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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian mohammad asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen Ying mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated mHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

对称系泊半潜平台在各种可能系泊组合下的动力学分析

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哈尔滨工程大学学报（英文版） 2024年第1期23卷 160-181页

作者： syed Azeem Uddin mohd Tousif Department of Ocean Engineering IIT MadrasChennai 600036India Department of mechanical Engineering IIT MadrasChennai 600036India

In this technologically advancing world,the demand for more energy,oil and gas production is rapidly *** accomplish this,people have inclined more towards completely floating offshore structures,deployed in deep waters.A semi-submersible is selected in the present study,due to its better response characteristics and stability under harsh environmental *** semi-submersible is position restrain with spread mooring lines incorporated with submerged buoy at different locations has been studied.A detailed numerical analysis is carried out using Ansys Aqwa for dynamic response analysis of semi-submersible under the combination of wind,wave,and current forces for 0°,45°,and 90°*** was observed that damping ratios and natural periods had been affected based on the position and number of submerged buoys in the mooring ***,reduction in mooring force after incorporating buoy in the mooring lines was ***,a matlab code based on the S-N curve approach was generated and employed to investigate the fatigue damage of mooring lines under dynamic variation of mooring *** pegged with submerged buoys,fatigue life of mooring lines is increased under intact and postulated damaged mooring ***,coupling of motion responses of semi-submersible is observed,and unbounded response is not seen in any degrees-offreedom,even during damaged condition of mooring lines.

关键词： Dynamic analysis Fatigue damage Offshore Structures Postulated failure Submerged buoy mooring lines

Hybrid IPOm: A Novel Technique for the management of Incisional Hernia

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Surgical Science 2024年第3期15卷 125-134页

作者： syed Asim Yamin Shahnawaz Ahangar Fadi Albadawi Abdullah Alqarni Abdulaziz m. Alzahrani Department of Specialised Surgery King Abdullah Medical City Hospital Makkah Saudi Arabia

Background and Aim: The incidence of incisional hernias has been reported to be around 15%. In the present scenario, a wide array of surgical procedures are available for their better management. In this study, we intend to share our experience with one novel technique, “Hybrid IPOm (Intraperitoneal onlay meshplasty)” as a management option for a selected cohort of patients. methods: This prospective study was undertaken during January 2019 to July 2023 at King Abdullah medical city, makkah. A total of 51 cases were selected for Hybrid IPOm repair as per inclusion criteria;medium sized (4 - 10 cm) hernia defects;uncomplicated hernias;age more than 18 years. The follow-up period of the patients varied from 6 months to 4 years. The operation commenced with open hernia dissection, mesh deployment into abdomen, defect closure and then conversion to laparoscopy for the posterior mesh placement. Results: A total of 51 cases were repaired successfully with this technique. 48 out of 51 cases were incisional hernias secondary to some primary procedure done either for hernias itself or some other intra-abdominal pathology. The three cases were primary hernias falling in medium to large category with unaesthetic overlying skin. The age range was 19 to 72 years. The mean (range) operative time was 135 (90 - 240) min, and the average blood loss was 70 ml. The mean (range) hospital stay was 3 (2 - 11) days. All patients returned to routine work within 2 - 3 weeks of surgery. The median follow-up was 15 (6 - 48) months. Of the 51 cases, 3 patients developed seroma (managed conservatively), 1 patient developed a large hematoma (needed evacuation), and 1 patient developed superficial wound infection (managed with antibiotics). Two patients had recurrences;one patient had previously failed multiple repairs, and the other developed a postoperative hematoma. None of our patients had an iatrogenic bowel injury. Conclusion: Hybrid IPOm technique is a safe, feasible and easily reproducibl

关键词： Incisional Hernias Hybrid Surgery Open to Laparoscopic Conversion Safety Feasibility

Intrusion Detection System for Smart Industrial Environments with Ensemble Feature Selection and Deep Convolutional Neural Networks

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Intelligent Automation & Soft Computing 2024年第3期39卷 545-566页

作者： asad Raza Shahzad memon muhammad Ali Nizamani mahmood Hussain Shah Dr.AHS Bukhari Postgraduate Centre of Information and Communication Technology Faculty of Engineering and TechnologyUniversity of SindhJamshoro76060Pakistan Newcastle Business School Northumbria UniversityNewcastleNE1UK

