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临床检验杂志 2013年第5期31卷 382-387页

作者： Gary L.myers Peter W.F.Wilson Gerald R.cooper Scott m.Grundy Darwin R.Labarthe 王永志郑芳鄢盛恺

对载脂蛋白AⅠ与载脂蛋白B的建议根据对文献的综述,提出以下载脂蛋白AⅠ（apo AⅠ）和载脂蛋白B（apo B）在CHD和卒中一级预防危险评估中的临床应用及测定建议。

关键词：载脂蛋白AⅠ 载脂蛋白B 心血管病危临床应用危险评估一级预防 CHD

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Assessment of cancer risk in two rural West Texas communities using anthropometrics, diet, and physical activity

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Open Journal of Preventive medicine 2013年第3期3卷 285-292页

作者： Natalie masis Debra B. Reed Barent N. mcCool Jamie A. cooper Conrad Lyford Department of Agricultural & Applied Economics Texas Tech University Lubbock USA Department of Nutrition Hospitality and Retail Management Texas Tech University Lubbock USA Former m.S. Nutritional Sciences Graduate Student Texas Tech University Lubbock USA

Cancer risks in the United States are linked to undesirable dietary and physical activity habits that may be more common in rural communities. This study assessed the cancer risk in two rural West Texas communities through anthropometrics, diet, and physical activity measures (n = 374). No significant relationships were found between body mass index (BmI) and waist circumference (WC) with consumption of fruits, vegetables, whole grains, and sugar-sweetened beverages;however, data showed significant negative associations between BmI and WC and physical activity. Over 58% of the sample was unaware of the link between obesity and cancer risk. Further evaluation of cancer risk in rural communities is needed to develop effective interventions and reduce health disparities.

关键词： Nutrition Obesity Cancer Risk Rural Communities

Cryo-Em structure of a tetrameric photosystem I from Chroococcidiopsis TS-821, a thermophilic, unicellular, non-heterocyst-forming cyanobacterium

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Plant Communications 2022年第1期3卷 53-70页

作者： Dmitry A.Semchonok Jyotirmoy mondal Connor J.cooper Katrina Schlum meng Li muhamed Amin Carlos O.S.Sorzano Erney Ramirez-Aportela Panagiotis L.Kastritis Egbert J.Boekema Albert Guskov Barry D.Bruce Groningen Biomolecular Sciences&Biotechnology Institute University of GroningenGroningenthe Netherlands Biochemistry&Cellular and molecular Biology Department University of TennesseeKnoxvilleTNUSA Program in Genome Science and Technology University of TennesseeKnoxvilleTNUSA Bredesen Center for Interdisciplinary Research&Education University of TennesseeKnoxvilleTNUSA Department of Sciences University College GroningenGroningenthe Netherlands Biocomputing Unit National Center for Biotechnology(CSIC)Darwin 3Campus Universidad Auto´noma de MadridCantoblanco28049 MadridSpain Universidad CEU San Pablo Campus Urb.Monteprı´ncipeBoadilla del Monte28668 MadridSpain Institute of Biochemistry and Biotechnology Martin Luther University Halle-WittenbergHalle/SaaleGermany microbiology Department University of TennesseeKnoxvilleTNUSA Present address:Institute of Biochemistry and Biotechnology Martin Luther University Halle-WittenbergHalle/SaaleGermany School of Oceanography University of WashingtonSeattleWAUSA

Photosystem I(PSI)is one of two photosystems involved in oxygenic *** of cyanobacteria exists in monomeric,trimeric,and tetrameric forms,in contrast to the strictly monomeric form of PSI in plants and *** tetrameric organization raises questions about its structural,physiological,and evolutionary *** we report the3.72 A˚resolution cryo-electron microscopy structure of tetrameric PSI from the thermophilic,unicellular cyanobacterium Chroococcidiopsis *** structure resolves 44 subunits and 448 cofactor *** conclude that the tetramer is arranged via two different interfaces resulting from a dimer-of-dimers *** localization of chlorophyll molecules permits an excitation energy pathway within and between adjacent *** analysis reveals conserved regions in the PsaL subunit that correlate with the oligomeric *** PSI may function as a key evolutionary step between the trimeric and monomeric forms of PSI organization in photosynthetic organisms.

