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Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis

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Journal of Intensive medicine 2024年第1期4卷 46-61页

作者： Nishel m shah Esmita Charani Damien ming Fook-Choe Cheah mark R Johnson Department of metabolism Digestion and ReproductionImperial College LondonChelsea and Westminster HospitalLondonUK Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance Imperial College LondonLondonUK Division of Infectious Diseases and HIV medicine Department of MedicineGroote Schuur HospitalUniversity of Cape TownCape TownSouth Africa Department of Infectious Diseases Imperial College LondonChelsea and Westminster HospitalLondonUK Department of Paediatrics Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia

Pregnant and postnatal women are a high-risk population particularly prone to rapid progression to sepsis with significant morbidity and mortality ***,severe maternal infections can have a serious detrimental impact on neonates with almost 1 million neonatal deaths annually attributed to maternal infection or *** this review we discuss the susceptibility of pregnant women and their specific physiological and immunological adaptations that contribute to their vulnerability to sepsis,the implications for the neonate,as well as the issues with antimicrobial stewardship and the challenges this poses when attempting to reach a balance between clinical care and urgent ***,we review advancements in the development of pregnancy-specific diagnostic and therapeutic approaches and how these can be used to optimize the care of pregnant women and neonates.

关键词： Sepsis Pregnancy Immunology Cardiovascular Personalised medicine Antibiotic stewardship

Twinning aspects and their efficient roles in wrought mg alloys:A comprehensive review

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Journal of magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： S.S.A.shah manping Liu Azim Khan Farooq Ahmad m.R.Abdullah Xingquan Zhang Shiwei Xu Zhen Peng School of materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(mg)***,twins play a crucial role in initiating dynamic recrystallization(DRX),while twin regions experience rapid recrystallization during static recrystallization(SRX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in magnesium-rare earth(mg-RE)***{10-11}contraction twins(CT)and{10-11}-{10-12}double twins(DT)can promote dynamic recrystallization(DRX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.©2024 Chongqing *** services provided by Elsevier *** behalf of KeAi Communications ***.

关键词： mg alloys Twinning Recrystallization Texture mechanical properties

日粮精粗比、能量和酵母培养物添补对体外干物质降解的影响

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动物营养学报 2004年第3期16卷 26-32页

作者：谭支良 m.a.shah m.R.murphy 中国科学院亚热带农业生态研究所 Department of Animal Science University of IllinoisUrbanaIL 61801USA

本试验采集泌乳期奶牛的瘤胃液,按2×4×2因子设计,用体外尼龙袋发酵技术研究了60:40和50:50两种精粗比日粮,棉籽油作为能源在奶牛日粮中分别添补0%、2.5%、5%、10%和在日粮中分别添加0%、0.5%的酵母培养物及其互作对体外干物质降解率... 详细信息

本试验采集泌乳期奶牛的瘤胃液,按2×4×2因子设计,用体外尼龙袋发酵技术研究了60:40和50:50两种精粗比日粮,棉籽油作为能源在奶牛日粮中分别添补0%、2.5%、5%、10%和在日粮中分别添加0%、0.5%的酵母培养物及其互作对体外干物质降解率的影响。体外实验结果表明,对于高产泌乳期奶牛而言,精粗比为60:40的奶牛日粮其干物质降解率高于50:50的精粗比日粮;奶牛日粮中添补植物油和酵母培养物均能显著提高体外干物质降解率(P<0.05);日粮精粗比与能量的互作对6小时的干物质降解率有显著影响(P<0.01);日粮能量添补与酵母培养物添补亦对体外干物质降解率有显著互作影响(P<0.05);而日粮精粗比与酵母培养物添补的互作影响则不明显;植物油作为奶牛日粮能源其添补量不宜超过10%。

关键词：泌乳期奶牛日粮能量酵母培养物体外发酵精粗比

体外法研究日粮不同来源氮和碳水化合物比例对干物质体外降解率的影响

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动物营养学报 2004年第4期16卷 18-24页

作者：谭支良周传社 m.a.shah m.R.murphy 中国科学院亚热带农业生态研究所 DepartmentofAnimalScience UniversityofIllinois UrbanaIL61801USA

