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Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders

Neural Regeneration Research 2024年第6期19卷 1256-1261页

作者： Helen m.Knight merve Demirbugen ?z Adriana PerezGrovas-Saltijeral Division of Cells Organisms and Molecular Genetics School of Life Sciences University of Notingham Department of Pharmaceutical Toxicology Faculty of Pharmacy Ankara University

The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms. methylation of N6 adenosine(m6A) and C5 cytosine(m5C) bases occur on mRNAs, tRNA, mt-tRNA, and rRNA species as well as non-coding RNAs. With emerging knowledge of RNA binding proteins that act as writer, reader, and eraser effector proteins, comes a new understanding of physiological processes controlled by these systems. Such processes when spatiotemporally disrupted within cellular nanodomains in highly specialized tissues such as the brain, give rise to different forms of disease. In this review, we discuss accumulating evidence that changes in the m6A and m5C methylation systems contribute to neurocognitive disorders. Early studies first identified mutations within FmR1 to cause intellectual disability Fragile X syndromes several years before FmR1 was identified as an m6A RNA reader protein. Subsequently, familial mutations within the m6A writer gene mETTL5, m5C writer genes NSUN2, NSUN3, NSUN5, and NSUN6, as well as THOC2 and THOC6 that form a protein complex with the m5C reader protein ALYREF, were recognized to cause intellectual development disorders. Similarly, differences in expression of the m5C writer and reader effector proteins, NSUN6, NSUN7, and ALYREF in brain tissue are indicated in individuals with Alzheimer’s disease, individuals with a high neuropathological load or have suffered traumatic brain injury. Likewise, an abundance of m6A reader and anti-reader proteins are reported to change across brain regions in Lewy bodies diseases, Alzheimer’s disease, and individuals with high cognitive reserve. m6A-modified RNAs are also reported significantly more abundant in dementia with Lewy bodies brain tissue but significantly reduced in Parkinson’s disease tissue, whilst modified RNAs are misplaced within diseased cells, particularly where synapses are located. In parahippocampal brain tissue, m6A modification is en

关键词： 5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Technology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath m.N Chikmath L. murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring heavy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finishes and rubbing displacement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is modelled as a through-pit at one of the identified critical locations through stress *** effect of this pit on fatigue crack initiation life is ***-hole is pre-stressed by cold-working and the benefits of inducing plastic wake on the intended performance of the lug joint during the damages due to corrosion are brought out and compared with non-cold-worked *** analysis is performed on this lug joint with *** results obtained highlight the benefits of cold-working and the methodology can be extended to damage growth and analyse the effect of surface treatments for better structural integrity of components of aerospace vehicles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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Evaluation of the seismic behavior of reinforced concrete structures with flat slab-column gravity frame and shear walls through nonlinear analysis methods

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 713-726页

作者： m.A.Najafgholipour S.Heidarian Radbakhsh E.Erfani Department of Civil and Environmental Engineering Shiraz University of TechnologyShiraz ***Iran Department of Building Civiland Environmental EngineeringConcordia UniversityMontréal H3G 1M8Canada

This paper presents an investigation of the seismic behavior of reinforced concrete(RC)structures in which shear walls are the main lateral load-resisting elements and the participation of flat slab floor systems is not considered in the seismic design *** this regard,the behavior of six prototype structures(with different heights and plan layouts)is investigated through nonlinear static and time history analyses,implemented in the OpenSees *** results of the analyses are presented in terms of the behavior of the slab-column connections and their mode of failure at different loading ***,the global response of the buildings is discussed in terms of some parameters,such as lateral overstrength due to the gravity flat slab-column *** to the nonlinear static analyses,in structures in which the slab-column connections were designed only for gravity loads,the slab-column connections exhibited a punching mode of failure even in the early stages of ***,the punching failure was eliminated in structures in which a minimum transverse reinforcement recommended in ACI 318(2019)was provided in the slabs at joint ***,despite neglecting the contribution of gravity flat slab-column frames in the lateral load resistance of the structures,a relatively significant overstrength was imposed on the structures by the gravity frames.

关键词： RC flat slab-column frames seismic behavior nonlinear analysis time history analysis

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Effectiveness of external prestressing in enhancing the non-ductile hanger failure mechanism in reinforced concrete inverted T-beams

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1050-1065页

作者： Ahmed m.ATTA Reda N.BEHIRY mohammed I.HARAZ Structural Engineering Department Faculty of EngineeringTanta UniversityTanta 33511Egypt Nile Higher Institute for Engineering and Technology Mansoura 11001Egypt

Recently,inverted T-beams have been used in reinforced concrete(RC)bridges to support transverse precast *** T-beams,contrary to practice with conventional beams,are loaded on the flanges upper *** loading configuration causes hanger failure due to the generation of vertical tensile stresses near the bottom of the *** key purpose of this study is to investigate the efficiency of vertical external prestressing stainless-steel bars in mitigating non-ductile hanger failure in reinforced concrete inverted *** experimental study on six inverted-T beams,including two un-strengthened specimens,was carried *** study showed that the value of the prestressing level had a considerable impact on the performance of hanger mechanism in relation to crack pattern,ultimate loads,cracking behavior,load-deflection,strains,and *** experimental results indicated that the suggested method for strengthening inverted T-beams had efficacy in reducing the seriousness of the non-ductile hanger failure and resulted in a strength increase of up to 53% when compared to that of the un-strengthened ***,two analytical models for estimating the hanger capacity and the average crack width of the strengthened RC inverted T-beams were *** models that were proposed exhibited a high degree of agreement with the experimental results.

