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horm.ne-based pharm.cotherapy for m.tabolic dysfunction-associated fatty liver disease

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m.dical Review 2024年第2期4卷 158-168页

作者： Zara siu wa Chui Yaqian Xue Aim.n Xu state Key Laboratory of Pharm.ceutical biotechnology The University of Hong KongHong Kong SARChina Departm.nt of m.dicine The University of Hong KongHong Kong SARChina school of biom.dical sciences The University of Hong KongHong Kong SARChina state Key Laboratory of Pharm.ceutical biotechnology The University of Hong Kong999077Hong Kong SARChina Departm.nt of m.dicine The University of Hong Kong999077Hong Kong SARChina Departm.nt of Pharm.cology and Pharm.cy The University of Hong Kong999077Hong Kong SARChina

m.tabolic dysfunction-associated fatty liver disease(m.FLD)has reached epidem.c proportions globally in parallel to the rising prevalence of *** its significant burden,there is no approved pharm.cotherapy specifically tailored for this *** potential drug candidates for m.FLD have encountered setbacks in clinical trials,due to safety concerns or/and insufficient therapeutic ***,several investigational drugs that m.m.c the actions of endogenous m.tabolic horm.nes,including thyroid horm.ne receptorβ(thRβ)agonists,fibroblast growth factor 21(FGF21)analogues,and glucagon-like peptide-1 receptor agonists(GLP-1RAs),showed prom.sing therapeutic efficacy and excellent safety *** them.resm.tirom.a liver-targeted thRβ-selective agonist,has m.t the prim.ry outcom.s in alleviation of m.tabolic dysfunction-associated steatohepatitis(m.sh),the advanced form.of m.FLD,and liver fibrosis in phase-3 clinical *** horm.ne-based pharm.cotherapies not only exhibit varied degrees of therapeutic efficacy in m.tigating hepatic steatosis,inflam.ation and fibrosis,but also im.rove m.tabolic ***m.re,these three horm.nal agonists/analogues act in a com.lem.ntary m.nner to exert their pharm.cological effects,suggesting their com.ined therapies m.y yield synergistic therapeutic *** in-depth studies on the intricate interplay am.ng these m.tabolic horm.nes are im.erative for the developm.nt of m.re efficacious com.ination therapies,enabling precision m.nagem.nt of m.FLD and its associated com.rbidities.

关键词： m.tabolic horm.nes m.tabolic dysfunctionassociated steatohepatitis(m.sh) liver fibrosis biopharm.ceutical developm.nt clinical trials

m.ltiple scales m.thod for analyzing a forced dam.ed rotational pendulum.oscillatorwithgallows

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Com.unications in theoretical Physics 2024年第5期76卷 58-67页

作者： haifa A Alyousef Alvaro h salas b m.Alotaibi s A El-tantawy Departm.nt of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Departm.nt of m.them.tics and statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Departm.nt of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

this study reports the analytical solution for a generalized rotational pendulum.system.with gallows and periodic excited *** m.ltiple scales m.thod(m.m.is applied to solve the proposed *** types of rotational pendulum.oscillators are studied and talked about in *** include the forced dam.ed rotating pendulum.oscillator with gallows,the dam.ed standard sim.le pendulum.oscillator,and the dam.ed rotating pendulum.oscillator without *** m.m.first-order approxim.tions for all the cases m.ntioned are derived in *** obtained results are illustrated with concrete num.rical *** first-order m.m.approxim.tions are com.ared to the fourth-order Runge-Kutta(RK4)num.rical ***,the m.xim.m.error is estim.ted for the first-order approxim.tions obtained through the m.m.com.ared to the num.rical approxim.tions obtained by the RK4 ***,we conducted a com.arative analysis of the outcom.s obtained by the used m.thod(m.m.and he-m.m.to ascertain their respective levels of *** proposed m.thod can be applied to analyze m.ny strong nonlinear oscillatory equations.

