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Low-dose X-ray induced long afterglow NIR luminescence from cr3+ doped Zn1-xcdxGa2O4 spinel solid solutions

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Journal of Rare Earths 2025年第2期43卷 246-252页

作者： Tingting Zhao Wenzhi Sun Shuya Wang Wei meng chunqing fu Xiaoyan fu Hongwu Zhang School of chemistry and material Sciences Ludong University college of materials Science and Engineering Xiamen University of Technology

The low-dose X-ray induced long afterglow near infrared（NIR） luminescence from cr3+doped Zn1-xcdxGa2O4spinel solid solutions was *** structure analysis shows the good formation of Zn1-xcdxGa2O4spinel solid solutions,which possesses a cubic spinel structure with Fd3m space *** formation of Zn1-xcdxGa2O4spinel solid solutions induces the obvious increase of long afterglow near infrared luminescence excited by low-dose X-ray,When the content of doped cd2+reaches 0.1,the low-dose X-ray induced long afterglow NIR luminescence is the *** importantly,only 5 s Xray irradiation can induce more than 6 h NIR afterglow emission,of which the afterglow luminescent intensity is still 5 times stronger than the background intensity after 6 *** thermoluminescent results show that under the 5 s exposure of X-ray,the trap density of Zn0.9cd0.1Ga2O4:cr3+is much higher than that of ZnGa2O4:cr3+.The replacement of cd2+ions with large radius at Zn2+sites causes the increase of de fects and dislocations,which results in the obvious increase of trap co *** the addition of high-z number elements cd2+would enhance the X-ray absorption of the solid solutions,which thus can be easily excited by low-dose ***0.9cd0.1Ga2O4:1%cr3+solid solution is a potential candidate of lowdose X-ray induced long afterglow luminescent materials.

关键词： Phosphors Rare earths Solid solutions X-ray induced long afterglow luminescence Zn1–xcdxGa2O4:1%cr3+

catalytic detoxification of mitoxantrone by graphitic carbon nitride(g-c_(3)N_(4))supported Fe/Pd bimetallic nanoparticles

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Journal of Environmental Sciences 2025年第2期148卷 614-624页

作者： Qianyu Xu Haoyang fu Jiyuan Gu Liyu Lei Lan Ling State Key Laboratory for Pollution control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China

The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs,causing detrimental ecological effects,which have attracted attention towards effective and sustainable methods for antibiotics and antitumor drug ***,the hybrid nanomaterial(g-c_(3)N_(4)@Fe/Pd)was synthesized and used to remove a kind of both an antibiotic and antitumor drug named mitoxantrone(mTX)with 92.0%removal efficiency,and the mTX removal capacity is 450 mg/*** exposing to the hybrid material the mTX aqueous solution changed color from dark blue to lighter progressively,and Lc-UV results of residual solutions showthat a newpeak at 3.0min(mTX:13.2min)after removal by g-c_(3)N_(4)@Fe/Pd appears,with the simultaneous detection of intermediate products indicating that g-c_(3)N_(4)@Fe/Pd indeed degrades *** mass spectrometric analysis suggests that the nuclear mass ratio decreased from 445.2(m+1H)to 126.0(m+1H),169.1(m+1H),239.2(m+1H),267.3(m+1H),285.2(m+1H),371.4(m+1H)and 415.2(m+1H),and the maximum proportion(5.63%)substance of all degradation products(126.0(m+1H))is 40-100 times less toxic than mTX.A mechanism for the removal and degradation of mitoxantrone was ***,actual water experiments confirmed that the maximum removal capacity of mTX by g-c_(3)N_(4)@Fe/Pd is up to 492.4 mg/g(0.02 g/L,10 ppm).

关键词： degradation Lc-QTOF-mS Nanoparticles mitoxantrone Aqueous solution

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang daniel fu Alison N.deVore marisol Lauffer Nilufer S.Atasoy deniz Atasoy Rory A.Fisher department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural circuits and Behavior core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Theoretical Study on cO_(2)Hydrogenation on In_(2)O_(3)(111)Supported Single-Atom catalysts:Horiuti-Polanyi versus Non-Horiuti-Polanyi mechanism

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chinese Journal of chemical Physics 2025年第1期38卷 54-62,I0055,I0056页

作者： Xiang Li Gang fu State Key Laboratory for Physical chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

