检索结果-南通市图书馆

国际医学放射学杂志 2016年第6期 681-682页

作者： m.Koini m.filippi m.A.Rocca T.Yousry O.Ciccarelli G.Tedeschi 徐佳圆 Department of Neurology Medical University of Graz

摘要目的研究多发性硬化病人脑结构和功能mRI之间的关系,从而解释病人信息处理速度和执行功能的改变。方法本次前瞻性的多中心研究经所有中心的伦理委员会批

关键词：执行功能信息处理计算机应用多发性硬化病丘脑区 mR

联合钆和超顺磁性氧化铁对比剂mR增强成像评估多发性硬化的活动性

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2012年第5期 478-479页

作者： T.Tourdias S.Roggerone m.filippi m.Kanagaki m.Rovaris D.H.miller 刘永康 Department of Neuroradiology and INSERm U1049 CHU de BordeauxUniversité Bordeaux SegalenBordeauxFrance

摘要目的应用钆和超微超顺磁性氧化铁(USPIO)颗粒作为对比剂,比较多发性硬化病变随时间变化的mR成像特征。方法该研究获得当地伦理委员会批准,所有受试者签署知情同意书。对24例多发性硬化病人(10例复发型、14例进展型)给予钆和USPIO增... 详细信息

摘要目的应用钆和超微超顺磁性氧化铁(USPIO)颗粒作为对比剂,比较多发性硬化病变随时间变化的mR成像特征。方法该研究获得当地伦理委员会批准,所有受试者签署知情同意书。对24例多发性硬化病人(10例复发型、14例进展型)给予钆和USPIO增强mRI检查并随访6个月。采用Pearsonχ2或Fisher确切检验比较单独使用钆增强强化的病变、USPIO增强强化的病变及两者都强化的病变数量,用U检验比较病变大小。

关键词：对比剂病灶进展型 USPIO 活动性 mR

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第1期16卷 75-90页

作者： matheus Truccolo michalczuk Larisse Longo melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo filippi-Chiela mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIm07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(mASLD).AIm To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(mmp2),and metalloproteinases-9(mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(map1 Lc3b),and p62/sequestosome-1(p62/SQSTm1)-*** with controls,map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(Pm1 was lower in HCC compared to RIF(Pmmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(Pm1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-B,alpha-fetoprotein,and mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(PmiR-26b was lower in HCC compared to RIF,and the inverse was observed for miR-224(Pmong groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma metabolic dysfunction-associated steatotic liver disease Rifaximin

Radioisotope production using lasers:From basic science to applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.D.Rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.filippi P.L.Andreoli m.Huault H.Larreur D.Singappuli D.molloy D.Raffestin m.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.La Cognata S.Palmerini T.Carriere m.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.margarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

Final results of the first phase of the PROTO-SPHERA experiment: obtainment of the full current stable screw pinch and first evidences of the jet + torus combined plasma configuration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2024年第2期26卷 31-43页

作者： Paolo mICOZZI Franco ALLADIO Alessandro mANCUSO Vincenzo ZANZA Gerarda APRUZZESE Francesca BOmBARDA Luca BONCAGNI Paolo BURATTI Francesco filippi Giuseppe GALATOLA TEKA Francesco GIAmmANCO Edmondo GIOVANNOZZI Andrea GROSSO matteo IAFRATI Alessandro LAmPASI Violeta LAZIC Simone mAGAGNINO Simone mANNORI Paolo mARSILI Valerio PIERGOTTI Giuliano ROCCHI Alessandro SIBIO Benedetto TILIA Onofrio TUDISCO FSN Dipartimento Fusione e tecnologie per la Sicurezza Nucleare ENEA Agenzia Nazionale per Le Nuove Tecnologie Energia e lo Sviluppo Economico SostenibileFrascati(Rome)00044Italy IAPS Istituto di Astrofisica e Planetologia Spaziali INAF Istituto Nazionale di AstrofisicaRome O133Italy Physics Department University of Pisa Faculty of Natural Sciences Mathematics and PhysicsPisa 56127 Italy

In astrophysics, the boundary conditions for plasma phenomena are provided by nature and the astronomer faces the problem of understanding them from a variety of observations [Hester J J et al 1996 Astrophys. J. 456 225], on the other hand, in laboratory plasma experiments the electromagnetic boundary conditions become a major problem in the set-up of the machine that produces the plasma, an issue that has to be investigated step by step and to be modified and adapted with great patience, in particular in the case of an innovative plasma confinement experiment. The PROTO-SPHERA machine [Alladio F et al 2006 Nucl. Fusion 46 S613] is a magnetic confinement experiment, that emulates in the laboratory the jet + torus plasma configurations often observed in astrophysics: an inner magnetized jet of plasma centered on the(approximate) axis of symmetry and surrounded by a magnetized plasma torus orthogonal to this jet. The PROTO-SPHERA plasma is simply connected, i.e., no metal current conducting rod is linked to the plasma torus, while instead it is the inner magnetized plasma jet(in the following always called the plasma centerpost) that is linked to the torus. It is mandatory that no spurious plasma current path modifies the optimal shape of the plasma centerpost. moreover, as the plasma torus is produced and sustained, in absence of any applied inductive electric field, by the inner plasma centerpost through magnetic reconnections [Taylor J B and Turner m F 1989 *** 29 219], it is required as well that spurious current paths do not surround the torus on its outboard, in order not to lower the efficiency of the magnetic reconnections that maintain the plasma torus at the expense of the plasma centerpost. Boundary conditions have been corrected,up to the point that the first sustainment in steady state has been achieved for the combined plasma.

