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格陵兰岛的结核病危险因素:病例对照研究

国际结核病与肺部疾病杂志 2011年第4期6卷 180-186页

作者： K.Ladefoged T.Rendal T.Skifte m.andersson B.Sorg A.Koch 彭红王雪静 medical Department Queen Ingrids Hospital Nuuk National Board of Health in Greenland Nuuk Greenland Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark

背景和目的:在格陵兰岛,尽管进行了疾病控制的多方努力,但结核病发病率仍很高。1998—2007年间,平均发病率为131/10万人口。本研究的目的是揭示与结核病相关的危险因素。方法:对2004—2006年间诊断为结核病的146例患者进行病例对照研究... 详细信息

背景和目的:在格陵兰岛,尽管进行了疾病控制的多方努力,但结核病发病率仍很高。1998—2007年间,平均发病率为131/10万人口。本研究的目的是揭示与结核病相关的危险因素。方法:对2004—2006年间诊断为结核病的146例患者进行病例对照研究。为每例患者选择年龄、性别相当,居住在同一地区的4名健康人作为对照。所有参与者完成有关社会人口统计学和生活方式因素的调查问卷。运用logistic回归模型进行危险因素分析。结果:与结核病相关的危险因素包括因纽特种族、生活在较小的定居点、失业、无自来水、无厕所或抽水马桶、体重不足、吸烟、经常饮酒和免疫抑制治疗。多变量模型显示,因纽特种族(OR15.3)、生活在定居点(OR5.1)、失业(OR4.1),以及经常饮酒(OR3.1)是独立的决定性危险因素。失业与最高人群归因危险度相关(29%)。结论:应对与居住在小定居点相关的危险因素做进一步探讨,而且有必要开展遗传学易感性调查。

关键词：结核病社会决定因素因纽特格陵兰危险因素

Detection of Stiff Nodules Embedded in Soft Tissue Phantoms,mimicking Cancer Tumours,Using a Tactile Resonance Sensor

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Journal of Biomedical Science and Engineering 2014年第4期7卷 181-193页

作者： Anders P.Astrand Ville Jalkanen Britt m.andersson Olof A.Lindahl Department of Applied Physics and Electronics Umea UniversityUmeaSweden Centre for Biomedical Engineering and Physics Umea UniversityUmeaSweden Industrial Doctoral School Umea UniversityUmeaSweden Department of Radiation Sciences Biomedical EngineeringUmea UniversityUmeaSweden Department of Engineering Sciences and mathematics Lulea University of TechnologyLuleaSweden

Background: Prostate cancer (PCa) is the most common form of cancer among males in Europe and in the USA and the most common curative treatment is removal of the prostate, i.e. prostatectomy. After the removal, the prostate is histopathologically analysed. One area of interest is to examine the perifery of the prostate, as tumours on and near the surface can indicate that the PCa has spread to other parts of the body. There are no current methods to examine the surface of the prostate at the time of surgery. Tactile resonance sensors can be used for detecting areas of different stiffness in soft tissue. Human prostate tissue affected by cancer is usually stiffer than healthy tissue, and for this purpose, a tactile resonance sensor was developed. The aim of this study was to investigate the depth at which embedded stiffer volumes could be detected, using soft tissue phantoms. methods: With the tactile resonance sensor used in this study, the shift of the resonance frequency and the force at contact with tissue can be measured, and combined into a tissue stiffness parameter. The detection sensitivity of the sensor at impression depths, 0.4 and 0.8 mm, was measured for detection of inserted nodules of stiff silicone in softer silicone and in chicken muscle tissue, mimicking prostate tissue with cancer tumours. Results: measurements on the silicone samples detected the hidden stiffer object at a depth of 1 - 4 mm with a difference in the stiffness parameter of 80 - 900 mN/kHz (p mm the difference was smaller but still significant mN/kHz (p measurements on chicken muscle, the detectable depth was 4 mm (p model study suggests that, with only a small impression depth of ≤1 mm, the resonance sensor system described here can detect stiffness variations located at least 4 mm in silicone and chicken muscle, mimicking tumours in prostate tissue.

