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Dendritic spine degeneration:a primary mechanism in the aging process

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neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(InCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto nacional de medicina Genómica(InmeGen) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(Gm)(mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

effect of Breathwalk on body composition,metabolic and mood state in chronic hepatitis C patients with insulin resistance syndrome

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World Journal of Gastroenterology 2007年第46期13卷 6213-6218页

作者： m vázquez-vandyck S Roman JL vázquez L Huacuja G Khalsa R Troyo-Sanromán A Panduro molecular Biology in medicine Civil Hospital of GuadalajaraFray Antonio AlcaldeGuadalaiara JaliscoMéxico Health Sciences University CenterUniversity of GuadalajaraGuadalajara JaliscoMéxico epidemiology Department Regional General Hospital No.110Mexican Institute of Social Security and Public Health DepartmentUniversity of GuadalajaraGuadalajara JaliscoMéxico Chronic Degenerative Diseases Institute Health Sciences University CenterUniversity of GuadalajaraGuadalajara JaliscoMéxico Kundalini Research Institute Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States Research Unit Health Sciences University CenterUniversity of GuadalajaraGuadalajara JaliscoMéxico

AIm： To identify the anthropometric, metabolic and mood state in hepatitis C virus （HCv）-infected patients from the west of mexico and to evaluate the effect of 13reathwalk （13W）, a combination of walking, synchronized breathing and focussed attention, on those patients. meTHODS： In an experimental study, 17 patients with serological and molecular diagnosis of HCv, not receiving pharmacological treatment, were studied. One hour sessions of 13W were practiced 3 times at week for six months. Body composition was assessed by electric impedance. Biochemical profiles and insulin resistance （IR） risk was assessed by conventional methods. mood state was evaluated with specific and open questions at the beginning and at the end of the program. ReSULTS： Seventy percent of patients were overweight or obese, and 77% of the patients presented with IR at the beginning of the study. Improvements were observed at the 3^rd mo, and statistically significant differences were recorded at the 6^th mo using the fitness score （76 vs 83, P 〈 0.01）, in alanine aminotransferase （ALT）（106±93 U/L vs 59 ± 32 U/L, P 〈 0.01）, total bilirubin （0.09 ± 1 mg/dL vs 0.62 ± 0.2 mg/dL, P 〈 0.01）, ALT/ AST ratio （1.04 vs 0.70, P 〈 0.01）, triglycerides （165 ± 86 mg/dL vs 124 ± 49 mg/dL, P 〈 0.01） and the IR risk （4.0 vs 2.7）. most patients （88%） indicated to feel better at the end of BW （P 〈 0.01）.COnCLUSIOn： Breathwalk has an important effect on body composition, lipid profile and liver enzymes. It is also easy, inexpensive and has a beneficial effect on metabolic and mood state in HCv patients.

关键词： Breathwalk Chronic hepatitis C Insulinresistance Obesity Quality of life

Risk factors for antenatal depression: A review

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World Journal of Psychiatry 2021年第7期11卷 325-336页

作者： m Carmen míguez m Belén vázquez Department of Clinical Psychology and Psychobiology Faculty of PsychologyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain

Depression is the most prevalent mental disorder in pregnancy, and yet it is lessstudied than postpartum depression despite the consequences it may have onboth the pregnant woman and her offspring. Therefore, it would be important toknow which risk factors may favour the appearance of antenatal depression inorder to carry out appropriate prevention interventions. The aim of the presentreview was to identify the main risk factors of antenatal depression. We searchedin databases Pubmed and PsycInFO for articles published about the factorsassociated with antenatal depression from January 2010 through December *** literature review identified three main groups of antenatal depression riskfactors: sociodemographic, obstetric, and psychological. First, among thesociodemographic variables, the low level of studies and the economic incomeclearly stood out from the rest. Then, not having planned the pregnancy was themain obstetric variable, and finally, the main psychological risk factors werehaving a history of psychological disorders and/or depression as well aspresenting anxiety, stress, and/or low social support during pregnancy. Thisreview shows that the antenatal depression is affected by multiple factors. mostcan be identified at the beginning of the pregnancy, and some are risk factorspotentially modifiable through appropriate interventions, such as psychologicalfactors. For this reason, it is important to carry out a good screening for depressionduring pregnancy and consequently, be able to prevent its appearance ortreat it if necessary.

关键词： Depression Antenatal Antenatal depression Pregnancy Risk factors Review

ＣＯＭＰＬＥＸＩＴＹＯＦＬＡＲＧＥＴＩＭＥＢＥＨＡＶＩＯＵＲＯＦＥＶＯＬＵＴＩＯＮＥＱＵＡＴＩＯＮＳＷＩＴＨＢＯＵＮＤＥＤＤＡＴＡ

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Chinese Annals of mathematics,Series B 2002年第2期23卷 293-310页

作者： J.L.vzquez e.ZUAZUA Departamento de matematicas Universidad AutonomaDepartamento de Matematica AplicadaUniversidadComplutense 28049MadridSpain28040 M

The authors study the asymptotic behaviour of solutions of the heat equation and a number of evolution equations using scaling techniques. It is proved that in the framework of bounded data stabilization need not occur and the general asymptotic behaviour is complex. This behaviour reflects for large times, even on compact sets, the complexity of the initial data at infinity.

