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Place of Exercise Echocardiography in Stable Coronary Artery Disease in Sub-Saharan Africa:A Series in Senegal

World Journal of Cardiovascular Diseases 2020年第1期10卷 19-29页

作者： F.Aw m.b.ndiaye C.m.b.m.Diop S.A.Sarr J.S.mingou m.T.Diouf m.m.Ka m.ndiaye Hariniaina Ravaoavy m.bodian A.A.Ngaide m.Dioum m.Leye A.mbaye A.D.Kane A.Kane m.Diao S.A.ba Cardiology Department Teaching Hospital Aristide Le DantecDakarSenegal Cardiology Department General Hospital of Grand YoffDakarSenegal Cardiology Department Teaching National Hospital of Fann Le DantecDakarSenegal Research and Training Unit of Thies ThiesSenegal Cardiology Department Regional Hospital of Saint LouisSaint LouisSenegal Cardiology Department Dalal Jamm HospitalDakarSenegal

Introduction: Exercise echocardiography is a non-invasive technique that occupies a special place for the detection of stable coronary disease. The main objective of this study was to report our experience and assess our practice in the diagnosis of stable coronaryartery disease. methodology: We conducted a retrospective study, descriptive over a period of 34 months, from December 1, 2016 to September 30, 2019. All the patients received during the study period for stress echocardiography as part of a suspicion of stable coronary artery disease were included. A total of 100 examinations were completed during the study period. Results: Ninety (90) exams were studied. There were 56 men or a sex-ratio of 1.64. The mean age was of 57.3 ± 10 years. Hypertension (31 patients or 62%) was the most frequent risk factor. Typical chest pain was noticed in 45 patients (52.3%). The pre-test probability was intermediate in 77 patients (89.5%). Echocardiography at rest was normal in 86 patients (95.6%). A total of 62 tests were negative (69%) and 02 (2.2%) were non-contributory. Ten tests (10) of 26 electrical positive tests were associated with segmental kinetics disorders. In the 10 patients who had exercise kinetic disorders, 08 had coronary angiography. It was normal in 04 of them. The positive predictive value of exercise echography was 50% in our study. In a patient with a negative exercise echocardiography with a high clinical probability of coronary disease, the coronary angiography showed a two-vessel impairment with an intermediate lesion of Cx2 and an intermediate lesion of RCA2. It thus constitutes a false negative. Sensitivity was 80% in our study. We noticed an incident like non-sustained ventricular tachycardia. Conclusion: Exercise echocardiography is a safe and reliable examination for the diagnosis of stable coronary artery disease. A good selection of patients based on the clinical probability of coronary ischemia should improve our sensitivity. This is even more

关键词： Exercise Echocardiography Coronary Artery Disease

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for molecular and Cell biology(IbmC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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ADEFGuard:Anomaly detection framework based on Ethereum smart contracts behaviours

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blockchain(Research and Applications) 2023年第3期4卷 88-97页

作者： malaw ndiaye Thierno Ahmadou Diallo Karim Konate Computer Science Department UCAD DakarSenegal Computer Science Department UASZ ZiguinchorSenegal

Smart contracts are the building blocks of blockchain systems that enable automated peer-to-peer transactions and decentralized *** contracts certainly provide a powerful functional surplus for maintaining the consistency of transactions in applications governed by blockchain *** contracts have become lucrative and profitable targets for attackers because they can hold a large amount of *** verification and symbolic analysis have been employed to combat these destructive scams by analysing the codes and function calls,yet each scam's vulnerability should be discreetly *** this work,we introduce ADEFGuard,a new anomaly detection framework based on the behaviour of smart contracts,as a new *** design a learning and monitoring module to determine fraudulent smart contract *** framework is advantageous over basic algorithms in three ***,ADEFGuard provides a unified solution to different genres of scams,relieving the need for code analysis ***,ADEFGuard's inference is orders of magnitude faster than code ***,the experimental results show that ADEFGuard achieves high accuracy(85%),precision(75%),and recall(90%)for malicious contracts and is potentially useful in detecting new malicious behaviours of smart contracts.

