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Synthetic and Systems Biotechnology 2024年第3期9卷 406-415页

作者： Rana Azeem.ashraf matthias Bureik mario Andrea marchisio School of Pharmaceutical Science and Technology Tianjin University300072TianjinChina

Gene circuits allow cells to carry out complex functions such as the precise regulation of biological metabolic *** this study,we combined,in the yeast ***,genetic regulatory elements with the enzymatic reactions of the human CYP2C9 and its redox partner CPR on luciferin substrates and *** cells were permeabilized and used as enzyme bags in order to host these metabolic *** engineered three different(genetic)-enzymatic basic Boolean gates(YES,NOT,and N-ImPLY).In the YES and N-ImPLY gates,human CYP2C9 was expressed under the galactose-inducible GAL1 *** carbon monoxide releasing molecule CORm-401 was used as an input in the NOT and N-ImPLY gates to impair CYP2C9 activity through inhibition of the Fe+2-heme prosthetic group in the active site of the human *** study provides a new approach in designing synthetic bio-circuits and optimizing experimental conditions to favor the heterologous expression of human drug metabolic enzymes over their endogenous *** new approach will help study precise metabolic attributes of human P450s.

关键词： Cytochrome P450 Drug metabolism Budding yeast Diclofenac Synthetic biology CORm-401 Boolean gates

modifying effects and mechanisms of superfine stainless wires on microstructures and mechanical properties of ultra-high performance seawater sea-sand concrete

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Science China Technological Sciences 2024年第10期67卷 3205-3220页

作者： YU Feng DONG SuFen ASHOUR ashraf DING SiQi HAN BaoGuo School of Infrastructure Engineering Dalian University of Technology Faculty of Engineering & Informatics University of Bradford Department of Civil and Environmental Engineering The Hong Kong Polytechnic University

Ultra-high-performance seawater sea-sand concrete（UHPSSC） presents a prospective solution to address the natural resource shortage in marine infrastructure construction. To eliminate the corrosion risk of steel fibers and broaden the applicability of UHPSSC, this study investigates the mechanical properties and free chloride ion content as well as microstructures of UHPSSC reinforced with superfine stainless wires（SSWs） under natural curing. The results indicate that 1.5% SSWs can remarkably improve the flexural strength and toughness of UHPSSC by 127% and 1724%, respectively, and mitigate the long-term strength degradation of UHPSSC. The strong interfacial bond between SSW and UHPSSC improves the compactness of UHPSSC, thus reducing the growth space for Ca（OH）2crystals and swelling hydration products generated by sulfate and magnesium ions. This can be supported by the observed reduction in the Ca/Si ratio of C–S–H gels, CH crystal orientation index, and ***, through mechanisms such as pull-out, rupture, overlapping network, and internal anchor interface, SSWs effectively prevent microcrack growth and propagation, transforming single long-connected microcracks into multiple-emission microcracks centered on SSW. Additionally, the free chloride ion content of the composites at 28 and 180 d meets the ACI 318-19 standard requirements for concrete exposed to seawater. This compliance is attributed to the chloride immobilization facilitated by Friedel's salt and C–S–H gels within the interfaces around SSWs and sea-sand. Consequently, SSWs-reinforced UHPSSC exhibits considerable potential for applications in sustainable marine infrastructures, demanding long-term mechanical properties and high durability.

关键词： ultra-high performance seawater sea-sand concrete superfine stainless wire mechanical properties chloride ion content microstructure

Complex Decision modeling Framework with Fairly Operators and Quaternion Numbers under Intuitionistic Fuzzy Rough Context

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Computer modeling in Engineering & Sciences 2024年第5期139卷 1893-1932页

作者： Nadeem Salamat muhammad Kamran Shahzaib ashraf manal Elzain mohammed Abdulla Rashad Ismail mohammed m.Al-Shamiri Institute of mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of mathematics Thal University BhakkarPunjab30000Pakistan Department of mathematics Faculty of Science and ArtsKing Khalid UniversityMuhayl Assir61913Saudi Arabia

