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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia guglielmo Patelli Ali mohamed margherita Piccolella mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

具有230μm空间分辨率可覆盖全心的CT扫描对房颤病人冠状动脉CT成像诊断准确性的研究

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国际医学放射学杂志 2017年第6期 711-711页

作者： D.Andreini G.Pontone S.mushtag E.Conte m.Perchinunno m.guglielmo 文娣娣 Department of Clinical Sciences and Community Health Cardiovascular Section IRCCS

摘要目的以有创性冠状动脉造影(ICA)为参考标准,评估具有16 cm全心覆盖及230μm空间分辨率的CT对房颤病人冠状动脉CT血管成像(CTA)的影像质量、可读性、诊

关键词：冠状动脉 CTA 房颤病人 CT 诊断准确性空间分辨率 230

ADV36 adipogenic adenovirus in human liver disease

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World Journal of Gastroenterology 2014年第40期20卷 14706-14716页

作者： Francesca m Trovato Daniela Catalano Adriana Garozzo G Fabio martines Clara Pirri guglielmo m Trovato Department of medical anPediatric Sciences Internal Medicine University of Catania95100 Catania Italy Department of Biomedical Science University of Catania 95100 Catania Italy

obesity and liver steatosis are usually described as related *** is regarded as exclusive consequence of an imbalance between food intake and physical exercise,modulated by endocrine and genetic ***-alcoholic fatty liver disease(NAFLD),is a condition whose natural history is related to,but not completely explained by over-nutrition,obesity and insulin *** is evidence that environmental infections,and notably adipogenic adenoviruses(ADV)infections in humans,are associated not only with obesity,which is sufficiently established,but also with allied conditions,such as fatty *** order to elucidate the role,if any,of previous ADV36 infection in humans,we investigated association of ADV36-ADV37 seropositivity with obesity and fatty liver in ***,the possibility that lifestyle-nutritional intervention in patients with NAFLD and different ADV36 seropositive status,achieves different clinical outcomes on ultrasound bright liver imaging,insulin resistance and obesity was ***36 seropositive patientshave a more consistent decrease in insulin resistance,fatty liver severity and body weight in comparison with ADV36 seronegative patients,indicating a greater responsiveness to nutritional *** effects were not dependent on a greater pre-interventional body weight and older *** results imply that no obvious disadvantage-and,seemingly,that some benefit-is linked to ADV36 seropositivity,at least in ***36 previous infection can boost weight loss and recovery of insulin sensitivity under interventional treatment.

关键词： Non-alcoholic fatty liver disease Human adenovirus 36 Obesity Insulin resistance mediterranean diet Ultrasound

Non-alcoholic fatty liver disease and Atherosclerosis at a crossroad:The overlap of a theory of change and bioinformatics

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World Journal of Gastrointestinal Pathophysiology 2020年第3期11卷 57-63页

作者： guglielmo m Trovato Department of Clinical and Experimental medicine the School of Medicine of the University of CataniaCatania 95125Italy

Atherosclerosis(ATH)and non-alcoholic fatty liver disease(NAFLD)are medical conditions that straddle a communal epidemiology,underlying mechanism and a clinical syndrome that has protean manifestations,touching every organ in the *** twin partners,ATH and NAFLD,are seemingly straightforward and relatively simple topics when considered alone,but their interdependence calls for more *** study of the mutual relationship of NAFLD and ATH should involve big data analytics approaches,given that they encompass a constellation of diseases and are related to several recognized risk factors and health determinants and calls to an explicit theory of change,to justify *** studies on the“association between aortic stiffness and liver steatosis in morbidly obese patients”,published recently,sparsely hypothesize new mechanisms of disease,claiming the“long shadow of NAFLD”as a risk factor,if not as a causative factor of arterial stiffness and *** statement is probably overreaching the argument and harmful for the scientific credence of this area of *** the verification that NAFLD and cardiovascular disease are strongly interrelated,current evidence is that NAFLD may be a useful indicator for flagging early arteriosclerosis,and not a likely causative *** sustainable contribution by precision medicine tools,by validated bioinformatics approaches,is needed for substantiating conjectures,assumptions and inferences related to the management of big data and addressed to intervention for behavioral changes within an explicit theory of change.