本试验的氮源是纯化大豆蛋白(IsolatedSoybeanProtein,ISP)和尿素(NPN),按80:20、50:50和20:80分3组;碳水化合物源分别是从干草中提取的中性洗涤纤维(NDF)、玉米淀粉和蔗糖,按10:85:5、10:80:10、10:75:15、30:65:5、30:60:10、30:55:15、50:45:5、50:40:10和50:35:15分9组的3×9因子实验设计。应用体外尼龙袋发酵技术,研究了奶牛日粮不同来源氮和碳水化合物及其比例对干物质(Dm)体外降解率的影响。结果表明,过量补充尿素及随着日粮中淀粉和蔗糖比例的增加,日粮干物质的体外降解率均下降。根据试验结果,建议在泌乳期奶牛的全混合日粮中尿素的补充量应低于干物质的2.8%,非结构性碳水化合物的含量不应超过干物质的45%。

关键词：氮碳水化合物干物质降解率体外法

Ir single atoms on NiFeZn-LDH matrix for exceptional oxygen evolution reaction

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Nano Research 2024年第8期17卷 7039-7044页

作者： muhammad Israr muhammad Humayun Jiaqi Zhang Khadim shah Xin Tan Chen Chen Yadong Li Department of Chemistry Tsinghua UniversityBeijing 100084China Energy Water and Environment LabCollege of Humanities and SciencePrince Sultan UniversityRiyadh11586Saudi Arabia

To address the sluggish kinetics of the oxygen evolution reaction(OER),a potential approach is to rationally design and fabricate extremely effective single atom catalysts(SACs).Using an appropriate matrix to stabilize single-atom active centers with optimal geometric and electronic structures is crucial for enhancing catalytic ***,we report the design and fabrication of Ir single atoms on NiFeZn layered double hydroxide(Ir-SAC/NiFeZn-LDH)electrocatalyst for highly efficient and stable *** is investigated that the NiFeZn support exhibits abundant defect sites and unsaturated coordination *** sites function to anchor and stabilize single Ir single atoms on the *** strong synergetic electronic interaction between the Ir single atoms and the NiFeZn matrix resulted in remarkable OER performance of the as-fabricated Ir-SAC/NiFeZn *** a loading Ir content of 1.09 wt.%,this catalyst demonstrates a highly stable OER activity,with an overpotential of 196 mV at 10 mA·cm^(−2)and a small Tafel slope of 35 mV·dec^(−1)for the OER in a 1 m KOH *** results significantly surpass the performance of the commercially available IrO_(2)catalyst.

关键词： Ir single atoms layered double hydroxides rational design geometric optimization oxygen evolution reaction

Enhancing mild Cognitive Impairment Detection through Efficient magnetic Resonance Image Analysis

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Computers, materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif mehmood Zhonglong Zheng Rizwan Khan Ahmad Al Smadi Farah shahid shahid Iqbal mutasem K.Alsmadi Yazeed Yasin Ghadi Syed Aziz shah mostafa m.Ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).mild cognitive impairment(mCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify mCI,AD,and normal control(NC)*** paper focuses on using gray matter(Gm)scans obtained through magnetic resonance imaging(mRI)for the diagnosis of individuals with mCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and mCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose mCI,AD,and normal control individuals using Gm *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

Al3+ doped CeO2 for proton conducting fuel cells

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International Journal of minerals,metallurgy and materials 2024年第10期31卷 2253-2262页

作者： Sarfraz shahzad Rasool muhammad Khalid m.A.K.Yousaf shah Bin Zhu Jung-Sik Kim muhammad Imran Asghar Nabeela Akbar Wenjing Dong Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology/Energy Storage joint Research Center School of Energy and Environment Southeast University Sino-French Engineer School/School of General Engineering Beihang University Renewable Energy Technologies Group Faculty of Engineering and Natural Sciences Tampere University School of microelectronics Hubei University

Developing high ionic conducting electrolytes is crucial for applying proton-conducting fuel cell （PCFCs） *** current study investigates the effect of alumina on the structural,morphological,electrical,and electrochemical properties of *** oxygen vacancies are induced in CeO2by a general doping concept that enables fast ionic conduction at low-temperature ranges（300–500°C） for *** refinement of the X-ray diffraction （XRD） patterns established the pure cubic fluorite structure of Aldoped CeO2（ADC） samples and confirmed Al ions’fruitful integration in the *** electronic structure of the alumina-doped ceria of the materials （10ADC,20ADC,and 30ADC） has been *** a result,it was found that the best composition of 30ADC-based electrolytes induced maximum lattice oxygen *** corresponding PCFC exhibited a maximum power output of 923 mW/cm2at 500°***,the investigation proves the proton-conducting ability of alumina-doped ceria-based fuel cells by using an oxide ion-blocking layer.