In the field of catalytic hydro-genation,two primary mecha-nistic pathways,namely the Ho-riuti-Polanyi(HP)mechanism and the non-HP mechanism,have been extensively *** understandings suggested that the non-HP mechanism preferred to occur on the coinage metal surfaces,such as copper,silver,and gold,which exhibited low activity towards H_(2) ***,we offered a detailed theoretical investigation into the mechanisms of cO_(2)hydrogenation to formic acid on m_(1)-In_(2)O_(3)(111)surfaces,using density functional theory *** calculations provided novel in-sights into the preference of the non-HP mechanism on reduced single-atom noble metal cata-lysts,such as r-Rh_(1)-In_(2)O_(3)(111)and r-Ir_(1)-In_(2)O_(3)(111).In these cases,molecularly adsorbed H_(2) would be polarized into H^(δ−)-H^(δ+),thus facilitating the electrophilic attack to the O in cO_(2).conversely,the H^(δ+)species,derived from heterolytically dissociated H_(2),exhibited a strong affinity on the adjacent oxygen site at the m-O-In *** strong adsorption resulted in a higher energy barrier for cO_(2)hydrogenation,thereby rendering the HP mechanism less viable than the non-HP *** results were anticipated to provide a deeper understanding of hydrogenation reactions on oxide-supported noble single-atom catalysts and theoretical guidance for the development of novel high-performance catalysts for catalytic hydrogena-tion reactions.

关键词： Reduced single-atom catalysts cO_(2)hydrogenation density functional theory calculation Heterolytic dissociation of H_(2) molecular adsorption of H_(2)

The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma

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Hepatobiliary & Pancreatic diseases International 2025年第1期24卷 67-75页

作者： chu-Li fu Zheng-Wei Zhao Qiang-Nu Zhang department of Hematology and Oncology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Biomedicine Research center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and Gynecologythe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150China

Background:Within the tumor microenvironment,survival pressures are prevalent with potent drivers of tumor progression,angiogenesis,and therapeutic resistance.N6-methyladenosine(m6 A)methylation has been recognized as a critical post-transcriptional mechanism regulating various aspects of mRNA *** the intricate interplay between survival pressures and m6 A modification pro-vides new insights into the molecular mechanisms underlying hepatocellular carcinoma(Hcc)progres-sion and highlights the potential for targeting the survival pressures-m6 A axis in Hcc diagnosis and *** sources:A literature search was conducted in Pubmed,mEdLINE,and Web of Science for relevant articles published up to April *** keywords used for the search included hepatocellular carcinoma,cellular survival,survival pressure,N6-methyladenosine,tumor microenvironment,stress response,and ***:This review delves into the multifaceted roles of survival pressures and m6 A RNA methylation in Hcc,highlighting how survival pressures modulate the m6 A landscape,the impact of m6 A modifica-tion on survival pressure-responsive gene expression,and the consequent effects on Hcc cell survival,proliferation,metastasis,and resistance to ***,we explored the therapeutic potential of targeting this crosstalk,proposing strategies that leverage the understanding of survival pressures and m6 A RNA methylation mechanisms to develop novel,and more effective treatments for ***:The interplay between survival pressures and m6 A RNA methylation emerges as a complex regulatory network that influences Hcc pathogenesis and progression.

关键词： Hepatocellular carcinoma N6-methyladenosine methylation Hypoxia Target therapy Survival pressure

Joint Retrieval of Pm_(2.5) concentration and Aerosol Optical depth over china Using multi-Task Learning on FY-4A AGRI

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Advances in Atmospheric Sciences 2025年第1期42卷 94-110页

作者： Bo LI disong fu Ling YANG Xuehua FAN dazhi YANG Hongrong SHI Xiang’ao XIA Electronic Engineering college Chengdu University of Information TechnologyChengdu 610225China Tianjin meteorological Radar Research Trial center Tianjin Meteorological BureauTianjin 300074China Key Laboratory of middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Research centre on meteorological Observation Engineering Technology China Meteorological AdministrationBeijing 100081China Key Laboratory of Atmospheric Environment and Extreme meteorology Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001China University of chinese Academy of Sciences Beijing 100049China