关键词： Non-alcoholic fatty liver disease Fatty liver Arterial stiffness Bioinformatics methodology of research

Thoracic ultrasound: A complementary diagnostic tool in cardiology

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World Journal of Cardiology 2016年第10期8卷 566-574页

作者： guglielmo m Trovato Department of Clinical and Experimental medicine The University Hospital of the University of Catania

Clinical assessment and workup of patients referred to cardiologists may need an extension to chest disease. This requires more in-depth examination of respiratory co-morbidities due to uncertainty or severity of the clinical presentation. The filter and integration of ecg and echocardiographic information, addressing to the clues of right ventricular impairment, pulmonary embolism and pulmonary hypertension, and other less frequent conditions, such as congenital, inherited and systemic disease, usually allow more timely diagnosis and therapeutic choice. The concurrent use of thoracic ultrasound (TUS) is important, because, despite the evidence of the strict links between cardiac and respiratory medicine, heart and chest US imaging approaches are still separated. Actually, available expertise, knowledge, skills and training and equipment’s suitability are not equally fitting for heart or lung examination and not always already accessible in the same room or facility. Echocardiography is useful for study and monitoring of several respiratory conditions and even detection, so that this is nowadays an established functional complementary tool in pulmonary fibrosis and diffuse interstitial disease diagnosis and monitoring. Extending the approach of the cardiologist to lung and pleura will allow the achievement of information on pleural effusion, even minimal, lung consolidation and pneumothorax. Electrocardiography, pulse oximetry and US equipment are the friendly extension of the physical examination, if their use relies on adequate knowledge and training and on appropriate setting of efficient and working machines. Lacking these premises, overshadowing or misleading artefacts may impair the usefulness of TUS as an imaging procedure.

关键词： Thoracic ultrasound Echocardiography Congestive heart failure Pneumonia Pleural effusion Cancer Pneumothorax Clinical risk management

Neglected features of lifestyle: Their relevance in nonalcoholic fatty liver disease

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World Journal of Hepatology 2016年第33期8卷 1459-1465页

作者： Francesca m Trovato Giuseppe Fabio martines Daniela Brischetto guglielmo Trovato Daniela Catalano Department of Clinical and Experimental medicine Postgraduate School of Clinical Echo-graphythe University of Catania Clinical Research and Innovation Project Planning Unit the School of Medicine and AOU Policlinicothe University of Catania Department of medicine the School of Medicine of the University of Catania

AImTo investigated in non-alcoholic-fatty-liver-disease (NAFLD), with ultrasound (US)-detected fatty liver, and in a group of non-alcoholic and otherwise healthy subjects, relationship of neglected features of lifestyle with NAFLD and obesity. mETHODSFive hundred and thirty-two NAFLD and 667 non-NAFLD healthy subjects, age 21-60 years were studied. Severity of liver steatosis was assessed by US bright liver score. The adherence to mediterranean diet score (AmDS) was assessed on the basis of a 1-wk recall computerized questionnaire which included a detailed physical activity reports (Baecke questionnaire). The western dietary profile score, as a simplified paradigm of unhealthy diet, a questionnaire quantifying sun exposure score and a sleep habits questionnaires provided a further comprehensive lifestyle assessment. RESULTSBody mass index (BmI), insulin resistance (HOmA), and triglycerides, poorer adherence to a mediterranean diet profile, sedentary habits, minor sun exposure and use of “western diet” foods are greater in NAFLD. multiple linear regression analysis, weighted by years of age, displays BmI, HOmA and AmDS as the most powerful independent predictors of fatty liver severity; however, also the physical activity score, the western diet habit and the sun exposure score are acting inside the model with significant independent effects. CONCLUSIONArticulated clinical intervention, according to our results, are justified in NAFLD and can be pursued addressing by focused intervention nutritional profile, physical exercise mainly in open-air subsets for enhancing sun exposure and healthier sleep duration and rhythm.

关键词： Fatty liver Ultrasound Diet malnutrition Sleep Clinical risk management Health psychology Sun exposure Obesity

Challenges of liver cancer:Future emerging tools in imaging and urinary biomarkers

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World Journal of Hepatology 2015年第26期7卷 2664-2675页

作者： Francesca m Trovato Joshua m Tognarelli mary mE Crossey Daniela Catalano Simon D Taylor-Robinson guglielmo m Trovato Dipartimento di medicina Clinica e Sperimentale Scuola di Medicina Università di Catania Department of medicine Imperial College London St Mary’s Campus

