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International Journal of minerals,metallurgy and materials 2015年第4期22卷 389-394页

作者： S.Deepak Kumar A.mandal m.chakraborty School of mechanical Sciences Indian Institute of Technology Bhubaneswar School of minerals Metallurgical and Materials Engineering Indian Institute of Technology Bhubaneswar

The key factor in semi-solid metal processing is the solid fraction at the forming temperature because it affects the microstructure and mechanical properties of the thixoformed components. Though an enormous amount of data exists on the solid fraction-temperature re- lationship in A356 alloy, information regarding the solid fraction evolution characteristics of A356-TiB2 composites is scarce. The present article establishes the temperature-solid fraction correlation in A356 alloy and A356-xTiB2 （x = 2.5wt% and 5wt%） composites using dif- ferential thermal analysis （DTA）. The DTA results indicate that the solidification characteristics of the composites exhibited a variation of 2℃ and 3℃ in liquidus temperatures and a variation of 3℃ and 5℃ in solidus temperatures with respect to the base alloy. moreover, the eutectic growth temperature and the solid fraction（fs） vs. temperature characteristics of the composites were found to be higher than those of the base alloy. The investigation revealed that in-situ formed TiB2 particles in the molten metal introduced more nucleation sites and reduced undercooling.

关键词： particle reinforced composites aluminum alloys titanium boride casting solid fraction differential thermal analysis

Influence of Discharge Voltage on Charged Particles in a multi-Dipole Device in the Presence of an Ion Collecting Surface

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Chinese Physics Letters 2013年第1期30卷 122-126页

作者： m.K.mishra A.Phukan m.chakraborty Department of Physics Baosi Banikanta Kakati CollegeNagaonBarpetaAssam-781311India Department of Physics Madhabdev CollegeNarayanpurLakhimpurAssam-784164India Centre of Plasma Physics-Institute for Plasma Research TepesiaSonapurAssam-782402India

The influence of discharge voltage on ion collecting surfaces in the form of a metal plate and a mesh grid is investigated in a multi-dipole *** the experiment,a solid metal plate and a mesh grid are placed alternately at one end of the multi-dipole *** is seen that except for high negative bias,the ion space charge layer in front of the grid gets depleted with the increase in discharge voltage whereas it gets thickened in front of the *** is also observed that the electron loss at the cusp(anode current)changes accordingly in both the *** increase in discharge voltage can enhance the Bohm speed of ions towards the ion collecting ***,the negative potential applied to the ion collecting surfaces lowers the bulk plasma potential,which in turn affects the anode current.

关键词： dipole anode thick

Integrating QoS management in TLmm:Three Level mobility model for Next Generation Wireless IP-Based Networks

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China Communications 2008年第3期5卷 125-139页

作者： m.chakraborty I.S.misra A.mukherjee Department of Information Technology Institute of Engineering & Management Department of Electronics and Telecommunication Engineering Jadavpur University IBm Global Services

In this paper we have designed an implemented an integrated framework of QoS for Three Level mobility model(TLmm),which has been recently proved to be the optimal mobility management solution for next generation wireless IP-based *** QoS solution uses a combination of IntServ and DiffServ models incorporated in TLmm *** paper also proposes an effi cient dynamic handover policy that takes care of false *** and analytical results have shown that this infrastructure guarantees eff icient QoS handling and scalability among end *** provide a comparative understanding of the QoS mechanism and signaling load of TLmm we have used TelemIP(without QoS support) and mIP as alternative mobility management protocols.

关键词： Qos NGN wireless IP network

Influence of in-flight particle state diagnostics on properties of plasma sprayed YSZ-CeO_(2) nanocomposite coatings

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International Journal of Smart and Nano materials 2014年第3期5卷 207-216页

作者： S.mantry B.B.Jha A.mandal D.K.mishra B.K.mishra m.chakraborty CSIR-Institute of minerals&materials Technology Bhubaneswar 751013OdishaIndia School of minerals Metallurgical and Materials EngineeringIndian Institute of Technology BhubaneswarBhubaneswar 751007OdishaIndia Department of Physics Institute of Technical Education and ResearchSiksha‘O’Anusandhan UniversityKhandagiri SquareBhubaneswar 751030OdishaIndia Department of Physics College of ScienceEngineering and TechnologyUniversity of South AfricaJohannesburgSouth Africa

This article describes the influence of controlling in-flight hot particle characteristics on properties of plasma sprayed nanostructured yttria stabilized zirconia(YSZ)*** article depicts dependence of adhesion strength of as-sprayed nanostructured YSZ coatings on particle temperature,velocity and size of the splat prior to impact on the metallic *** temperature measurement is based on two-color pyrometry and particle velocities are measured from the length of the particle traces during known exposure *** microstructure and adhesion strength of as-sprayed nano-YSZ coatings were *** emission scanning electron microscopy results revealed that morphology of coating exhibits bimodal microstructure consisting of nano-zones reinforced in the matrix of fully melted *** coating adhesion strength is noticed to be greatly affected by the melting state of *** adhesion strength of 42.39 mPa has been experimentally found out by selecting optimum levels of particle temperature and *** enhanced bond strength of nano-YSZ coating may be attributed to higher interfacial toughness due to cracks being interrupted by adherent nano-zones.

关键词： CeYSZ nano-zones spray diagnostics adhesion plasma spraying

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

关键词： Galerkin methods