关键词： RC bridges inverted T-beams strengthening hanger failure external prestressing

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Semi-analytical investigation of heat transfer in a porous convective radiative moving longitudinal fin exposed to magnetic field in the presence of a shape-dependent trihybrid nanofluid

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Applied mathematics and mechanics(English Edition) 2024年第1期45卷 197-216页

作者： C.G.PAVITHRA B.J.GIREESHA m.L.KEERTHI Department of PG Studies and Research in mathematics Kuvempu UniversityShankaraghatta 577451India Department of mathematics and Statistics M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presence of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is carried out. Three types of nanoparticles, each having a different shape, are considered. These shapes include spherical(Fe_3O_4), cylindrical(Au), and platelet(Zn) configurations. The combination approach is utilized to evaluate the physical and thermal characteristics of the trihybrid and hybrid nanofluids, excluding the thermal conductivity and dynamic viscosity. These two properties are inferred by means of the interpolation method based on the volume fraction of nanoparticles. The governing equation is transformed into a dimensionless form, and the Adomian decomposition Sumudu transform method(ADSTm) is adopted to solve the conundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numerical simulation results, indicating that this research is reliable. The influence of diverse factors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphical representations. Furthermore, the fluctuations in the heat transfer concerning the pertinent parameters are studied. The results show that the heat flux in the presence of the combination of spherical, cylindrical, and platelet nanoparticles is higher than that in the presence of the combination of only spherical and cylindrical nanoparticles. The temperature at the fin tip increases by 0.705 759% when the value of the Peclet number increases by 400%, while decreases by 11.825 13% when the value of the Hartman number increases by 400%.

关键词： convection radiation moving longitudinal fin Adomian decomposition Sumudu transform method(ADSTm) trihybrid nanofluid magnetic field

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Pressurized environments directly influence friction and wear of dry steel contacts—Investigations in a novel high fluid pressure tribometer

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Friction 2024年第7期12卷 1599-1617页

作者： Paul REICHLE Jakob BARZ Georg UmLAUF Günter E.m.TOVAR Institute of Interfacial Process Engineering and Plasma Technology(IGVP) University of StuttgartStuttgart 70569Germany Fraunhofer Institute for Interfacial Engineering and Biotechnology(IGB) Stuttgart 70569Germany

To reduce the usage of classical lubricants in deep drawing,a new tribological system based on volatile lubricants was ***,a volatile medium is injected under high pressure into the interstice between drawing tool and sheet *** on temperature and pressure,the temporary lubricant may exist in its gaseous or liquid *** this study,a novel high fluid pressure tribometer was designed to investigate the friction and wear of dry steel contacts under comparable conditions like in dry deep ***,a new ball-on-disc tribometer was designed and integrated into a high-pressure *** specifically investigate the effects of different environments(technical air,liquid and gaseous carbon dioxide,nitrogen,argon)at atmospheric and high pressure(0.1 mPa,6 mPa)on tribology,the specimens and all components were operating *** the experiments,the friction was measured *** show that the highest friction occurs in air and the lowest in carbon dioxide *** to the experiments,the wear of the specimens was assessed along with changes in surface chemistry related to tribochemical ***,the tribology of the dry sliding contacts is correlated to changes of the surface *** differences as well as similarities regarding the different fluid environments are *** the results show,the differences between the media used are most pronounced at elevated ***,this work gives clear indications on the suitability of volatile lubricants in dry friction or rather gas lubrication,especially for dry deep drawing.

关键词： dry friction and dry wear gas lubrication carbon dioxide tribo-layer dry metal forming

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A new technique for fault diagnosis in transformer insulating oil based on infrared spectroscopy measurements

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High Voltage 2024年第2期9卷 319-335页

