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Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asianpopulations

Cancer Biology & medicine 2022年第10期19卷 1440-1459页

作者： Zongchao mo Junyi Xin Ruichao Chai Peter Y.m.Woo Danny T.m.Chan Jiguang Wang Division of Life Science and State Key Laboratory of molecular Neuroscience The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute Shenzhen 518000China Department of molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of Neurosurgery Kwong Wah HospitalHong Kong SARChina Hong Kong Neuro-Oncology Society Hong Kong SARChina Division of Neurosurgery Department of SurgeryPrince of Wales HospitalHong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Hong Kong Center for Neurodegenerative Diseases Hong Kong Science ParkHong Kong SARChina

Understanding the racial specificities of diseases—such as adult diffuse glioma,the most common primary malignant tumor of the central nervous system—is a critical step toward precision ***,we comprehensively review studies of gliomas in East Asian populations and other ancestry groups to clarify the racial differences in terms of epidemiology and genomic ***,we observed a lower glioma incidence in East Asians than in Whites;notably,patients with glioblastoma had significantly younger ages of onset and longer overall survival than the *** genome-wide association studies of various cohorts have revealed single nucleotide polymorphisms associated with overall and subtype-specific glioma ***,only 3 risk loci—5p15.33,11q23.3,and 20q13.33—were shared between patients with East Asian and White ancestry,whereas other loci predominated only in particular *** instance,risk loci 12p11.23,15q15-21.1,and 19p13.12 were reported in East Asians,whereas risk loci 8q24.21,1p31.3,and 1q32.1 were reported in studies in White *** the somatic mutational profiles of gliomas between East Asians and non-East Asians were broadly consistent,a lower incidence of EGFR amplification in glioblastoma and a higher incidence of 1p19q-IDH-TERT triple-negative low-grade glioma were observed in East Asian *** summarizing large-scale disease surveillance,germline,and somatic genomic studies,this review reveals the unique characteristics of adult diffuse glioma among East Asians,to guide clinical management and policy design focused on patients with East Asian ancestry.

关键词： Glioma East Asian epidemiology germline somatic

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Effect of particle size distribution on magnetic behavior of nanoparticles with uniaxial anisotropy

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Chinese Physics B 2018年第9期27卷 572-576页

作者： S Rizwan Ali Farah Naz Humaira Akber m Naeem S Imran Ali S Abdul Basit m Sarim Sadaf Qaseem Department of Physics Federal Urdu University of Arts Science and Technology Department of Applied Chemistry and Chemical Technology University of Karachi Department of Computer Science Federal Urdu University of Arts Science and Technology

The effect of particle size distribution on the field and temperature dependence of the hysteresis loop features like coercivity（HC）, remanence（mR）, and blocking temperature（TB） is simulated for an ensemble of single domain ferromagnetic nanoparticles with uniaxial anisotropy. Our simulations are based on the two-state model for T 〈 TB and the metropolis monte-Carlo method for T 〉 TB. It is found that the increase in the grain size significantly enhances HC and TB. The presence of interparticle exchange interaction in the system suppresses HC but causes mRto significantly *** results show that the parameters associated with the particle size distribution（D（d,δ）） such as the mean particle size d and standard-deviation δ play key roles in the magnetic behavior of the system.

关键词： magnetic nanoparticles monte Carlo simulations size distribution interparticle interaction hysteresis

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multi-quasiparticle excitations in ^(145)Tb

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Science China(Physics,mechanics & Astronomy) 2004年第5期47卷 561-570页

作者： T. Hayakawa m. Oshima T. Toh T. Shizuma J. Katakura Y. Hatsukawa m. matsuda H. Kusakari m. Sugawara Japan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanJapan Atomic Energy Research Institute Tokai Ibaraki 319-1195 JapanChiba University Inage-ku Chiba 263-8512 JapanChiba Institute of Technology Narashino Chiba 275-0023 Japan

High-spin states in 145Tb have been populated using the 118Sn (32S, 1p4n) reaction at beam energy of 165 meV. The level scheme of 145Tb has been established up to Ex ≈7.4 meV. The level scheme shows characteristics of a spherical or slightly oblate nucleus. Based on the systematic trends of the level structure in the neighboring N = 80 isotones, the level structure in 145Tb below 2 meV excitation is well explained by coupling an h11/2valence proton to the even-even 144Gd core. Above 2 meV excitation, most of the yrast levels are interpreted with multi-quasiparticle shell-model configurations.