The main goal of informal computing is to overcome the limitations of hypersensitivity to defects and uncertainty while maintaining a balance between high accuracy,accessibility,and *** paper investigates the potential applications of intuitionistic fuzzy sets(IFS)with rough sets in the context of sparse *** it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy rough numbers(IFRNs)are superior to intuitionistic fuzzy sets and pythagorean fuzzy sets,*** use rough sets in conjunction with IFSs to develop several fairly aggregation operators and analyze their underlying *** present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally within these *** operations lead to the development of the intuitionistic fuzzy rough weighted fairly aggregation operator(IFRWFA)and intuitionistic fuzzy rough ordered weighted fairly aggregation operator(IFRFOWA).These operators successfully adjust to membership and non-membership categories with fairness and *** highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making *** use the intuitionistic fuzzy rough environment’s architecture to create a novel strategy in situation involving several decision-makers and non-weighted ***,we developed a novel technique by combining the IFSs with quaternion *** establish a unique connection between alternatives and qualities by using intuitionistic fuzzy quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty in real-world situations and address a number of decision-making *** the examples we have released,we offer a sophisticated and systematically constructed illustrative scenario that is intricately wo

关键词： Intuitionistic fuzzy set quaternion numbers fuzzy logic decision-making rough set

Intangibles and management earnings forecasts

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China Journal of Accounting Research 2024年第2期17卷 54-73页

作者： ashraf Khallaf Yezen Kannan American University of Sharjah United Arab Emirates Zayed University United Arab Emirates

We investigate how the accounting treatment of intangible assets on managers’likelihood of issuing voluntary earnings guidance(mEF).We find that unrecognized intangibles(immediately expensed)are negatively associated with mEF issuance,while recognized intangibles(capitalized)show a positive asso*** findings hold across various factors such as analysts’coverage,industry type and for a subsample that excludes software firms permitted to capitalize software development costs under SFAS *** additional,we investigate the cross-sectional determinants of mEF issuance based on the characteristics of firm *** find a significant increase in the likelihood of mEF issuance for higher unrecognized intangibles with greater earnings *** suggests that managers may prioritize delivering valuerelevant information to market participants to alleviate uncertainty.

关键词： Voluntary disclosures management earnings forecasts Intangibles Information asymmetry Uncertainty

Optimization Algorithms of PERT/CPm Network Diagrams in Linear Diophantine Fuzzy Environment

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Computer modeling in Engineering & Sciences 2024年第4期139卷 1095-1118页

作者： mani Parimala Karthikeyan Prakash ashraf Al-Quran muhammad Riaz Saeid Jafari Department of mathematics Bannari Amman Institute of TechnologySathyamangalamTamil Nadu638401India Basic Sciences Department Preparatory Year DeanshipKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of mathematics University of the PunjabLahorePakistan College of Vestsjaelland South Herrestraede 11Slagelse4200Denmark

The idea of linear Diophantine fuzzy set(LDFS)theory with its control parameters is a strong model for machine learning and optimization under *** activity times in the critical path method(CPm)representation procedures approach are initially static,but in the Project Evaluation and Review Technique(PERT)approach,they are *** study proposes a novel way of project review and assessment methodology for a project network in a linear Diophantine fuzzy(LDF)*** LDF expected task time,LDF variance,LDF critical path,and LDF total expected time for determining the project network are all computed using LDF numbers as the time of each activity in the project *** primary premise of the LDF-PERT approach is to address ambiguities in project network activity timesmore simply than other approaches such as conventional PERT,Fuzzy PERT,and so *** LDF-PERT is an efficient approach to analyzing symmetries in fuzzy control systems to seek an optimal *** also present a new approach for locating LDF-CPm in a project network with uncertain and erroneous activity *** the available resources and activity times are imprecise and unpredictable,this strategy can help decision-makers make better judgments in a project.A comparison analysis of the proposed technique with the existing techniques has also been *** suggested techniques are demonstrated with two suitable numerical examples.

关键词： Linear Diophantine fuzzy graphs project management PERT CPm linear Diophantine fuzzy numbers score function accuracy function

machine learning-based multi-objective optimization and thermal assessment of supercritical CO_(2) Rankine cycles for gas turbine waste heat recovery

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Energy and AI 2024年第2期16卷 363-384页

作者： Asif Iqbal Turja Ishtiak Ahmed Khan Sabbir Rahman ashraf mustakim mohammad Ishraq Hossain m monjurul Ehsan Yasin Khan Department of mechanical and Production Engineering(mPE) Islamic University of Technology(IUT)Board BazarGazipur1704Bangladesh

