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Extracellular vesicles-coupled miRNAs from oviduct and uterus modulate signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1528-1549页

作者： Rosane mazzarella Karina canon‑Beltran Yulia N.cajas meriem Hamdi Encina m.Gonzalez Juliano c.da Silveira claudia L.V.Leal D.Rizos Department of Animal Reproduction INIA-CSICMadridSpain Department of Biochemistry and molecular Biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain Department Agrarian Production Technical University of MadridUPMMadridSpain Departamento de ciencias Biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador Department of Anatomy and Embryology FV-UCMMadridSpain Department of Veterinary medicine FZEA-USPPirassunungaBrazil

Background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and modulating lipid metabolism-related genes(LmGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. Bioactive molecules within EVs in maternal reproductive fluids, such as micro RNAs(miRNAs), may contribute to this regulatory process as they modulate gene expression through post-transcriptional *** This study evaluated miRNA cargo in OF-EVs from the early luteal phase and UF-EVs from the mid-luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on LmGs and sign-aling pathways crucial for early embryo development. A total of 333 miRNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed miRNAs, 19 up-regulated in UF-EVs(bta-miR-134, bta-miR-151-3p, bta-miR-155, bta-miR-188, bta-miR-181b, bta-miR-181d, bta-miR-224, bta-miR-23b-3p, bta-miR-24-3p, bta-miR-27a-3p, bta-miR-29a, bta-miR-324, bta-miR-326, bta-miR-345-3p, bta-miR-410, bta-miR-652, bta-miR-677, bta-miR-873 and bta-miR-708) and one(bta-miR-148b) in OF-EVs. These miRNAs were predicted to modulate several pathways such as Wnt, Hippo, mAPK, and lipid metabolism and degradation. Differ-ences in miRNAs found in OF-EVs from the early luteal phase and UF-EVs from mid-luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, miRNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes mammalian Preimplantation Reproductive fluids

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Advancements in Web3 Infrastructure for the metaverse

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ZTE communications 2024年第2期22卷 1-2页

作者： Victor c.m.LEUNG cAI Wei the Artificial Intelligence Research Institute Shenzhen MSU-BIT University Shenzhen mSU-BIT University Shenzhen University the Wireless Networks and mobile Systems(WiNmoS)Laboratory at UBc the School of Science and Engineering at The chinese University of Hong Kong Shenzhen the Human-crypto Society Laboratory the cUHK(SZ)White matrix Joint metaverse Laboratory

Web3,also known as Web 3.0,has recently been attracting increasing attention from industry and *** the potential of blockchain technologies,Web3 has emerged as a pivotal foundation in the realm of metaverse development,which is considered by many as the next-generation ***,Web3 technologies such as smart contracts and protocols like non-fungible tokens(NFTs)have supported the immersive and content-rich experience of current Web3 metaverse projects.

关键词： Web token attracting

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cFD-DEm analysis of particle polydispersity on the performance of fluidised bed reactor during silane pyrolysis Author links open overlay panel

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Particuology 2024年第8期91卷 72-87页

作者： Akshayveer Vijay m.Shinde mS2Discovery Interdisciplinary Research Institute Wilfrid Laurier UniversityWaterlooOntarioN2L3C5Canada Department of chemical Engineering Indian Institute of Technology(BHU)Varanasi221005India

A cFD-DEm model is developed for chemical vapour deposition of silane in a fluidized bed reactor to investigate the effect of polydispersity on local phase dynamics,mass and heat transport,as well as the rate of Si *** gas-phase fines formation and heterogeneous deposition on the seed particle,as well as the scavenging effect for Si particle growth,are *** method is first validated against the experimentally measured Si deposition rate,percentage of fine production and minimum fluidisation ***,the properties,primarily particle intermixing,fluidisation behaviour and bubble dynamics along with the deposition process,are analyzed for several polydisperse beds under various operating *** effect of polydispersity of the bed on a fraction of the bubble size,dense phase expansion and interchange coefficient between various phases is thoroughly investigated to establish a correlation with reactor *** results show that broad-Gaussian particle size distribution(PSD)exhibits excellent improvement in fluidisation behaviour,resulting in a high deposition rate,and minimum formation of Si fines.