关键词： cryo-Em photosystem I non-heterocyst-forming cyanobacteria Chroococcidiopsis evolution of chloroplast high light adaptation

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雌激素受体α基因突变和卒中风险的关系

世界核心医学期刊文摘(神经病学分册) 2006年第2期 60-61页

作者： Shearman A.m. cooper J.A. Kotwinski P.J. 张慧 77 massachusetts Ave. Cambridge MA 02139 United States.Dr

Background -Estrogen receptor α(ESR1) gene variation is associated with a range of important estrogen-dependent characteristics, including responses of lipid profile and atherosclerotic severity to hormone replacement therapy, coronary heart disease risk, and migraine. The roles that reproductive steroids play in cerebrovascular pathophysiology and ischemia are an important area of investigation. Given that there is a significantly higher risk of myocardial infarction among men with the CC genotype (PP of PvuII) of c.454-397T >C (rs2234693), we asked whether this genotype is associated with a higher risk of stroke. methods -Relative risk of stroke by genotype was determined in 2709 participants of the Second Northwick Park Heart Study, white males with a mean baseline age 56 years and follow up 10.5 years. Results -Compared with participants with the ESR1 c.454-397CT or TT genotype, those with the CC genotype had a relative risk of stroke of 1.92 (95%confidence interval, 1.06 to 3.48, P=0.03) after adjustment for age, primary care practice; additional adjustment for body mass index, serum cholesterol and triglyceride levels, hypertension, diabetes, and smoking status. Exclusion of stroke cases with coronary heart disease gave results that were essentially unchanged. Conclusions -In this study, subjects with the common ESR1 c.454-397CC genotype have a substantial increase in risk of stroke. In another publication, other ESR1 variation was associated with migraine. We thus hypothesize that estrogen receptor variation may provide a basis for the established re lationship among estrogens, migraine, and stroke.

关键词：卒中风险偏头痛脑病受试者

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用分层抽样法来估计林木落叶

中南林业调查规划 1988年第4期 56-60+46页

作者： R·J·cooper k·m·Dodge R·C·uchitmore 文彦

本文介绍一种估计落叶百分数的方法,这种方法是在一个基准年里,在一块样地上用一根瞄准管来测出叶子的大小并与在相同的样地上相同的点出现的叶子进行比较。当测量结果不是独立时,从麦克尼马的典型统计量得出一个非参数的程序,用于估计... 详细信息

本文介绍一种估计落叶百分数的方法,这种方法是在一个基准年里,在一块样地上用一根瞄准管来测出叶子的大小并与在相同的样地上相同的点出现的叶子进行比较。当测量结果不是独立时,从麦克尼马的典型统计量得出一个非参数的程序,用于估计落叶的百分率及标准差。对于一块样地,可把它划分为各个树冠高类型来估计,下面举例说明。

关键词：瞄准管列联表麦克尼马实验舞毒蛾

美国临床生化科学院检验医学实践指南:心血管疾病和卒中一级预防中新的生物标志物第3章炎症生物标志物和心血管疾病危险

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临床检验杂志 2013年第5期31卷 365-376页

作者： mary Cushman Christie m.Ballantyne Daniel Levy Nader Rifai Gerald R.cooper Gary L.myers 梁红艳王腾姣姜晓峰郑芳鄢盛恺

对炎症生物标志物的建议炎症参与许多疾病过程,近10年来,炎症参与CVD的病理生理过程这一理论受到广泛赞同。目前发现多种炎症标志物,表3中24种炎症标志物已被许多观察研究数据所证实。根据炎症标志物的临床应用实际，如是否可有标准化... 详细信息

对炎症生物标志物的建议炎症参与许多疾病过程,近10年来,炎症参与CVD的病理生理过程这一理论受到广泛赞同。目前发现多种炎症标志物,表3中24种炎症标志物已被许多观察研究数据所证实。根据炎症标志物的临床应用实际，如是否可有标准化的商品化检测试剂及观察数据是否充分等进行归类。CRP、Fib和WBC被挑选作进一步评估。

关键词：炎症标志物生物标志物心血管病危病理生理过程疾病过程临床应用检测试剂

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A SYNDROmE OF SEVERE HYPOGLYCEmIA AND ACIDOSIS IN YOUNG ImmUNOSUPPRESSED DIABETIC mONKEYS - ASSOCIATION WITH SEPSIS

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A SYNDROME OF SEVERE HYPOGLYCEMIA AND ACIDOSIS IN YOUNG IMMU...

