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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Latest Generation Equipment, Processes and Technologies in Wire Rod Production. Opportunities Galore for the World Steel market

Latest Generation Equipment, Processes and Technologies in W...

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第八届（2011）中国钢铁年会

作者： A.Celano N.Redolfi O.englund A.Taurino Area Sales manager Bar & Wire Rod mills-Danieli & C.Officine meccaniche S.p.A.–Italy Executive Product manager Bar & Wire Rod mills-Danieli & C. Officine meccaniche S.p.A.–Italy Sales Director–Sund Birsta AB–Sweden marketing manager Long Products Division – Danieli & C. Officine meccaniche S.p.A.–Italy

＜正＞1 Introduction The large number of steel producers and the continuously progressing technology make the long products market day by day more competitive and *** the conquest of a market niche can be achieved only by combining high plant productivity and efficiency with a superior quality of the finished *** requirements call for a continuous development in technology in order to provide long product rolling mills with modern production processes and highly efficient and productive finishing *** the various latest Danieli morgrdshammar innovations and technology advances,particular

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macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of methodology 2025年第1期15卷 88-94页

作者： Chinmay mahatme madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna m Shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NmOSD)or myelin oligodendrocyte glycoprotein antibody disease(mOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NmOSD and 17 mOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(mVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in mVD in NmOSD and mOGAD affected as well as unaffected eyes when compared with healthy *** and mOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to mOGAD unaffected *** comparing NmOSD with mOGAD,there was no significant difference in terms of mVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NmOSD and mOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis macular microvascular changes Neuromyelitis optica spectrum disorders myelin oligodendrocyte glycoprotein antibody disorder

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Exogenous BDNF and Chondroitinase ABC Consisted Biomimetic microenvironment Regulates Survival,migration and Differentiation of Human Neural Progenitor Cells Transplanted into a Rat Auditory Nerve

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Neuroscience & medicine 2014年第2期5卷 86-100页

作者： Ajay Kale Ekaterina Novozhilova Ulrica englund-Johansson Samuel I.Stupp Bjorn Palmgren Petri Olivius Department of Clinical Sciences Intervention and TechnologyKarolinska InstitutetKarolinska University HospitalStockholmSweden Division of Otorhinolaryngology Department of Clinical and Experimental MedicineUniversity of LinkopingLinkopingSweden Department of Ophthalmology Institution of Clinical Sciences in LundLund UniversityLundSweden Department of Chemistry Materials Science and Engineeringand Medicine and Institute for BioNanotechnology in MedicineNorthwestern UniversityChicagoUSA Division of Otorhinolaryngology Linkoping University HospitalLinkopingSweden

Current putative regeneration oriented studies express possible role of stem cell based implantation strategy in the restoration of fundamental perception of hearing. The present work utilizes a rat auditory nerve (AN) directed transplantation of human neural progenitor cells (HNPCs) as a cell replacement therapy for impaired auditory function. Groups of b-bungarotoxin induced auditory function compromised female rats were used to transplant HNPCs in the nerve trunk. In the treatment groups, brain derived neurotrophic factor (BDNF), peptide amphiphile nanofiber bioactive gel (Bgel) and Chondroitinase ABC (ChABC), a digestive enzyme that cleaves the core of chondroitin sulphate proteoglycans, were added along with HNPCs while the control groups were with PA inert gel (Igel) and devoid of ChABC. Six weeks post transplantation survival, migration, and differentiation of HNPCs were studied and compared. The groups treated with BDNF and Bgel showed improved survival and differentiation of transplanted HNPCs while the ChABC treated group showed significant migration of HNPCs along the AN and elongation of neuronal fibers along the nerve towards the cochlear nucleus (CN) which was characterized by immunocytochemical markers for human Nuclei (HuN), human mitochondria (Hum) and neuronal β-tubulin (Tuj1). These findings show that addition of BDNF and ChABC consisted Bgel environment facilitated HNPC survival, migration and differentiation along the transplanted rat AN towards the CN. This transplantation strategy provides unique experimental validation for futuristic role of cell based biomaterial consisted neurotrophic factor application in clinically transferable treatment of sensorineural hearing loss (SNHL) along with cochlear implants (CI).

