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Non-functional neuroendocrine tumors of the pancreas: Advances in diagnosis and management

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World Journal of Gastroenterology 2015年第32期21卷 9512-9525页

作者： jordan m Cloyd George A Poultsides Department of Surgery Stanford University Stanford

Nonfunctional neuroendocrine tumors of the pancreas(NF-PNETs) are a heterogeneous group of neoplasms. Although rare, the incidence of NF-PNETs is increasing significantly. The classification of PNETs has evolved over the past decades and is now based on a proliferation grading system. While most NF-PNETs are slow growing, tumors with more aggressive biology may becomeincurable once they progress to unresectable metastatic disease. Tumors of higher grade can be suspected preoperatively based on the presence of calcifications, hypoenhancement on arterial phase computed tomography, positron emission technology avidity and lack of octreotide scan uptake. Surgery is the only curative treatment and is recommended for most patients for whom complete resection is possible. Liver-directed therapies(thermal ablation, transarterial embolization) can be useful in controlling unresectable hepatic metastatic disease. In the presence of unresectable progressive disease, somatostatin analogues, everolimus and sunitinib can prolong progression-free survival. This article provides a comprehensive review of NF-PNETs with special emphasis on recent advances in diagnosis and management.

关键词： Pancreas Neuroendocrine tumor Neuroendocrine carci

Polar comonomer incorporation using cationic Ni α-diimine olefin polymerization catalysts

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Science China Chemistry 2019年第2期62卷 153-154页

作者： jordan m.Kaiser Brian K.Long Department of Chemistry University of Tennessee

Polyolefins are an indispensable class of materials that have become the most widely produced and utilized polymers *** are readily synthesized from cheap and abundant monomer feedstocks,such as ethylene and propylene,and are capable of achieving a vast array of thermal and mechanical properties based upon their composition and ***,despite their numerous advantages, polyolefins are typically devoid of functional groups which can limit their applicability to many product families,such as coatings,adhesives,and cross-linked polyolefins.

关键词： Ni α-diimine olefin polymerization catalysts

Neoadjuvant chemotherapy for colorectal liver metastases:A contemporary review of the literature

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1043-1061页

作者： marissa Guo Ning Jin Timothy Pawlik jordan m Cloyd Department of Surgery The Ohio State University Medical CenterColumbusOH 43210United States Department of Internal medicine Division of Medical OncologyThe Ohio State University Medical CenterColumbusOH 43210United States Department of Surgery The Ohio State UniversityColumbusOH 43210United States Department of Surgery Division of Surgical OncologyThe Ohio State University Medical CenterColumbusOH 43210United States

Colorectal carcinoma(CRC)is one of the leading causes of cancer-related deaths worldwide,and up to 50%of patients with CRC develop colorectal liver metastases(CRLm).For these patients,surgical resection remains the only opportunity for cure and long-term *** the past few decades,outcomes of patients with metastatic CRC have improved significantly due to advances in systemic therapy,as well as improvements in operative technique and perioperative *** in the modern era of oxaliplatin-and irinotecancontaining regimens has been augmented by the introduction of targeted biologics and immunotherapeutic *** increasing efficacy of contemporary systemic therapies has led to an expansion in the proportion of patients eligible for curative-intent ***,the use of neoadjuvant strategies is becoming progressively more *** patients with CRLm,the primary advantage of neoadjuvant chemotherapy(NCT)is the potential to down-stage metastatic disease in order to facilitate hepatic *** the other hand,the routine use of NCT for patients with resectable metastases remains controversial,especially given the potential risk of inducing chemotherapy-associated liver injury prior to *** guidelines recommend upfront surgery in patients with initially resectable disease and low operative risk,reserving NCT for patients with borderline resectable or unresectable disease and high operative *** undergoing NCT require close monitoring for tumor response and conversion of CRLm to *** light of the growing number of treatment options available to patients with metastatic CRC,it is generally agreed that these patients are best served at tertiary centers with an expert multidisciplinary team.

