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High-speed water impacts of flat plates in different ditching configuration through a Riemann--ALE SPH m.del

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Journal of Hydrodynamics 2018年第1期30卷 38-48页

作者： S.marrone A.Colagrossi L.Chiron m.de Leffe D.Le Touzé CNR-INSEAN Marine Technology Research Institute Rome Italy NEXTFLOW Software Nantes France LHEEA Laboratory (UmR CNRS) Ecole Centrale de Nantes Nantes France

The violent water entry of flat plates is investigated using a Riemann-arbitrary Eulerian-Lagrangian（ALE） smoothed particle hydrodynamics（SPH） m.del. The test conditions are of interest for problems related to aircraft and helicopter emergency landing in water. Three main parameters are considered： the horizontal velocity, the approach angle（i.e., vertical to horizontal velocity ratio） and the pitch angle, a. Regarding the latter, small angles are considered in this study. As described in the theoretical work by Zhao and Faltinsen（1993）, for small a a very thin, high-speed jet of water is formed, and the time-spatial gradients of the pressure field are extremely high. These test conditions are very challenging for numerical solvers. In the present study an enhanced SPH m.del is firstly tested on a purely vertical impact with deadrise angle α=4°. An in-depth validation against analytical solutions and experimental results is carried out, highlighting the several critical aspects of the numerical m.delling of this kind of flow, especially when pressure peaks are to be captured. A discussion on the main difficulties when comparing to m.del scale experiments is also provided. Then, the more realistic case of a plate with both horizontal and vertical velocity components is discussed and compared to ditching experiments recently carried out at CNR-INSEAN. In the latter case both 2-D and 3-D simulations are considered and the importance of 3-D effects on the pressure peak is discussed for α=4° and α=10°.

关键词： Aircraft ditching high-speed water entry smoothed particle hydrodynamics(SPH)

NETosis,complement,and coagulation:a triangular relationship

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Cellular & molecular Immunology 2019年第1期16卷 19-27页

作者： Cynthia m.de Bont Wilbert C.Boelens Ger J.m.Pruijn department of Biomolecular Chemistry Institute for Molecules and Materials(IMM)Radboud UniversityNijmegenThe Netherlands

NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in *** NETosis,neutrophils release neutrophil extracellular traps(NETs),which can capture and kill bacteria and other pathogens to prevent them from *** substantial progress has been m.de in our understanding of NETosis,the precise mechanism underlying NETosis is still a matter of *** continues to elucidate the molecular pathways involved in *** recent years,interactions with the complement and coagulation systems have become increasingly *** complement proteins can stimulate NET formation,and NETs,in turn,can serve as a platform for complement *** addition,NETs can act as a scaffold for thrombus formation during *** crosstalk between the coagulation and complement systems has been previously described,NETosis appears to be a third important player in this consortium to protect the host against *** review summarizes our current knowledge on the mutual interactions between NETosis,the complement system and the coagulation system,with an emerging description of their complex triangular relationship.

关键词： coagulation complement NETosis neutrophils thrombosis

Optimized high performance liquid chromatography–ultraviolet detection method using core-shell particles for the therapeutic monitoring of methotrexate

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Journal of Pharmaceutical Analysis 2016年第2期6卷 103-111页

作者： milagros montemurro maría m.de zan juan c.robles Laboratorio de Control de Calidad de medicamentos Facultad de Bioqufmica y Ciendas Biologicas Universidad Nacional del Litoral Santa Fe Argentina

methotrexate （mTX） is an antineoplastic drug, and due to its high toxicity, the therapeutic drug mon- itoring is strictly conducted in the clinical practice. The chemometric optimization and validation of a high performance liquid chromatography （HPLC） method using core-shell particles is presented for the determination of mTX in plasma during therapeutic monitoring. Experimental design and response surface methodology （RSm） were applied for the optimization of the chromatographic system and the analyte extraction step. A Poroshel1120 EC-C18 （3.0 mm × 75 mm, 2.7 μm） column was used to obtain a fast and efficient separation in a complete run time of 4 min. The optimum conditions for the chroma- tographic system resulted in a mobile phase consisting of acetic acid/sodium acetate buffer solution （85.0 mm, pH =4.00） and 11.2% of acetonitrile at a flow rate of 0.4 mL/min. Selectivity, linearity, accuracy and precision were demonstrated in a range of 0.10-6.0 μm of mTX. The application of the optimized method required only 150μL of patient plasma and a low consumption of solvent to provide rapid re- sults.