关键词： Tissue Stiffness Resonance Sensor Prostate Cancer Piezoelectric Depth Sensitivity Tactile Sensor

Search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

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中国物理C:英文版 2023年第9期47卷 14-26页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva m.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio m.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle R.Amalric S.Amato J.L.Amey Y.Amhis L.An L.Anderlini m.andersson A.Andreianov m.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov m.Artuso E.Aslanides m.Atzeni B.Audurier S.Bachmann m.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite m.Barbetti R.J.Barlow S.Barsuk W.Barter m.Bartolini F.Baryshnikov J.m.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck m.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Benane G.Bencivenni E.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian m.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini m.Birch F.C.R.Bishop A.Bitadze A.Bizzeti m.P.Blago T.Blake F.Blanc J.E.Blank S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev C.S.Bolognani R.Bolzonella N.Bondar F.Borgato S.Borghi m.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi m.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine m.Calvi m.Calvo Gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse m.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick m.G.Chapman m.Charles Ph.Charpentier C.A.Chavez Barajas m.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak m.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone m.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke m.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cognera Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany max-Planck-Institut für Kernphysik(mPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di milano MilanoItaly INFN Sezione di milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV,corresponding to an integrated luminosity of 2.0fb−1.No significant signal is observed for either decay mode and upper limits on their branching fractions are set using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization channels.The upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,respectively.This is the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

Search for the doubly heavy baryon Ξ_(bc)^(+)→ decaying to J/ψΞ_(c)^(+)

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中国物理C:英文版 2023年第9期47卷 1-13页

作者： R.Aaij A.S.W.Abdelmotteleb C.Abellan Beteta F.Abudinén T.Ackernley B.Adeva m.Adinolfi H.Afsharnia C.Agapopoulou C.A.Aidala S.Aiola Z.Ajaltouni S.Akar K.Akiba J.Albrecht F.Alessio m.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle S.Amato J.L.Amey Y.Amhis L.An L.Anderlini m.andersson A.Andreianov m.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov m.Artuso E.Aslanides m.Atzeni B.Audurier S.Bachmann m.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de Souza Leite m.Barbetti R.J.Barlow S.Barsuk W.Barter m.Bartolini F.Baryshnikov J.m.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck m.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian m.S.Bieker N.V.Biesuz S.Bifani P.Billoir A.Biolchini m.Birch F.C.R.Bishop A.Bitadze A.Bizzeti m.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev N.Bondar S.Borghi m.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi m.J.Bradley S.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura L.Buonincontri A.T.Burke C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice S.Cali R.Calladine m.Calvi m.Calvo Gomez P.Camargo magalhaes P.Campana D.H.Campora Perez A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse m.Cattaneo G.Cavallero V.Cavallini S.Celani J.Cerasoli D.Cervenkov A.J.Chadwick m.G.Chapman m.Charles Ph.Charpentier C.A.Chavez Barajas m.Chefdeville C.Chen S.Chen A.Chernov S.Chernyshenko V.Chobanova S.Cholak m.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone m.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke m.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Université Savoie mont Blanc CNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany max-Planck-Institut für Kernphysik(mPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di milano MilanoItaly INFN Sezione di milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universitàdegli Studi di Padova Universitàe INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer Scienc

A first search for the Ξ_(bc)^(+)J/ψΞ_(c)^(+) decay is performed by the LHCb experiment with a data sample of proton-proton collisions, corresponding to an integrated luminosity of 9 fb−1 recorded at centre-of-mass energies of 7, 8, and 13 TeV. Two peaking structures are seen with a local (global) significance of 4.3(2.8) and 4.1(2.4) standard deviations at masses of 6571 and 6694 meV/c2, respectively. Upper limits are set on the Ξ+bc baryon production cross-section times the branching fraction relative to that of the B+c→J/ψD+s decay at centre-of-mass energies of 8 and 13 TeV, in the Ξ+bc and in the B+c rapidity and transverse-momentum ranges from 2.0 to 4.5 and 0 to 20GeV/c, respectively. Upper limits are presented as a function of the Ξ+bc mass and lifetime.