Smart Industrial environments use the Industrial Internet of Things(IIoT)for their routine operations and transform their industrial operations with intelligent and driven ***,IIoT devices are vulnerable to cyber threats and exploits due to their connectivity with the *** signature-based IDS are effective in detecting known attacks,but they are unable to detect unknown emerging ***,there is the need for an IDS which can learn from data and detect new *** machine Learning(mL)and individual Deep Learning(DL)based IDS have been developed,and these individual models achieved low accuracy;however,their performance can be improved with the ensemble stacking *** this paper,we have proposed a Deep Stacked Neural Network(DSNN)based IDS,which consists of two stacked Convolutional Neural Network(CNN)models as base learners and Extreme Gradient Boosting(XGB)as the meta *** proposed DSNN model was trained and evaluated with the next-generation dataset,TON_*** pre-processing techniques were applied to prepare a dataset for the model,including ensemble feature selection and the SmOTE ***,precision,recall,F1-score,and false positive rates were used to evaluate the performance of the proposed ensemble *** experimental results showed that the accuracy for binary classification is 99.61%,which is better than in the baseline individual DL and mL *** addition,the model proposed for IDS has been compared with similar *** proposed DSNN achieved better performance metrics than the other *** proposed DSNN model will be used to develop enhanced IDS for threat mitigation in smart industrial environments.

关键词： Industrial internet of things smart industrial environment cyber-attacks convolutional neural network ensemble learning

Comprehensive Analysis of Estrogen Receptor 1 Dysregulation in Liver Hepatocellular Carcinoma: Implications for Prognosis and Therapeutic Targeting - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 51-59页

作者： syed Hussain Raza Yasir Hameed Department of Biochemistry and Biotechnology The Islamia University of BahawalpurBahawalpurPakistan

The study investigates the expression pattern and regulatory mechanisms of estrogen receptor 1 (ESR1) in liver hepatocellular carcinoma (LIHC) through comprehensive bioinformatics analysis. Utilizing UALCAN and GEPIA2 databases, significant down-regulation of ESR1 expression is observed in LIHC samples compared to normal controls, indicating its potential role in tumor progression. Further analysis reveals consistent down-regulation across different clinical variables including patient age, gender, race, and various stages of LIHC, affirming the regulatory role of ESR1 in tumor development and progression. Additionally, promoter methylation analysis demonstrates hypermethylation of ESR1 in LIHC samples, negatively correlating with its expression. This association persists across different clinical parameters, emphasizing the inverse relationship between ESR1 methylation and expression levels. Survival analysis indicates that up- regulation of ESR1 is associated with better overall survival, suggesting its potential as a prognostic biomarker in LIHC. Furthermore, genetic mutation analysis using cBioPortal reveals a spectrum of alterations in ESR1, including amplification, missense mutation, deep deletion, splice mutation, and truncating mutation, highlighting the genetic complexity of ESR1 in LIHC. These findings collectively contribute to a deeper understanding of ESR1 dysregulation in LIHC and its clinical implications as a potential therapeutic target and prognostic marker.

关键词： Estrogen receptor 1 Liver hepatocellular carcinoma Biomarker Prognosis

Classification and Comprehension of Software Requirements Using Ensemble Learning

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Computers, materials & Continua 2024年第8期80卷 2839-2855页

作者： Jalil Abbas Arshad Ahmad syed muqsit Shaheed Rubia Fatima Sajid Shah mohammad Elaffendi Gauhar Ali School of Computer Science and Technology Anhui UniversityHefei230039China School of Computing Sciences Pak Austria FachhochschuleInstitute of Applied Sciences and TechnologyHaripur22620Pakistan Department of Computer Science and IT University of LahoreLahore55150Pakistan Department of Computer Science Emerson UniversityPunjabMultan60000Pakistan EIAS(Emerging Intelligent Autonomous Systems)Data Science Lab Prince Sultan UniversityRiyad12435Saudi Arabia

The software development process mostly depends on accurately identifying both essential and optional ***,user needs are typically expressed in free-form language,requiring significant time and human resources to translate these into clear functional and non-functional *** address this challenge,various machine learning(mL)methods have been explored to automate the understanding of these requirements,aiming to reduce time and human ***,existing techniques often struggle with complex instructions and large-scale *** our study,we introduce an innovative approach known as the Functional and Non-functional Requirements Classifier(FNRC).By combining the traditional random forest algorithm with the Accuracy Sliding Window(ASW)technique,we develop optimal sub-ensembles that surpass the initial classifier’s accuracy while using fewer *** results demonstrate that our FNRC methodology performs robustly across different datasets,achieving a balanced Precision of 75%on the PROmISE dataset and an impressive Recall of 85%on the CCHIT *** datasets consistently maintain an F-measure around 64%,highlighting FNRC’s ability to effectively balance precision and recall in diverse *** findings contribute to more accurate and efficient software development processes,increasing the probability of achieving successful project outcomes.