关键词： blockchain Smart contract Security Anomaly

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Nonlinear forced vibration in a subcritical regime of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAmI m.EFTEKHARI Department of mechanical Engineering Shahid Bahonar University of Kerman

This study examines the nonlinear behaviors of a clamped-clamped porous pipe made of a functionally graded material(FGm) that conveys fluids and is equipped with a retaining clip, focusing on primary resonance and subcritical dynamics. The nonlinear governing equations for the FGm pipe are derived by the extended Hamilton's principle, and subsequently discretized through the application of the Galerkin *** direct method of multi-scales is then used to solve the derived equations. A thorough analysis of various parameters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a comprehensive understanding of the system's nonlinear dynamics. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the comparisons with metallic pipes emphasize the role of FGm composition. The examination of the forced response curves reveals saddle-node bifurcations and their dependence on parameters such as the detuning parameter and the power-law index, offering valuable insights into the system's nonlinear resonant behavior. Furthermore, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system response and resonance characteristics. This comprehensive analysis enhances the understanding of nonlinear behaviors in FGm porous pipes with a retaining clip, providing key insights for practical engineering applications in system design and optimization.

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Numerical Approach of Network Problems in Optimal mass Transportation

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Applied mathematics 2012年第5期3卷 457-466页

作者： Lamine ndiaye babacar mbaye ndiaye Pierre mendy Diaraf Seck Laboratory of mathematics of Decision and Numerical Analysis (LmDAN) FASEG University of Cheikh Anta Diop Dakar Senegal Unité mixte Internationale UMMISCO Institut de Recherche pour le Développement Bondy France

In this paper, we focus on the theoretical and numerical aspects of network problems. For an illustration, we consider the urban traffic problems. And our effort is concentrated on the numerical questions to locate the optimal network in a given domain (for example a town). mainly, our aim is to find the network so as the distance between the population position and the network is minimized. Another problem that we are interested is to give an numerical approach of the monge and Kantorovitch problems. In the literature, many formulations (see for example [1-4]) have not yet practical applications which deal with the permutation of points. Let us mention interesting numerical works due to E. Oudet begun since at least in 2002. He used genetic algorithms to identify optimal network (see [5]). In this paper we introduce a new reformulation of the problem by introducing permutations . And some examples, based on realistic scenarios, are solved.

关键词： Optimal mass Transportation Network Urban Traffic monge-Kantorovich Problem Global Optimization

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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Combining Fractals and box-Counting Dimension

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Applied mathematics 2021年第9期12卷 818-834页

作者： m. ndiaye mathematics and Computer Sciences Department Marist College Poughkeepsie NY USA

In this paper, the box-counting dimension is used to derive an explicit formula for the dimension of a fractal constructed using several contractions or by combining fractals. This dimension agrees with the Hausdorff dimension in the particular case when the scales factors considered are all the same. A more general sufficient condition for the box-counting dimension and the Hausdorff dimension to be the same is given. It is also shown that the dimension of the fractal obtained by combining two fractals is the weighted average of the dimensions of the two fractals.

关键词： box-Counting Dimension Combining Fractals

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de biología molecular Severo Ochoa(Cbm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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沿冰层表面流注传播场稳定性的实验研究与分析(英文)

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高电压技术 2009年第6期35卷 1284-1293页

作者： I.ndiaye m.Farzaneh K.D.Srivastava NSERC/Hydro-Quebec/UQAC Industrial Chair on Atmospheric Icing of Power Network Equipment(CIGELE) and Canada Research Chair on Engineering of Power Network Atmospheric Icing(INGIVRE) at Universit du Qubec Chicoutimi University of british Columbia Department of Electrical & Computer EngineeringVancouver

The electric field required for stable propagation of a positive streamer along an ice surface was investigated by measuring the currents associated with the streamer *** influence of the surface properties,namely the existence of a water film on the ice surface and surface contamination,was *** showed that in the presence of an ice surface,except in case of low conductive surface,streamers propagate stably with an external field lower than that generally measured for propagation in air alone(approximately 5 kV/cm).For higher contamination levels,the stability field was found to be slightly influenced by the temperature,while for lower contamination levels,it decreased significantly with an increase in temperature.

关键词：电场电子稳定性绝缘技术

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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN T.ASGHAR Z.AbbAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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