Technologies for utilizing waste heat for power generation have attracted significant attention in recent years due to their potential to enhance energy efficiency and reduce greenhouse gas *** research focuses on the comparative and optimization analysis of three supercritical carbon dioxide(sCO_(2))Rankine cycles(simple,cascade,and split)for gas turbine waste heat *** study begins with parametric analysis,investigating the significant effects of key variables,including turbine inlet temperature,condenser inlet temperature,and pinch point temperature,on the thermal performance of advanced sCO_(2) power *** identify the most efficient cycle configuration,a multi-objective optimization approach is *** approach combines a Genetic Algorithm with machine learning regression models(Random Forest,XGBoost,Artificial Neural Network,Ridge Regression,and K-Nearest Neighbors)to predict cycle performance using a dataset extracted from cycle *** decision-making process for determining the optimal cycle configuration is facilitated by the TOPSIS(technique for order of preference by similarity to the ideal solution)*** study's major findings reveal that the split cycle outperforms the simple and cascade configurations in terms of power generation across various operating *** optimized split cycle not only demonstrates superior power output but also exhibits enhanced net power output,heat recovery,system and exergy efficiency of 7.99 mW,76.17%,26.86%and 57.96%,respectively,making it a promising choice for waste heat recovery *** research has the potential to contribute to the advancement and widespread adoption of waste heat recovery in energy technologies boosting system efficiency and economic *** provides a new perspective for future research,contributing to the improvement of energy generation infrastructure.

关键词： Supercritical co2 Rankine cycle Waste heat recovery Gas turbine Thermodynamic analysis machine Learning Optimization

The Spherical q-Linear Diophantine Fuzzy multiple-Criteria Group Decision-making Based on Differential measure

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Computer modeling in Engineering & Sciences 2024年第2期138卷 1925-1950页

作者： Huzaira Razzaque Shahzaib ashraf muhammad Naeem Yu-ming Chu Institute of mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of mathematics Deanship of Applied SciencesUmm Al-Qura UniversityMeccaSaudi Arabia Department of mathematics Huzhou UniversityHuzhou313000China

Spherical q-linearDiophantine fuzzy sets(Sq-LDFSs)provedmore effective for handling uncertainty and vagueness in multi-criteria decision-making(mADm).It does not only cover the data in two variable parameters but is also beneficial for three parametric *** Pythagorean fuzzy sets,the difference is calculated only between two parameters(membership and non-membership).According to human thoughts,fuzzy data can be found in three parameters(membership uncertainty,and non-membership).So,to make a compromise decision,comparing Sq-LDFSs is *** measures of different fuzzy sets do,however,can have several flaws that can lead to counterintuitive *** instance,they treat any increase or decrease in the membership degree as the same as the non-membership degree because the uncertainty does not change,even though each parameter has a different *** the Sq-LDFSs comparison,this research develops the differentialmeasure(DFm).Themain goal of the DFm is to cover the unfair arguments that come from treating different types of FSs opposing criteria *** to their relative positions in the attribute space and the similarity of their membership and non-membership degrees,two Sq-LDFSs formthis preference connectionwhen the uncertainty remains same in both *** to the degree of superiority or inferiority,two Sq-LDFSs are shown as identical,equivalent,superior,or inferior over one *** suggested DFm’s fundamental characteristics are *** on the newly developed DFm,a unique approach tomultiple criterion group decision-making is *** suggestedmethod verifies the novel way of calculating the expert weights for Sq-LDFSS as in *** proposed technique in three parameters is applied to evaluate solid-state drives and choose the optimum photovoltaic cell in two applications by taking uncertainty parameter *** method’s applicability and validity shown by the findings are contrasted with those obtained using various

关键词： multi-criteria group decision-making spherical q-linear Diophantine fuzzy sets differencemeasures photovoltaic cells medical diagnosis

New Antenna Array Beamforming Techniques Based on Hybrid Convolution/Genetic Algorithm for 5G and Beyond Communications

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Computer modeling in Engineering & Sciences 2024年第3期138卷 2749-2767页

作者： Shimaa m.Amer ashraf A.m.Khalaf Amr H.Hussein Salman A.Alqahtani mostafa H.Dahshan Hossam m.Kassem Electronics and Communications Engineering Department Higher Institute of Engineering and TechnologyKafr ElsheikhEgypt Electronics and Electrical Communications Engineering Department Faculty of EngineeringMinia UniversityMiniaEgypt Electronics and Electrical Communications Engineering Department Faculty of EngineeringTanta UniversityTantaEgypt Electronics and Electrical Communications Engineering Department Faculty of EngineeringHorus University EgyptNew DamiettaEgypt Department of Computer Engineering College of computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia School of Computing Mathematics and EngineeringCharles Sturt UniversityBathurstNSW2795Australia