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Toward a comprehensive hypothesis of oxygen-evolution reaction in the presence of iron and gold

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Journal of Energy Chemistry 2024年第2期89卷 172-183,I0005页

作者： Negah Hashemi Jafar Hussain shah Cejun Hu Subhajit Nandy Pavlo Aleshkevych Sumbal Farid Keun Hwa Chae Wei Xie Taifeng Liu Junhu Wang mohammad mahdi Najafpour Department of Chemistry Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Center for Advanced mössbauer Spectroscopy Mössbauer Effect Data CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Lab of Advanced Energy materials Chemistry(ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Institute of Physics Polish Academy of SciencesWarsaw 02-668Poland National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004HenanChina Center of Climate Change and Global Warming Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Research Center for Basic Sciences&modern Technologies(RBST) Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran

This study investigates the effects of Fe on the oxygen-evolution reaction(OER)in the presence of *** distinct areas of OER were identified:the first associated with Fe sites at low overpotential(~330 mV),and the second with Au sites at high overpotential(~870 mV).Various factors such as surface Fe concentration,electrochemical method,scan rate,potential range,concentration,method of adding K_(2)Fe O_(4),nature of Fe,and temperature were varied to observe diverse behaviors during OER for Fe O_(x)H_(y)/*** amounts of Fe ions had a significant impact on OER,reaching a saturation point where the activity did not increase *** electronic interaction between Fe and Au ions was indicated by X-ray photoelectron spectroscopy(XPS)and electron paramagnetic resonance(EPR)*** situ visible spectroscopy confirmed the formation of Fe O_(4)^(2-)during *** situ mossbauer and surfaceenhanced Raman spectroscopy(SERS)analyses suggest the involvement of Fe-based species as intermediates during the rate-determining step of OER.A lattice OER mechanism based on Fe O_(x)H_(y)was proposed for operation at low *** functional theory(DFT)calculations revealed that Fe oxide,Fe-oxide clusters,and Fe doping on the Au foil exhibited different activities and stabilities during *** study provides insights into the interplay between Fe and Au in OER,advancing the understanding of OER mechanisms and offering implications for the design of efficient electrocatalytic systems.

关键词： DFT calculation Fe/Au electrocatalysis mechanism Oxygen evolution Water oxidation

日粮不同来源氮和碳水化合物比例对中性洗涤纤维体外降解率的影响

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动物营养学报 2005年第1期17卷 29-29页

作者：谭支良周传社 m.a.shah m.R.murphy 中国科学院亚热带农业生态研究所 DepartmentofAnimalScience UniversityofIllinoisUrbanaIL61801USA

本试验的目的是研究日粮纯化大豆蛋白与尿素蛋白比例和NDF、淀粉与蔗糖比例及其组合对NDF和Dm体外降解率的影响,为优化高产泌乳期荷尔斯坦奶牛的日粮结构提供营养参数。试验将纯化大豆蛋白和尿素分别组合成80∶20、50∶50和20∶80三个比... 详细信息

本试验的目的是研究日粮纯化大豆蛋白与尿素蛋白比例和NDF、淀粉与蔗糖比例及其组合对NDF和Dm体外降解率的影响,为优化高产泌乳期荷尔斯坦奶牛的日粮结构提供营养参数。试验将纯化大豆蛋白和尿素分别组合成80∶20、50∶50和20∶80三个比例,将干草中提取的NDF、玉米淀粉和蔗糖分别组合成10∶85∶5、10∶80∶10、10∶75∶15、30∶65∶5、30∶60∶10、30∶55∶15、50∶45∶5、50∶40∶10和50∶35∶15九个比例,然后按3×9因子实验设计。应用体外尼龙袋发酵技术,研究了奶牛日粮不同来源氮和碳水化合物及其比例对中性洗涤纤维体外降解率的影响。结果表明,过量补充尿素及随着日粮中淀粉和蔗糖比例的增加,日粮纤维的体外降解率下降。建议在泌乳期奶牛的全混合日粮中尿素的补充量应低于干物质的2.8%,非结构性碳水化合物的含量不能超过干物质的45%。

关键词：中性洗涤纤维降解率比例体外非结构性碳水化合物氮大豆蛋白全混合日粮 NDF 营养参数日粮结构玉米淀粉实验设计发酵技术奶牛日粮日粮纤维泌乳期组合成干物质尿素蔗糖分尼龙袋补充量纯化试验干草