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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

The multiplicity of particle production from hadron-hadron and nucleus-nucleus interaction

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Natural Science 2010年第4期2卷 388-397页

作者： Ahmed abdo Ahmed Al-Haydari mohmmed Tarek Hussein 不详

The particle production in hadron-nucleon (h-N), hadron-nucleus (h-A) and nucleus-nucleus (A-A) collisions at high energies are studied in view of the multi-peripheral model. A multi-peripheral T-matrix element is assumed with multi surface parameter that is functionally dependent on the number of particles in the final state and control the kinematical path of the reaction. A monte Carlo code is designed to simulate events ac-cording to a hypothetical model, the quark structure of the interacting nucleons is consid-ered. The number of possible nucleon collisions inside the target nucleus plays an important role in folding the (h-N) to generate the (h-A) and (A-A) collisions. The predictions of the model give reasonable agreement with the recently examined experimental data.

关键词： monte-Carlo Generators multiplicity Distribution Integral Phase Space

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多模式匹配算法

多模式匹配算法

作者： AHmED abdo FARHAN SAIF 吉林大学

学位级别：硕士

大多数信息安全应用程序如反病毒程序以及入侵检测系统，都会选择多模式匹配算法作为其核心组成部分。该算法能够同时搜索千上万的模式串并且判断出这些模式串的位置。本文提出了两种多模式匹配算法，分别属于标准的多模式匹配算法和... 详细信息

大多数信息安全应用程序如反病毒程序以及入侵检测系统，都会选择多模式匹配算法作为其核心组成部分。该算法能够同时搜索千上万的模式串并且判断出这些模式串的位置。本文提出了两种多模式匹配算法，分别属于标准的多模式匹配算法和带有通配符的模式匹配算法。在标准方式下，多模式匹配算法的研究是基于哈希函数的。它对Karp-Rabin算法进行了扩展，其预处理时间为O(|P|)。如果没有匹配结果并且所有模式串长度相同，则算法执行时间为O(n+nlogk)。如果匹配后得到的模式串长度为l则验证函数需要时间l来检查是否真正匹配，其算法所用时间为O(n+nlogk+ooc(l))。如果模式串的长度不同则时间为O(mn+nk+ooc(l))(最会条件)，其中occ是真假匹配的数量。算法能够计算的最大的哈希值为xm(m+1)其中σ≈x/lnx。该算法不容易被攻击并且能够较好的运行在多处理器的并行模式下。此外本文提出的包含通配符的模式匹配算法是基于欧几里得距离和哈希函数的，该算法使用FFT来计算欧几里得距离和哈希函数。如果没有匹配结果，算法执行时间为O(k n logl)。如果匹配结果带有通配符并且通配符的符号仅存在于模式串中，需要时间为O(k n logl+ox)。如果文本中也包含了通配符，那么算法的执行时间要增加到O(k n log l+2ox)。对于匹配后的任意模式串，该算法存在1/σ的错误匹配率，其中k是模式串的数量，l为块长度，o是完成匹配的模式串的数量，x是完成匹配的模式串中块的数量。

关键词：多模式匹配 FFT 哈市函数欧几里得距离

metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis

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World Journal of Gastroenterology 2015年第16期21卷 4975-4985页

作者： Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan m abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández Liver Clinic Gastroenterology DepartmentHospital General de MéxicoDr.Eduardo LiceagaMexico City 06720Mexico Internal medicine Department Hospital General de MéxicoDr.Eduardo LiceagaMexico City 06720Mexico Fundación mexicana para la Salud A.C Mexico City 06720Mexico

AIm:To evaluate the impact of metadoxine(mTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).mETHODS:This study was an open-label clinical trial,performed at the"Hospital General de méxico,*** Liceaga".We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+mTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+mTD 500 mg three times *** duration of the treatment for all of the groups was 30 ***:In the groups treated with the mTD,thesurvival rate was higher at 3 mo(PTX+mTD 59.4%vs PTX 33.3%,P=0.04;PDN+mTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+mTD 50%vs PTX18.2%,P=0.01;PDN+mTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with mTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 *** patients receiving mTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:mTD improves the 3-and 6-mo survival rates in patients with severe *** abstinence is a key factor for survival in these *** patients who received the combination therapy with mTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX.

关键词： Alcoholic hepatitis metadoxine Survival Alcohol abstinence

碳氮共修饰Nb2O5的合成及其可见光下催化降解RhB的活性评价

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碳氮共修饰Nb2O5的合成及其可见光下催化降解RhB的活性评价

作者： Fahim abdo Ali Qaraah 天津大学

学位级别：硕士

非均相光催化和基于半导体的光催化过程在最近几年受到全球范围的广泛关注,包括太阳能光催化水解产氢以及通过光降解污染物处理废气和废水等有前景的应用。在近几年中,科学家们已经研究了大量的半导体材料,其中二氧化钛因其化学稳定性,... 详细信息