Aerosol optical depth(AOd)and fine particulate matter with a diameter of less than or equal to 2.5μm(Pm_(2.5))play crucial roles in air quality,human health,and climate ***,the complex correlation of AOd–Pm_(2.5)and the limitations of existing algorithms pose a significant challenge in realizing the accurate joint retrieval of these two parameters at the same *** this point,a multi-task learning(mTL)model,which enables the joint retrieval of Pm_(2.5)concentration and AOd,is proposed and applied on the top-of-the-atmosphere reflectance data gathered by the Fengyun-4A Advanced Geosynchronous Radiation Imager(FY-4A AGRI),and compared to that of two single-task learning models—namely,Random Forest(RF)and deep Neural Network(dNN).Specifically,mTL achieves a coefficient of determination(R^(2))of 0.88 and a root-mean-square error(RmSE)of 0.10 in AOd *** comparison to RF,the R^(2)increases by 0.04,the RmSE decreases by 0.02,and the percentage of retrieval results falling within the expected error range(Within-EE)rises by 5.55%.The R^(2)and RmSE of Pm_(2.5)retrieval by mTL are 0.84 and 13.76μg m~(-3)*** with RF,the R^(2)increases by 0.06,the RmSE decreases by 4.55μg m~(-3),and the Within-EE increases by 7.28%.Additionally,compared to dNN,mTL shows an increase of 0.01 in R^(2)and a decrease of 0.02 in RmSE in AOd retrieval,with a corresponding increase of 2.89%in *** Pm_(2.5)retrieval,mTL exhibits an increase of 0.05 in R^(2),a decrease of 1.76μg m~(-3)in RmSE,and an increase of 6.83%in *** evaluation suggests that mTL is able to provide simultaneously improved AOd and Pm_(2.5)retrievals,demonstrating a significant advantage in efficiently capturing the spatial distribution of Pm_(2.5)concentration and AOd.

关键词： AOd Pm_(2.5) FY-4A multi-task learning joint retrieval

Biomaterial‑based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

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military medical Research 2025年第1期12卷 96-120页

作者： Ying-Ying Li Shuai-Fei Ji Xiao-Bing fu Yu-Feng Jiang Xiao-Yan Sun Research center for Tissue Repair and Regeneration Affiliated to the medical Innovation Research department Chinese PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China Research Unit of Trauma care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China 2Department of Tissue Regeneration and Wound RepairChinese PLA General HospitalBeijing 100853China

Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages,ultimately impairing its normal physiological *** evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration,promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic *** field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical ***,a comprehensive understanding of the underlying mechanisms remains somewhat elusive,limiting the broader application of these *** this review,we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised *** first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for *** second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity,facilitating efficient cellular reprogramming and,consequently,promoting the regeneration of skin *** summary,the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing,coupled with the restoration of multiple skin appendage functions.

关键词： Scarless Wound healing Biomaterials mechanical cues Skin appendages

Self-assembly of two pairs of homochiral m2L4 coordination capsules with varied confined space using Tr?ger's base ligands

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chinese chemical Letters 2025年第2期36卷 360-365页

作者： Yi Zhou Wei Zhang Rong fu Jiaxin dong Yuxuan Liu Zihang Song Han Han Kang cai college of chemistry Nankai University department of chemistry Northwestern University department of chemistry The University of Hong Kong

chiral coordination molecular cages/capsules with discrete nanoconfined chiral cavities demonstrate significant potential applications across various fields. In this study, we utilized Tr?ger's base as the building block to design and synthesize two pairs of enantiopure ligands. These ligands were then self-assembled with Pd(II) ions through chiral self-sorting coordination, resulting in the formation of two pairs of homochiral m2L4-type coordination molecular capsules. Notably, due to differences in the substitution positions on the Tr?ger's base, these two pairs of enantiomeric coordination molecular capsules exhibited distinct levels of cavity closures, cavity sizes, and host-guest recognition properties. This research offers valuable insights into the construction of novel chiral molecular capsules and the regulation of confined cavities.

关键词： chirality Host-guest recognition metal-organic capsule Self-sorting Tröger's base

Bacterial indole-3-propionic acid inhibits macrophage IL-1β production through targeting methionine metabolism

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Science china Life Sciences 2025年

作者： Ziyi Han Jian fu Aiyan Gong Wenkai Ren State Key Laboratory of Livestock and Poultry Breeding College of Animal Science South China Agricultural University Animal disease-resistant Nutrition Key Laboratory of Sichuan Province Sichuan Agricultural University china Institute of Veterinary drug control

The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown. Here, we found that bacterial indole-3-propionic acid(IPA) downregulates interleukin-1beta(IL-1β) production in m1 macrophages through inhibition of nuclear factor-kappa B(NF-κB) signaling. mechanistically, IPA binds specifically with methionine adenosyltransferase 2A(mAT2A) to promote S-adenosylmethionine(SAm) synthesis, which facilitates the dNA methylation of ubiquitin-specific peptidase 16(USP16, a deubiquitinase), and in turn promotes Toll-like receptor 4(TLR4) ubiquitination and NF-κB inhibition. furthermore,IPA administration attenuates sepsis in mouse models induced by lipopolysaccharides(LPS), showcasing its potential as a microbial-derived adjunct in alleviating inflammation. collectively, our findings reveal a newly found microbial metabolite-immune system regulatory pathway mediated by IPA.

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