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胰腺导管腺癌的多层CT:管电压和碘负荷对肿瘤显示和影像质量的影响

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国际医学放射学杂志 2017年第1期 104-105页

作者： L.Loizou N.Albiin B.Leidner E.Axelsson m.a.fischer A.Grigoriadis 谢双双 Division of medical Imaging and Technology Department of Clinical Science Intervention and Technology (CLINTEC)Karolinska Institutet

摘要目的在胰腺导管腺癌(PDAC)病人中,比较伴或不伴高碘负荷的低管电压多层CT(mDCT)扫描方案与正常管电压、正常碘负荷(标准)扫描方案在肿瘤显示和影像质量

关键词：胰腺导管腺癌 CT 影像质量管电压

Convective drying of wood chips:Accelerating coupled DEm-CFD simulations with parametrized reduced single particle models

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Particuology 2024年第1期84卷 158-167页

作者： Lucas Reineking Jonas fischer Ali mjalled Enric Illana Siegmar Wirtz Viktor Scherer martin monnigmann Automatic Control and System Theory Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany Energy Plant Technology Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany

The simulation of industry-scale reactive bulks is challenging due to the complex interaction between fluid and *** particles in the bulk and their interaction with the fluid flow can be described by combined Discrete Element method-Computational Fluid Dynamics(DEm-CFD)***,the computational cost of the Finite Volume(FV)methods deployed in these models can become prohibi-tively expensive,especially for high inner-particle *** particle Reduced models(Rms)can be used to achieve both fast and accurate descriptions of the processes in each *** an example of bulk systems comprising heat and mass transfer,we compared FV and Rm simulations for the drying of wood chips in a bulk reactor.A manifold-based nonlinear interpolation was applied to resolve changing boundary conditions for the *** simulations showed that Rms provide accurate values for the thermodynamic state variables of the ***,the time required for the bulk simulation was reduced by 67%with the *** is evident that simulations with high inner-particle resolution can be accelerated by Rms if manifold-based nonlinear interpolation is used to address changing boundary conditions.

关键词： Reduced model Reactive bulk Discrete element method manifold-based interpolation Drying of porous mediaDEm-CFD

双源CT大螺距冠状动脉成像:心率过快时心脏收缩期的数据采集

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国际医学放射学杂志 2011年第1期34卷 89-90页

作者： R.Goetti G.Feuchtner P.Stolzmann L.Desbiolles m.a.fischer C.Karlo 李瑞丽 Institute of Radiology Kantonsspital St.GallenRorschacherstrasse 959007 St.GallenSwitzerland

目的评估双源螺旋CT心电门控大螺距对心率过快病人冠状动脉成像心脏收缩期数据采集的效果。方法选择连续80例心率>70次/min病人[女15例,年龄(67±14)岁],

关键词：大螺距 CT 收缩期重建冠状动脉心率辐射剂量

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In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

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Nano Research 2024年第2期17卷 875-881页

作者： Rossella Labarile Danilo Vona maria Varsalona matteo Grattieri melania Reggente Roberto Comparelli Gianluca m.Farinola Fabian fischer Ardemis A.Boghossian massimo Trotta Istituto per i Processi Chimico Fisici Consiglio Nazionale delle RicercheBari 70126Italy Dipartimento di Chimica Universitàdegli Studi di BariBari 70126Italy Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Institute of Life Technologies HES-SO Valais-Wallis1950 SionSwitzerland Institute for Renewable Energy HES-SO Valais-Wallis1950 SionSwitzerland

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial *** devices are limited by the poorly conductive interface between phototrophs and synthetic materials that inhibit charge *** study focuses on overcoming this bottleneck through the metabolically-driven encapsulation of photosynthetic cells with a bio-inspired conductive *** of the purple non sulfur bacterium Rhodobacter sphaeroides were coated with a polydopamine(PDA)nanoparticle layer via the self-polymerization of dopamine under anaerobic *** treated cells show preserved light absorption of the photosynthetic pigments in the presence of dopamine concentrations ranging between 0.05–3.5 *** thickness and nanoparticle formation of the membrane-associated PDA matrix were further shown to vary with the dopamine concentrations in this *** to uncoated cells,the encapsulated cells show up to a 20-fold enhancement in transient photocurrent measurements under mediatorless *** biologically synthesized PDA can thus act as a matrix for electronically coupling the light-harvesting metabolisms of cells with conductive surfaces.

