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Simulation of heat transfer in steel billets during continuous casting

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International Journal of minerals,metallurgy and materials 2010年第4期17卷 403-416页

作者： A.Ramirez-López R.Aguilar-López m.Palomar-Pardavé m.a.romero-romo D.muoz-Negrón Department of materials metropolitan Autonomous University Mexico City C.P.02200Mexico Institute Polytechnic National Mexico City C.P.07300Mexico Institute Technologic Autonomous of mexico Mexico City C.P.01080Mexico Institute Polytechnic National mexico City C.P.07300 Mexico

This work is focused on the development of computational algorithms to create a simulator for solving the heat transfer during the continuous casting process of steel. The temperatures and the solid shell thickness profiles were calculated and displayed on the screen for a billet through a defined continuous casting plant （CCP）. The algorithms developed to calculate billet temperatures, involve the solutions of the corresponding equations for the heat removal conditions such as radiation, forced convection, and conduction according to the billet posi- tion through the CCP. This is done by a simultaneous com.a.ison with the kinematics model previously developed. A finite difference method known as Cmnk-Nicholson is applied to solve the two-dimensional computational array （2D model）. Enthalpy （HIJ） and temperature （TIL） in every node are updated at each step time. The routines to display the results have been developed using a graphical user interface （GUI） in the programming language C＋＋. Finally, the results obtained are com.a.ed with those of industrial trials for the surface temperature of three steel casters with different plant configurations in different casting conditions.

关键词： continuous casting heat transfer heat removal simulation numerical methods

Structural, elastic and electronic properties for m_2 XC (m=Ti and Cr, X=Ga and Al) phases from.a. initio calculations

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Acta metallurgica Sinica(English Letters) 2011年第4期24卷 255-270页

作者： B. Ghebouli m.a. Ghebouli m. Fatmi N. Bouarissa m. Benkerri I.A. Ibrahim Laboratory of Study of Surfaces and Interfaces of Solids materials Department of Physics Faculty of Science University of Setif Department of Physics University Center Research Unit on Emerging materials Ferhat Abbas University of Setif Department of Physics Faculty of Sciences King Khalid University Central metallurgical Research and Development Institute P.O. Box: 87 Helwan 11424 Cairo Egypt

The first-principles study of the structural, elastic and electronic properties of the m2XC phases depending on the type of m transition metal （m.a.e Ti and Cr） and on X （X are Ga and A1） was reported. The calculations are performed using the pseudo-potential plane-wave approach in both the local density and generalized gradient approximations. The elastic constants are calculated using the static finite strain technique. Features such as structural and elastic parameters, Debye tem- perature, sound velocities and their pressure dependence have been investigated. In agreement with experimental and previous theoretical findings, it is found that the compressibility along a and c axis depends on the valence electron concentration （VEC）. Correlations revealing the governing role of the X and m elements on the machinability indices of the material have been examined. The electronic properties have been discussed in terms of chemical bonding showing that bonding is due to md-Cp and md-Xp hybridizations. m-C bonds are stiffer than m-X ones and A1-Ti （Cr-C） bonds are stiffer than those corresponding to Ti-C （A1-Cr）. It is shown that the stiffness of the m-X and m-C bonds increases with increasing the number of VEC.

关键词： m2XC phases ab initio Pressure effect Band structures

Cluster Partition Function and Invariants of 3-manifolds

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Chinese Annals of mathematics,Series B 2017年第4期38卷 937-962页

作者： mauricio romo School of-Natural Sciences Institute for Advanced Study Princeton NJ 08540 USA.

The author reviews some recent developments in Chern-Simons theory on a hyperbolic 3-manifold m with complex gauge group G. The author focuses on the case of G = SL(N, C) and m being a knot complement: m = S^3\ K. The main result presented in this note is the cluster partition function, a computational tool that uses cluster algebra techniques to evaluate the Chern-Simons path integral for G = SL(N, C). He also reviews various applications and open questions regarding the cluster partition function and some of its relation with string theory.

关键词： Chern-Simons theory Knots Cluster algebras

Algorithm for repairing the damaged images of grain structures obtained from the cellular automata and m.a.urement of grain size

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International Journal of minerals,metallurgy and materials 2012年第10期19卷 899-907页

作者： A.Ramírez-López m.a.romero-romo D.muñoz-Negron S.López-Ramírez R.Escarela-Pérez C.Duran-Valencia Department of materials and Energy Metropolitan Autonomous UniversityMexico City 02200Mexico Department of Industrial Engineering Technological Autonomous Institute of MexicoMexico City 01080Mexico Department of molecular Engineering Mexican Institute of PetroleumMexico City 07730Mexico

Computational models are developed to create grain structures using mathematical algorithms based on the chaos theory such as cellular automaton, geometrical models, fractals, and stochastic methods. Because of the chaotic nature of grain structures, some of the most popular routines are based on the monte Carlo method, statistical distributions, and random walk methods, which can be easily programmed and included in nested loops. Nevertheless, grain structures are not well defined as the results of computational errors and numerical incon- sistencies on mathematical methods. Due to the finite definition of numbers or the numerical restrictions during the simulation of solidifica- tion, damaged images appear on the screen. These images must be repaired to obtain a good m.a.urement of grain geometrical properties. Some mathematical algorithms were developed to repair, m.a.ure, and characterize grain structures obtained from cellular automata in the present work. An appropriate m.a.urement of grain size and the corrected identification of interfaces and length are very important topics in materials science because they are the representation and validation of mathematical models with real samples. As a result, the developed al- gorithms are tested and proved to be appropriate and efficient to eliminate the errors and characterize the grain structures.

关键词： grain size and shape image restoration mathematical algorithms cellular automata solidification

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.a.iah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly im.a.ts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them.a.tractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm.a.ainst JAK2 kinase and 200.9 nm.a.ainst PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment com.a.ed to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.a.ing-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, m.a.ing “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Com.a.ibility of Fibreglass Woven Roving and Commercially Available Phenolic Resins

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Journal of materials Science & Technology 1997年第5期13卷 379-382页

作者： Hayat, m.a. Suliman, S.m.a. Dept. of mechanical Engineering Bahrain University Box 32038 Isa Town Bahrain

Three commercially available phenolic resins are assessed for com.a.ibility with a fibreglass wovenroving reinforcement. Com.a.ibility assessment is based on laminate physical properties f flexuralstrength and modulus in three and four point bending, interlaminar shear strength, and tensilestrength and modulus. The physical properties are also used for assessment of hand laminatedglass/phenolic systems

关键词： Glass fibers

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic