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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H W m Lemlijn-Slenter Karolina AP Wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico Wolter Angelique E de Rijk Ad am masclee Department of Social medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the maastricht University medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with mcDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valuemensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

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Cellulose Derivative and Lanthanide Complex Thin Film

Cellulose Derivative and Lanthanide Complex Thin Film

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作者： ALI ABDULLAH SALEH HZam ALT am（艾力）东华大学

学位级别：硕士

纤维素是世界上最丰富的天然聚合物,因此它被视为非常重要的多用途的原材料,基于其特殊的结构和功能性质,广泛应用于医疗产品。纤维素的结构中有羟基,能够部分的或者完全的与不同元素发生反应,得到的衍生物具有多功能性质,例如纤维素酯... 详细信息

纤维素是世界上最丰富的天然聚合物,因此它被视为非常重要的多用途的原材料,基于其特殊的结构和功能性质,广泛应用于医疗产品。纤维素的结构中有羟基,能够部分的或者完全的与不同元素发生反应,得到的衍生物具有多功能性质,例如纤维素酯和纤维素醚。纤维素衍生物在日常生活中被广泛应用,因此它必须无致癌性、无毒性、生物相容性并且对生物环境无排斥性。在食品和药物企业,纤维素醚是最广泛应用的纤维素衍生物,如羧甲基纤维素(CmC),阳离子纤维素(CC)。纤维素醚是通过用烷基或者羟烷基置换羟基得到的,取代基的化学性质,数量和分布影响着纤维素醚的溶解性、热稳定性、胶体性质、表面活性、热塑性、薄膜属性和生物降解性。镧系元素原子结构有4f轨道,使得它们表现出特殊的化学和光谱性质。镧系元素的麻醉剂吸引了人们的极大兴趣,因其在催化和发光领域的潜在应用。一些镧系离子,如铽和铕,已经广泛应用于原子聚集和生物分子结构的发冷光试验和染色试验中。理解高分子与金属离子间的相互作用对科学研究和创新实验具有重大意义。两者的相互作用力主要是静电力和配位作用力。金属很容易失去电子变成离子,同时自然界中有很多带负电荷的高分子,因此静电力相互作用较为常见。同时,金属离子的原子结构有空轨道,并且高分子上的基团能够提供电子对,以此形成配位键。有研究表明羧酸基团和金属离子的配位相互作用分为单齿,双齿,和三齿螯合。在过去几年,人们尝试了许多界面复合的方法来组装纤维素衍生物到聚电解质多层薄膜中,如基于静电作用为主要驱动力的层层组装技术,该技术是一个简单高效的制备薄膜的方法。层层组装薄膜有诸多应用,如光学过滤膜、离子交换膜、防腐涂层、化学和生物传感器以及药物传递层。层层组装技术也可以用来扩展纤维素的应用,但是纤维素不能直接用来制备薄膜,只有通过化学改性,纤维素才可以。最近,高分子螯合物已经被用于层层组装的基础材料。有一类的高分子螯合物是超高分子聚集体,它是基于不同的二级相互作用形成的,包含有高分子-高分子螯合物,高分子-金属螯合物和高分子-表面活性剂螯合物。高分子螯合物的层层组装使得它易于形成微米级的薄膜并且能引入更多的材料进入薄膜中,这对材料的多功能应用有很大意义,例如超疏水、自修复等。在我的研究体系,研究工作的主要目的是引入镧系离子进入纤维素衍生物薄膜中,先制备带负电荷的CmC-Ln的复合物纳米颗粒,然后与带正电荷的CC层层组装,通过这种方法,成功得到CmC-Ln-QC复合物薄膜。我们分别制备了pH=4和pH=6两个pH条件下的CmC-Ln-QC复合物薄膜.研究工作的第一部分是在pH4和pH6的条件下制备CmC-Ln的配合物。CmC包含很多羧酸根和羟基基团,能够基于配位作用和镧系离子形成聚合物金属复合物。在严格控制的pH值和质量百分比的条件下混合相同体积的CmC和Ln离子溶液制备CmC-Ln复合物纳米颗粒。在pH6,质量百分比4:1和pH4,质量百分比6:1的条件下,能得到分散的CmC-Ce复合物纳米颗粒;(i)直接混合Ce离子溶液和CmC溶液(m1),(ii)逐滴地滴加Ce离子溶液到CmC溶液中,滴加速率为1m L/h(m2),(iii)逐滴地滴加CmC溶液到Ce离子溶液中,滴加速率为1m L/h(m3)。我们使用动态光散射(DLS)测试了CmC-Ce复合物纳米颗粒的尺寸和分布,在pH4,m1,m2和m3的平均流体动力学直径分别是610nm,450 nm和740 nm。在pH6时,分别是650 nm,350 nm和1150 nm,同时使用紫外可见光谱UV-Vis证明了纳米颗粒中包含有铈离子。对于m1,m2,m3,CmC-Ce复合物纳米颗粒在pH4的Zeta电位分别是-21.2,-19.2,-20.6,在pH6分别是-43.7,-36.8,-38.6。随着pH值的增加,去离子化增强,得到更多的羧酸根离子。红外光谱FT-IR可用来表征CmC的去离子化程度。根据公式(1)的计算,在pH=2时,CmC的去离子化程度是15%,在pH=4是55%,在pH=6时接近100%。羧酸根离子COO-的对称和非对称伸缩振动峰的差值,可以反映CmC和铈离子的配位作用方式,不同的方式取决于组装的pH和质量百分比。研究工作的第二部分是利用两种带有相反电荷的物质制备薄膜。层层组装技术将负电荷的均匀分散的CmC-Ln配合物胶体颗粒和正电荷的阳离子纤维素交替沉积在石英片或者硅片上来制备薄膜。在pH4和pH6的不同条件下制备薄膜,并且薄膜的性质可通过不同的光谱技术来研究。反射光谱用来表征薄膜厚度,pH=4的条件下制备的[CC/(CmC-Ce)]薄膜非常浑浊,在光谱上没有指纹峰出现,厚度很难测试。在pH=6的条件下制备的薄膜比较透明,可用公式(2)计算厚度。在pH=6的m1和m2方法制备的薄膜厚度分别为1222 nm和750 n