关键词： rotational pendulum.system m.ltiple scales m.thod approxim.te solution dam.ed oscillations forced pendulum.with gallows he-m.ltiple scales m.thod

the earliest evidence for a m.croblade adaptation in the rem.te,high altitude regions of the tibetan Plateau

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science China Earth sciences 2024年第5期67卷 1561-1573页

作者： Yingshuai JIN Xiaoling ZhANG shejiang waNG Junyi GE Wei hE wa DA Yunyao tAN Ziyi YANG Christopher m.RGAN Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academ. of sciences Beijing 100049China Cultural Relics Conservation Institute of the Xizang Autonom.us Region Lhasa 850000China Nagqu Culture and tourism.bureau Nagqu 852000China University of Nevada Reno 89557USA

m.croblade assem.lages are am.ng the m.st com.on prehistoric archaeological m.terials found on the tibetan Plateau(tP)and are thought to indicate large scale m.gration to and settlem.nt of the *** m.croblade sites,however,have been system.tically excavated,especially in the rem.test,highest-elevation regions of the *** tim.ng of the large-scale arrival,spread,and perm.nent settlem.nt of people on the tP therefore rem.ins *** this paper,we report on a recently excavated site,Locality 3 of the Nwya Devu site(ND3),located at 4600 m.ters above sea level(m.sl),near the shore of Ngoin Lake,on the interior *** analyses reveal a fairly typical m.croblade technological orientation and two types of m.croblade cores:wedge-shaped and sem.-conical,which are sim.lar to those found throughout North *** Optically stim.lated Lum.nescence(OsL)dating and Am.^(14)C dating,the age of ND3 ranges from.11 to 10 *** date range indicates ND3 is the oldest m.croblade site yet recorded in the rem.te,high-elevation regions of the tP and thus provides im.ortant inform.tion about when and how hunter-gatherers using m.croblades began exploiting the higher altitudes of the *** together,studies at ND3 and throughout the tP suggest that a m.croblade adaptation is associated with the first prolonged hum.n occupation of the plateau and that m.croblades played a significant role in m.diating the risks and facilitating the m.bility necessary to perm.nently inhabit the tP.

关键词： the interior of tibetan Plateau Nwya Devu locality 3 m.croblade Early holocene high altitude adaption

strengthening and control of second-phase particle precipitation in ferritic/austenitic/m.rtensitic heat-resistant alloys:a review

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Journal of Iron and steel Research International 2024年第1期31卷 3-23页

作者： Xue-cheng Peng han-jie Guo Xin-fang Zhang Yi-wa Luo Ye sun Jing Guo Rong-guang Yang Xiao-dan Zheng school of m.tallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China beijing Key Laboratory of special m.lting and Preparation of high-End m.tal m.terials University of Science and Technology Beijing(USTB)Beijing100083China beijing shougang Gitane New m.tERIALs Co. Ltd.Beijing102206China

heat-resistant alloys with excellent m.chanical properties are widely used in various fields,and further im.rovem.nt in their properties is essential to m.et the requirem.nts in new-generation advanced supercritical boilers,nuclear reactors,superheaters,and other new m.terials *** effectively enhance the com.rehensive perform.nce of heat-resistant alloys,second-phase particle strengthening has been widely studied,and in the face of different service envi-ronm.nts of advanced heat-resistant steels,the selection of suitable second-phase particles is essential to m.xim.ze the perform.nce of these *** this end,three m.jor types of reinforcing phases in heat-resistant alloys such as carbides,rare earth oxides,and interm.tallic com.ounds are sum.arized.A com.arative analysis of the precipitation behavior of the reinforcing phases with different types as well as the risks and m.ans of controlling their use in service,is *** param.ters for the application of various types of second-phase particles in heat-resistant alloys are provided to support the design and preparation of new ultrahigh-perform.nce heat-resistant alloys.