关键词： Auditory Nerve Brain Derived Neurotrophic Factor Chondroitinase Cochlear Nucleus Human Neural Progenitor Cells Transplantation Transitional Zone Sensorineural Hearing Loss

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基于多模型的平版胶印过程墨流控制

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中国印刷与包装研究 2009年第1期1卷 102-103页

作者： Cristofer englund Antanas Verikas Intellignet Systems Laboratory School of Information Science Computer and Electrical Engineering Department of Applied Electronics Kaunas University of Technology LT-51368

为控制平版胶印过程中的油墨流动,本文提出了一种基于多模型的控制系统。该控制系统包括一个由4对正反向模型组成的模型池。每组模型对多个可能的控制信号进行评价,生成最优控制信号以实时控制印刷。该控制系统在报纸印刷车间的正常印... 详细信息

为控制平版胶印过程中的油墨流动,本文提出了一种基于多模型的控制系统。该控制系统包括一个由4对正反向模型组成的模型池。每组模型对多个可能的控制信号进行评价,生成最优控制信号以实时控制印刷。该控制系统在报纸印刷车间的正常印刷生产中进行实验,实验结果表明,本文提出的模型及其控制系统能够使印刷机的生产效果达到期望水平。

关键词：多模型过程控制自适应模型印刷机彩色印刷神经网络

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Rice plant growth and yield: foliar application of plasma activated water

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Plasma Science and Technology 2021年第7期23卷 134-143页

作者： m m RASHID mamunur RASHID m m HASAN m R TALUKDER Plasma Science and Technology Lab Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology and mycology Lab Department of BotanyUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology Lab Department of Agronomy and Agricultural ExtensionUniversity of RajshahiRajshahi 6205Bangladesh

Plasma activated water(PAW)was prepared for 10 min to be applied one toﬁve times as a foliar spray to rice plants,to investigate plant growth,yield and the concentrations of total soluble protein and sugar in the rice grains *** results reveal that(1)the plant height,stem diameter,dry weight,chlorophyll and total carotene concentrations were improved by∼15%,∼25%,∼24%,∼47%and∼45%,respectively,with respect to control,(2)defense mechanisms of the plants treated with PAW were improved,(3)concentrations of total soluble protein and sugar were enhanced in the rice grains of PAW treated plants and(4)yield was increased by∼14%.

关键词： plasma agriculture plasma activated water rice plant growth rice yield total soluble protein

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未来十年技术对专家系统的影响

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世界科学 1988年第7期 44-47页

作者： Lynn.A.englund 侯保霞

人工智能的分支——专家系统是当今的热门。这是第一个以商品和设备的形式出现在市场上的分支。报刊上连篇累牍的文章高度赞颂专家系统奇迹般的应用,从而推动着新产品新设备的问世。这种令人兴奋的基调,力求加强这样一个时代的神秘感,... 详细信息

人工智能的分支——专家系统是当今的热门。这是第一个以商品和设备的形式出现在市场上的分支。报刊上连篇累牍的文章高度赞颂专家系统奇迹般的应用,从而推动着新产品新设备的问世。这种令人兴奋的基调,力求加强这样一个时代的神秘感,在这个时代里智能的和谐的机器帮助人们解决多种复杂的问题。

关键词：专家人工智能自然语言处理

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Numerical method for simulating rarefaction shocks in the approximation of phase-flip hydrodynamics

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Applied mathematics and mechanics(English Edition) 2021年第6期42卷 871-884页

作者： m.m.BASKO Keldysh Institute of Applied mathematics Russian Academy of SciencesMiusskaya Square 4Moscow 125047Russia

A finite-difference algorithm is proposed for numerical modeling of hydrodynamic flows with rarefaction shocks, in which the fluid undergoes a jump-like liquid-gas phase transition. This new type of flow discontinuity, unexplored so far in computational fluid dynamics, arises in the approximation of phase-flip(PF) hydrodynamics, where a highly dynamic fluid is allowed to reach the innermost limit of metastability at the spinodal, upon which an instantaneous relaxation to the full phase equilibrium(EQ) is assumed. A new element in the proposed method is artificial kinetics of the phase transition, represented by an artificial relaxation term in the energy equation for a "hidden"component of the internal energy, temporarily withdrawn from the fluid at the moment of the PF transition. When combined with an appropriate variant of artificial viscosity in the Lagrangian framework, the latter ensures convergence to exact discontinuous solutions, which is demonstrated with several test cases.

关键词： fluid dynamics with phase transitions two-phase flow rarefaction shock Lagrangian scheme artificial viscosity artificial kinetics

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