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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via c AmP-PKA signal pathway

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 552-559页

作者： Ruihua Zhang Dan-Ning Hu Richard rosen Eye and Vision Research Institute Department of OphthalmologyIcahn School of Medicine at Mount SinaiNew York 10029USA Department of Ophthalmology New York Eye and Ear Infirmary of Mount SinaiNew York 10003USA

AIm: To test our hypothesis that activation of protein kinase A(PKA) signal pathway by β-adrenergic agonist plays an important role in the protecting of cultured retinal pigment epithelial(RPE) cells against the hydroxychloroquine(HCQ) toxicity. mETHODS: Cultured human RPE cells were treated with 1) HCQ, 2) HCQ with salbutamol(a β2-adrenergic receptor agonist), and 3) HCQ with salbutamol and a PKA inhibitor, and compared these to 4) untreated cells(controls). After treated for 24 h, cell vacuolation, cells viability, PKA and PKA kinase activity levels were determined by the measurement of the size of vacuoles using Image J software, the cell counting with a dye-exclusion testing, Western blot and PKA kinase detection, respectively. RESULTS: Cell vacuolation and cell death of cultured RPE cells were significantly increased by the treatment of HCQ. Salbutamol significantly elevated PKA and PKA activity levels and this was associated with the inhibition of the vacuolation and cell death. The PKA inhibitor significantly decreased the PKA levels and eliminated the protective effects of salbutamol on HCQ-treated RPE cells. CONCLUSION: The PKA pathway plays an important role in the protective effects of β2-adrenergic agonist on the RPE cells against HCQ toxicity. These findings reveal a novel potential strategy against HCQ retinopathy by treatment with PKA activating medications.

关键词： hydroxycholoroquine retinal pigment epithelial cells retinopathy protein kinase A vacuolation

Solution‑Processed Thin Film Transparent Photovoltaics:Present Challenges and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.S.Almutairi Jie ma Aisling Stewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics and Astronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for modern society to sustain economic *** soaring demand for the electrical energy,together with an awareness of the environmental impact of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,limiting their practicality in a dense urban *** overcome the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancements are focused on improving both transparency and power output to rival commercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of merit and theoretical limits of TPVs are discussed to comprehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film photovoltaics(PVs),including colloidal quantum dot PVs,metal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with emphasis on agrivoltaics,smart windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent semiconductors Solution-processable transparent solar cell Emerging solar cell materials Buildingintegrated photovoltaics

Advancing healthcare through laboratory on a chip technology:Transforming microorganism identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

Advanced Functional Electromagnetic Shielding materials:A Review Based on micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed m.Asiri Runzhou Huang Hua Hou Zeinhom m.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EmI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EmI shielding *** concerted efforts on the EmI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EmI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EmI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EmI shielding field are critically discussed in this paper,and similar biomass EmI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EmI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding micro-nano structure interface control Conductivity

A GLOBALLY CONVERGENT ALGORITHm FOR THE EUCLIDEAN mULTIPLICITY LOCATION PROBLEm

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Acta mathematicae Applicatae Sinica 1992年第4期8卷 357-366页

作者： J.B.rosen 薛国良 Computer Science Department University of MinnesotaMinneapolisMN 55455USA Institute of Operations Research Qufu Normal University Qufu 278165 Chinahe Euclidean single facility location problem (ESFL) and the Euclidean multiplicity lo-cation problem (EMFL) are two special nonsmooth convex programming problems which haveattracted a largr literature. For the ESFL problem. there are algorithms which converge bothglobally and quadratically For the EMFL problem there are some quadratically convergentalgorithms. but for global convergencel they all need nontrivial assumptions on the problem.In this paper we present an algorithm for EMFL. With no assumption on the problem it isproved that from any initial point this algorithm generates a sequence of points which convergesto the closed convex set of optimal solutions of EMFL.

The Euclidean single facility location problem (ESFL) and the Euclidean multiplicity lo-cation problem (EmFL) are two special nonsmooth convex programming problems which haveattracted a largr literature. For the ESFL problem. there are algorithms which converge bothglobally and quadratically For the EmFL problem, there are some quadratically convergentalgorithms. but for global convergencel they all need nontrivial assumptions on the *** this paper, we present an algorithm for EmFL. With no assumption on the problem, it isproved that from any initial point, this algorithm generates a sequence of points which convergesto the closed convex set of optimal solutions of EmFL.

关键词： A GLOBALLY CONVERGENT ALGORITHm FOR THE EUCLIDEAN mULTIPLICITY LOCATION PROBLEm

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU W.m.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词： three-dimensional (3D) braided composite braiding direction composite thin plate large overall motion dynamic model O313.7

Treatment of recurrent carpal tunnel syndrome with fat grafting as an adjunct

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Plastic and Aesthetic Research 2023年第1期10卷 670-675页

作者： Raysa Cabrejo Alison Podsednik Joseph rosen Department of Surgery Dartmouth Hitchcock Medical CenterLebanonNH 03766USA Department of medical School University of Texas Rio Grande ValleyEdinburgTX 78539USA

Aim:The purpose of this study is to compare the surgical outcomes of treating recurrent carpal tunnel with recurrent carpal tunnel release only compared to recurrent carpal tunnel release with fat grafting as an ***:Retrospective case-control study was performed of the recurrent carpal tunnels treated,excluding explicit nerve injury such as transections,neuromas in continuity,*** with recurrent carpal tunnel received re-release of carpal tunnel only or fat grafting as an *** outcomes of both groups were compared utilizing chi-square ***:A total number of 81 patients were found to meet the inclusion *** the recurrences,a total of 16 patients did not receive fat grafting and 65 *** rate of improvement in symptoms for performing a carpal tunnel release was only 50.0%and for performing carpal tunnel release with fat grafting was 92%,with P-valuem cells as an adjunct to carpal tunnel release increased the rate of improvement in symptoms of carpal tunnel compression after recurrence compared to carpal tunnel release *** studies need to be performed to confirm the validity of these findings.

关键词： Carpal tunnel surgery fat grafting peripheral nerve

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting