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Frontier of the Paleo-Tethys Ocean in the western mediterranean:Isotopic(Sm-Nd)constraints on sources of devonian units from menorca Island

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Geoscience Frontiers 2024年第5期15卷 323-338页

作者： Ricardo Arenas Jose m.Fuenlabrada Cristian Timoner Rubén díez Fernández Esther Rojo-Pérez departamento de mineralogía y Petrología and Instituto de Geociencias(UCm CSIC)Universidad ComplutenseMadridSpain Unidad de Geocronología(CAI de Ciencias de la Tierra y Arqueometría) Universidad ComplutenseMadridSpain Bayerisches Geoinstitut University of BayreuthBayreuthGermany Instituto Geológico y minero de España–CSIC SalamancaSpain

The c.1000-m-thick pre-orogenic devonian mainly metapelitic sequence of North menorca Island shows a fairly complete stratigraphic *** rocks of this sequence indicate gradually increasing deeper marine conditions of sedimentation towards its uppermost ***,the obtained sedimentary characteristics resemble those related to a deep and narrow basin-associated *** sills of Ti-augite-bearing alkaline gabbros occur within the devonian *** intensity of Variscan deformation increases downwards through the *** to the characteristics of the devonian sequence and its location within the Variscan Orogen,a correlation with similar units located in the southern sectors of the Central Iberian Zone(Iberian massif)is *** devonian metapelitic rocks have geochemical characteristics suggesting that they represent moderately recycled mature siliciclastic sediments,generated from erosion of distant source areas belonging to an upper continental *** relatively narrow range of variation observed in initial^(143)Nd/^(144)Nd ratios supports a similar source for the menorcan slates(0.51165–0.51182).However,a marked trend is observed in these isotope ratios,from lower values at the base of the stratigraphic column(minimum value of 0.511941)to higher values at the top(maximum value of 0.512131).The^(147)Sm/^(144)Nd ratios vary between 0.1074 and 0.1238,within the range defined for siliciclastic rocks with felsic crustal *** Nd model ages define a narrow range between 1496 ma and 1754 ma(Late Paleoproterozoic–Early mesoproterozoic),and they are consistently younger *** data rule out a provenance from the erosion of the West Africa Craton,as they are more compatible with a provenance from regions located in the Trans-Saharan Belt or Sahara *** characteristics of the menorcan devonian sequence are compatible with its deposition in a narrow and deep peri-Gondwanan transtensional basin,gener

关键词： Western Paleo-Tethys frontiers menorca Island Sm-Nd isotopic constraints devonian sequence provenance in Gondwana

Therapeutic advances in neural regeneration for Huntington’s disease

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Neural Regeneration Research 2024年第9期19卷 1991-1997页

作者： Francesco d’Egidio Vanessa Castelli Giorgia Lombardozzi Fabrizio Ammannito Annamaria Cimini michele d’Angelo department of Life Health and Environmental SciencesUniversity of L’AquilaL’AquilaItaly

Huntington’s disease is a neurodegenerative disease caused by the expansion mutation of a cytosine-adenine-guanine triplet in the exon 1 of the HTT gene which is responsible for the production of the huntingtin (Htt) protein. In physiological conditions, Htt is involved in many cellular processes such as cell signaling, transcriptional regulation, energy metabolism regulation, dNA maintenance, axonal trafficking, and antiapoptotic activity. When the genetic alteration is present, the production of a mutant version of Htt (mHtt) occurs, which is characterized by a plethora of pathogenic activities that, finally, lead to cell death. Among all the cells in which mHtt exerts its dangerous activity, the GABAergic medium Spiny Neurons seem to be the most affected by the mHtt-induced excitotoxicity both in the cortex and in the striatum. However, as the neurodegeneration proceeds ahead the neuronal loss grows also in other brain areas such as the cerebellum, hypothalamus, thalamus, subthalamic nucleus, globus pallidus, and substantia nigra, determining the variety of symptoms that characterize Huntington’s disease. From a clinical point of view, Huntington’s disease is characterized by a wide spectrum of symptoms spanning from motor impairment to cognitive disorders and dementia. Huntington’s disease shows a prevalence of around 3.92 cases every 100,000 worldwide and an incidence of 0.48 new cases every 100,000/year. To date, there is no available cure for Huntington’s disease. Several treatments have been developed so far, aiming to reduce the severity of one or more symptoms to slow down the inexorable decline caused by the disease. In this context, the search for reliable strategies to target the different aspects of Huntington’s disease become of the utmost interest. In recent years, a variety of studies demonstrated the detrimental role of neuronal loss in Huntington’s disease condition highlighting how the replacement of lost cells would be a reasonable strategy to o