关键词： QCD B physics charm physics spectroscopy

Risk factors and outcomes for patients with pancreatic cancer undergoing surgical exploration without resection due to metastatic disease:A national cohort study

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 279-284页

作者： Emil Sahlstrom Paulina Bereza-Carlson Johan Nilsson Bobby Tingstedt Bodil andersson Department of Clinical Sciences Lund SurgeryLund UniversitySweden Department of Surgery Central Hospital KristianstadSweden Department of Translational medicine Cardiothoracic surgery and bioinformaticsLund UniversitySweden Department of Thoracic and vascular surgery Skane University hospitalLundSweden Department of Surgery Skane University HospitalLundSweden

Background:Unresectable disease is sometimes diagnosed during surgery in patients with pancreatic ductal adenocarcinoma(PDAC).This study aimed to identify preoperative risk factors for metastatic disease diagnosed at surgical exploration and to investigate and compare survival in resected and nonresected patients.methods:Patients were identified from the Swedish National Pancreatic and Periampullary Cancer Registry 2010-2018.Predictors of metastatic disease were evaluated with a multivariable logistic regression model,and survival was evaluated with Kaplan-meier estimates and log-rank tests.Results:In total,1938 patients with PDAC were scheduled for surgery.An unresectable situation was diagnosed intraoperatively in 399 patients(20.6%),including 234(12.1%)with metastasized disease.Independent risk factors for metastasis were involuntary weight loss(OR=1.72;95%CI:1.27-2.33)and elevated carbohydrate antigen 19-9(CA19-9)(35-599 U/m L,OR=1.79,95%CI:1.11-2.89;≥600 U/m L,OR=3.24,95%CI:2.04-5.17).Overall survival was lower among patients with metastasized disease than that among patients with a resectable tumor(Pmetastasized disease during surgical exploration.

关键词： Pancreatic cancer Surgery metastasized Exploration

maximizing recovery time between knock-out races improves sprint cross-country skiing performance

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Journal of Sport and Health Science 2022年第1期11卷 21-29页

作者： Kerry mcGawley Coline Van Waerbeke Karl-Johan Westberg Erik P.andersson Swedish Winter Sports Research Centre Department of Health SciencesMid Sweden UniversityOstersund 83125Sweden

Background:In a sprint cross-country(XC)ski competition,the difference in recovery times separating the first and the second semi-final(SF)heats from the final(F)may affect performance.The aim of the current study was to compare the effects of longer vs.shorter recovery periods prescribed between the 3 knock-out races of a simulated sprint XC ski competition involving a prologue(P),quarter-final(QF),SF,and F.methods:Eleven well-trained XC ski athletes completed 2 simulated sprint XC ski competitions on a treadmill involving 4×883-m roller-ski bouts at a 4°incline using the gear 3 ski-skating sub-technique.The first 3 bouts were completed at a fixed speed(PFIX,QFFIX,and SFFIX)corresponding to~96%of each individual’s previously determined maximal effort.The final bout was performed as a self-paced sprint time trial(FSTT).Test conditions differed by the time durations prescribed between the QFFIX,SFFIX,and FSTT,which simulated real-world XC ski competition conditions using maximum(mAX-REC)or minimum(mIN-REC)recovery periods.Results:The FSTT was completed 5.4±5.5 s faster(p=0.009)during mAX-REC(179.2±18.1 s)compared to mIN-REC(184.6±20.0 s),and this was linked to a significantly higher power output(p=0.010)and total metabolic rate(p=0.009).The pre FSTT blood lactate(BLa)concentration was significantly lower during mAX-REC compared to mIN-REC(2.5±0.8 mmol/L vs.3.6±1.6 mmol/L,respectively;p=0.027),and the pre-to-post FSTT increase in BLa was greater(8.8±2.1 mmol/L vs.7.1±2.3 mmol/L,respectively;p=0.024).No other differences for mAX-REC vs.mIN-REC reached significance(p>0.05).Conclusion:Performance in a group of well-trained XC skiers is negatively affected when recovery times between sprint heats are minimized which,in competition conditions,would occur when selecting the last QF heat.This result is combined with a higher pre-race BLa concentration and a reduced rise in BLa concentration under shorter recovery conditions.These findings may help inform decision making when XC skiers are faced with selecting a QF heat wi

关键词： Energetics Repeated sprints Roller skiing Simulated competition Tactics

Luminescent line art by direct-write patterning

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Light(Science & Applications) 2016年第1期5卷 518-521页