关键词：纤维素纤维素衍生物羧甲基纤维素阳离子纤维素镧系离子层层组装

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Structural, elastic and electronic properties for m_2 XC (m=Ti and Cr, X=Ga and Al) phases from ab initio calculations

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Acta metallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.A. Ghebouli m. Fatmi N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids materials Department of Physics Faculty of Science University of Setif Department of Physics University Center Research Unit on Emerging materials Ferhat Abbas University of Setif Department of Physics Faculty of Sciences King Khalid University Central metallurgical Research and Development Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m2XC phases depending on the type of m transition metal （m are Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are performed using the pseudo-potential plane-wave approach in both the local density and generalized gradient approximations. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic parameters, Debye tem- perature, sound velocities and their pressure dependence have been investigated. In agreement with experimental and previous theoretical findings, it is found that the compressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m elements on the machinability indices of the material have been examined. The electronic properties have been discussed in terms of chemical bonding showing that bonding is due to md-Cp and md-Xp hybridizations. m-C bonds are stiffer than m-X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m-X and m-C bonds increases with increasing the number of VEC.

关键词： m2XC phases ab initio Pressure effect Band structures

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Qualitative analysis of catechins from green tea GmB-4 clone using HPLC and LC-mS/mS

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Asian Pacific Journal of Tropical Biomedicine 2015年第12期5卷 1046-1050页

作者： Erna Susanti Ciptati Retty Ratnawati Aulanni'am Achmad Rudijanto Doctoral Program of Biomedical Science Faculty of Medicine Brawijaya University Department of Chemistry Faculty of Science Bandung Institute of Technology Biomedical Science Faculty of Medicine Brawijaya University