关键词： cell therapy exosomes extracellular vesicles Huntingtin Huntington’s disease medium spiny neurons neurodegenerative disease neurogenesis neuronal loss stem cells

One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei Jiao Guang-Xin Zhang E.N.Cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian daniele mengoni Wei-Wei Qu Cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang Chun-Lei Zhang J.J.Valiente-dobón d.Testov m.mazzocco A.Gozzelino C.Parascandolo d.Pierroutsakou m.La Commara A.Goasduff d.Bazzacco d.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis m.Siciliano R.menegazzo S.m.Lenzi S.Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANdAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in Nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and manufacture of High Purity Germanium materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and material modification of ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly department of Natural and mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics division Argonne National LaboratoryLemontILUSA department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 meV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

microscale shaping and rounding of ridge arrays and star pattern features on nickel mould via electrochemical polishing

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Advances in manufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki Nan Zhang michael d.Gilchrist School of mechanical and materials Engineering University College DublinBelfieldDublin 4Ireland

High quality micro mould tools are critical for ensuring defect-free production of micro injection moulded *** demoulding stage of the micro injection moulding can adversely affect the surface integrity due to friction,adhesion and thermal stresses between the metallic mould and polymeric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of micro features in order to ease *** defects that occur in replicated polymer parts include cracks,burrs and distorted features.A nickel mould having multiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dimensions ranging from 10μm to 150μm and with various aspect ratios to study the effect of electropolishing on modifying the shape of micro features and surface morphology.A transient 2d computational analysis has been conducted to anticipate the effect of shaping on the Ni mould after electrochemical polishing with non-uniform material removal rates,based on the distribution of current *** experimental results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approximately 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be maintained under 50 *** work uses a green and environmental friendly nickel sulfamate electrolyte which can be effective for shaping of nickel micro features without causing any surface deposition.

关键词： micro feature shaping and electropolishing micro mould tools Green electrolyte demoulding micro patterns

Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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Journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： meichen Wang Kelly J Rivenbark Timothy d Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AmPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AmPA ***,clay-based sorption strategies for mixtures of GLP and AmPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AmPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(Cm)and acid processed montmorillonite(APm)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APm inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AmPA in soils and plants.

关键词： Glyphosate AmPA Adsorption Soil remediation Plant Hydroponic system

Nonlinear dynamic modeling of planar moving Timoshenko beam considering non-rigid non-elastic axial effects

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Applied mathematics and mechanics(English Edition) 2024年第3期45卷 479-496页

作者： m.ABBASI GAVARI m.R.HOmAEINEZHAd Faculty of mechanical Engineering K.N.Toosi University of TechnologyTehran 19991-43344Iran

due to the importance of vibration effects on the functional accuracy of mechanical systems,this research aims to develop a precise model of a nonlinearly vibrating single-link mobile flexible *** manipulator consists of an elastic arm,a rotary motor,and a rigid carrier,and undergoes general in-plane rigid body motion along with elastic transverse *** accurately model the elastic behavior,Timoshenko’s beam theory is used to describe the flexible arm,which accounts for rotary inertia and shear deformation *** applying Newton’s second law,the nonlinear governing equations of motion for the manipulator are derived as a coupled system of ordinary differential equations(OdEs)and partial differential equations(PdEs).Then,the assumed mode method(Amm)is used to solve this nonlinear system of governing equations with appropriate shape *** assumed modes can be obtained after solving the characteristic equation of a Timoshenko beam with clamped boundary conditions at one end and an attached mass/inertia at the *** addition,the effect of the transverse vibration of the inextensible arm on its axial behavior is *** the axial rigidity,the effect makes the rigid body dynamics invalid for the axial behavior of the ***,numerical simulations are conducted to evaluate the performance of the developed model,and the results are compared with those obtained by the finite element *** comparison confirms the validity of the proposed dynamic model for the *** to the mentioned features,this model can be reliable for investigating the system’s vibrational behavior and implementing vibration control algorithms.

