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Y^(3+) substituting-adjusted mechanical,dielectric,and impedance properties of cobalt copper zinc nanoferrites for high frequency applications

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Journal of Rare Earths 2023年第10期41卷 1597-1605,I0005页

作者： S.F.mansour N.S.Al-Bassami m.Afifi m.a.abdo Physics Department Faculty of ScienceZagazig UniversityZagazigEgypt General Studies Department Jubail Industrial CollegeJubail Industrial CitySaudi Arabia Faculty of Nanotechnology for Postgraduate Studies Cairo UniversityEl-Sheikh Zayed12588Egypt

Upgrading mechanical-dielectric features of ferrites through rare-earth yttrium(Y^(3+))doping provides feasibility to evolving high-frequency electronic *** paper reports the mechanical and dielectric properties of Co_(0.5)Cu_(0.25)Zn_(0.25)Y_(x)Fe_(2-x)O_(4)ferrite nanoparticles labeled as CCZYF#0,CCZYF#1,CCZYF#2,CCZYF#3,CCZYF#4 and CCZYF#5 for x=0.***.0.02,0.04,0.06,0.08,and 0.1,*** frequency and temperature dependence of dielectric parameters and co nductivity of all CCZYF nanoferrites are well *** nanoferrite CCZYF#5 has the highest dielectric constant(enhancing ratio 170%)and the highest conductivity(enhancing ratio 7125.81%)compared with the undoped *** plots of all CCZYF nano ferrites manifest two arcs;the main reasons for the dielectric process are the grain boundaries and bulk *** impedance parameters were determined,which showed the effective role of Y^(3+)ions on their *** nanoferrite CCZYF#5 has the highest grain boundaries capacitance(with enhancing ratio of 59.40%)and the highest grains capacitance(with enhancing ratio of 22.53%)with a relaxation time decrement efficiency of 62.51%.An ultrasonic flaw detector was utilized to determine the elastic moduli of all CCZYF *** nanoferrite CCZYF#5 has the highest longitudinal modulus(with enhancing ratio of 20.95%),the highest shear modulus(with enhancing ratio of48.72%),highest Young's modulus(with enhancing ratio of 88.47%),the highest bulk modulus(with enhancing ratio 13.27%)and the highest micro hardness(with enhancing ratio 77.77%).Hence,Y3+tuned Co-Cu-Zn nanoferrites possess new opportunities for high-frequency and storage applications.

关键词： Nanoferrites Rare arth ions mechanical properties Dielectric parameters Impedance spectroscopy

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SARS-CoV-2 spike behavior in situ:a Cryo-Em images for a better understanding of the COVID-19 pandemic

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Signal Transduction and Targeted Therapy 2020年第1期5卷 326-327页

作者： Alaa m.Ismail abdo A.Elfiky Biophysics Department Faculty of SciencesCairo UniversityGizaEgypt

most recently in Nature Journal,Ke et *** investigate the SARS-CoV-2 spike in situ by using cryo-electron microscopy(Cryo-Em)to reveal its different conformations,orientations,and distribution over the virion particles.

关键词： particles thoroughly behavior

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Investigation of a New Formula for Gurney Velocity Estimation

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火炸药学报 2018年第4期41卷 340-344页

作者： Tamer Elshenawy Ahmed Elbeih Qing ming Li Gamal m. abdo Technical Research Centre Cairo Egypt military Technical College Kobry Elkobbah Cairo Egypt The University of manchester School of Mechanical Aerospace and Civil Engineering Manchester UK mechanical Engineering Department Modern Acade

The formula for the analytical calculations of the shaped charge jetting parameters exhibit an explicit dependence upon the Gurney velocity of an explosive *** attempts have been done to approximate the characteristic constant 2E^(1/2) and to make its use more *** is shown herein that the characteristic Gurney velocity parameter depends on the ratio of the Chapman Jouguet-pressure to explosive impulse ratio by the formula:2E^(1/2)=0.2415(P_(CJ)/I_(SP)ρ_0)-970.76,where PCJis the Chapman Jouguet pressure(Pa),ISPis the specific impulse of the explosive used as a monopropellant(N·s/kg)andρois the explosive density(kg/m^3).The proposed empirical formula was found to be reasonable and quite accurate approximation that can be implemented over a wide range of explosives,where the maximum deviation between the measured and the calculated Gurney velocities was nearly 6%.Besides,the proposed approach has been used analytically to calculate the jet tip velocity of a small caliber shaped charge,which is measured *** difference between the measured and the calculated jet tip velocity was only 1.6%.

