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RBC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from L-Arginine and sodium nitroprusside

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 53-65页

作者： m.K.maksimov P.B.ermolinskiy O.N.Scheglovitova N.N.Sklyankina A.V.muravyov A.e.Lugovtsov A.V.Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia N.F.Gamaleya National Research Center for epidemiology and microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State Pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which impacts hemorheology and *** turn,RBC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(NO),which is mainly produced by endothelial cells(eC)from L-arginine amino acid in the circulatory *** the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced NO on RBC aggregation and adhesion to endothelium;(2)the NO e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitroprusside without the presence of endothelium in the *** RBC aggregation and adhesion to a monolayer of eC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and myrenne *** con¯rmed that NO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only NO signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RBC aggregation force on L-arginine concentration was observed,which improves our knowledge about the process of NO production by ***,data related to L-arginine accumulation by endothelium were obtained:Necessity of the presence of extracellular L-arginine stated by other authors was put under *** our study,NO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.

关键词： Red blood cells aggregation L-arginine endothelium optical tweezers myrenne flow chamber

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Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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Ieee/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： Rong Zhao Jun-e Feng Dawei Zhang the School of mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

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Nonlinear wave dispersion in monoatomic chains with lumped and distributed masses:discrete and continuum models

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Applied mathematics and mechanics(english edition) 2024年第4期45卷 633-648页

作者： e.GHAVANLOO S.eL-BORGI School of mechanical engineering Shiraz UniversityShiraz 71963-16548Iran mechanical engineering Program Texas A&M University at QatarDoha 23874Qatar

The main objective of this paper is to investigate the influence of inertia of nonlinear springs on the dispersion behavior of discrete monoatomic chains with lumped and distributed *** developed model can represent the wave propagation problem in a non-homogeneous material consisting of heavy inclusions embedded in a *** inclusions are idealized by lumped masses,and the matrix between adjacent inclusions is modeled by a nonlinear spring with distributed ***,the model is capable of depicting the wave propagation in bi-material bars,wherein the first material is represented by a rigid particle and the second one is represented by a nonlinear spring with distributed *** discrete model of the nonlinear monoatomic chain with lumped and distributed masses is first considered,and a closed-form expression of the dispersion relation is obtained by the second-order Lindstedt-Poincare method(LPm).Next,a continuum model for the nonlinear monoatomic chain is derived directly from its discrete lattice model by a suitable continualization *** subsequent use of the second-order method of multiple scales(mmS)facilitates the derivation of the corresponding nonlinear dispersion relation in a closed *** novelties of the present study consist of(i)considering the inertia of nonlinear springs on the dispersion behavior of the discrete mass-spring chains;(ii)developing the second-order LPm for the wave propagation in the discrete chains;and(iii)deriving a continuum model for the nonlinear monoatomic chains with lumped and distributed ***,a parametric study is conducted to examine the effects of the design parameters and the distributed spring mass on the nonlinear dispersion relations and phase velocities obtained from both the discrete and continuum *** parameters include the ratio of the spring mass to the lumped mass,the nonlinear stiffness coefficient of the spring,and the wave amplitude.

关键词： nonlinear mass-spring chain discrete model continuum model LindstedtPoincare method(LPm) method of multiple scales(mmS) dispersion phase velocity

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Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： Gustavo J.Fernandez mariana e.Carro Paulo e.Llambías Grupo de Investigacion en ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

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BaTiO3 solid solutions co-doped with Gd3+ and eu3+:Synthesis,structural evolution and dielectric properties

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Journal of Rare earths 2024年第10期42卷 1920-1926页

作者： R.martínez-López m.Pérez-Labra J.A.Romero-Serrano F.R.Barrientos-Hernández m.Reyes-Pérez m.I.Valenzuela-Carrillo G.Urbano-Reyes V.e.Reyes-Cruz G.I.Dávila-Pulido Academic Area of earth Sciences and materials Autonomous University of Hidalgo State metallurgy and materials Department ESIQIE-IPNUPALM Autonomous University of Coahuila Boulevard Adolfo López Mateos S/n

In this paper,the synthesis,structural evolution,and dielectric properties of BaTiO3solid solutions codoped with rare earth elements(Gd3+and eu3+) prepared using the solid-state reaction method are *** pure precursor powders of BaCl3,TiO2,Gd2O3,and eu2O3were mixed in stoichiometric proportions,ground in an agate mortar before being uniaxially pressed at 250 mPa and sintered at 1300℃ in air atmosphere for 6 h to obtain Ba1-3xGd2xTi1-3xeu4xO3（x=0,0.0015,0.01 and0.1）.X-ray diffraction（XRD） and Rietveld's refinement results reveal the crystal phase ferroelectric tetragonal BaTiO3for the samples with x=0,0.0015 and 0.01, as well as a consistent increment in the lattice parameters caused by the *** solubility limit of Gd3+and eu3+in the BaTiO3structure is reached for the sample with x>0.01,and the orthorhombic eu2TiO5and monoclinic BaTi2O5secondary phases were *** Raman results show the characteristic peaks of ferroelectric tetragonal BaTiO3around 716 cm-1（LO of A1 symmetry）,515 cm-1（TO of A1 symmetry）,and 305 cm-1（B1）.The maximum relative permittivity measured at 1 kHz was recorded to be 6151.8 for the sample with x=0.0015,and a decrease in the Curie temperature to 105℃ with respect to the undoped sample was *** punctual microanalysis for the samples with x=0.0015,0.01,and 0.1 reveals grains composed of Ba,Ti,O,Gd,and eu homogeneously distributed in the *** Ba/Ti ratios for samples with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for samples with x=0.0015 and 0.01 and a substitution at the Ba site for the sample with x=0.1.