关键词： planar moving Timoshenko beam non-rigid non-elastic axial effect as-sumed mode method(Amm) nonlinear motion analysis

Free vibration and buckling analysis of polymeric composite beams reinforced by functionally graded bamboo fbers

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Applied mathematics and mechanics(English Edition) 2024年第3期45卷 543-562页

作者： H.m.FEIZABAd m.H.YAS department of mechanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent *** fibers are renowned for their good mechanical properties,abundance,and short cycle *** beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic *** different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the *** elastic properties of the composite are determined with the law of *** Hamilton’s principle,the governing equations of motion are *** generalized differential quadrature method(GdQm)is then applied to the equations to obtain the *** achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam ***,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber ***,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.

关键词： bamboo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature method(GdQm)

Chebyshev polynomial-based Ritz method for thermal buckling and free vibration behaviors of metal foam beams

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Applied mathematics and mechanics(English Edition) 2024年第5期45卷 891-910页

作者： N.d.NGUYEN T.N.NGUYEN Faculty of Civil Engineering Ho Chi Minh City University of Technology and EducationHo Chi Minh City 71309Viet Nam Faculty of Engineering and Technology Kien Giang UniversityChau Thanh 92000Viet Nam

This study presents the Chebyshev polynomials-based Ritz method to examine the thermal buckling and free vibration characteristics of metal foam *** analyses include three models for porosity distribution and two scenarios for thermal *** material properties are assessed under two conditions,i.e.,temperature dependence and temperature *** theoretical framework for the beams is based on the higher-order shear deformation theory,which incorporates shear deformations with higher-order *** governing equations are established from the Lagrange equations,and the beam displacement fields are approximated by the Chebyshev *** simulations are performed to evaluate the effects of thermal load,slenderness,boundary condition(BC),and porosity distribution on the buckling and vibration behaviors of metal foam *** findings highlight the significant influence of temperature-dependent(Td)material properties on metal foam beams'buckling and vibration responses.

关键词： Ritz method Chebyshev function buckling vibration metal foam beam higher-order beam theory(HOBT)

Parallelization of frequency domain quantum gates:manipulation and distribution of frequency-entangled photon pairs generated by a 21 GHz silicon microresonator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine Henry dario A.Fioretto Lorenzo m.Procopio Stéphane monfray Frédéric Boeuf Laurent Vivien Eric Cassan Carlos Alonzo-Ramos Kamel Bencheikh Isabelle Zaquine Nadia Belabas Institut Polytechnique de Paris LTCITélécom ParisPalaiseauFrance Université Paris-Saclay CNRSCentre for Nanosciences and NanotechnologyUMR 9001PalaiseauFrance Weizmann Institute of Science RehovotIsrael STmicroelectronics SAS CrollesFrance

Harnessing the frequency dimension in integrated photonics offers key advantages in terms of scalability,noise resilience,parallelization,and compatibility with telecom multiplexing *** ring resonators have been used to generate frequency-entangled states through spontaneous four-wave ***,state-of-the-art integrated resonators are limited by trade-offs among size,spectral separation,and efficient photon pair *** have developed silicon ring resonators with a footprint below 0.05 mm^(2)providing more than 70 frequency channels separated by 21 *** exploit the narrow frequency separation to parallelize and independently control 34 single qubit-gates with a single set of three off-the-shelf electro-optic *** fully characterize 17 frequency-bin maximally entangled qubit pairs by performing quantum state *** demonstrate for the first time,we believe,a fully connected five-user quantum network in the frequency *** results are a step towards a generation of quantum circuits implemented with scalable silicon photonics technology,for applications in quantum computing and secure communications.

关键词： integrated photonics frequency domain quantum gates quantum networks