关键词： Colorectal liver metastases Neoadjuvant chemotherapy Hepatic resection Conversion therapy Chemotherapy-associated liver injury Disappearing liver metastases Future liver remnant Immunotherapy

memory access optimization for particle operations in computational fluid dynamics-discrete element method simulations

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Particuology 2023年第7期78卷 97-110页

作者： Deepthi Vaidhynathan Hariswaran Sitaraman Ray Grout Thomas Hauser Christine m.Hrenya jordan musser Computational Science Center National Renewable Energy LaboratoryUnited States Research Computing University of ColoradoBoulderUnited States Chemical and Biological Engineering University of ColoradoBoulderUnited States Computational Science and Engineering National Energy Technology LaboratoryUnited States

Computational Fluid Dynamics-Discrete Element method is used to model gas-solid systems in several applications in energy,pharmaceutical and petrochemical *** performance bot-tlenecks often limit the problem sizes that can be simulated at industrial *** data structures used to store several millions of particles in such large-scale simulations have a large memory footprint that does not fit into the processor cache hierarchies on current high-performance-computing platforms,leading to reduced computational *** paper specifically addresses this aspect of memory access bottlenecks in industrial scale *** use of space-flling curves to improve memory access patterns is described and their impact on computational performance is quantified in both shared and distributed memory parallelization *** morton space flling curve applied to uniform grids and k-dimensional tree partitions are used to reorder the particle data-structure thus improving spatial and temporal locality in *** performance impact of these techniques when applied to two benchmark problems,namely the homogeneous-cooling-system and a fluidized-bed,are *** optimization techniques lead to approximately two-fold performance improvement in particle focused operations such as neighbor-list creation and data-exchange,with~1.5 times overall improvement in a fluidization simulation with 1.27 million particles.

关键词： CFD-DEm memory access optimization Spatial reordering Performance optimization

Trends in the use of adjuvant therapy for resected intrahepatic cholangiocarcinoma: getting ahead of the data

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 515-517页

作者： jordan m.Cloyd Timothy m.Pawlik Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA

Intrahepatic cholangiocarcinoma(ICC),the second most common primary liver malignancy,is an aggressive cancer occurring with increasing global *** advances in our understanding of its pathogenesis and molecular underpinnings,diagnostic and staging capabilities,and locoregional and systemic treatment options have occurred over the past several decades(1).

关键词： hepatic adjuvant pathogenesis

Chronic disease care integration into primary care services in sub-Saharan Africa:a‘best fit’framework synthesis and new conceptual model

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Family medicine and Community Health 2022年第3期10卷 43-59页

作者： Simon R Harrison Aileen m jordan Biomedical Sciences The University of Edinburgh College of Medicine and Veterinary MedicineEdinburghUK

Objective To examine the relevance of existing chronic care models to the integration of chronic disease care into primary care services in sub-Saharan Africa and determine whether additional context-specific model elements should be ***‘Best fit’framework synthesis comprising two systematic *** systematic review of existing chronic care conceptual models with construction of a priori *** systematic review of literature on integrated HIV and diabetes care at a primary care level in sub-Saharan Africa,with thematic analysis carried out against the a priori *** conceptual model constructed from a priori themes and new *** of bias of included studies was assessed using CASP and *** criteria Conceptual models eligible for inclusion in construction of a priori framework if developed for a primary care context and described a framework for long-term management of chronic disease *** eligible for inclusion in second systematic review described implementation and evaluation of an intervention or programme to integrate HIV and diabetes care into primary care services in *** sources Pubmed,Embase,CINAHL Plus,Global Health and Global Index medicus databases searched in April 2020 and September *** Two conceptual models of chronic disease care,comprising six themes,were used to develop the a priori *** systematic review of primary research identified 16 articles,within which all 6 of the a priori framework themes,along with 5 new themes:Improving patient access,stigma and confidentiality,patient-provider partnerships,task-shifting,and clinical mentoring.A new conceptual model was constructed from the a priori and new *** The a priori framework themes confirm a need for co-ordinated,longitudinal chronic disease care integration into primary care services in sub-Saharan *** of the primary research suggests integrated care for HIV and diabetes at a

