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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m Ardila Department of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,emphasized the crucial role of rapidly and accurately identifying pathogens to optimize patient treatment ***-on-a-chip(LOC)technology has emerged as a transformative tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a comprehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from the field have demonstrated the practical benefits of LOC devices in clinical diagnostics,epidemiology,and food *** studies have underscored the superiority of LOC technology over traditional methods,showcasing improvements in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics promises further innovation and *** call to action emphasizes the importance of continued research,investment,and adoption to realize the full potential of LOC technology in improving healthcare outcomes worldwide.

关键词： Laboratory-on-a-chip microorganism identification Diagnostics Point-ofcare testing Biosensors

Advanced Functional Electromagnetic Shielding materials:A Review Based on micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo mohammed A.Amin Hua Qiu Jinxuan Jiang Yazeed m.Asiri Runzhou Huang Hua Hou Zeinhom m.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EmI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EmI shielding *** concerted efforts on the EmI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EmI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EmI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EmI shielding field are critically discussed in this paper,and similar biomass EmI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EmI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding micro-nano structure interface control Conductivity

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU W.m.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词： Constitutive equations

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Collective Bargaining During the Crisis： The Portuguese Case

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Chinese Business Review 2011年第6期10卷 406-414页

作者： Joao Dias maria da Conceicao cerdeira ISEG Technical University of Lisbon and UECE Lisbon Portugal ISCSP Technical University of Lisbon Lisbon Portugal

Following a period of significant development at the end of the 1990s, with economic growth rates greater than those of the European Union, the Portuguese economy stagnated in 2002 and even declined in 2003. The current context of international crisis has just interrupted the fragile growth trend initiated in 2004： In fact, real GDP, which increased by 1.9 percent in 2007, had a growth rate of zero in 2008 and declined by 2.9 percent in 2009. The crisis has abruptly increased the closure of companies and unemployment jumped from 7.3% in the second haft of 2008 to 10.1% in the forth quarter of 2009. Notwithstanding, social dialog was resilient to this situation of economic crisis, as shown by the number of collective agreements negotiated by the social partners, the number of workers covered by collective agreements and the observed increase in real wages. Additionally, social partners have agreed on a reform of the Labour Code. Are this data enough evidence of social concentration on crisis management？ This paper will analyze this issue, giving particular attention to collective bargaining in Portugal and the crisis impact on the industrial relations system and their actors

关键词： collective bargaining industrial relations financial crisis

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Shared-role of vegetation types,elevation and soil affecting plant diversity in an old-tropical mountain hotspot

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Journal of mountain Science 2023年第7期20卷 1842-1853页

作者： Priscilla P.LOIOLA Leonor Patrícia cerdeira mORELLATO maria Gabriela Gutierrez CAmARGO Vitor A.KAmImURA Jacqueline S.mATTOS Annia Susin STREHER Soizig LE STRADIC Department of Biodiversity Laboratory of PhenologySão Paulo State University(UNESP)Av 24A 151513506-900Rio ClaroSão PauloBrazil Instituto Tecnológico Vale(ITV) R.Boaventura da Silva955BelémPará66055-090Brazil Laboratory of Evolutionary Ecology and Plant Genomics Department of Plant BiologyInstitute of BiologyUniversity of CampinasBrazil Earth Observation and Geoinformatics Division National Institute for Space Research(INPE)São Josédos CamposBrazil French National Institute for Agriculture Foodand Environment(INRAE)UMR 1202 INRAE/Univ Bordeaux-BIOGECOParisFrance

Despite the exceptional species richness and endemism,the environmental drivers of plant diversity along old tropical mountains remain *** respective importance of vegetation types,elevation,slope,and soil to drive diversity across life-forms is poorly ***,we tested whether environmental variables drove local and regional plant diversity along an old tropical mountain according to the three main life-forms:graminoids,herbaceous and woody *** sampled all Angiosperm species on 180 plots across five elevations,at the tropical old-mountain region of Serra do Cipó,South-eastern *** assessed soil,slope,and vegetation types,and calculated richness and beta-diversity,applying generalized least square models,linear mixed-models and partial mantel tests to test for *** of graminoids and herbaceous species increased with greater elevation and more nutrient-impoverished soils,while woody richness showed the inverse ***-diversity was primarily driven by species turnover,correlated with elevation and soil and higher in less dominant vegetation types,with unique *** the limited elevational range in these old mountains,it still played an important role in filtering woody species,while fostering graminoid and herbaceous *** and restoration actions need to foster the high regional diversity supported by the old mountain heterogeneous landscape and the diversity of life-forms,especially the dominant and highly diverse grassy component.

关键词： Beta-diversity Campos rupestres Cerrado Grassland Herbaceous Species turnover

The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER mULLA YOUSEF KATIB ASIm m.ALmUGHAmSI DUAA S.ALKHAYAT mOHAmED mOSAAD SAmIR T.ALFOTIH RAWAN ALAOFI Department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz medical City Madinah42311Saudi Arabia Prince mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of TNm staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and OS(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： mackenzie m.Spicer Jianqi Yang Daniel Fu Alison N.DeVore marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Giant magnetoimpedance of Cube/Feconi Electroplated Wires: Focus on Angular Sensoric

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World Journal of Condensed matter Physics 2013年第1期3卷 21-27页

作者： Galina Kurlyandskaya Pongsakorn Jantaratana maria Angeles cerdeira Vladimir Va′kovskiy Department of Electricity and Electronics University of the Basque Country UPV-EHU Campus of Leioa Leioa Spain Department of magnetism and magnetic Nanomaterials Ural Federal University Ekaterinburg Russia Department of magnetism and magnetic Nanomaterials Ural Federal University Ekaterinburg Russia Department of Physics Kasetsart University Bangkok Thailand Department of Physics University of Oviedo Oviedo Spain

Giant magnetoimpedance effect (GmI) is a subject of special interest proved by applied electrodynamic and technological applications. GmI effect in ferromagnetic tubes is connected with the high sensitivity of the magnetic system to a circular magnetic field near the spin-reorientation magnetic phase transitions offering high sensitivity with respect to an external magnetic field. In this work the non-magnetic CuBe wires were covered by Fe20Co6Ni74 layers by electrodeposition. The thickness of 1 μm for magnetic layer was high enough in order to ensure the high GmI value. Longitudinal magnetic anisotropy was induced by post preparation annealing in a magnetic field of 160 A/m at 320℃ during 1 hour in order to obtain appropriate magnetisation process. Angular dependencies of GmI were measured in a frequency range of 1 to 10 mHz for driving currents of 2.5 to 20 mA. High longitudinal GmI of the order of 400% was observed at quite low frequency of 1 mHz. The highest value of the sensitivity of 520%/Oe was found for the active resistance: Linear sensitivities of 0.023 Ω/° and 0.05 Ω/° were observed for reasonably low fields of 240 and275 A/m respectively for small angles, where planar GmI elements are less effective.

关键词： Giant magnetoimpedance magnetization Process magnetic Anisotropy magnetic Field Sensors