关键词： HPLC Core-shell particles methotrexate Drug monitoring

A versatile microfluidic device for multiple ex vivo/ in vitro tissue assays unrestrained from tissue topography

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microsystems & Nanoengineering 2020年第1期6卷 806-819页

作者： Jose m.de Hoyos-Vega Alan m.Gonzalez-Suarez Jose L.Garcia-Cordero Unidad monterrey Centro de Investigacion y de Estudios Avanzados del IPNVia del conocimiento 201Parque PIITApodacaNL 66628Mexico

Precision-cut tissue slices are an important in vitro system to study organ function because they preserve most of the native cellular microenvironments of organs,including complex intercellular ***,during sample manipulation or slicing,some of the natural surface topology and structure of these tissues is lost or ***,we introduce a microfluidic platform to perform multiple assays on the surface of a tissue section,unhindered by surface *** device consists of a valve on one side and eight open microchannels located on the opposite side,with the tissue section sandwiched between these two *** the valve is actuated,eight independent microfluidic channels are formed over a tissue *** strategy prevents cross-contamination when performing assays and enables *** irregular tissues such as an aorta,we conducted multiple in vitro and ex vivo assays on tissue sections,including short-term culturing,a drug toxicity assay,a fluorescence immunohistochemistry staining assay,and an immune cell assay,in which we observed the interaction of neutrophils with lipopolysaccharide(LPS)-stimulated *** microfluidic platform can be employed in other disciplines,such as tissue physiology and pathophysiology,morphogenesis,drug toxicity and efficiency,metabolism studies,and diagnostics,enabling the conduction of several assays with a single biopsy sample.

关键词： metabolism topography versatile

Contemporary diagnostics and treatment options for female stress urinary incontinence

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Asian Journal of Urology 2018年第3期5卷 141-148页

作者： Allert m.de Vries John P.F.A.Heesakkers department of Urology Radboud University Medical CenterNijmegenThe Netherlands

Stress urinary incontinence is not a deadly disease,but for the large population of women suffering from it,it is a very important *** in the continuously aging population all over the world,there is more and more need for treatment of this serious medical *** of female stress urinary incontinence exists already for *** the 20th century invasive treatments like Burch colposuspension and pubovaginal slings were the mainstay of surgical *** introduction of the midurethral sling m.de the procedure less invasive and accessible for more *** there are many options available and the field is developing *** recent years many new medical devices have been developed,that increase the number of treatment options available and make it possible to find a suitable solution for the individual patient based on subjective and objective results and the chances of *** manuscript provides an introduction to the therapeutical options that are available nowadays for female stress urinary incontinence.

关键词： Female Stress urinary incontinence Treatment Urinary incontinence Pelvic floor muscle training Suburethral slings

Natural,synthetic and commercially-available biopolymers used to regenerate tendons and ligaments

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Bioactive materials 2023年第1期19卷 179-197页

作者： Behzad Shiroud Heidari Rui Ruan Ebrahim Vahabli Peilin Chen Elena m.de-Juan-Pardo minghao Zheng Barry Doyle Vascular Engineering Laboratory Harry Perkins Institute of Medical ResearchQEII Medical Centre and the UWA Centre for Medical ResearchThe University of Western AustraliaNedlands6009Australia School of Engineering The University of Western AustraliaPerthAustralia Australian Research Council Centre for Personalised Therapeutics Technologies Australia Division of Surgery(Orthopaedics) Medical SchoolThe University of Western AustraliaPerthAustralia T3mPLATE Harry Perkins Institute of Medical ResearchQEII Medical Centre and the UWA Centre for Medical ResearchThe University of Western AustraliaNedlands6009Australia Science and Engineering Faculty Queensland University of TechnologyBrisbaneQueenslandAustralia Perron Institute for Neurological and Translational Science Nedlands6009Australia BHF Centre for Cardiovascular Science The University of EdinburghUK