关键词： services integration synthesis

Iridoid glycosides from fruits reduce the growth of fungi associated with fruit rot

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Journal of Plant Ecology 2016年第3期9卷 357-366页

作者： Susan R.Whitehead jordan Tiramani m.Deane Bowers Department of Ecology and Evolutionary Biology University of Colorado BoulderBoulderCO 80309USA Department of Entomology Cornell UniversityIthacaNY 14853USA museum of Natural History University of Colorado BoulderBoulderCO 80309USA

Aims Ripe,fleshy fruits generally function as rewards to attract mutualistic seed dispersers,but many fruits also contain high concentrations of toxic secondary *** compounds may serve a variety of adaptive roles in seed dispersal or as a defense against non-dispersing seed predators or *** tested the effects of iridoid glycosides from fruits of a hybrid bush honeysuckle,Lonicera×bella,on the growth of two pathogenic fungal strains associated with fruit rot,Alternaria tenuissima and Aspergillus *** Fungi were isolated from field-collected L.×bella fruits and identified using molecular *** growth rates were assessed in vitro in the presence of varying concentrations of pure loganin,one of the most abundant iridoid glycosides in fruits,as well as fruit extracts containing a mix of at least seven different iridoid *** FindingsLoganin had strong dose-dependent negative effects on the growth of both *** from fruits had no effect on Aspergillus but a strong antifungal effect on Alternaria that increased with fruit *** iridoid glycoside concentrations in extracts were not good predictors of variation in fungal growth,but several individual compounds had significant negative *** iridoid glycosides have primarily been studied as antiherbivore defenses in leaves,these results indicate that they can also function to reduce the growth of fungi associated with fruit rot.

关键词： Caprifoliaceae fruit rot fruit secondary metabolites generalized defense Lonicera plant-pathogen interactions

Neoadjuvant therapy for pancreatic ductal adenocarcinoma:Opportunities for personalized cancer care

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World Journal of Gastroenterology 2021年第27期27卷 4383-4394页

作者： Ahmad Hamad Zachary J Brown Aslam m Ejaz mary Dillhoff jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43215United States

Pancreatic ductal adenocarcinoma(PDAC)is an aggressive malignancy that is best treated in a multidisciplinary fashion using surgery,chemotherapy,and *** chemotherapy has shown to have a significant survival benefit in patients with resected ***,up to 50%of patients fail to receive adjuvant chemotherapy due to postoperative complications,poor patient performance status or early disease *** order to ensure the delivery of chemotherapy,an alternative strategy is to administer systemic treatment prior to *** oncology refers to the application of diverse strategies to target therapies specific to characteristics of a patient’s *** traditionally emphasized in selecting targeted therapies based on molecular,genetic,and radiographic biomarkers for patients with metastatic disease,the neoadjuvant setting is a prime opportunity to utilize personalized *** this article,we describe the current evidence for the use of neoadjuvant therapy(NT)and highlight unique opportunities for personalized care in patients with PDAC undergoing NT.

关键词： Pancreatic cancer Preoperative therapy FOLFIRINOX Precision oncology Patient-reported outcomes Personalized medicine Targeted therapy Whipple Pancreatectomy

Predicting post-operative pancreatic fistula:one size may not fit all

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 113-115页

作者： mariam F.Eskander jordan m.Cloyd Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA

Post-operative pancreatic fistula(POPF)is a common and dangerous complication of pancreatic resection,occurring in 5-30%of *** is a significant source of morbidity and mortality,leading to prolonged hospital stays and increased healthcare costs(1).The most widely accepted definition of POPF comes from the International Study Group on Pancreatic Fistula(ISGPF).Initially created in 2005,this classification system for POPF was revised in 2016 such that POPF should be associated with a clinically relevant change in status,deeming what was originally defined as a Grade A fistula as a biochemical leak and grade B and C fistulas as clinically relevant(CR)fistulae(Table 1)(2).

关键词： fistula operative mortality