非均相光催化和基于半导体的光催化过程在最近几年受到全球范围的广泛关注,包括太阳能光催化水解产氢以及通过光降解污染物处理废气和废水等有前景的应用。在近几年中,科学家们已经研究了大量的半导体材料,其中二氧化钛因其化学稳定性,低成本和无毒性而被证明是最佳选择之一。然而,其广泛的实际应用主要限制于转换效率低以及可靠性差等。此外,电子-空穴复合的焦点问题依然没有得到解决。因此,我们的工作主要集中在寻找有效的半导体材料作为二氧化钛的替代品。本论文工作主要目的是设计和制备具有良好性能的半导体材料,该材料可以利用可见光来进行光催化反应,包括水中有机化合物的降解。这样做时,废水中的污染物的消除等生态问题也可以得到有效的解决。所采用的办法是利用可行的方法制备在紫外光下具有活性的高表面积材料,然后通过表面修饰的方法使得材料对可见光响应。本论文以草酸铌作为前驱体,以2-甲基咪唑(Hmim)同时作为结构导向剂以及氮和碳的来源,通过水热-煅烧过程成功地合成了碳,氮共修饰的氧化铌纳米线。采用扫描电子显微镜(SEm),透射电子显微镜(TEm),X射线粉末衍射(XRD),X射线光电子能谱(XPS),傅里叶变换红外光谱(FTIR),高分辨率透射电子显微镜(HRTEm)和Brunauere-Emmette-Teller(BET)分析等手段对合成的碳,氮共修饰的氧化铌进行了表征。通过考察2-甲基咪唑的浓度,反应温度,共溶剂和焙烧温度的影响,对氧化铌纳米线的形成过程进行了详细研究。结果表明,最佳参数为:2-甲基咪唑浓度,33.33 mmol/L;反应温度,180℃;乙醇(共溶剂):水,1:2(体积比);焙烧温度,350℃。制备的氧化铌纳米线不仅比可商购的德固赛P25,N-TiO和NbO-CS在可见光下对10mg L的罗丹明B(RhB)溶液光降解效率更高,而且在5次循环使用后,依然表现出良好的稳定性。

关键词：五氧化铌纳米线碳,氮共修饰 2-甲基咪唑光催化降解可见光

Weighing of risk factors for penetrating keratoplasty graft failure：application of Risk Score System

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 372-377页

作者： abdo Karim Tourkmani Valeria Sánchez-Huerta Guillermo De Wit Jaime D.martínez David mingo Ignacio mahillo-Fernández Ignacio Jiménez-Alfaro Asociación Para Evitar la Ceguera en méxico Hospital Luis Sáinchez Bulnes Mexico City 04030 México Hospital Fundación Jiménez Diaz Madrid 28040 Spain

AIm：To analyze the relationship between the score obtained in the Risk Score System（RSS）proposed by Hicks et al with penetrating keratoplasty（PKP）graft failure at 1y postoperatively and among each factor in the RSS with the risk of PKP graft failure using univariate and multivariate ***：The retrospective cohort study had 152 PKPs from 152 patients. Eighteen cases were excluded from our study due to primary failure（10 cases）,incomplete medical notes（5 cases）and follow-up less than 1y（3cases）. We included 134 PKPs from 134 patients stratified by preoperative risk score. Spearman coefficient was calculated for the relationship between the score obtained and risk of failure at 1y. Univariate and multivariate analysis were calculated for the impact of every single risk factor included in the RSS over graft failure at 1y. RESULTS：Spearman coefficient showed statistically significant correlation between the score in the RSS and graft failure（P〈0.05）. multivariate logistic regression analysis showed no statistically significant relationship（P〉0.05）between diagnosis and lens status with graft failure. The relationship between the other risk factors studied and graft failure was significant（P〈0.05）,although the results for previous grafts and graft failure was unreliable. None of our patients had previous blood transfusion,thus,it had no impact. CONCLUSION：After the application of multivariate analysis techniques,some risk factors do not show the expected impact over graft failure at 1y.

关键词： penetrating keratoplasty graft failure score

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也门公路典型路面病害分析及养护对策研究

也门公路典型路面病害分析及养护对策研究

作者： SALAH abdo mOHSEN AL-NAHAm 上海交通大学

学位级别：硕士

公路作为国家重要基础设施,是国民经济快速稳定发展的保障。近年来,也门战争的不断爆发,经济水平受到了严重破坏。受战争影响,也门公路建设事业停滞不前,部分公路损坏严重。同时,由于也门尚没有成熟的养护系统,对公路路面的养护维修不当... 详细信息