Objective:To identify the bioactive compounds in catechins isolation and its components from green tea GmB-4 ***:Green tea GmB-4 clones were extracted with distilled water at *** were eluted into the column with 10%***,the column was eluted with95%ethanol and evaporated *** tea extract was identified by thin layer *** were separated by the stationary phase in column chromatography using polyamide with 10%ethanol eluent and 95%*** results of isolations were analyzed by high performance liquid chromatographic(HPLC)and LCmS/*** of catechins by HPLC was done by external ***:Fraction from 10%ethanol showed that four major peaks at retention time of1.663,2.367,2.950 and 4.890,indicated the presence of four catechins components including catechin,epicatechins,gallocatechin and ***,fraction from 95%ethanol showed two main peaks at retention time of 5.167 and 9.82,which indicated the presence of epigallocatechin gallate(EGCG)and epicatechin gallate(ECG).EGCG(m/z 459),epigallocatechin(m/z 307),ECG(m/z 443),and epicatechin(m/z 291)were isolated and separated successfully using HPLC and LC-mS/***:The HPLC and LC-mS/mS methods were successfully tuned for the qualitative analysis of green tea extract with EGCG and *** major catechins were separated and identified by LC-mS/mS,such as EGCG,epigallocatechin,ECG and *** result of HPLC analysis showed that EGCG and ECG were main components from catechins isolation of green tea GmB-4 clone.

关键词： Catechins Green tea GmB-4 clone LC-mS/mS HPLC

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Influence of FCA Welding Process Parameters on Distortion of 409m Stainless Steel for Rail Coach Building

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Journal of Iron and Steel Research International 2013年第1期20卷 71-78页

作者： m V Venkatesan N murugan B m Prasad A manickavasagam Department of mechanical Engineering Coimbatore Institute of TechnologyCoimbatore 641014TNIndia Integral Coach Factory Indian RailwaysChennai 600038TNIndia

The influence of flux cored arc welding （FCAW） process parameters such as welding current, travel speed, voltage and CO2 shielding gas flow rate on bowing distortion of 409m ferritic stainless steel sheets of 2 mm in thickness was discussed. The bowing distortions of the welded plates were measured using a simple device called profile tracer. An experimental regression equation was developed to predict the bowing distortion and with this equation, it is easy to select optimized process parameters to achieve minimum bowing distortion. It is revealed that the FCAW process parameters have significant influence on bead profile and the bowing distortion.

关键词： bowing distortion ferritic stainless steel flux cored arc welding statistical model rail coach distortion measurement

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Holmium Oxide Film as a Saturable Absorber for 2μm Q-Switched Fiber Laser

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Chinese Physics Letters 2017年第5期34卷 48-51页

作者： m.F.A.Rahman m.F.m.Rusdi m.Q.Lokman m.B.H.mahyuddin A.A.Latiff A.H.A.Rosol K.Dimyati S.W.Harun Department of Electrical Engineering University of Malaya Kuala Lumpur 50603 Malaysia Photonics Research Centre University of Malaya Kuala Lumpur 50603 Malaysia Faculty of Electrical Engineering University Teknologi Mara Shah Alam 40450 Malaysia

This work reports on the use of the holmium oxide （Ho2O3） polymer film as a saturable absorber （SA） for generating stable Q-switching pulses operating in a 2μm region in a thulium-doped fiber laser cavity. The SA is prepared by diluting a commercial Ho3O2 powder and then mixing it with polyvinyI alcohol （PVA） solution to form a Ho2O3-PVA film. A tiny part of the film about 1mm×1 mm in size is sandwiched between two fiber ferrules with the help of index matching gel. When incorporated in a laser cavity driven by a 1552-nm pump, stable Q-switching pulses are observed at 1955nm within the pump power range of 363 491 roW. As the pmnp power increases within this range, the repetition rate rises from 26 kHz to 39 kHz, as the pulse width drops from 4.22μs to 2.57μs. The laser operates with a signal-to-noise ratio of 47dB, and the maximum output power and the pulse energy obtained are 2.67mW and 69ng, respectively. Our results successfully demonstrate that the Ho2O3 film can be used as a passive SA to generate a 2μm pulse laser.