关键词： high-spin states, level scheme, multi-quasiparticle excitations.

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A new design approach for the established flow region of vertical,dilute-phase pneumatic conveyors

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Particuology 2022年第7期20卷 10-20页

作者： John m.Wheeldon Jan Baeyens Shuo Li Yimin Deng European Powder and Process Technology Longfellow DriveKetteringUnited Kingdom KU Leuven Department of Chemical EngineeringProcess and Environmental Technology LabJ.De Nayerlaan 52860 Sint-Katelijne-WaverBelgium Beijing University of Chemical Technology Beijing Advanced Centre of Smart Matter Science and EngineeringBeijingChina

An analysis has been completed for a comprehensive set of vertical,dilute-phase pneumatic conveying pressure drop data from an investigation by *** data were collected in the established flow region for eight different materials conveyed in 0.05-,0.10-,0.20-m internal diameter,20-m tall steel *** velocities derived from the pressure drop data were used to develop an equation of motion that includes terms for pipe diameter,terminal velocity,coefficient of restitution,and particle *** best data fit was achieved using the actual gas density and the actual gas velocity adjusted for *** the terminal velocity for voidage,an approach recommended by many investigators,did not improve the fit for reasons identified by the present *** the equation of motion,particle velocities were predicted and used to calculate total pressure drops that are within±15%of the measured *** calculated values also produce the characteristic trough-shaped total pressure drop curves allowing the minimum pressure drop gas velocity to be determined without recourse to a separate correlation.A comparison with other studies using shorter risers indicates that data from these studies likely include acceleration effects.A separate study will investigate this observation further.

关键词： Dilute-phase Vertical Pneumatic conveying Design equations Pressure drops

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Hazards and Landscape Changes(Degradations) on Hungarian Karst mountains Due to Natural and Human Effects

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Journal of mountain Science 2013年第1期10卷 16-28页

作者： móga JNOS Kiss KLAUDIA Szabó mRIA Kériné Borsodi ANDREA Kéri ANDRS mari LSZLó Knáb móNIKA Iván VERONIKA Geography and Earth Science Institute Etvs Loránd University Biology Institute Etvs Loránd University

In order to study the karstological processes within the karst ecological system,the geohazards and degradation of karst landscapes on the karst areas of the Bakony mountains(Hungary),we investigated the abiotic elements of the environment,soil and cover deposits,erosion soil decay;the changes in the quantity and quality of karst waters:contamination at swallow holes,contamination of karst springs;and the biogenic factors:surface vegetation coverage by the corine land cover method,plant-ecological examinations,qualification of surface waters with the help of biological water *** recognized that the increasing human activities during the past few centuries have had significant impact on the investigated landscapes of karst areas because of their spatial *** the scope of our research we concluded that the landscape changes due to natural and human effects can vary strongly on the different karst *** differences can arise from the climatic and geomorphologic situation,the coverlayer's qualities,etc.,but primarily from the different utilization of the investigated karst areas(*** intensity,characteristics and territorial extension of utilization).On the spot investigation we detected traces of new and fast geomorphological processes(gully formation,landslides,collapses,new sinkhole development) and landforms(sinkholes,gullies,swallow holes),which are clear evidences of the effect of climatic changes.