关键词： Ensemble learning machine learning non-functional requirements requirement engineering accuracy sliding window

Systematic Review:Load Balancing in Cloud Computing by Using metaheuristic Based Dynamic Algorithms

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Intelligent Automation & Soft Computing 2024年第3期39卷 437-476页

作者： Darakhshan syed Ghulam muhammad Safdar Rizvi Department of Computer Science Bahria UniversityKarachi CampusKarachiPakistan

Cloud Computing has the ability to provide on-demand access to a shared resource *** has completely changed the way businesses are managed,implement applications,and provide *** rise in popularity has led to a significant increase in the user demand for ***,in cloud environments efficient load balancing is essential to ensure optimal performance and resource *** systematic review targets a detailed description of load balancing techniques including static and dynamic load balancing ***,metaheuristic-based dynamic load balancing algorithms are identified as the optimal solution in case of increased *** a cloud-based context,this paper describes load balancing measurements,including the benefits and drawbacks associated with the selected load balancing *** also summarizes the algorithms based on implementation,time complexity,adaptability,associated issue(s),and targeted QoS ***,the analysis evaluates the tools and instruments utilized in each investigated ***,comparative analysis among static,traditional dynamic and metaheuristic algorithms based on response time by using the CloudSim simulation tool is also ***,the key open problems and potential directions for the state-of-the-art metaheuristic-based approaches are also addressed.

关键词： Cloud computing load balancing metaheuristic algorithm dynamic algorithm load balancer QoS

Prevalence of post-traumatic stress disorder and depressive symptoms among civilians residing in armed conflict-affected regions:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 324-334页

作者： syed Hassan Ahmed AabiaZakai maha Zahi muhammad Youshay Jawad Rui Fu michael Chaiton Dow University of Health Sciences KarachiPakistan Department of Psychiatry and Behavioral Health Penn State College of MedicineHersheyPennsylvaniaUSA Dalla Lana School of Public Health University of TorontoTorontoOntarioCanada institute of mental Health Policy Research The Center of Addiction and Mental HealthTorontoOntarioCanada

Background Globally,populations afflicted by armed conflict are known to have high rates of mental health *** This meta-analysis aims to estimate the prevalence of post-traumatic stress disorder(PTSD)and depressive symptoms among civilians residing in armed conflictaffected *** This meta-analysis was conducted in accordance with the Preferred Reporting Items forSystematic Reviews and meta-Analyses.A literature search employing mEDLINE(R),Embase Classic+Embase,APA PsyclNFO,Ovid Healthstar,Journal@Ovid Full Text,Cochrane,PTSDpubs and CINAHL was conducted from inception until 19 march 2024 to identify relevant *** assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies,and a Comprehensive meta-Analysiswas usedto conduct the statistical *** The search yielded 38595 articles,of which 57 were considered eligible for *** included studies comprised data from 64596 *** estimated a prevalence of 23.70%(95%CI 19.50%to28.40%)forPTSD symptomsand 25.60%(95%Cl 20.70%to 31.10%)for depressive features among war-afflicted *** subgroup analysis based on time since the war and the country's economic status revealed the highest prevalence for both PTSD and depressive symptoms was present during the years of war and in low/*** The results of this study provide conclusive evidence of the detrimental impacts of armed conflict on mental health ***,it is crucial to emphasise the significance of both physical and mental health in the aftermath of war and take appropriate humanistic measures to overcome challenges in the management of psychiatric illnesses.

关键词： analysis stress armed

Chemical constituents and anticoagulant activity from Delphinium brunonianum Royle

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未来食品学报(英文) 2024年第3期4卷 241-247页

作者： Changyang ma Sitan Chen syed Arif Hussain Rizvi Huihui Zhou Wenyi Kang Xuefeng Xi Zhenhua Liu National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&medicine Resource Function Henan ProvinceKaifeng 475004China Pakistan Agricultural Research Council Islamabad 450000Pakistan College of Physical Education Henan UniversityKaifeng 475004China

Delphinium brunonianum Royle belongs to Ranunculaceae family and has the effects of dispelling wind to relieve itching and cooling blood to *** was found that the extracts of *** had good anticoagulant activity which was extracted with 70%ethanol in our previous ***,16 compounds were isolated and identified from the extract of ***,among which compounds 5,7-10,12,14,15-16 were isolated from this genus for the first time,and compounds 2-4 were isolated from this plant for the first *** the coagulation activity assay showed that compounds 10,14 and 15 had good anticoagulant activity by activated partial thromboplastin time(APTT),thrombin time(TT)and prothrombin time(PT)in vitro.

关键词： Delphinium brunonianum Royle 9-Hydroxy-megastigma-4,7-dien-3-one-9-β-Dglucopyranoside 4-O-α-D-Glucosyl benzoic acid Isolariciresinol 4-O-β-D-glucopyranoside Anticoagulant activity