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Comprehensive review of hepatocellular carcinoma with portal vein tumor thrombus:State of art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis Timothy m Pawlik Daniel Azoulay Department of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Department of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Department of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinoma(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tumor thrombus(PVTT)is among the most ominous signs of advanced stage disease and has been associated with poor survival if *** sources:A systematic search of mEDLINE(Pubmed),Embase,Cochrane Library and Database for Systematic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until December 2022 was conducted using free text and meSH terms:hepatocellular carcinoma,portal vein tumor thrombus,portal vein thrombosis,vascular invasion,liver and/or hepatic resection,liver transplantation,and systematic ***:Centers of surgical excellence have reported promising results related to the individualized surgical management of portal thrombus versus arterial chemoembolization or systemic *** elements to the individualized surgical management of HCC and portal thrombus include precise classification of the portal vein tumor thrombus,accurate identification of the subgroups of patients who may benefit from resection,as well as meticulous surgical *** review addressed five specific areas:(a)formation of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatments versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from Chinese and Japanese high-volume centers demonstrated that patients with HCC and associated PVTT can be managed with surgical resection with acceptable results.

关键词： Hepatectomy Liver surgery Liver neoplasms Portal vein tumor thrombus

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Towards implementation of alloy-specific thermo-fluid modelling for laser powder-bed fusion of mg alloys

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Journal of magnesium and Alloys 2024年第6期12卷 2327-2344页

作者： mohammad Hoseini-Athar mikael Ersson Peter Hedström Department of material Science and Engineering KTH Royal Institute of TechnologyStockholmSE-10044 Sweden

multi-physics thermo-fluid modeling has been extensively used as an approach to understand melt pool dynamics and defect formation as well as optimizing the process-related parameters of laser powder-bed fusion(L-PBF).However,its capabilities for being implemented as a reliable tool for material design,where minor changes in material-related parameters must be accurately captured,is still in *** the present research,first,a thermo-fluid computational fluid dynamics(CFD)model is developed and validated against experimental *** the predicted material properties of the pure mg and commercial ZK60 and WE43 mg alloys,parametric studies are done attempting to elucidate how the difference in some of the material properties,i.e.,saturated vapor pressure,viscosity,and solidification range,can influence the melt pool *** is found that a higher saturated vapor pressure,associated with the ZK60 alloy,leads to a deeper unstable keyhole,increasing the keyhole-induced porosity and evaporation mass *** viscosity and wider solidification range can increase the non-uniformity of temperature and velocity distribution on the keyhole walls,resulting in increased keyhole instability and formation of ***,the WE43 alloy showed the best behavior in terms of defect formation and evaporation mass loss,providing theoretical support to the extensive use of this alloy in *** summary,this study suggests an approach to investigate the effect of materials-related parameters on L-PBF melting and solidification,which can be extremely helpful for future design of new alloys suitable for L-PBF.

关键词： mg alloys Laser powder-bed fusion(L-PBF) melt pool dynamics Computational fluid dynamics Fluid flow

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Carbon monoxide as C1 Building Block in Fine Chemical Synthesis

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Chinese Journal of Chemistry 2024年第2期42卷 199-221页

作者： Rui m.B.Carrilho mario J.F.Calvete Gabor mikle Laszlo Kollar mariette m.Pereira University of Coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Department of General and Inorganic Chemistry and ELKH-PTE Research Groupfor Selective Chemical Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Carbon monoxide(CO)has become one of the most relevant and versatile renewable C1 building blocks for chemical synthesis,especially in the fine chemicals industry,due to the development of efficient and selective catalysts for its *** this review,we present a comprehensive critical analysis of the last 10 years literature on the use of CO as a renewable feedstock for fine chemicals *** review is organized by type of catalytic reaction,namely alkene and alkyne carbonylation,hydroformylation,carbonylation of aryl halides,carbonylative cross-coupling and C-H *** examples of the synthesis of relevant building blocks and/or known pharmaceuticals are *** is placed on examples of utilizing CO as the C1 building block in one or more catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the examples.

