves Thais deOliveira Conceição Henrique hesse Rosa Andrea Nogueira Laiso Daniel da Conceição Rabelo Durvanei Augusto maria Development and Innovation Laboratory Butantan InstituteSao PauloSP 05503-900Brazil Faculty of medicine University of São PauloSao PauloSP 01246-000Brazil

Background: Breast cancer is a type of cancer that affects more women throughout the world, in developing anddeveloped countries. 2-AEH2P is a phospholipid analog of cellular membrane, which makes it different from existing molecules fortheir absorption, stability and display anti-inflammatory, anti-proliferative and pro-apoptotic properties. methods: mCF-7 humanbreast adenocarcinoma cells were treated with 2-AEH2P. The viability and adhesion cells were evaluated by mTT assay. Cell cyclephases, apoptosis, markers and mitochondrial potential were assessed by flow cytometry. morphological ultrastructural analyzeswere performed by laser confocal microscopy. Results: mCF-7 Tumor cells acquired round shapes, lost cytoplasmic expansions,formed clusters in suspension and decreased significantly viability. There were changes in the morphology, membrane fragmentationand loss of cytoplasmic projection. The obtained concentrations for IC50% were 37.2;25.8;1.8 mm for periods of 24, 48 and 72 h,respectively. Changes in the distribution of cell population phases of the cell cycle showed an increase in fragmented DNA and anincrease in the G2/m phase. The expression β-gal showed proliferative reduction induced by 2-AEH2P. Laser confocal microscopyshowed changes in the mitochondrial membrane and alteration in distribution. Proliferative index of mCF-7 tumor cells treated with2-AEH2P decreased significantly when compared to fibroblast normal cells. The compound 2-AEH2P is a phospholipid withantiproliferative potential and apoptosis modulator.

关键词： Human Breast Adenocarcinoma mCF-7 2-AEH2P Antitumor Apoptosis Cell cycle Senescence