2012中国器官移植大会

作者： Dirk J.van der Windt Eefje m.Dons Gabriel J. Echeverri Noriko murase Rita Bottino martin Wijkstrom Robert Wagner David K.C.cooper Thomas E.Starzl Transplantation Institute Department of SurgeryUniversity of Pittsburgh Medical CenterPittsburghPAUSA Division of Immunogenetics Department of PediatricsChildren's Hospital of PittsburghPittsburghPAUSA

Large animals treated with immunosuppressive drug regimens for preclinical experiments of transplantation have increased risks of infection,as do individuals with *** we report our experience with severe sepsis in two young cynomolgus monkeys that were subjected to diabetes induction +/- islet *** both monkeys,infection was associated with a syndrome of profound hypoglycemia accompanied by severe *** the discussion of these cases we include information on five immunosuppressed pigs that also experienced severe hypoglycemic episodes after diabetes induction and islet

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指南帕金森病：NICE指南更新概要

英国医学杂志中文版 2018年第5期21卷 280-284页

作者：马俊(译) 王含(校) 北京协和医院神经科

帕金森病是最常见的神经科疾病之一，在英国，每10万人中估计约有250人患病。典型帕金森病患者表现出的运动症状包括运动迟缓、肌强直、静止性震颤和姿势不稳；然而，非运动症状也可能很突出，包括抑郁、认知障碍和自主神经功能障碍。

关键词：帕金森病 NICE指南

腹腔镜下子宫内膜异位症切除术主要并发症的多中心前瞻性研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 20-21页

作者： Kaloo P.D. cooper m.J.W. Reid G. 朱磊 Royal Hampshire County Hospital Romsey Road Winchester Hampshire SO22 5DG United Kingdom

Objective: To clarify the rate of major intra-operative and post-operative complications experienced during excisional surgery for endometriosis. Design: Prospective multi-centre observational study set in two University teaching hospitals and three private hospitals in Sydney, Australia. All consecutive subjects undergoing laparoscopic excisional surgery for minimal to severe endometriosis were recruited (790 subjects). Complications were recorded intra-opera- tively or post-operatively on a secure computerised patient database. major intra-and post-operative complications i.e. inadvertent visceral or vascular injury or other complications directly related to surgery that either significantly prolonged the operating time, delayed discharge or necessitated re-admission. Results: Seven hundred and ninety subjects were recruited over a 3-year period. Seven major complications were experienced (8.8/1000); four bowel injuries, one cystotomy, one ureteric transection, and one major vascular injury. All visceral or vascular injuries were diagnosed prior to completion of the surgery. No significant longterm sequelae were experienced. Conclusion: The incidence of major complications in this study of 8.8/1000 compares favourably with other similar reports. In view of the potential symptom relief obtained, the authors continue to believe the benefits of such surgery significantly outweigh the risks of subsequent operative-related morbidity.

关键词：子宫内膜异位症切除术腔镜大学教学医院手术时间观察性研究远期后遗症血管损伤肠损伤术后

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Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

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World Journal of Gastroenterology 2022年第31期28卷 4390-4398页

作者： Alnoor Ramji Karen Doucette Curtis cooper Gerald Yosel minuk mang ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong Lisa Barrett Hin Hin Ko Sarah Haylock-Jacobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin Department of medicine University of British ColumbiaVancouver v6t 1z3Canada Department of medicine University of AlbertaEdmonton t6g 2r7Canada Department of medicine The Ottawa Hospital Research InstituteUniversity of OttawaOttawa ON K1H 8L6Canada Department of medicine University of ManitobaWinnipeg r3e 3j7Canada Department of medicine University of SaskatchewanSaskatoon s7n 5e5Canada Department of medicine University Health NetworkToronto m5g 2c4Canada Pacific Gastroenterology Associates Vancouver v6z 2k5Canada Vancouver Infectious Disease Centre Vancouver v6z 2c7Canada Department of medicine McGill UniversityMontreal h3a 0g4Canada Department of microbiology and Immunology Dalhousie UniversityHalifax b3h 4r2Canada Cumming School of medicine University of CalgaryCalgary t2n 1n4Canada

BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)*** is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAm)to tenofovir disoproxil fumarate(TDF).AIm To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSm)(i.e.,FibroScan®).mETHODS Retrospective,observational cohort study from the Canadian HBV *** collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and *** were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year *** In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAm-treated with similar median duration of 3.9 and 3.7 years,*** mean baseline LSm was 11.2 kPa(TDF)vs 8.3 kPa(LAm)(P=0.003).At 5-year follow-up,the mean LSm was 7.0 kPa in TDF vs 6.7 kPa in LAm(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAm,Pment showed that all had normal ALT,but more TDF patients were virologically suppressed(mL)(n=170/190,89%)vs LAm-treated(n=35/58,60%)(Pmerican study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss.

关键词： Nucleos(t)ide analog therapy Functional cure Hepatitis B virus surface antigen loss Fibrosis regression Liver stiffness measurement Transient elastography