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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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The Prospects for Renewable Energy through Hydrogen Energy Systems

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Journal of Power and Energy Engineering 2015年第4期3卷 373-377页

作者： marc A. rosen Faculty of Engineering and Applied Science University of Ontario Institute of Technology Oshawa Ontario Canada

The prospects for renewable energy are enhanced through the use of hydrogen energy systems in which hydrogen is an energy carrier. As easily accessible fossil fuel supplies become scarcer and environmental concerns increase, hydrogen is likely to become an increasingly important chemical energy carrier. As the world’s energy sources become less fossil fuel-based, hydrogen and electricity are expected to be the two dominant energy carriers for the provision of end-use services, in a hydrogen economy. Thus, hydrogen energy systems allow greater use of renewable energy resources. In this paper, the role of hydrogen as an energy carrier and hydrogen energy systems, and their economics, are described and reviewed.

关键词： Renewable Energy Hydrogen Hydrogen Economy

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Crowth Arrest Recovery Lines in Hypoparathyroidism 1

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实用放射学杂志 1987年第3期 166-167页

作者： Richard A. rosen, m. D Sheila m. Deshmukh, m. D.

BECAUSE of the infrequency of hypoparathyroidism and the Paucity of radiographic findings observed in this disease, the diagnosis is rarely made by the radiologist. By far the most common cause of the process is the i... 详细信息

关键词： Crowth Arrest Recovery Lines in Hypoparathyroidism 1

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management of low transsphincteric anal fistula with serial setons and interval muscle-cutting fistulotomy

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Journal of Integrative medicine 2016年第2期14卷 154-158页

作者： Chen Wang Lester rosen Department of Colorectal Surgery Cleveland Clinic Florida WestonFL 33331USA Department of Anorectal Surgery Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

This study evaluates low transsphincteric anal fistula managed by serial setons and interval fistulotomy, with attention to healing without recurrence and preservation of continence. Following Institutional Review Board approval, consecutive anal fistula operations performed by a single surgeon from January 1, 2009 to December 31, 2013 were retrospectively reviewed using electronic medical records and telephone interviews for patients lost to follow up. Of the 71 patients, 26（37%） had low transsphincteric fistula（23 males and 3 females; mean age： 46 years）, treated at our institution by seton placement followed by interval surgical muscle cutting and subsequent seton replacement or final fistulotomy. Of the 26 patients, 22（85%） were initially referred due to previous failed treatment, with a 30.6 month mean duration of fistula prior to referral and a mean of 2.2（range： 0–6） prior anorectal surgeries. At a mean follow-up of 11.9 months, none of the 21 patients experienced recurrence or fecal incontinence. Serial seton with interval muscle-cutting sphincterotomy followed by complete fistulotomy is an effective treatment for the management of patients who are either initially seen for low transsphincteric fistula, or referred after failed anorectal surgery for that condition.

关键词： low transshpincteric fistula serial seton fistulotomy recurrent fistula fecal incontinence

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Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2014年第3期5卷 122-138页

作者： John m rosen Jose T Cocjin Jennifer V Schurman Jennifer m Colombo Craig A Friesen Division of Gastroenterology Hepatology and Nutrition Children’s Mercy Kansas CityKansas CityMO 64108United States

Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets.

关键词： motility Visceral hypersensitivity Functional dyspepsia

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Weight trends in United States living kidney donors:Analysis of the UNOS database

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World Journal of Transplantation 2015年第3期5卷 137-144页

作者： mala Sachdeva Lisa m rosen Jeny Varghese Steven Fishbane Ernesto P molmenti Department of medicine Division of Kidney Diseases and HypertensionNorth Shore University Hospital and LIJ Medical CenterHofstra North Shore-LIJ School of Medicine Department of Biostatistics Feinstein Institute For Medical ResearchNorth Shore University Hospital and LIJ Medical CenterHofstra North Shore-LIJ School of Medicine Department of Surgery North Shore University Hospital and LIJ Medical CenterHofstra North Shore-LIJ School of Medicine

AIm: To analyze the national trends associated with body mass index(BmI) and living kidney ***: Forty-seven thousand seven hundred and five adult living kidney donors as reported to the Organ Procurement and Transplantation Network from 1999 to 2011 were analyzed using their pre-donation BmI. Predictor variables of interest included age, gender, ethnicity, relationship, education status, and transplant ***: Sixteen thousand nine hundred and seventyone of the living kidney donors were normal weight(35.6%); 19337 were overweight(40.5%); 9007 were mildly obese(18.9%); 1992 were moderate to morbidly obese(4.2%). Overweight and mildly obese kidney donors have increased through time by 12% and 20% every 5 years, respectively(P males or females and black females, those with high school diploma or general Education Degree, and biologically related or partner/spouses were more likely to be ***: Over the past 13 years, the majority of living kidney donors have spanned the overweight to obese categories. Paralleling the national rise is an increase in overweight and mildly obese kidney donors. A fair number of moderate to morbidly obese living kidney donors are still allowed to donate.

关键词： Transplantation Obesity Donor Kidney Living

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Clouds:The most Useful metaphor of All Time?

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考试（高考英语） 2011年第12期 30-32页

作者： Rebecca J.rosen 不详

云计算、云服务,不止文学,科技也喜欢用＂云＂做比喻。

关键词：英语学习高中英语英语美文英语阅读

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China-Brazil,Both Challenges and Opportunities for the Cooperation

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China's Foreign Trade 2011年第23期 18-21页

作者： David mann Bret rosen Standard Chartered Bank

■ Latin America-Brazil trade corridor grows ahead of global development speed ■ From logistics to tax regulations, Sino-Brazilian trade cooperation faces a series of obstacles ■ Sino-Brazilian economic and trade co... 详细信息

关键词： Brazil cooperation logistics regulations ahead obstacles companies imports venture engaged

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macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of methodology 2025年第1期15卷 88-94页

作者： Chinmay mahatme madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna m Shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NmOSD)or myelin oligodendrocyte glycoprotein antibody disease(mOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NmOSD and 17 mOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(mVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in mVD in NmOSD and mOGAD affected as well as unaffected eyes when compared with healthy *** and mOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to mOGAD unaffected *** comparing NmOSD with mOGAD,there was no significant difference in terms of mVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NmOSD and mOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis macular microvascular changes Neuromyelitis optica spectrum disorders myelin oligodendrocyte glycoprotein antibody disorder

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele L Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

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