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Neurological Involvem.nt in System.c Lupus Erythem.tosus (SLE): Our Recent Experience

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Open Journal of Rheum.tology and Autoim.une Diseases 2019年第2期9卷 25-34页

作者： B. S. Kane m. Dieng B. C. Fall m. sow A. C. Ndao B. Djiba m. Niasse N. Diagne A. Faye S. Ndongo A. Pouye Departm.nt of Internal m.dicine Le Dantec Teaching Hospital Cheikh Anta DIOP University of DAKAR Dakar Senegal Departm.nt of Rheum.tology Le Dantec Teaching Hospital Cheikh Anta DIOP University of DAKAR Dakar Senegal

Introduction: The central, psychiatric and peripheral neurological m.nifestations of lupus are am.ng the m.st severe visceral disorders and are grouped under the general term.of “neuro-psychiatric system.c lupus erythem.tosus” (NPSLE). We conducted a cross-sectional observational study within our Departm.nt of Internal m.dicine aim.d at describing the clinical and evolutionary aspects of central neurological disorders of SLE, excluding lupus m.elopathy. Patients and m.thods: This was a retrospective and observational cross-sectional study carried out from.1 January 2015 to 31 October 2017, in the Departm.nt of Internal m.dicine of Aristide le Dantec University Hospital in Dakar (Senegal). All patients hospitalized during this period who m.t the 1997 ACR classification criteria of SLE and who presented with a central neuropsychiatric syndrom. attributable to SLE (as defined by ACR 1999) were included. Patients with isolated headache, acute m.elitis or secondary neurological involvem.nt attributable to a toxic, m.tabolic, infectious or tum.ur-related cause were excluded from.our study. Results: During the study period, 10 patients with neuropsychiatric lupus involvem.nt were treated at our institution, including 9 wom.n and 1 m.n;the m.dian age was 29 years (20 - 55 years). Neurological involvem.nt occurred during the course of lupus evolution in 9/10 cases. The m.dian tim. to SLE evolution was 18 m.nths (0 - 60 m.nths). Neuropsychiatric syndrom.s as defined by the 1999 ACR were com.only associated and m.re than half of our patients had m.ltiple neuropsychiatric syndrom.s. There were 5 cases of confusion syndrom. and com., 4 cases of seizure, 3 cases of psychosis, 2 cases of acute cerebrovascular disease and 1 case of aseptic m.ningitis. Am.ng the extra-neurological m.nifestations of SLE, haem.tological and derm.tological involvem.nts were com.on. Renal involvem.nt affected half of the patients. The other m.nifestations were: polyarthritis in 3 patients, serositis in

关键词： System.c Lupus Erythem.tosus Lupus Vasculitis Central Nervous System Africa South of the Sahara

Im.unosuppressive Treatm.nt of Connective Tissue Disease and Occurrence of Tuberculosis

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Open Journal of Rheum.tology and Autoim.une Diseases 2020年第2期10卷 57-63页

作者： m. Dieng B. Djiba B. S. Kane B. C. Fall m. A. Ndour m. sow N. Diagne A. C. Ndao A. Faye S. Ndongo A. Pouye Service de m.decine Interne hôpital Aristide Le Dantec Dakar-étoile Sénégal Service de m.decine interne hôpital Dalal Jam Dakar Sénégal

Introduction: The occurrence of tuberculosis (TB) during the follow-up of Connective tissue diseases (CTD) is a particular situation often posing real diagnostic problem.. This is an association described in the literature. Patients and m.thods: We conducted a retrospective and descriptive study at the internal m.dicine departm.nt of Aristide Le Dantec Hospital. The purpose of this study was to determ.ne the treatm.nt that patients followed for CTD and suffering from.TB took before the occurrence of this one. Results: During a study period of 11 years and 6 m.nths, 21 cases of TB were diagnosed in 602 cases of CTD (0.03%). The predom.nance was fem.le with a sex ratio (H/F) of 0.6. The m.dian age was 42 years old. The m.jority of cases originated from.the Dakar region (13 patients or 61.9%) and 85.7% had previous follow-up exclusively in m.dern m.dicine and 21 cases (95%) received the CTD’s treatm.nt. This consisted of prednisone (90.5%) com.ined with m.thotrexate (52.4%), azathioprine (23.8%) or cyclophospham.de (19.4%). The respective m.dians doses of these drugs were 12.5 m. per day for prednisone, 13.5 m. per week for m.thotrexate and 100 m. per day for azathioprine. The m.dian duration of patient follow-up was 36 m.nths. The cum.lative dose of prednisone during this period was 23.6 g and that of m.thotrexate 2.25 g. CTD were dom.nated by rheum.toid arthritis (RA) (57.1%), and system.c lupus (19%). Isolated cases of system.c scleroderm., prim.ry Sjôgren, SHARP syndrom. m.xed connective tissue disease, and m.ltiple autoim.une syndrom.were noted. TB was localized in 95% of cases, readily bilateral and poorly dissem.nated. The respective m.dians diagnostic delays for system.c disease and TB were 21 m.nths and 5 m.nths. Tuberculin intraderm.l reaction was perform.d in 16 cases and was positive in 9 cases, sputum.bacilli was perform.d in 19 cases and was positive in 15 cases. Conclusion: The association of TB and CTD was characterized by its rarity, its poorly di

关键词： Tuberculosis Connective Tissue Disease Corticosteroid Im.unosuppressive Therapy