关键词： Karst landscape Geological hazards Soil erosion Limestone mountain

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Dissipation of chlorpyrifos, pendimethalin, and thiophanate-methyl pesticides in compost based-versus peat-moss based-biomixture of biobeds

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Waste Disposal and Sustainable Energy 2023年第4期5卷 461-470页

作者： Talaat N.m.El-Sebai Wafaa m.H.Zidan Alaa marzouk marion Divers Fabrice martin-Laurent Agricultural microbiology Dept.Agricultural and Biology Research Institute National Research CentreCairoEgypt Laboratory of Pesticide Analysis Agriculture Research CentreCairoEgypt Laboratory of Soil microbiology National Institute of Agricultural ResearchDijonFrance

Biobed is a smart bioremediation system used to treat point-source pesticide *** is the main component of biobeds,and pesticide dissipation is affected by its *** study aimed to compare the effectiveness of compost-based(C)versus peat-moss-based(P)biomixtures of biobeds on tested pesticide *** concentrations(25,50,and 75 mg/kg)of chlorpyrifos,pendimethalin,and thiophanate methyl were added separately and as a mix to both biomixtures C and *** data showed the effect of biomixture type on the dissipation of the tested *** chlorpyrifos,its dissipation rate in biomixture P was more rapid than that in biomixture *** result was confirmed by the mineralization kinetic experiment,since 25%of the initial ^(14)C-chlorpyrifos concentration accumulated in the form ^(14)CO_(2) in biomixture P compared to only 14%in biomixture *** addition,the chlorpyrifos dissipation rate was influenced by the initial concentration when applied individually in biomixture *** contrast,biomixture C was more effective at pendimethalin dissipation than biomixture P,since>76%of pendimethalin was dissipated in biomixture C versus 67%in biomixture P at the same incubation *** thiophanate-methyl,the abilities of both biomixtures C and P were similar and less efficient than those of the other tested *** addition of the three tested pesticides to biomixture C only had a positive effect on both chlorpyrifos and thiophanate-methyl dissipation,while pendimethalin dissipation was similar when applied separately or as a *** activity was stimulated by the addition of separately or mixed pesticides to biomixtures C and P as measured by dehydrogenase activity.

关键词： Biopurification system Pesticides Contamination Point-source Bioremediation Biomixture

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In-situ alloyed CoCrFemnNi high entropy alloy:microstructural development in laser powder bed fusion

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Journal of materials Science & Technology 2022年第28期123卷 123-135页

作者： Peng Chen Xiyu Yao moataz m.Attallah ming Yan Department of materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Advanced materials Processing Laboratory University of BirminghamBirmingham B152TTUK

In-situ alloying has the potential to combine the compositional flexibility of high entropy alloys(HEAs)and the advanced forming capability of laser powder bed fusion(LPBF).This study fundamentally investigated the elemental homogenisation and grain development in the in-situ alloying process of CoCrFemnNi HEA,by analysing the basic units,i.e.,tracks and layers,and introducing mn as an alloying element to the base Co Cr Fe Ni *** modelling methods were employed to predict meltpool dimensions,and the results indicated the dependence of the modelling on practical meltpool *** of elemental distribution was found in keyhole meltpools since an intensive flow was generated due to recoil *** homogeneity of in-situ alloyed mn in single tracks was insufficient whether operated in conduction mode or keyhole mode,which required remelting from adjacent tracks and following layers to promote homogenisation *** preferred orientation in single tracks along scanning directions changed fromtoas the scanning speed increased,although the cross-sections were similar in size with identical linear energy *** preference can be inherited during the printing process and lead to different textures in three-layer *** was also observed that applying hatch spacing smaller than a half meltpool width could coarsen the grains in a *** results from this study provide structure-parameter correlations for future microstructural tailoring and manipulation.