Tendon and ligament(TL)injuries affect millions of people *** play a significant role in TL tissue repair,whether the treatment relies on tissue engineering strategies or using artificial tendon *** biopolymer governs the mechanical properties,biocompatibility,degradation,and fabrication method of the TL *** natural,synthetic and hybrid biopolymers have been studied in TL regeneration,often combined with therapeutic agents and minerals to engineer novel scaffold ***,most of the advanced biopolymers have not advanced to clinical use ***,we aim to review recent biopolymers and discuss their features for TL tissue *** introducing the properties of the native tissue,we discuss different types of natural,synthetic and hybrid biopolymers used in TL tissue ***,we review biopolymers used in commercial absorbable and non-absorbable TL ***,we explain the challenges and future directions for the development of novel biopolymers in TL regenerative treatment.

关键词： Synthetic biopolymers Natural biopolymers Hybrid composites Tendon scaffolds Commercial grafts

Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

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Cancer Biology & medicine 2022年第7期19卷 1047-1060页

作者： Yu Han Yuming Yang Qiuyang Sun Bin Li Caixia Yue Yanlei Liu Jesús m.de la Fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of EducationShanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science&EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Center for Nanotechnology Collaborative Innovational Center for System BiologyShanghai 200241China department of Neurosurgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Instituto de Nanociencia de Aragon(INA) Universidad de ZaragozaZaragoza 50018Spain

Objective:Although great progress has been m.de in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA ***:We developed an up-conversion nanoparticle-based nanocage *** system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites,due to modifications of targeted molecules on the surfaces of nanocages and local ***:The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from.degradation in transit to the tumor sites,where they *** with the passive target and control groups,the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of ***:The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor *** with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes,high tumor inhibition ratios,and longer survival times.

关键词： Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery

Controlling the Cassie-to-Wenzel Transition: an Easy Route towards the Realization of Tridimensional Arrays of Biological Objects

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Nano-micro Letters 2014年第3期6卷 280-286页

作者： G.Ciasca m.Papi m.Chiarpotto A.de Ninno E.Giovine G.Campi A.Gerardino m.de Spirito L.Businaro Istituto di Fisica Universit'a Cattolica S. Cuore L.go Francesco Vito 1 I-00168 Roma Italy Istituto di Fotonica e Nanotecnologie - CNR Via Cineto Romano 42 Roma 00156 Italy Institute of Crystallography – CNR Via Salaria Km 29 0016 Monterotondo Roma Italy

In this paper we provide evidence that the Cassie-to-Wenzel transition, despite its detrimental effects on the wetting properties of superhydrophobic surfaces, can be exploited as an effective micro-fabrication strategy to obtain highly ordered arrays of biological objects. To this purpose we fabricated a patterned surface wetted in the Cassie state, where we deposited a droplet containing genomic DNA. We observed that, when the droplet wets the surface in the Cassie state, an array of DNA filaments pinned on the top edges between pillars is formed. Conversely, when the Cassie-to-Wenzel transition occurs, DNA can be pinned at different height between pillars. These results open the way to the realization of tridimensional arrays of biological objects.

关键词： Superhydrophobic patterned surfaces Cassie-to-Wenzel transition DNA arrays

^(236)U AmS measurement at CIRCE

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Chinese Physics C 2010年第11期34卷 1729-1732页

作者：管永精 m.de Cesare F.Terrasi F.Quinto C.Sabbarese N.de Cesare A.D'Onofrio 王慧娟 College of Physics Science and Technology Guangxi University department of Environmental Sciences II University of Naples

In order to measure the isotopic ratio of actinides,the upgrade of the accelerator mass spectrometry system at the Center for Isotopic Research on Cultural and Environmental heritage at the Second University of Naples,Italy,was *** beam emittance of 238U and the isotopic abundance sensitivity of 236U were measured on the present beam *** a 16-strip silicon detector,the sensitivity of 236U/238U≈ 1×10-11 was obtained.

关键词： uranium AmS beam emittance sensitivity