Side lobe level reduction(SLL)of antenna arrays significantly enhances the signal-to-interference ratio and improves the quality of service(QOS)in recent and future wireless communication systems starting from 5G up to ***,it improves the array gain and directivity,increasing the detection range and angular resolution of radar *** study proposes two highly efficient SLL reduction *** techniques are based on the hybridization between either the single convolution or the double convolution algorithms and the genetic algorithm(GA)to develop the Conv/GA andDConv/GA,*** convolution process determines the element’s excitations while the GA optimizes the element *** m elements linear antenna array(LAA),the convolution of the excitation coefficients vector by itself provides a new vector of excitations of length N=(2m−1).This new vector is divided into three different sets of excitations including the odd excitations,even excitations,and middle excitations of lengths m,m−1,andm,*** the same element spacing as the original LAA is used,it is noticed that the odd and even excitations provide a much lower SLL than that of the LAA but with amuch wider half-power beamwidth(HPBW).While the middle excitations give the same HPBWas the original LAA with a relatively higher *** the increased HPBWof the odd and even excitations,the element spacing is optimized using the ***,the synthesized arrays have the same HPBW as the original LAA with a two-fold reduction in the ***,for extreme SLL reduction,the DConv/GA is *** this technique,the same procedure of the aforementioned Conv/GA technique is performed on the resultant even and odd excitation *** provides a relatively wider HPBWthan the original LAA with about quad-fold reduction in the SLL.

关键词： Array synthesis convolution process genetic algorithm(GA) half power beamwidth(HPBW) linear antenna array(LAA) side lobe level(SLL) quality of service(QOS)

Development of biomedical hydrogels for rheumatoid arthritis treatment

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 35-48页

作者： mirza muhammad Faran ashraf Baig Lee KiWong Abdul Wasy Zia Hongkai Wu Department of Chemistry Hong Kong University of Science and TechnologyHong Kong 999077China Institute of mechanical Process and Energy Engineering(IMPEE)School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburghUnited Kingdom

Rheumatoid Arthritis(RA)is an autoimmune disorder that hinders the normal functioning of bones and joints and reduces the quality of human *** year,millions of people are diagnosed with RA worldwide,particularly among elderly individuals and ***,there is a global need to develop new biomaterials,medicines and therapeutic methods for treating *** will improve the Healthcare Access and Quality Index and also relieve administrative and financial burdens on healthcare service providers at a global *** are soft and cross-linked polymeric materials that can store a chunk of fluids,drugs and biomolecules for hydration and therapeutic *** are biocompatible and exhibit excellent mechanical properties,such as providing elastic cushions to articulating joints by mimicking the natural synovial ***,hydrogels create a natural biological environment within the synovial cavity to reduce autoimmune reactions and *** also lubricate the articulating joint surfaces to prevent degradation of synovial surfaces of bones and cartilage,thus exhibiting high potential for treating *** work reviews the progress in injectable and implantable hydrogels,synthesis methods,types of drugs,advantages and ***,it discusses the role of hydrogels in targeted drug delivery,mechanistic behaviour and tribological performance for RA treatment.

关键词： Rheumatoid arthritis Orthopeadic joints Hydrogel Therapeutics mechanical properties medicine

IoT Smart Devices Risk Assessment model Using Fuzzy Logic and PSO

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Computers, materials & Continua 2024年第2期78卷 2245-2267页

作者： ashraf S.mashaleh Noor Farizah Binti Ibrahim mohammad Alauthman mohammad Almseidin Amjad Gawanmeh School of Computer Sciences Universiti Sains MalaysiaPenangMalaysia Department Computer Center Al-Balqa Applied UniversitySaltJordan Department of Information Security Faculty of Information TechnologyUniversity of PetraAmmanJordan Department of Computer Science Tafila Technical UniversityTafilaJordan College of Engineering and IT University of DubaiDubaiUnited Arab Emirates

Increasing Internet of Things(IoT)device connectivity makes botnet attacks more dangerous,carrying catastrophic *** IoT botnets evolve,their dynamic and multifaceted nature hampers conventional detection *** paper proposes a risk assessment framework based on fuzzy logic and Particle Swarm Optimization(PSO)to address the risks associated with IoT *** logic addresses IoT threat uncertainties and ambiguities *** component settings are optimized using PSO to improve *** methodology allows for more complex thinking by transitioning from binary to continuous *** of expert inputs,PSO data-driven tunes rules and membership *** study presents a complete IoT botnet risk assessment *** methodology helps security teams allocate resources by categorizing threats as high,medium,or low *** study shows how CICIoT2023 can assess cyber *** research has implications beyond detection,as it provides a proactive approach to risk management and promotes the development of more secure IoT environments.

关键词： IoT botnet detection risk assessment fuzzy logic particle swarm optimization(PSO) cybersecurity interconnected devices