关键词： BaTiO3 Doping europium Gadolinium Rare earths Synthesis

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Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression

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World Journal of Clinical Cases 2024年第32期12卷 6538-6542页

作者： Basma m e mohamed mohamed e A Abdelrahim Department of Clinical Pharmacy Faculty of PharmacyBeni-Suef UniversityBeni-Suef 343433Egypt

In this editorial,we comment on the article by Lei et al,with a specific focus on the timing of the initiation of the antifibrotic agent pirfenidone(PFD)in the management of idiopathic pulmonary fibrosis(IPF)and its impact on lung function of IPF *** is an antifibrotic agent that is widely used in the management of IPF in both early and advanced *** inhibits various pathways and has antifibrotic,anti-inflammatory,and antioxidant *** dosage lowering,PFD slowed IPF progression and maintained functional *** 6-min walk distance test indicated that patients tolerated adverse events well,and PFD significantly reduced the incidence of progression episodes and *** when a single disease-progression event occurred,continuing PFD treatment had benefits.

关键词： Idiopathic pulmonary fibrosis Pirfenidone Pirfenidone anti-inflammatory mechanism Pirfenidone antifibrotic activity Timing impact

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The Alzheimer’s Dementia Patients’ Observed Illness Course and experience in Ghana and Care Lessons to Be Learnt: A mental Health Professional’s Perspective

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Open Journal of Psychiatry 2024年第2期14卷 91-106页

作者： Albert m. e. Coleman Centre for Bioethics Medical Law and Patient Advocacy Sekondi Ghana

Alzheimer’s disease (AD) and associated dementia patient numbers continue to increase globally with associated economic costs to healthcare systems. Of note is the increase in numbers in lower and middle-income countries (LmICs) including Sub-Saharan African (SSA) countries, which already face challenges with their health budgets from communicable and non-communicable diseases. Ghana, an SSA country, faces the problem of healthcare budgetary difficulties and the additional impact of AD as a consequence of increasing population strata of old aged persons (OAPs) due to the demographic transition effect. This article uses examples of known patients’ illness courses to give a perspective on the lived experience of patients with dementia (PWD) in Ghana, living amongst a populace with a culture of stigmatization of PWD, and a relatively fragile public mental health system (PmHS) for those with mental illness, including AD. The lived experience of AD patients is characterised by stigmatisation, discrimination, non-inclusiveness, diminished dignity and human rights abuses in the face of their mental disability, and eventually death. This article is an advocacy article giving voice to the voiceless and all persons suffering from AD and other dementias in Ghana, whilst pleading for a call to action from healthcare professionals and responsible state agencies.

关键词： Alzheimer’s Dementia Patients Ghana Stigmatization Discrimination Human Rights Dignity

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Optimization of Cooperative Relayingmolecular Communications for Nanomedical Applications

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Computer modeling in engineering & Sciences 2024年第2期138卷 1259-1275页

作者： eman S.Attia Ashraf A.m.Khalaf Fathi e.Abd el-Samie Saied m.Abd el-atty Konstantinos A.Lizos Osama Alfarraj Heba m.el-Hoseny Department of electrical engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of electronics and electrical Communications engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-systems based on molecular communications via diffusion(mCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDS)***,because the mCvD is unreliable and there exists molecular noise and inter symbol interference(ISI),cooperative nano-relays can acquire the reliability for drug delivery to targeted diseased cells,especially if the separation distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by themodified Central Force Optimization(mCFO)*** the previous work,the probability of bit error is expressed in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

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Hydroxyapatite composites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana V.Kharissova Lucy T.González Yolanda Peña méndez Igor e.Uflyand Idalia Gómez de la Fuente Universidad Autónoma de Nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de monterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico Department of Chemistry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its composites with inorganic additives,dopants,and polymers is a rapidly developing branch in the materials *** particular,carbon allotropes are widely used in these composites being widely applied for medical *** a gap of insufficient generalization of recent achievements in the field of the HA/Carbon composites,in this review we present the state of the art of the field of HA composites and hybrids with classic carbon allotropes and *** composites are known for carbon nanotubes,nanofibers,graphene and its oxidized forms,as well as,in a lesser grade,for graphite,fullerenes,nanodiamonds,carbon nanofoams,*** composites can be fabricated by a variety of classic and less-common methods,such as co-precipitation(with or without ultrasonic treatment),CVD,hot isostatic pressing,hydrothermal,spark plasma sintering,biomimetic mineralization,thermal and plasma spray,electrochemical and electrophoretic deposition,self-assembling,3D printing,electrospinning,and lyophilisation,among *** of various synthesis techniques can be also carried out for composite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;similarly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from *** biocompatible composites can be produced in the form of coatings,powders,and scaffolds and can additionally contain quantitative amounts of third phases,frequently natural or synthetic *** these composites,especially with O-containing functionalizing groups,HA disadvantages could be considerably decreased with simultaneous enhancement of mechanical properties,becoming similar to human bone,chemical stability and biocompatibility,as well as possessing antibacterial ***→G reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum dots Fullerenes Nanodiamonds

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Remodeling Tumor Immune microenvironment by Using Polymer-Lipid-manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb e.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan Taksim Ahmed Chunsheng He Jeffrey T.Henderson Andrew m.Rauth Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLmDs) to remodel the tumor immune microenvironment (TIme) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLmD treatment sensitized hypoxic human and murine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLmDs also polarized hypoxic murine RAW264.7 macrophages toward the m1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine CRPC TRAmP-C2 cells. In a syngeneic TRAmP-C2 tumor model, intravenous injection of PLmDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and myeloid-derived suppressor cells. Pretreatment with PLmDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor CD8+ T cells and m1 macrophages to tumor sites. Taken together, TIme modulation by PLmDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLmDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAW264.7 alone treatment

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