公路作为国家重要基础设施,是国民经济快速稳定发展的保障。近年来,也门战争的不断爆发,经济水平受到了严重破坏。受战争影响,也门公路建设事业停滞不前,部分公路损坏严重。同时,由于也门尚没有成熟的养护系统,对公路路面的养护维修不当,随着公路运营年限的增加,路面的损坏越来越严重,最终造成路面结构整体性破坏。基于这一现实背景,本文对也门的公路路面现状进行了探讨和分析,以期对也门未来公路路面的养护和保护提供积极的贡献和借鉴。研究首先分析了也门路面所面临的主病害,如:裂缝、松散和车辙等。讨论了路面检测和修复(包括目标,类型,策略和技术),并对其进行了分析。其次,利用横断面分析法,对也门Qattbah-Dhale Road的十个路段研究后发现,在路基出现车辙损伤的路段,其损伤的具体位置介于基层与路基交界处。最后,以micro PAVER软件为基础,试图建构一套适合也门首都萨那的路面养护管理系统,期望能够对也门的路面维护提供一定的帮助,在今后路面的保护上得以有效和积极的发展。

关键词：也门路面病害车辙横断面分析养护管理系统

The Potential Role of Cu<sup>2+</sup>and Combined Action with IAA on Tolerance Strategy of Two Broad Bean Cultivars

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American Journal of Plant Sciences 2018年第10期9卷 2100-2119页

作者： Hamdia m. Abd El-Samad mohamed abdo K. Shaddad Kholoud N. Abd El-Hakeem Botany Department and microbiology Faulty of Science Minia University El-Minia Egypt Botany Department Faulty of Science Assiut University Assiut Egypt

The present work was conducting to study the strategy response of two broad bean cultivars Assiut 84 and Assiut 125 to different Cu2+ concentrations 100 ppm, 200 ppm, 300 ppm and 350 ppm in addition to control and interactions with IAA treatments. The dry matter exhibited the biphasic effect of Cu2+ on the growth criteria of the two broad bean cultivars. While the lower and moderate doses of Cu2+ (100 ppm and 200 ppm) stimulated the growth of the two cultivars, the higher doses revealed the opposite event where the growth dropped in both cultivars. This effect was more pronounced in cv. Assiut 84 than in cv. Assiut 125 and also at the higher Cu2+ concentration the growth dropped slightly in cv. Assiut 84 and highly significantly in cv. Assiut 125. The percent of increase in dry matter at 200 ppm in stem and leaf of cv. Assiut 84 was 120.45% and 155.31%, otherwise this percent of increase in these organs of cv. Assiut 125 was 114.29% and 131.41%. However the percent of reduction at 350 ppm Cu2+ in root and stem of cv. Assiut 84 was 74.13%, 79.23% and in root, stem and leaf of cv. Assiut 125 was 59.27%, 70.91%, 70.76% compared with control plants. Soluble carbohydrate in cv. Assiut 84 and cv. Assiut 125 was markedly increased while soluble protein was decreased in root, stem and in leaves at lower Cu2+ concentration. Also while Cu2+-stressed cv. Assiut 84 maintained potassium and magnesium levels around the control values and some promotion occurred especially in roots and stems, these cations dropped markedly in cv. Assiut 125 as a result of Cu2+ treatments. While Cu2+ had a marked stimulatory effect in the absorption and accumulation of calcium in the different organs of cv. Assiut 84, it, on the other hand, significantly inhibited the accumulation of this cation in the different organs of cv. Assiut 125. Treatments broad bean cultivars with Cu2+ plus IAA induced an increase in growth parameters, soluble suga, soluble protein, K+, Ca++ and mg++ in different parts of

关键词： Broad Bean Cultivars Sensitive Tolerant Copper IAA

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也门气候因素对沥青路面性能的影响

也门气候因素对沥青路面性能的影响

作者： Salah Saeed abdo Al-Khulaidi 西南交通大学

学位级别：硕士

随着也门经济的发展,道路建设将在促进区域经济发展中发挥越来越不可或缺的角色。由于也门的高温、低降水率、施工质量不理想等诸多因素,新建公路经常出现沥青路面裂缝、凹坑、车辙、移位等现象。本文通过室内试验和理论分析,选择适合... 详细信息

随着也门经济的发展,道路建设将在促进区域经济发展中发挥越来越不可或缺的角色。由于也门的高温、低降水率、施工质量不理想等诸多因素,新建公路经常出现沥青路面裂缝、凹坑、车辙、移位等现象。本文通过室内试验和理论分析,选择适合地区的沥青和沥青混合料品种,并提出相应的改进措施。本文首先对路面损坏的原因进行了调查,对局部沥青路面损坏的原因进行了分析和探讨。认为长时期的高温、沥青品种选择不当、路面结构组合不合理是造成路面有车辙破坏的主要原因。沥青测定性能分级法测定了沥青路面设计中的高温设计,通过对常用的70号基质沥青和SBS改性沥青在室内试验中进行对比试验,分析出了其高温指标。试验结果表明,也门常用的70号基质沥青难以满足要求。为了提高道路的抗车辙性能,路面表层应采用SBS改性沥青。然后本文选取当地常用的级配,参照中国有关沥青路面规范推荐的级配,进行室内配比试验,确定最优沥青含量,并制作车辙板进行车辙试验。试验结果表明,现有的抗车辙级配能力明显不足,并提出了改善级配和配合比的措施,最后路面采用AASHTO 1993设计规范对某实体工程进行了结构验算。

关键词：气候因素车辙疲劳试验 Super-pave