关键词： heat-resistant alloy second-phase particle Carbide Rare earth oxide Interm.tallic com.ound strengthening

Direct m.crowave leaching conditions of rare earth elem.nts in fluorescent wastes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.bilen b.birol m.N.saridede s.s.Kaplan m.s.sonm.z Departm.nt of m.tallurgical and m.terials Engineering Yildiz Technical UniversityIstanbulTurkey Departm.nt of Chem.cal Engineering and m.terials science Stevens Institute of TechnologyNew JereyUSA Departm.nt of m.tallurgical and m.terials Engineering Istanbul Technical UniversityIstanbulTurkey

the lum.nescent phosphor powder in the fluorescent lam. constitutes 2%of the lam.’s *** can be m.ntioned that fluorescent wastes are a crucial raw m.terial to produce rare earth *** the present study,m.crowave leaching process was conducted to dissolve rare earth elem.nts yttrium.Y),europium.Eu),and rem.ining rare earth elem.nts(REEs)present in the phosphor powder of the fluorescent *** the yields were *** the m.crowave leaching process,the effects of the tem.erature(80-160℃),acid type(hydrochloric acid(hCl),nitric acid(hNO_(3)),sulphuric acid(h_(2)sO_(4))),acid concentration(0.5-6 m.l/L),solid to liquid ratio(0.1:10-0.5:10)and reaction tim.(5-90 m.n)param.ters on leaching efficiencies of varying rare earth elem.nts and calcium.were *** highest yield was obtained in the direct m.crowave leaching of fluorescent waste with the experim.ntal conditions of 6 m.l/L hCl,160℃,0.1:10 solid-to-liquid ratio(s:L),and 90 *** energy calculations were m.de,and kinetic m.dels of the reactions were obtained,and it is observed that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum.La),cerium.Ce),and terbium.tb)were exam.ned to be chem.cal reaction ***,calcium.Ca)and gadolinium.Gd)seem.coherent with the m.xed ***,m.them.tical m.dels of all experim.ntal studies are created with the response surface box-behnken m.thod and the correlation coefficients of all the m.dels are over 90%.

关键词： Rare earth elem.nts(REEs) Direct m.crowave leaching Fluorescent waste Kinetic m.dels Response surface m.thod

search for production of dark ferm.on candidates in association with heavy neutral gauge boson decaying to dim.on in proton-proton collisions at√s=8 teV using Cm. open data

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.m.hm.ud h.Abdallah m.t.hussein s.Elgam.al Centre for theoretical physics The British University in EgyptEgypt Physics Departm.nt Faculty of ScienceCairo UniversityEgypt

In this study,we conducted a search for dark m.tter using a part of the data recorded by the Cm. experim.nt during run-I of the LhC in 2012 with a center of m.ss energy of 8 teV and an integrated lum.nosity of 11.6 fb−*** data were gathered from.the Cm. open *** m.tter,in the fram.work of the sim.lified m.del(m.no-Z′),can be produced from.proton-proton collisions in association with a new hypothetical gauge boson,Z′.thus,the search was conducted in the dim.on plus large m.ssing transverse m.m.ntum.*** benchm.rk scenario of m.no-Z′,which is known as light vector,was used for interpreting the Cm. open *** evidence of dark m.tter was observed,and exclusion lim.ts were set on the m.sses of dark m.tter and Z′at 95%confidence level.

关键词： dark m.tter large hadron collider Cm. open data search for new physics dark ferm.on

Cr-induced fusion reactions to synthesize superheavy elem.nts

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Nuclear science and techniques 2024年第5期35卷 122-130页

作者： s.m.dhu h.C.m.njunatha N.sowm.a b.m.Rajesh L.seenappa R.s.susheela Departm.nt of Physics R V College of EngineeringBangalore 560074India Visvesvaraya technological University BelagaviKarnataka 590018India Departm.nt of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Departm.nt of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Departm.nt of Physics Government First Grade CollegeMulbagalKarnataka 563131India Departm.nt of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)Cr-induced fusion reactions for the synthesis of the superheavy elem.nt in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)Cr projectiles were com.ared with those obtained in prior *** estim.ted cross sections from.this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 m.V for ^(53)Cr+^(243)Am.23.2 fb at 236 m.V for ^(54)Cr+^(247)Cm.95.6 fb at 240 m.V for ^(53)Cr+248bk,and 1.33 fb at 242 m.V for ^(53)Cr+***,these projected cross sections with excitation energy and beam.energy will be useful in future Cr-induced fusion reaction investigations.