关键词： Laser powder bed fusion High entropy alloy In-situ alloying Single track Elemental homogenisation

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Business Continuity management,Operational Resilience,and Organizational Resilience:Commonalities,Distinctions,and Synthesis

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International Journal of Disaster Risk Science 2023年第5期14卷 713-721页

作者： S.E.Galaitsi Elizaveta Pinigina Jeffrey m.Keisler Gianluca Pescaroli Jesse m.Keenan Igor Linkov US Army Engineer Research and Development Center VicksburgMS39180USA College of management University of Massachusetts BostonBostonMA02125USA Institute for Risk and Disaster Reduction University College LondonLondonWC1E 6BTUK School of Architecture Tulane UniversityNew OrleansLA70118USA

The concepts of business continuity management,operational resilience,and organizational resilience each refer to actions that businesses and organizations can take in anticipating and responding to ***,the existing definitions and usages are difficult to differentiate due to overlapping objectives,implementation processes,and *** article examines definitions and approaches for these three concepts and suggest a framework to operationalize methods and tools relevant to *** definitions emphasize three dyads:risk versus resilience;organizational processes versus assets;and normal operating conditions versus crisis *** these dyads to differentiate the concepts of business continuity management,operational resilience,and organizational resilience can support planners in clarifying objectives and identifying which approach will be most beneficial as businesses or organizations plan for and encounter *** article evaluates these concepts by examining illustrative examples of disruptions and responses.

关键词： Business continuity management Disruptions Operational resilience Organizational resilience

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Optimal Bandgap of Double Perovskite La-Substituted Bi2FeCrO6 for Solar Cells:an ab initio GGA+U Study

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Chinese Physics Letters 2017年第1期34卷 81-85页

作者： B.merabet H.Alamri m.Djermouni A.Zaoui S.Kacimi A.Boukortt m.Bejar Electrotechnics Department Faculty of TechnologyMustapha Stambouli UniversityMascara 29000Algeria Computational materials Physics Laboratory UDL-SBA 22000Algeria Physics Department-University College Umm Ai-Qura UniversityMakkahSaudi Arabia Centre Universitaire Ahmed Zabana Relizane 48000Algeria Elaboration Characterization Physico-mechanics of materials and metallurgical Lboratory ECP3m Faculty of Sciences and TechnologyAbdelhamid Ibn Badis University of MostaganemMostaganem 27000Algeria Laboratoire de Physique Appliquee Faculte des SciencesUniversite de SfaxSfax 3000Tunisie

The ab initio generalized gradient approximation (GGA)+U study of multiferroic (La Bi )2FeCrO6 in pnma structure and ferri-magnetic order, including Hubbard corrections ( eV) for transition metal/rare earth d-electrons with 20 atoms cell, shows optimum local magnetic moments of (Cr , Fe equal to (−2.56, 4.14) μB and an ideal spin-down band gap of 1.54 eV. Tuned-band gap La-substituted double oxide perovskites BFCO should exhibit enhanced visible-light absorption and carrier mobility, thus could be convenient light absorbers and then efficient alternatives to wide-gap chalcopyrite absorber-based solar cells failing to achieve highest power conversion efficiencies, and even compete with their metal-organic halide perovskites counterparts.

关键词： Cr La Optimal Bandgap of Double Perovskite La-Substituted Bi2FeCrO6 for Solar Cells:an ab initio GGA+U Study Fe Bi GGA

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Deformation and failure in nanomaterials via a data driven modelling approach

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Theoretical & Applied mechanics Letters 2020年第4期10卷 249-252页

作者： m.Amir Siddiq School of Engineering University of AberdeenAB243UEAberdeenUK

A data driven computational model that accounts for more than two material states has been presented in this work. Presented model can account for multiple state variables, such as stresses,strains, strain rates and failure stress, as compared to previously reported models with two *** is used to perform deformation and failure simulations of carbon nanotubes and carbon nanotube/epoxy nanocomposites. The model capability of capturing the strain rate dependent deformation and failure has been demonstrated through predictions against uniaxial test data taken from literature. The predicted results show a good agreement between data set taken from literature and simulations.

关键词： Data driven computational mechanics Nanomaterials Carbon nanotubes Nanocomposites

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