关键词： Carbon monoxide Fine chemicals Carbonylation Hydroformylation C-H functionalization

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Quantum correlations and entanglement in coupled optomechanical resonators with photon hopping via Gaussian interferometric power analysis

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Chinese Physics B 2024年第5期33卷 204-211页

作者： Y.Lahlou B.maroufi m.Daoud LPHE-mS Department of PhysicsFaculty of SciencesMohammed V UniversityRabatMorocco LPmS Department of PhysicsFaculty of SciencesIbn Tofail UniversityKénitraMorocco

Quantum correlations that surpass entanglement are of great importance in the realms of quantum information processing and quantum ***,for quantum systems prepared in pure states,it is difficult to differentiate between quantum entanglement and quantum ***,this indistinguishability is no longer holds for mixed *** contribute to a better understanding of this differentiation,we have explored a simple model for both generating and measuring these quantum *** study concerns two macroscopic mechanical resonators placed in separate Fabry–Pérot cavities,coupled through the photon hopping *** system offers a comprehensively way to investigate and quantify quantum correlations beyond entanglement between these mechanical *** key ingredient in analyzing quantum correlation in this system is the global covariance *** forms the basis for computing two essential metrics:the logarithmic negativity(E_(N)^(m))and the Gaussian interferometric power(P_(G)^(m)).These metrics provide the tools to measure the degree of quantum entanglement and quantum correlations,*** study reveals that the Gaussian interferometric power(P_(G)^(m))proves to be a more suitable metric for characterizing quantum correlations among the mechanical modes in an optomechanical quantum system,particularly in scenarios featuring resilient photon hopping.

关键词： quantum correlations entanglement Gaussian interferometric power logarithmic negativity optomechanics photon hopping

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Role of Air Staging in a Batch-Type Fixed Bed Biomass Combustor under Constant Primary Air

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Journal of Thermal Science 2024年第1期33卷 284-299页

作者： Awais JUNEJO Yasir m.AL-ABDELI Jacobo PORTEIRO School of Engineering Edith Cowan UniversityJoondalupWA 6027Australia CINTECX Universidade de Vigo Grupo de Tecnoloxia Enerxetica(GTE)36310 VigoEspana

Staged combustion of biomass is the most suitable thermo-chemical conversion for achieving lower gaseous emissions and higher fuel conversion *** a staged fixed bed combustion of biomass,combustion air is supplied in two *** the first stage,primary air is provided below the fuel,whereas in the later stage,secondary air is supplied in the freeboard *** available literature on the effects of air staging(secondary air location) at a constant primary air flow rate on combustion characteristics in a batch-type fixed bed combustor is limited and hence warrants further *** study resolves the effect of air staging,by varying the location of secondary air in the freeboard at five secondary to total air ratios in a batch-type fixed bed *** are reported for the effects of these controlled parameters on fuel conversion rate,overall gaseous emissions(CO_(2),CO and NO_x) and temperature *** fuel used throughout was densified hardwood *** show that a primary freeboard length(distance between fuel bed top and secondary air injection) of200 mm has higher fuel conversion rates and temperatures as well as lower CO emissions,at a secondary to total air ratio of 0.75 as compared to primary freeboard length of 300 ***,NO_x emissions were found to be lower for a primary freeboard length of 300 mm as compared to 200 *** increase in secondary to total air ratio from 0.33 to 0.75 resulted in higher freeboard temperatures and lower CO as well as NO_x *** outcomes of this study will be helpful in the effective design of commercial scale biomass combustors for more efficient and environmentally friendly combustion.

关键词： fixed bed combustor biomass combustion air staging freeboard temperature burning rate gaseous emissions

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Taurine as a possible therapy for immunosenescence and inflammaging

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Cellular & molecular Immunology 2024年第1期21卷 3-5页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBmSO).Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid(CSIC/UAM)C/Nicolás Cabrera 1Campus de Cantoblanco28049MadridSpain

In their recent Science article,Singh et *** taurine as an endogenously produced anti-inflammatory,anti-immunosenescence,and anti-aging *** authors also show that restoring taurine to its“youthful”levels prevents in... 详细信息

关键词： Taurine inflam

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massive Dirac particles based on gapped graphene with Rosen-morse potential in a uniform magnetic field

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Chinese Physics B 2024年第8期33卷 170-178页

作者： A.Kalani Alireza Amani m.A.Ramzanpour Department of Physics Ayatollah Amoli BranchIslamic Azad UniversityAmolIran