关键词： m Q-Switched Fiber Laser SA FESEm

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CR1409拮抗缩胆囊素升高细胞内Ca^(2+)的作用

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中国药理学通报 1991年第6期7卷 425-429页

作者：陈蔚文 Cheret am Abastado m Lewin mJm 广州中医学院消化研究室 510407 法国胃肠病学研究所

CR1409是一种新合成的缩胆囊素(CCK)受体拮抗剂。本文使用荧光指示剂Fura-2作为细胞内钙离子的探测物,在离体的大白鼠胰腺细胞研究OR1409对CCK引起细胞内钙离子浓度升高的拮抗作用。结果表明:10μmol/L CR1409完全抑制1nmol/L CCK的作用... 详细信息

CR1409是一种新合成的缩胆囊素(CCK)受体拮抗剂。本文使用荧光指示剂Fura-2作为细胞内钙离子的探测物,在离体的大白鼠胰腺细胞研究OR1409对CCK引起细胞内钙离子浓度升高的拮抗作用。结果表明:10μmol/L CR1409完全抑制1nmol/L CCK的作用,半效抑制浓度为0.37μmol/L,比另一种拮抗剂双丁酰环鸟嘌呤核苷(db cGmP)强100倍。随着CR1409浓度的递增,使CCK升高细胞内钙离子浓度的量效曲线右移,根据Schild方法计算,pA_2值为6.93(r=0.992)。CR1409对氯氨甲酰胆碱和蛙皮素无拮抗作用。实验结果证明CR1409是一种效力较强的、特异性的和竞争性的CCK受体拮抗剂。

关键词：细胞内钙离子缩胆囊素 CR1409 Fura 2/am 离体细胞量效曲线量—效反应曲线

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Effects of meal size and proximal-distal segmentation on gastric activity

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World Journal of Gastroenterology 2010年第46期16卷 5861-5868页

作者： madileine F américo marjorie V Ietsugu Fernando G Romeiro Luciana A Corá Ricardo B Oliveira José Ricardo A miranda Department of Physics and Biophysics IBBUNESP-Sao Paulo State University Institute of Biological Sciences and Health ICBSUFMT-University of Mato Grosso Department of Clinical medicine FMBUNESP-Sao Paulo State University Department of Clinical medicine FMRPUSP-University of So Paulo UNCISAL-Alagoas State University of Health Sciences

AIm:To evaluate the effects of meal size and three segmentations on intragastric distribution of the meal and gastric motility,by ***:Twelve healthy volunteers were randomly assessed,twice,by *** test meal consisted of 60 or 180 mL of yogurt labeled with 64 mBq 99m Tc-tin *** and posterior dynamic frames were simultaneously acquired for 18 min and all data were analyzed in *** proximal-distal segmentations using regions of interest were adopted for both ***:Intragastric distribution of the meal between the proximal and distal compartments was strongly influenced by the way in which the stomach was divided,showing greater proximal retention after the 180 *** important finding was that both dominant frequencies (1 and 3 cpm) were simultaneously recorded in the proximal and distal stomach;however,the power ratio of those dominant frequencies varied in agreement with the segmentation adopted and was independent of the meal ***:It was possible to simultaneously evaluate the static intragastric distribution and phasic contractility from the same recording using our scintigraphic approach.

关键词： Gastric motility Phasic contractions Proximal stomach Scintigraphy meal size

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Charaeterizability of the Group ~2D_p(3) by its Order Components,Where p≥5 is a Prime Number Not of the Form 2~m+1

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Acta mathematica Sinica,English Series 2008年第7期24卷 1117-1126页

作者： m.R.DARAFSHEH School of mathematics College of ScienceUniversity of TehranTehranIran

The author will prove that the group ^2Dp（3） can be uniquely determined by its order components, where p ≠ 2^m ＋ 1 is a prime number, p ≥ 5. more precisely, if OC（G） denotes the set of order components of G, we will prove OC（G） = OC（^2Dp（3）） if and only if G is isomorphic to ^2Dp（3）. A main consequence of our result is the validity of Thompson＇s conjecture for the groups under consideration.

关键词： prime graph order component linear group

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