关键词： Fusion cross sections Com.ound nucleus form.tion probability survival probability Evaporation residue cross sections

Deuterium.distribution and behavior of blisters in pre-dam.ged and undam.ged tungsten

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tungsten 2024年第3期6卷 647-656页

作者： Cong Li Xiao-wa wang Ran-Ran su Xuan-Xin hu shu-Guang Wei han-Jun tu Li-Qun shi hong-Liang Zhang Key Laboratory of Nuclear Physics and Ion-beam.Application Institute of Modern Physics Fudan University school of m.chanical Engineering Shanghai Jiao Tong University Departm.nt of m.terials science and Engineering University of Wisconsin

tungsten(W),as a plasm.-facing m.terial,is subjected to high fluence plasm.,resulting in both radiation dam.ge and deuterium.D) *** study explores the blistering behavior and D supersaturated layers in both pre-dam.ged and undam.ged W *** achieve a uniform.dam.ge profile sim.lar to neutron irradiation,carbon(C) ions with m.ltiple energies and angles were *** sam.les were further irradiated with low-energy D ions under two fluences at tem.eratures from.～380 to 640 *** various experim.ntal techniques,we found that pre-dam.ged W sam.les can effectively suppress the form.tion of blistering and lower the threshold tem.erature at which the surface rem.ins free of *** also observed the prom.nent D supersaturated peaks within the depth of 20 nm.in both pre-dam.ged and undam.ged ***,a close correlation between blistering and the D supersaturation was *** results suggest that neutron irradiation in the fusion reactors could increase the critical D concentration for blistering,while a greater depth of dam.ge facilitated the inward diffusion of D,thereby reducing the D concentration gradient and alleviating surface blistering.

关键词： tungsten Deuterium supersaturated layer blister Ion irradiation Pre-dam.ge

supram.lecular m.nipulation of Intracellular Acidic Vesicles to Im.rove Cellular self-Repair and self-Defense

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CCs Chem.stry 2024年第6期6卷 1487-1498页

作者： Ziyi wang Chen sun Yu Dong Yuan-Fu Ding Chen Zhao Ian wa ho Jiahong Lu Ruibing wang state Key Laboratory of Quality Research in Chinese m.dicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao 999078China

Lysosom.s are the“cell stom.ch”that digests various species including m.crom.lecules and pathogens for self-repair and self-defense upon fusion with endosom.s,autophagosom.s,and ***,artificially m.nipulating intracellular vesicles could potentially prom.te lysosom.-m.diated intracellular digestion for disease prevention and ***,a supram.lecular strategy to efficiently tether and fuse acidic vesicles(i.e.,lysosom.s,late endosom.s,autolysosom.s,and phagosom.s)has been developed for the first tim. to enhance the digestion of cellular wastes and foreign m.tter,including pathogens.A linear polyethylene glycol(PEG)derivative dually tagged with m.rpholine(m.R)and adam.ntane(ADA)on the opposite side,nam.ly,m.R-PEG-ADA,was designed to target intracellular acidic vesicles via m.R and to decorate their surfaces with ***,the addition of cucurbit[7]uril(Cb[7])grafted hyaluronic acid(hA)induced supram.lecular tethering and fusion of acidic vesicles via strong host-guest interactions between Cb[7]of Cb[7]-hA and ADA residing on the surface of acidic *** a proof-ofconcept,the overall cellular m.tabolism.including endogenous autophagy and the exogenous endocytosis and phagocytosis,was effectively upregulated,dem.nstrating that supram.lecular regulation of the dynam.cs of intracellular acidic vesicles m.y prom.te the lysosom.’s digestion to significantly im.rove cellular self-repair and self-defense.

关键词： supram.lecular chem.stry organelle regulation intracellular acidic vesicles lysosom.s selfdefense self-repair