We explore the gapped graphene structure in the two-dimensional plane in the presence of the Rosen-morse potential and an external uniform magnetic *** order to describe the corresponding structure,we consider the propagation of electrons in graphene as relativistic fermion quasi-particles,and analyze it by the wave functions of two-component spinors with pseudo-spin symmetry using the Dirac ***,to solve and analyze the Dirac equation,we obtain the eigenvalues and eigenvectors using the Legendre differential *** that,we obtain the bounded states of energy depending on the coefficients of Rosen-morse and magnetic potentials in terms of quantum numbers of principal n and spin-orbit ***,the values of the energy spectrum for the ground state and the first excited state are calculated,and the wave functions and the corresponding probabilities are plotted in terms of coordinates *** what follows,we explore the band structure of gapped graphene by the modified dispersion relation and write it in terms of the two-dimensional wave vectors K_(x) and K_(y).Finally,the energy bands are plotted in terms of the wave vectors K_(x) and K_(y) with and without the magnetic term.

关键词： massive Dirac equation Rosen–morse potential Legendre polynomial gapped graphene pseudospin symmetry

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Hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

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Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： m.Grandin H.K.Connor S.Hoilijoki m.Battarbee Y.Pfau-Kempf U.Ganse K.Papadakis m.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight Center GreenbeltMD20771USA Space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** Solar wind magnetosphere Ionosphere Link Explorer(SmILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by SmILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SmILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation SmILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves

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On self-affine tiles that are homeomorphic to a ball

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Science China mathematics 2024年第1期67卷 45-76页

作者： Jorg m.Thuswaldner Shu-Qin Zhang mathematics and Statistics University of LeobenLeoben 8700Austria School of mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

Let m be a 3×3 integer matrix which is expanding in the sense that each of its eigenvalues is greater than 1 in modulus and let D?Z^(3)be a digit set containing|det m|*** the unique nonempty compact set T=T(m,D)defined by the set equation mT=T+D is called an integral self-affine tile if its interior is *** D is of the form D={0,v,...,(|det m|-1)v},we say that T has a collinear digit *** present paper is devoted to the topology of integral self-affine tiles with collinear digit *** particular,we prove that a large class of these tiles is homeomorphic to a closed 3-dimensional ***,we show that in this case,T carries a natural CW complex structure that is defined in terms of the intersections of T with its neighbors in the lattice tiling{T+z:z∈Z^(3)}induced by *** CW complex structure is isomorphic to the CW complex defined by the truncated octahedron.

关键词： self-afine sets tiles and tilings low-dimensional topology truncated octahedron

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Leveraging User-Generated Comments and Fused BiLSTm models to Detect and Predict Issues with mobile Apps

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Computers, materials & Continua 2024年第4期79卷 735-759页

作者： Wael m.S.Yafooz Abdullah Alsaeedi Department of Computer Science College of Computer Science and EngineeringTaibah UniversityMedina42353Saudi Arabia

In the last decade, technical advancements and faster Internet speeds have also led to an increasing number ofmobile devices and users. Thus, all contributors to society, whether young or old members, can use these mobileapps. The use of these apps eases our daily lives, and all customers who need any type of service can accessit easily, comfortably, and efficiently through mobile apps. Particularly, Saudi Arabia greatly depends on digitalservices to assist people and visitors. Such mobile devices are used in organizing daily work schedules and services,particularly during two large occasions, Umrah and Hajj. However, pilgrims encounter mobile app issues such asslowness, conflict, unreliability, or user-unfriendliness. Pilgrims comment on these issues on mobile app platformsthrough reviews of their experiences with these digital services. Scholars have made several attempts to solve suchmobile issues by reporting bugs or non-functional requirements by utilizing user ***, solving suchissues is a great challenge, and the issues still exist. Therefore, this study aims to propose a hybrid deep learningmodel to classify and predict mobile app software issues encountered by millions of pilgrims during the Hajj andUmrah periods from the user perspective. Firstly, a dataset was constructed using user-generated comments fromrelevant mobile apps using natural language processing methods, including information extraction, the annotationprocess, and pre-processing steps, considering a multi-class classification problem. Then, several experimentswere conducted using common machine learning classifiers, Artificial Neural Networks (ANN), Long Short-Termmemory (LSTm), and Convolutional Neural Network Long Short-Term memory (CNN-LSTm) architectures, toexamine the performance of the proposed model. Results show 96% in F1-score and accuracy, and the proposedmodel outperformed the mentioned models.

关键词： mobile apps issues play store user comments deep learning LSTm bidirectional LSTm

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