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具有极性反转的乳头状肾肿瘤常存在KRAS基因突变

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临床与实验病理学杂志 2020年第2期 232-232页

作者： Al-Obaidy K I Eble J N Nassiri m 魏建国方三高浙江省绍兴市人民医院病理科中国人民解放军陆军特色医学中心病理科

作者新近提出肾上皮性肿瘤亚型——"具有极性反转的乳头状肾肿瘤",是一个独特的肿瘤实体。在参与的研究机构中,具有极性反转的乳头状肾肿瘤占先前诊断为乳头状肾细胞癌的4%。组织学以乳头状或管状、乳头状结构为特征,由单层嗜酸性细胞衬... 详细信息

作者新近提出肾上皮性肿瘤亚型——"具有极性反转的乳头状肾肿瘤",是一个独特的肿瘤实体。在参与的研究机构中,具有极性反转的乳头状肾肿瘤占先前诊断为乳头状肾细胞癌的4%。组织学以乳头状或管状、乳头状结构为特征,由单层嗜酸性细胞衬覆,胞质呈细颗粒状,核位于细胞顶端。具有特征性的免疫表型:GATA3和L1cam均表达,vimentin表达缺失,AmACR/P504S轻度表达缺失。

关键词：肾肿瘤乳头状基因突变极性反转

Biosystems Design to Accelerate C3-to-cam Progression

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BioDesign Research 2020年第1期2020卷 18-33页

作者： Guoliang Yuan mdmahmudul Hassan Degao Liu Sung Don Lim Won Cheol Yim John C.Cushman Kasey markel Patrick m.Shih Haiwei Lu David J.Weston Jin-Gui Chen Timothy J.Tschaplinski Gerald A.Tuskan Xiaohan Yang Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Genetics and Plant Breeding Patuakhali Science and Technology UniversityDumkiPatuakhali 8602Bangladesh Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomicsand Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Applied Plant Sciences Kangwon National UniversityChuncheon 24341Republic of Korea Department of Biochemistry and molecular Biology University of NevadaRenoNVUSA Department of Plant Biology University of CaliforniaDavisDavisCAUSA Feedstocks Division Joint BioEnergy InstituteEmeryvilleCAUSA

Global demand for food and bioenergy production has increased rapidly,while the area of arable land has been declining for decades due to damage caused by erosion,pollution,sea level rise,urban development,soil salinization,and water scarcity driven by global climate *** order to overcome this conflict,there is an urgent need to adapt conventional agriculture to water-limited and hotter conditions with plant crop systems that display higher water-use efficiency(WUE).Crassulacean acid metabolism(cam)species have substantially higher WUE than species performing C3 or C4 *** plants are derived from C3 photosynthesis ***,it is extremely unlikely that the C3 or C4 crop plants would evolve rapidly into cam photosynthesis without human ***,there is growing interest in improving WUE through transferring cam into C3 ***,engineering a major metabolic plant pathway,like cam,is challenging and requires a comprehensive deep understanding of the enzymatic reactions and regulatory networks in both C3 and cam photosynthesis,as well as overcoming physiometabolic limitations such as diurnal stomatal *** advances in cam evolutionary genomics research,genome editing,and synthetic biology have increased the likelihood of successful acceleration of C3-to-cam ***,we first summarize the systems biology-level understanding of the molecular processes in the cam ***,we review the principles of cam engineering in an evolutionary ***,we discuss the technical approaches to accelerate the C3-to-cam transition in plants using synthetic biology toolboxes.

关键词： overcome acceleration evolve

超声诊断cam型股骨髋臼撞击综合征的定性诊断标准和α角测量

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国际医学放射学杂志 2011年第2期 194-194页

作者： F.m.Buck J.Hodler m.Zanetti C.Dora C.W.A.Pfirrmann 白荣杰 University Clinic Balgrist

目的创建cam型股骨髋臼撞击(FAI)综合征的超声(US)诊断技术并对其进行评价。方法 50例病人(女24例,男26例)纳入研究(年龄16～59岁,平均39.1岁)。获取

关键词：股骨髋臼撞击综合征 cam型畸形超声诊断 α角 mRI

意大利头痛诊所收治的进行补充和替代治疗(cam)偏头痛患者的患病率、模式和预测因素

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 10-10页

作者： Rossi P. Di Lorenzo G. malpezzi m.G. 夏峰 Via Suvereto 250 00139 Rome Italy Dr.