关键词：火药理论研究化学分析

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Fabrication of PmmA nanocomposite biomaterials reinforced by cellulose nanocrystals extracted from rice husk for dental applications

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Friction 2024年第12期12卷 2808-2825页

作者： Ahmed FOULY Walid m.DAOUSH Hesham I.ELQADY Hany S.abdo mechanical Engineering Department College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia The King Salman Center for Disability Research Riyadh 11421Saudi Arabia Department of Production Engineering and mechanical Design Faculty of EngineeringMinia UniversityMinia 61519Egypt Department of Chemistry College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh 11623Saudi Arabia Faculty of Technology and Education Helwan UniversityCairo 11281Egypt Faculty of Engineering Aswan UniversityAswan 81528Egypt Center of Excellence for Research in Engineering materials(CEREm) King Saud UniversityRiyadh 11421Saudi Arabia mechanical Design and materials Department Faculty of Energy EngineeringAswan UniversityAswan 81521Egypt

The primary objective of global studies is to develop the properties and durability of polymers for various *** it comes to dental disability,denture base materials must have sufficient mechanical and tribological performance in order to withstand the forces experienced in the *** work aims to investigate the effects of the addition of low content of cellulose nanocrystals(CNC)on the mechanical and tribological performance of the polymethyl methacrylate(PmmA)*** weight percent of CNC(0,0.2,0.4,0.6,and 0.8 wt%)were added to the PmmA matrix followed by ball milling to evenly distribute the nanoparticles reinforced phase in the matrix *** findings emphasize the significant impact of CNC integration on the performance of PmmA *** increasing the content of the CNC nanoparticles,the mechanical properties of PmmA were *** addition,the tribological outcomes demonstrated a significant reduction in the friction coefficient besides an enhancement in the wear resistance as the weight percentage of nanoparticles *** surface of the worn samples was investigated by utilizing SEm to identify the wear mechanisms corresponding to the different *** addition,a finite elment model(FEm)was developed to ascertain the thickness of the worn layer and the generated stressed on the surfaces of the nanocomposite throughout the friction process.

关键词： polymethyl methacrylate nanocomposite cellulose nanocrystals denture materials rice husk polymethyl methacrylate(PmmA) wear resistance

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Routine rectal retroflexion during colonoscopy has a low yield for neoplasia

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World Journal of Gastroenterology 2008年第42期14卷 6503-6505页

作者： abdo Saad Douglas Kevin Rex Department of medicine Division of Gastroenterology/Hepatology Indiana University School of Medicine Indianapolis IN 46202 United States

AIm： To investigate the value of retroflexion in detecting neoplasia in the distal rectum. mETHODS： This was a prospective observational study performed in an academic endoscopy unit. Consecutive patients undergoing colonoscopy had careful forward viewing of the distal rectum by retroflexion. Of 1502 procedures, 1076 （72%） procedures were performed with a 140^o angle of view colonoscope and 426 （28%） were performed with a 170^o angle of view colonoscope. The outcome measurement was the yield of neoplasia in the distal rectum detected by forward viewing vs retroflexion. RESULTS： A total of 1502 patients, including 767 （51%） females and 735 （49%） males, with mean age of 58.8 ± 12.5 years were enrolled. Retroflexion was successful in 1411 （93.9%） patients, unsuccessful or not performed because the rectum appeared narrow in 91 （6.1%）. Forty patients had a polyp detected in the distal rectal mucosa. Thirty-three were visible in both the forward and retroflexed view （25 hyperplastic, 8 adenomatous）. Seven polyps were visualized only by retroflexion （6 hyperplastic sessile polyps, one 4 mm sessile tubular adenoma）. There was no significant difference in information added by retroflexion with 140^o vs 170^o angle of view instrument. CONCLUSION： To our knowledge, this is the largest reported evaluation of retroflexion in the rectum. Routine rectal retroflexion did not detect clinically important neoplasia after a careful forward examination of the rectum to the dentate line. Since retroflexion has risks and may cause discomfort, theuse of routine retroflexion should be at the discretion of the endoscopist.

关键词： Colonoscopy Colorectal polyps Retroflexion Rectum

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maximizing the Benefit of Rate Transient Analysis for Gas Condensate Reservoirs

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Energy Engineering 2021年第5期118卷 1411-1423页

作者： mahmoud abdo Tantawy Ahmed A.m.Elgibaly Ahmed mohamed Farag Faculty of Petroleum and mining Engineering Suez UniversitySuezEgypt Abu Qir Petroleum Company AlexandriaEgypt

In recent years,many trials have been made to use the Rate Transient Analysis(RTA)techniques as a method to describe the gas condensate *** problem with using these techniques is the multi-phase behavior of the gas condensate ***,the Pressure Transient Analysis(PTA)is commonly used in this case to analyze the reservoir *** this paper,we are going to compare the results of both PTA and RTA of three wells in gas condensate *** comparison showed a great match between the results of the two mentioned techniques for the first time using a reference GOR of 75,000 SCF/***,we concluded that we could depend on RTA instead of PTA to spare the cost associated with the PTA in the gas condensate reservoirs.

关键词： Rate transient analysis production data analysis well testing permeability skin factor gas condensate

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