关键词： cFD-DEm method chemical vapour deposition(cVD) Particle size distribution Silicon Gas-solid fluidized bed

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Synthesis and Thermal characterization of Solar Salt-Based Phase change composites with Graphene Nanoplatelets

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Journal of Thermal Science 2024年第2期33卷 491-500页

作者： Pethurajan VIGNESHWARAN Saboor SHAIK Sivan SURESH müslüm ARIcI Asif AFZAL Department of Thermal and Energy Engineering School of Mechanical Engineering(SMEC)Vellore Institute of TechnologyVelloreTamil NaduIndia Nanotechnology Research Laboratory Department of Mechanical EngineeringNational Institute of TechnologyTiruchirappalliTamil NaduIndia mechanical Engineering Department Engineering FacultyKocaeli UniversityUmuttepe CampusKocaeli41001Turkey Department of mechanical Engineering P.A.College of Engineering(affiliated to Visvesvaraya Technological UniversityBelagavi)Mangaluru574153India

Thermal energy storage(TES) systems use solar energy despite its irregular availability and day-night temperature *** work reports the thermal characterizations of solar salt-based phase change composites in the presence of graphene nanoplatelets(GNP).Solar salt(60:40 of NaNO_(3):KNO_(3)) possessing phase transition temperature and melting enthalpy of 221.01℃ and 134.58 kJ/kg is proposed as a phase change material(Pcm) for high-temperature solar-based energy storage *** conductivity must be improved to make them suitable for widespread applications and to close the gap between the system needs where they are *** is added at weight concentrations of 0.1%,0.3%,and 0.5% with solar salt using the ball milling method to boost its thermal *** studies indicated the formation of a uniform surface of GNP on solar *** spectrum peaks identified the physical interaction between salt and *** characterization of the composites,such as thermal conductivity,DSc and TGA was carried out for the samples earlier and later 300 thermal cycles.0.5% of GNP has improved the thermal conductivity of salt by 129.67% and after thermal cycling,the enhancement reduced to 125.21% indicating that thermal cycling has a minor impact on thermal *** change temperature decreased by around 2.32% in the presence of0.5% GNP and the latent heat reduced by 4.34% after thermal *** thermograms depicted the composites initiated the weight loss at around 550℃ after which it was *** thermal cycling,the weight loss initiated at ~40℃ lower compared to pure salt,which was found to be a minor *** characterization of solar salt and GNP-based solar salt composites revealed that the composites can be used for enhanced heat transfer in high-temperature solar-based heat transfer and energy storage applications.

关键词： thermal energy storage high temperature solar salt graphene nanoplatelets thermal characterization

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Effect of Fluidic Diode on Performance of Unidirectional Impulse Turbine

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Journal of Thermal Science 2024年第3期33卷 807-814页

作者： DODDAmANI Hithaish ABDUS Samad mANABU Takao SHINYA Okuhara m m ASHRAFUL Alam Department of Ocean Engineering Indian Institute of Technology MadrasChennai600036India Department of mechanical Engineering National Institute of TechnologyMatsue CollegeShimane6908518Japan center of Support Practical Education National Institute of TechnologyMatsue CollegeShimane6908518Japan Department of Transportation Engineering Osaka Sangyo UniversityDaito5748530Japan

A pair of unidirectional turbines(UT)can operate in oscillatory airflow without additional ***,this arrangement suffers from poor flow rectification.A fluidic diode(FD)offers variable hydrodynamic resistance based on the flow direction,and this can be coupled with UT to improve flow *** this work,a numerical investigation on the effect of FD with UT is presented using the commercial fluid dynamics software ANSYS Fluent 16.1 with k-ωSST turbulence closure *** domains of UT and FD are numerically validated individually with experimental ***,both are coupled to obtain the combined effect,and these results are compared with the analytical *** was observed that coupling FD with UT improved the unit's performance at the lower flow coefficient(mance decreased as the flow coefficient *** to the diode's presence,fluid leaving the turbine experiences higher resistance at a higher flow coefficient,which decreases the overall performance of the combined unit.