The use of complementary and alternative medicine (cam)- in migraine is a gr owing phenomenon about which little is known. This study was undertaken to evalu ate the rates, pattern and presence of predictors of cam use in a clinical popul ation of patients with different migraine subtypes. Four hundred and eighty- on e migraineurs attending a headache clinic were asked to undergo a physician- ad ministered structured interview designed to gather information on cam use. Past use of cam therapies was reported by 31.4% of the patients surveyed, with 17.1 % having used cam in the previous year. cam therapies were perceived as benefi cial by 39.5% of the patients who had used them. A significantly higher propor tion of transformed migraine patients reported cam treatments as ineffective com pared with patients suffering from episodic migraine (73.1% vs. 50.7% , P most common source of a recommendation of cam was a friend or relativ e (52.7% ). In most cases, migraineurs’ recourse to cam treatments was specif ically for their headache (89.3% ). Approximately 61% of cam users had not in formed their medical doctors of their cam use. The most common reason for decidi ng to try a cam therapy was that it offered a ’ potential improvement of headac he’ (47.7% ). The greatest users of cam treatments were: patients with a diag nosis of transformed migraine; those who had consulted a high number of speciali sts and reported a higher lifetime number of conventional medical visits; those with a comorbid psychiatric disorder; those with a high income; and those whose headache had been either misdiagnosed or not diagnosed at all. Our findings sugg est that headache clinic migraine patients, in their need of and quest for care, seek and explore both conventional and cam approaches. Physicians should be mad e aware of this patient- driven change in the medical climate in order to preve nt misuse of healthcare resources and to be better equipped to meet patients’ needs.

关键词：偏头痛患者 cam 变异型执业医师医疗保健率比常规医疗

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装配顺序规划中的子装配体稳定性

西北大学学报（自然科学版） 1999年第4期29卷 289-292页

作者：张建标魏生民杨彭基西北工业大学CAD/cam研究中心陕西西安710072

介绍了子装配体内部运动自由度的概念及计算方法，给出了基于内部运动自由度的子装配体稳定性判别条件，且具有一定的通用性。经稳定性判别后可以大大缩小装配顺序规划中的方案数，可用于装配方案的选择及降低装配成本。

关键词：稳定性割集法装配顺序规划子装配体

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调钙蛋白在大鼠脑内的区域分布

基础医学与临床 1984年第Z1期 35-35页

作者：周隆武,moyer J.A.,muth E,Clark B.,Palkovits m,Weiss B 中日友好医院临床医学研究所美国费城Wyeth实验室神经药理系。美国费城Wyeth实验室神经药理系。美国密苏里州华盛顿大学神经学系匈牙利Semmelweis大学医学院解剖系美国费城宾州医学院药理系

广泛分布在体内的调钙蛋白(Calmodulin,简称cam)在脑内有极高的浓度。为进一步研究它在脑功能中的可能作用,本文测定了正常大鼠脑内69个区域和核团内cam活性的分布。用雄性大鼠(200～250克),断头,快速取出脑,在-70℃冰冻切片机内将脑切... 详细信息

广泛分布在体内的调钙蛋白(Calmodulin,简称cam)在脑内有极高的浓度。为进一步研究它在脑功能中的可能作用,本文测定了正常大鼠脑内69个区域和核团内cam活性的分布。用雄性大鼠(200～250克),断头,快速取出脑,在-70℃冰冻切片机内将脑切成300μ的薄片,铺在玻片上,将此玻片放在一冷板上,按标准的神经解剖界

关键词：调钙蛋白脑内玻片

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基于PDm的CAD/CAPP、cam集成

计算机工程与应用 1999年第12期35卷 19-21页

作者：孙知信李玲娟王绍棣南京邮电学院计算机科学与技术系南京210003

该文以８６３／ＣＩＭＳ示范工程的实践和开发为依据，对基于产品数据管理（ＰＯＭ）的ＣＡＤ／ＣＡＰＰ、ＣＡＭ集成进行了深入研究。文章首先给出了系统集成的原则，随后提出了ＰＤＭ的框架体系结构和基于ＰＤＭ的集成技术，最后讨论... 详细信息

该文以８６３／ＣＩＭＳ示范工程的实践和开发为依据，对基于产品数据管理（ＰＯＭ）的ＣＡＤ／ＣＡＰＰ、ＣＡＭ集成进行了深入研究。文章首先给出了系统集成的原则，随后提出了ＰＤＭ的框架体系结构和基于ＰＤＭ的集成技术，最后讨论了基于ＳＴＥＰ的产品数据交换和基于ＳＤＡＩ标准数据接口技术。

关键词：产品数据管理 CAD CAPP cam STEP CImS

髋关节cam型碰撞综合征髋臼软骨分离的mR关节成像表现

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国际医学放射学杂志 2008年第A6期31卷 503-503页

作者： C.W.A.Pfirrmann S.R.Duc m.Zanetti C.Dora J.Hodler 马立恒 Department of Radiology University Hospital Balgrist Forchstrasse 340 CH-8008 Zurich Switzerland.

目的回顾性分析mR关节成像显示cam型髋关节碰撞综合征(FAI)病人髋臼软骨分离的发生率并探讨其价值。材料和方法因为属于回顾性分析。

关键词：髋臼软骨 cam mR 成像显示脂肪饱和低信号区液体信号外科手术髋臼缘特异度