作者： mohamed m.F.Darwish mohamed H.A.Hassan Nagat m.K.Abdel-Gawad matti Lehtonen Diaa-Eldin A.mansour Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland Department of Electrical Power Engineering Egypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityEgypt Department of Electrical Power and machines Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Condition monitoring of the insulating system within power transformers has a massive importance according to the electrical *** gas analysis(DGA)is frequently used for this ***,DGA lacks the necessary level of accuracy to identify all equipment faults,particularly in their initial stages of ***,it does not have the capability for real-time monitoring and relies on manual sampling and laboratory testing,causing potential delays in fault ***,the interpretation of DGA data necessitates specialised expertise,which may pose difficulties for smaller entities that have limited access to ***,the contribution of this research is to use infrared spectroscopy measurements as a new effective technique substituting the DGA method for fault diagnosis in insulating *** inception faults that were considered in this study were the electrical fault(discharges of high energy)and the thermal fault(300°Cmperaturemulation processes inside the laboratory for both types of inception ***,six samples of pure paraffinic mineral oil were taken to be degraded in the *** that,all of them besides another sample that were not subjected to any kind of faults were taken to be examined by Fourier transform infrared(FTIR)spectroscopy to obtain an overview of the oil's behaviour in each fault *** that,the FTIR analysis was initially verified utilising the DGA ***,for further affirmation,the dielectric dissipation factor(DDF)for all samples was *** the final analysis,the verification tests provide experimental evidence about the outperformance of this new optical technique in detecting the transformer's inception faults in addition to proving its potential for being a superior alternative to the well-known traditional diagnostic techniques.

关键词： fault diagnosis spectroscopy

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Characterization of bright betatron radiation generated by direct laser acceleration of electrons in plasma of near critical density

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matter and Radiation at Extremes 2024年第2期9卷 26-35页

作者： J.Cikhardt m.Gyrdymov S.Zähter P.Tavana m.m.Günther N.Bukharskii N.Borisenko J.Jacoby X.F.Shen A.Pukhov N.E.Andreev O.N.Rosmej Faculty of Electrical Engineering Czech Technical University in Prague16627 Prague 6Czech Republic Goethe University FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany Focused Energy GmbH Im Tiefen See 4564293 DarmstadtGermany National Research Nuclear University mEPhI Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev Physical Institute RAS Leninskiy Prospekt 53119991 MoscowRussian Federation Heinrich-Heine-University Düsseldorf Universitätsstrasse 1DüsseldorfGermany Joint Institute for High Temperatures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation moscow Institute of Physics and Technology Institutskiy Pereulok 9141700 DolgoprudnyRussia

Directed x-rays produced in the interaction of sub-picosecond laser pulses of moderate relativistic intensity with plasma of near-critical density are investigated. Synchrotron-like (betatron) radiation occurs in the process of direct laser acceleration (DLA) of electrons in a relativisticlaser channel when the electrons undergo transverse betatron oscillations in self-generated quasi-static electric and magnetic fields. In anexperiment at the PHELIX laser system, high-current directed beams of DLA electrons with a mean energy ten times higher than the ponderomotive potential and maximum energy up to 100 meV were measured at 10^(19) W/cm^(2)laser intensity. The spectrum of directed x-raysin the range of 5–60 keV was evaluated using two sets of Ross filters placed at 0°and 10°to the laser pulse propagation axis. The differential x-ray absorption method allowed for absolute measurements of the angular-dependent photon fluence. We report 10^(13) photons/sr withenergies >5 keV measured at 0°to the laser axis and a brilliance of 10^(21) photons s^(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular distributionof the emission has an FWHm of 14°–16°. Thanks to the ultra-high photon fluence, point-like radiation source, and ultra-short emissiontime, DLA-based keV backlighters are promising for various applications in high-energy-density research with kilojoule petawatt-class laserfacilities.

关键词： laser acceleration critical

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía m.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.m.meziani J.m.Caridad J.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y materia Estructurada(LUmES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

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Journal of Renewable materials 2024年第2期12卷 369-380页

作者： m.F.Elkady E.m.El-Sayed mahmoud Samy Omneya A.Koriem H.Shokry Hassan Chemical and Petrochemical Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Fabrication Technology Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt Department of Public Works Engineering Faculty of EngineeringMansoura UniversityMansoura35516Egypt Environmental Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Electronic materials Research Department Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,green zinc oxide(ZnO)/polypyrrole(Ppy)/cellulose acetate(CA)film has been synthesized via solvent *** film was used as supporting material for glucose oxidase(GOx)to sensitize a glucose *** nanoparticles have been prepared via the green route using olive leaves extract as a ***/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole(Py)monomer using ferric chloride(FeCl3)as an oxidizing *** produced materials and the composite films were characterized using X-ray diffraction analysis(XRD),scanning electron microscope(SEm),Fourier transform infrared(FTIR)and thermogravimetric analysis(TGA).Glucose oxidase was successfully immobilized on the surface of the prepared film and then ZnO/Ppy/CA/GOx composite was sputtered with platinum electrode for the current determination at different initial concentrations of *** measurements proved the suitability and the high sensitivity of the constructed biosensor for the detection of glucose levels in different *** performance of the prepared biosensor has been assessed by measuring and comparing glucose concentrations up to 800 *** results affirmed the reliability of the developed biosensor towards real samples which suggests the wide-scale application of the proposed biosensor.

关键词： Biosensors composite films glucose polypyrrole green ZnO cellulose acetate

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