关键词： wave energy oscillating water column unidirectional impulse turbine fluidic diode flow rectification

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cooperative Target Fencing of multiple Vehicles for a General Target with connectivity Preservation and collision Avoidance

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Journal of Systems Science & complexity 2024年第1期37卷 136-151页

作者： PAN Zini cHEN Ben m Department of mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem for n-dimensional systems and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull formed by the ***,the dynamics of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the communication network and collision avoidance among the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a numerical example.

关键词： multi-agent systems networked systems target fencing

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metrology for sub-Rayleigh-length target positioning in~10^(22)W/cm^(2)laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo c.D.Armstrong T.A.Pikuz S.A.Pikuz W.Yan T.m.Jeong S.Singh P.Hadjisolomou O.Finke G.m.Grittani m.Nevrkla c.m.Lazzarini A.Velyhan T.Hayakawa Y.Fukuda J.K.Koga m.Ishino K.Kondo Y.miyasaka A.Kon m.Nishikino Y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.margarone P.V.Sasorov S.Weber m.Kando H.Kiriyama Y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina collaborative Innovation center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics AScR PragueCzech Republic FZU-Institute of Physics AScR PragueCzech Republic czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

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multivariate form of Hermite sampling series

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Applied mathematics(A Journal of chinese Universities) 2024年第2期39卷 253-265页

作者： Rashad m.Asharabi Department of mathematics College of Arts and SciencesNajran UniversityNajranSaudi Arabia

In this paper,we establish a new multivariate Hermite sampling series involving samples from the function itself and its mixed and non-mixed partial derivatives of arbitrary *** multivariate form of Hermite sampling will be valid for some classes of multivariate entire functions,satisfying certain growth *** will show that many known results included in commun Korean math Soc,2002,17:731-740,Turk J math,2017,41:387-403 and Filomat,2020,34:3339-3347 are special cases of our ***,we estimate the truncation error of this sampling based on localized sampling without decay *** examples are also presented.

关键词： multidimensional sampling series sampling with partial derivatives contour integral truncation error

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Probing turbulence in galaxies with fast radio burst scintillation

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Science china(Physics,mechanics & Astronomy) 2024年第1期67卷 177-178页

作者： James m.cordes Department of Astronomy the Cornell Center for Astrophysics and Planetary ScienceCornell UniversityIthaca NY 14853USA

Interstellar scintillation(ISS)is a well-known phenomenon observed from pulsars in the milky *** comprises intensity variations *** and frequency caused by constructive and destructive interference from multipath propagation,which is due to diffraction from fluctuations in electron density in the interstellar medium(ISm)on scales as small as~100 *** density fluctuations appear to be part of a turbulence process combined with discrete structures in electron density from other astrophysical processes;together these fluctuations extend to scales of pc or larger.

关键词： scales galaxies turbulence

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Pair of dyon production near magnetized dyonic Reissner-Nordstrom black holes

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chinese Physics c 2024年第5期48卷 257-271页

作者： Haryanto m.Siahaan Jurusan Fisika Universitas Katolik ParahyanganJalan Ciumbuleuit 94Bandung 40141Indonesia

We investigate the phenomenon of pair production of massive scalar particles with magnetic charge near the horizon of a magnetized dyonic Reissner-Nordstrom black *** intrinsic symmetry between the electric and magnetic quantities in the Einstein-maxwell equations suggests that the pair can be generated through Hawking radiation and the Schwinger effect,provided that the Dirac quantization condition is satisfied.

关键词： Dyon pair production black hole

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