关键词： laboratory plasmas magnetic confinement astrophysical plasmas

维普期刊数据库

视神经脊髓炎谱系疾病的脊髓萎缩在空间上与脊髓病变和残疾有关联

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2020年第6期 741-741页

作者：董力宁 L.Cacciaguerra P.Valsasina S.mesaros V.martinelli J.Drulovic m.filippi Neuroimaging Research Unit Institute of Experimental Neurology Division of Neuroscience IRCCS San Raffaele Scientific Institute

摘要视神经脊髓炎谱系疾病(NmOSD)病人的脊髓常被累及,但炎症和萎缩之间的关系仍不清楚。目的研究NmOSD病人mRI上脊髓内T1低信号病变的空间分布特征

关键词：

偏头痛患者T2可见损伤的脑灰质改变:一项3T mRI研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第12期 41-41页

作者： Rocca m.A. Ceccarelli A. Falini A. m.filippi 郭俊 Dr.Department of Neurology Scientific InstituteUniversity Ospedale San RaffaeleVia Olgettina6020132 MilanItaly

BACKGROUND AND PURPOSE-In migraine patients,functional imaging studies have shown changes in several brain gray matter(Gm)***,1.5-T mRI has failed to detect any structural abnormality of these *** used a 3-T mRI scanner and voxel-based morphometry(VBm)to assess whether Gm density abnormalities can be seen in patients with migraine with T2-visible abnormalities and to grade their ***-In 16 migraine patients with T2 visible abnormalities and 15 matched controls,we acquired a T2-weighted and a high-resolution T1-weighted *** loads were measured on T2-weighted *** optimized version of VBm analysis was used to assess regional differences in Gm densities on T1-weighted scans of patients versus *** parametric maps were thresholded at P multiple ***-Compared with controls,migraine patients had areas of reduced Gm density,mainly located in the frontal and temporal ***,patients showed increased periacqueduc-tal Gm(PAG)*** with patients without aura,migraine patients with aura had increased density of the PAG and of the dorsolateral *** migraine patients,reduced Gm density was strongly related to age,disease duration,and T2-visible lesion load(r ranging from-0.84 to-0.73).CONCLUSIONS-Structural Gm abnormalities can be detected in migraine patients with brain T2-visible lesions using VBm and a high-field mRI *** Gm changes comprise areas with reduced and increased density and are likely related to the pathological substrates associated with this disease.

关键词：偏头痛密度脑病 T2 患者脑灰质

弥散张量mRI对视神经脊髓炎和多发性硬化症的颈髓损害进行分级

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第12期 21-21页

作者： Benedetti B. Valsasina P. Judica E. m.filippi 郭俊 Dr.Department of Neurology Scientific InstituteUniversity Ospedale San RaffaeleVia Olgettina6020132 MilanItaly

The authors assessed the ability of diffusion tensor mRI to grade cervical cord damage in 10 patients with neuromyelitis optica,10 patients with multiple sclerosis,and 10 healthy *** three groups differed in terms of average mean diffusivity(p = 0.008)and average fractional anisotropy(p = 0.04).There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity(r = 0.52,p = 0.02).

关键词：多发性硬化症视神经脊髓炎 mRI 弥散张量颈髓

区域性而不是全脑性脑损伤导致多发性硬化的疲劳

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第1期 68-68页

作者： m.A.Rocca L.Parisi E.Pagani m.Copetti m.Rodegher m.filippi Neuroimaging Research Unit CERMACSan Raffaele Scientific InstituteVita-Salute San Raffaele University

目的使用mR成像和先进的分析评估正常白质(NAWm)和灰质(Gm)损伤、全脑与区域性损伤、萎缩与微结构异常病变在多发性硬化(mS)疲劳发病机制中的作用。材

关键词：多发性硬化灰质全脑异常病变发病机制扩散张量白质髓质脑损伤区域性

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

多发硬化病人的丘脑损伤和长期残障进展

国际医学放射学杂志 2011年第1期34卷 75-页

作者： m.A.Rocca S.mesaros E.Pagani m.P.Sormani G.Comi m.filippi 李睿 Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceScientific Institute and University Hospital San Raffaele

目的评估磁化转移(mT)mR成像所显示初期丘脑萎缩和异常及其后12个月的变化,以预测一组相对大样本的间断发作型多发硬化(mS)

关键词：多发硬化 mS 丘脑萎缩病人残障

维普期刊数据库