关键词： bioelectronics photosynthetic bacteria purple bacteria electron transfer polydopamine biophotovoltaics

Polydopamine-coated photoautotrophic bacteria for improving extracellular electron transfer in living photovoltaics

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Nano Research 2024年第2期17卷 866-874页

作者： melania Reggente Charlotte Roullier mohammed mouhib Patricia Brandl Hanxuan Wang Stefano Tacconi Francesco mura Luciana Dini Rossella Labarile massimo Trotta Fabian fischer Ardemis A.Boghossian Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Department of Biology and Biotechnology Charles Darwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied for Engineering of Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCF Consiglio Nazionale delle Ricerche–Istituto per i Processi Chimico Fisici Bari 70126Italy Institute of Life Technologies HES-SO Valais-WallisSion 1950Switzerland Institute for Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are microbial electrochemical devices that use whole cell–electrode interactions to convert solar energy to *** bottleneck in these technologies is the limited electron transfer between the microbe and the electrode *** study focuses on enhancing this transfer by engineering a polydopamine(PDA)coating on the outer membrane of the photosynthetic microbe Synechocystis *** coating provides a conductive nanoparticle shell to increase electrode adhesion and improve microbial charge extraction.A combination of scanning electron microscopy(SEm),transmission electron microscopy(TEm),UV–Vis absorption,and Raman spectroscopy measurements were used to characterize the nanoparticle shell under various synthesis *** cell viability and activity were further assessed through oxygen evolution,growth curve,and confocal fluorescence microscopy *** results show sustained cell growth and detectable PDA surface coverage under slightly alkaline conditions(pH 7.5)and at low initial dopamine(DA)concentrations(1 mm).The exoelectrogenicity of the cells prepared under these conditions was also characterized through cyclic voltammetry(CV)and chronoamperometry(CA).The measurements show a three-fold enhancement in the photocurrent at an applied bias of 0.3 V(***/AgCl[3 m KCl])compared to non-coated *** study thus lays the framework for engineering the next generation of living photovoltaics with improved performances using biosynthetic electrodes.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polydopamine adherence

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CT灌注成像检测肝硬化病人肝细胞肝癌

国际医学放射学杂志 2016年第1期 83-83页

作者： m.a.fischer N.Kartalis A.Grigoriadis L.Loizou P.Stal B.Leidner 张鑫 Department of Clinical Science Intervention and TechnologyDivision of Medical Imaging and TechnologyKarolinska Institute

摘要目的评估动态CT灌注成像(P-CT)对肝硬化病人肝细胞肝癌(HCC)检测的诊断效能。材料与方法收集怀疑HCC的肝硬化病人26例[男19例,平均年龄(69±10)岁,利用双源系统的4D螺旋模态(100/80 k V;150/175 m As/rot)行肝脏P-CT检查。2名阅片... 详细信息

摘要目的评估动态CT灌注成像(P-CT)对肝硬化病人肝细胞肝癌(HCC)检测的诊断效能。材料与方法收集怀疑HCC的肝硬化病人26例[男19例,平均年龄(69±10)岁,利用双源系统的4D螺旋模态(100/80 k V;150/175 m As/rot)行肝脏P-CT检查。2名阅片者评估:1分别独立评估动脉期肝脏灌注(ALP)、门静脉期肝脏灌注(PLP)、肝脏灌注指数

关键词：肝硬化 HCC 肝细胞肝癌灌注成像病人 CT

门静脉高压病人基于肾或脾的最大斜率的灌注CT模型对比

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国际医学放射学杂志 2017年第1期 105-105页

作者： m.a.fischer K.Brehmer A.Svensson P.Aspelin T.B.Brismar 谢双双 Department of Diagnostic and Interventional Radiology University Hospital Zurich

摘要目的比较不同程度门静脉高压(PVH)病人基于脾强化峰值(PSE)和基于肾强化峰值(PRE)的最大斜率模型所得肝灌注CT(P-CT)参数差异。材料与方法回顾性分析

关键词：门静脉高压 PSE 门脉高血压灌注参数肝细胞癌最大斜率病人 CT

A Golden Touch in the Design of multifunctional Porphyrin metallacages:Host-Guest Chemistry for Drug-Target Interactions

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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg Nicole Heiduk mihyun Park Nicole Strittmatter Roland A.fischer Angela Casini Guillermo moreno-Alcántar Chair of medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and metalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München munich Data Science Institute(mDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(mCgs)as multimodal drug platforms holds great ***,the synthesis of mCgs with increased complexity and functionality is a great challenge since understanding of the interaction of mCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic mCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

双能量CT在肝脏铁含量定量检测中的特殊应用价值

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国际医学放射学杂志 2011年第5期 507-507页

作者： m.a.fischer C.S.Reiner D.Raptis O.Donati R.Goetti P.A.Clavien 王翠 Institute of Diagnostic and Interventional Radiology University Hospital Zurich

目的本研究旨在评价采用铁特异性的3种物质分解算法时,双能量CT(DECT)在肝脏铁含量(LIC)定量检测方面的价值。方法采用双源CT对31个含有肝组织、脂肪

关键词：肝脏含铁量脂肪 CT 双能量