作者： Erik mattias Lindh Andreas Sandström mats Roland andersson Ludvig Edman The Organic Photonics and Electronics Group UmeaUniversityUmeaSweden LunaLEC AB UmeaSweden Future Industries Institute University of South AustraliaMawson LakesSA 5095Australia

We present a direct-write patterning method for the realization of electroluminescent(EL)line art using a surface-emissive light-emitting electrochemical cell with its electrolyte and EL material separated into a bilayer structure.The line-art emission is achieved through subtractive patterning of the electrolyte layer with a stylus,and the single-step patterning can be either manual for personalization and uniqueness or automated for high throughput and repeatability.We demonstrate that the light emission is effectuated by cation-assisted electron injection in the patterned regions and that the resulting emissive lines can be as narrow as a few micrometers.The versatility of the method is demonstrated through the attainment of a wide range of light-emission patterns and colors using a variety of different materials.Wepropose that this low-voltage-driven and easy-to-modify luminescent line-art technology could be of interest for emerging applications,such as active packaging and personalized gadgets.

关键词： direct-write patterning light-emitting electrochemical cell luminescent line art organic electronics

Dynamic energy system modeling using hybrid physics-based and machinelearning encoder–decoder models

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能源与人工智能(英文)

能源与人工智能(英文) 2022年第3期9卷 128-138页

作者： Derek machalek Jake Tuttle Klas andersson Kody m.Powell Department of Chemical Engineering University of UtahSalt Lake CityUTUnited States of America Taber International LLCUnited States of America Department of Space Earthand EnvironmentUniversity of ChalmersGothenburgSweden Department of mechanical Engineering University of UtahSalt Lake CityUTUnited States of America

Three model configurations are presented for multi-step time series predictions of the heat absorbed by thewater and steam in a thermal power plant. The models predict over horizons of 2, 4, and 6 steps into thefuture, where each step is a 5-minute increment. The evaluated models are a pure machine learning model, anovel hybrid machine learning and physics-based model, and the hybrid model with an incomplete dataset. Thehybrid model deconstructs the machine learning into individual boiler heat absorption units: economizer, waterwall, superheater, and reheater. Each configuration uses a gated recurrent unit (GRU) or a GRU-based encoder–decoder as the deep learning architecture. mean squared error is used to evaluate the models compared totarget values. The encoder–decoder architecture is over 11% more accurate than the GRU only models. Thehybrid model with the incomplete dataset highlights the importance of the manipulated variables to the system.The hybrid model, compared to the pure machine learning model, is over 10% more accurate on averageover 20 iterations of each model. Automatic differentiation is applied to the hybrid model to perform a localsensitivity analysis to identify the most impactful of the 72 manipulated variables on the heat absorbed in theboiler. The models and sensitivity analyses are used in a discussion about optimizing the thermal power plant.

关键词： Hybrid model Encoder-decoder Time series Automatic differentiation Thermal power plant

Regulation of HmGB1 release by infl ammasomes

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Protein & Cell 2013年第3期4卷 163-167页

作者： Ben Lu Haichao Wang Ulf andersson Kevin J.Tracey Laboratory of Biomedical Science Feinstein Institute for Medical Research350 Community DriveManhassetNY 11030USA The Elmezzi Graduate School of molecular medicine North Shore-LIJ Health system350 Community DriveManhassetNY 11030USA Department of Emergency medicine North Shore University HospitalManhassetNY 11030USA Department of Women’s and Children’s Health Karolinska InstitutetS-17677 StockholmSweden

High mobility group box 1(HmGB1)is an evolutionarily conserved non-histone chromatin-binding protein.During infection or injury,activated immune cells and damaged cells release HmGB1 into the extracellular space,where HmGB1 functions as a proinflammatory mediator and contributes importantly to the pathogenesis of inflammatory diseases.Recent studies reveal that infl ammasomes,intracellular protein complexes,critically regulate HmGB1 release from activated immune cells in response to a variety of exogenous and endogenous danger signals.Double stranded RNA dependent kinase(PKR),an intracellular danger-sensing molecule,physically interacts with inflammasome components and is important for infl ammasome activation and HmGB1 release.Together,these studies not only unravel novel mechanisms of HmGB1 release during infl ammation,but also provide potential therapeutic targets to treat HmGB1-related infl ammatory diseases.

关键词： HmGB1 infl ammasome PKR