Chronic liver disease has become a global health problem as a result of the increasing incidence of viral hepatitis, obesity and alcohol misuse. Over the past three decades, in the United Kingdom alone, deaths from chronic liver disease have increased both in men and in women. Currently, 2.5% of deaths worldwide are attributed to liver disease and projected figures suggest a doubling in hospitalisation and associated mortality by 2020. Chronic liver diseases vary for clinical manifestations and natural history, with some individuals having relatively indolent disease and others with a rapidly progressive course. About 30% of patients affected by hepatitis C has a progressive disease and develop cirrhosis over a 20 years period from the infection, usually 5-10 years after initial medical presentation. The aim of the current therapeutic strategies is preventing the progression from hepatitis to fibrosis and subsequently, cirrhosis. Hepatic steatosis is a risk factor for chronic liver disease and is affecting about the half of patients who abuse alcohol. moreover non-alcoholic fatty liver disease is part of the metabolic syndrome, associated with obesity, hypertension, type Ⅱ diabetes mellitus and dyslipidaemia, and a subgroup of patients develops non-alcoholic steatohepatitis and fibrosis with subsequent cirrhosis. The strengths and pitfalls of liver biopsy are discussed and a variety of new techniques to assess liver damage from transient elastography to experimental techniques, such as in vitro urinary nuclear magnetic resonance spectroscopy. Some of the techniques and tests described are already suitable for more widespread clinical application, as is the case with ultrasound-based liver diagnostics, but others, such as urinary metabonomics, requires a period of critical evaluation or development to take them from the research arena to clinical practice.

关键词： Virus hepatitis Liver cancer Ultrasound Fibrosis U

Thoracic ultrasound: An adjunctive and valuable imaging tool in emergency,resource-limited settings and for a sustainable monitoring of patients

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World Journal of Radiology 2016年第9期8卷 775-784页

作者： Francesca m Trovato Daniela Catalano guglielmo m Trovato Accident and Emergency Department Ospedale Civile Department of Clinical and Experimental medicine University of Catania Postgraduate School of Clinical Echography AOU Policlinico of the University of Catania Clinical Research and Innovation Project Planning Unit AOU Policlinico of the University of Catania

Imaging workup of patients referred for elective assessment of chest disease requires an articulated approach: Imaging is asked for achieving timely diagnosis. The concurrent or subsequent use of thoracic ultrasound(TUS) with conventional(chest X-rays-) and more advanced imaging procedures(computed tomography and magnetic resonance imaging) implies advantages, limitations and actual problems. Indeed, despite TUS may provide useful imaging of pleura, lung and heart disease, emergency scenarios are currently the most warranted field of application of TUS: Pleural effusion, pneumothorax, lung consolidation. This stems from its role in limited resources subsets; actually, ultrasound is an excellent risk reducing tool, which acts by:(1) increasing diagnostic certainty;(2) shortening time to definitive therapy; and(3) decreasing problems from blind procedures that carry an inherent level of complications. In addition, paediatric and newborn disease are particularly suitable for TUS investigation, aimed at the detection of congenital or acquired chest disease avoiding, limiting or postponing radiological exposure. TUS improves the effectiveness of elective medical practice, in resource-limited settings, in small point of care facilities and particularly in poorer countries. Quality and information provided by the procedure are increased avoiding whenever possible artefacts that can prevent or mislead the achievement of the correct diagnosis. Reliable monitoring of patients is possible, taking into consideration that appropriate expertise, knowledge, skills, training, and even adequate equipment's suitability are not always and everywhere affordable or accessible. TUS is complementary imagingprocedure for the radiologist and an excellent basic diagnostic tool suitable to be shared with pneumologists, cardiologists and emergency physicians.

关键词： Thoracic ultrasound Pneumonia Pleural effusion Pneumothorax Clinical risk management Overdiagnosis Wastebasket diagnosis

The Potentialities of the Expressive and Gestual Language

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Journal of Health Science 2016年第3期4卷 160-165页

作者： Giuliana De Rosa Caterina Francone guglielmo De Rosa Patrizia Bruno Educator A.m.N.E.S.LA. Villaricca Corso Italia 395 Napoli Italia Psychologist-A.m.N.E.S.I.A. Villaricea Corso Italia 395 Napoli Italia Geriatrician-UVA DS 35-37ASL NA2Nord Pozzuoli Via Corrado Alvaro 7 Napoli Italia

The aim of this work is to integrate the Educative intervention to Scientific research in support of the biological, psychological, social and economic discomfort of the Person affected by cognitive deficit. The specific objective is to stimulate the retained cognitive, emotive and motor abilities, educating to the theatricality through the establishment of a theatrical laboratory. Our experience was conducted with a group of elderly people affected by neuro-geriatric pathologies with medium-high cognitive decay. The encounters took place in the home of one of the members of the group. Fundamental was the actualisation of the process of individual and collective empowerment. They started with social activities and viewings of film scenes with Charlie Chaplin, actor to be observed, picked by the activities＇ participants. Finally, there was a re-enacting of a ＂wordless＂ scene through the reading of simple sentences to express in sign language. The parameters taken into consideration during the qualitative analysis are： attention, learning, expressivity and motor capabilities, measured at every encounter through a Likert scale of evaluation created ad hoc, directly proportional to the level of adequacy of the single ability. In conclusion, the maximum of scored points manifested itself in the attention and expressivity items.

关键词： Cognitive discomfort communicability theatre emotions mnemonic stimuli empowerment.