关键词： Asymptotic behaviour Scaling Omega-limit Heat equation Hyperbolic conservation laws

Bioactive peptides: A review

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Food Quality and Safety 2017年第1期1卷 29-46页

作者： Adrián Sánchez Alfredo vázquez Laboratorio de Investigación en Inmunoquímica Dr.Márquez 162CuauhtémocDoctores06720CDMX Departamento de Química Orgánica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoMéxico

Bioactive peptides(BP)are organic substances formed by amino acids joined by covalent bonds known as amide or peptide *** some BP exist free in its natural source,the vast majority of known BP are encrypted in the structure of the parent proteins and are released mainly by enzymatic *** BP have been prepared by chemical *** play a significant role in human health by affecting the digestive,endocrine,cardiovascular,immune,and nervous *** are considered the new generation of biologically active regulators;they can prevent oxidation and microbial degradation in foods and also improve the treatment of various diseases and disorders,thus increasing the quality of *** growing interest in BP has incentivized the scientific community and the food industry to exploring the development of new food additives and functional products based on these *** present review highlights the recent findings on the identification,bioassays,and use of BP,as well as their potential use as food additives and in the development of functional products.

关键词： peptides bioactivity marine origin nutraceutical hydrolysis fermentation

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura nadal marta Tomàs Carolina Silvera-Simón manel m.Santafé maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

nonlinear magnetoimpedance effect in FeConi Ferromagnetic Tubes

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Chinese Physics Letters 2001年第9期18卷 1268-1270页

作者： G.v.Kurlyandskaya H.Yakabchuk e.Kisker n.G.Bebenin H.García-miquel m.vázquez v.O.vas′kovskiy Dpto.de eiectricidad y electrica Universidad del Pa vasco UPv-eHU Apdo 64448080 BilbaoSpain Institut fiir Angewandte Physik Heinrich Heine Universitat DiisseldorfUniversitatstraβe 1Bld.25.33.01.24D-40225DiisseldorfGermany Institute of metal Physics UD RAS Kovalevskaya str.18GSP-170620219 EkaterinburgRussia Dpto.de Ing.electronica Universidad Poiitecnica de ValenciaCamino de Veras/n46022 ValenciaSpain Instituto de Ciencia de materiaies CSICP.O.Box 15528230 Las Rozas(Madrid)Spain Institute of Physics and Applied mathematics Ural State UniversityLenin Ave.51620083 EkaterinburgRussia

The very high (up to 820% of the magnetoimpedance ratio) and sensitive nonlinear giant magnetoimpedance effect has been studied in the FeCo1ni magnetic tubes electroplated onto Cu(3%)Be nonmagnetic wirefor frequencies from 1-10mHz. Special annealing was carried out in order to induce the magnetic anisotropy. The high harmonic generation was observed and the harmonics show larger variations with the external magnetic field than the fundamental frequency. The super high sensitivity of the harmonics is promising as regards the increase of the sensitivity of magnetoimpedance sensors.

关键词： harmonics magnetic impedance

Chirping instabilities produced by a runaway electron beam at a spherical tokamak

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Plasma Science and Technology 2023年第7期25卷 19-24页

作者： I m BALACHenKOv n n BAKHARev v K GUSev m v ILIASOvA e m KHILKevICH P S KORenev A e KOnKOv v B mInAev Yu v mITRIZHKIn m I PATROv Yu v PeTROv n v SAKHAROv A e SHeveLev O m SKReKeL Ioffe Institute Saint-Petersburg 194021Russia Lomonosov moscow State University Moscow 119991Russia

Two different types of mHD instabilities with rapidly chirping frequency were found to arise in the Globus-m2 spherical tokamak in substantially different frequency *** first type arises at frequencies of an order of 1 mHz in ohmic plasmas at relatively low density(n_(e))m^(-3) in a wide range of toroidal magnetic fields and plasma *** type of instability was identified as compressional Alfven waves,driven by electrons,accelerated during a sawtooth *** was found that the mode frequency is sweeping in time,according to the Berk-Breizman hole-clump nonlinear chirping *** second type of wave arises in a specific single-swing regime of the central solenoid current with a very narrow plasma column,when the plasma tends to decay at extremely low density(n_(e))m^(-3) and,in fact,is an instability of the runaway electron *** exited modes cover the whole observed frequency range and are divided into several(two or three)frequency regions:approximately 0-30 mHz,60-120 mHz and sometimes 30-60 *** of the branches was also *** chirps are more rapid than for 1 mHz Alfven instability and follow an exponential *** paper,to our knowledge,is the first report of frequency chirping instabilities excited by accelerated electrons at a spherical tokamak.

关键词： Alfvén waves chirping instability spherical tokamak runaway electrons