Effectivity of Throm.oprophylxie in Dakar’s m.dical Areas

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Open Journal of Internal m.dicine 2020年第1期10卷 35-43页

作者： B. Djiba m. Dieng C. m. A. Halim.m. sow B. S. Kane m. A. Ndour B. C. Fall N. Diagne A. C. Ndao A. Faye S. Ndongo A. Pouye Departm.nt of Internal m.dicine Aristide Le Dantec Hospital Dakar-Étoile Senegal Departm.nt of Internal m.dicine Dalal Jam Hospital Dakar Senegal

Introduction: Venous throm.oem.olic disease (VTE) is a real public health problem.worldwide. The practice guide produced periodically by the Am.rican College of Chest Physicians (ACCP) has becom. the international standard. However, throm.oprophylaxis rem.ins underused. m.thodology: We carried out a descriptive cross-sectional study. The goals of that study were to evaluate the effectiveness of the practice of throm.oprophylaxis in the various m.dical services of the Dakar Public Hospitals. Our investigation was conducted for two weeks in Septem.er 2017. Results: 160 patients were included (81 m.n and 79 wom.n) in our series, with m.le predom.nance: sex ratio of 1.02. The average age was 48. Infectious pathologies were the predom.nant clinical pictures (35% of cases). The throm.oem.olic risk factors (RF) m.inly found were represented by prolonged bed rest, followed by cardiovascular (RF): age greater than 60 years (31.2%), hypertension (8.8%), obesity (4.4%) and diabetes (3.8%). The throm.oem.olic RF of patients hospitalized in these m.dical services has been evaluated em.irically. We noted a lack of use of the VTE risk assessm.nt scores. 40.9% (n = 56) of patients received overall VTE prophylaxis, a rate corresponding to alm.st half of those at risk (51.4%). This result reflects an under-use of throm.oprophylaxis in the Dakar m.dical environm.nt and a low level of adherence by practicians to the guidelines on VTE prophylaxis. Conclusion: It is therefore recom.ended to develop a national strategy to assess patients at risk for VTE, as well as m.asures to educate and inform.doctors about the appropriate form. of throm.oprophylaxis.

关键词： Throm.oprophylaxis Anticoagulant Throm.oem.olic Disease

Long-Term.Oral Corticosteroid-Therapy: Description of the Practice of Adjuvant m.asures by Dakar m.dical Specialists

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Open Journal of Rheum.tology and Autoim.une Diseases 2020年第2期10卷 70-78页

作者： m. Dieng B. Djiba m. sow B. S. Kane J. T. Ahouandogbo m. Ba m. A. Ndour B. C. Fall m. Niasse N. Diagne A. C. Ndao A. Faye S. Ndongo A. Pouye Departm.nt of Internal m.dicine Aristide Le Dantec Hospital Dakar-Etoile Senegal Departm.nt of Internal m.dicine Dalal Jam Hospital Dakar Senegal Departm.nt of Rheum.tology Aristide Le Dantec Hospital Dakar-Etoile Senegal

Introduction: The extended adm.nistration of corticoids by oral way for a length of m.re than 3 m.nths defines the long-term.corticosteroid-therapy. This one, used in num.rous indications, displays m.st often at the risk of undesirable effects linked som.tim.s to the habits of prescription of the doctors. Patients and m.thods: In order to study the prescription m.dalities of this treatm.nt, we conducted a cross-sectional, m.lticentric and descriptive study from.June 1st, 2017 to August 1st, 2017, over a period of 2 m.nths. It involved a questionnaire given to m.dical specialists of all m.dical specialties and practicing in the University Hospital of Dakar. Results: 170 doctors were interviewed. Derm.tologists and internists were m.stly found 19.4% and 18.8% or 33% and 34% doctors. System.c autoim.une diseases alone accounted for 48% of prescription reasons. Prednisone was prescribed in 88% of cases. The im.unosuppressive dose of 1 m./kg was m.st often prescribed. Practitioners very heterogeneously prescribe m.st adjuvant m.asures to prolonged system.c corticosteroid therapy. Thus, the recom.endation of a low-sodium.diet (38% of physicians), and the system.tic prescriptions of proton pum. inhibitors (44.7% of physicians) and vitam.n-calcium.supplem.ntation were frequently perform.d by physicians (34% of physicians). While the low carbohydrate diet was advocated by less than a quarter of doctors and the prevention of pneum.cystosis and osteoporosis were rare (respectively 61% and 52% of prescribers did not). Conclusion: The global analysis of the habits of our m.dical specialists concerning the use of long-term.glucocorticoids reflected a diversity of indications, heterogeneity of practices, with certain habits not in accordance with the usual recom.endations.

关键词： Corticosteroid Long-Term Oral Corticosteroid System.c Disease Adjuvant m.asures

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

One-loop approxim.tion of m.ller scattering in generalized Krein-space quantization

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Science China(Physics,m.chanics & Astronom.) 2009年第2期52卷 212-217页

作者： F. PAYANDEH m. m.HRAFARIN m. V. TAKOOK Physics Departm.nt Amirkabir University of Technology Payam. Noor University Physics Departm.nt Razi University

It has been shown that the negative-norm.states necessarily appear in a covariant quantization of the free m.nim.lly coupled scalar field in de Sitter spacetim.. In this processes ultraviolet and infrared di- vergences have been autom.tically elim.nated. A natural renorm.lization of the one-loop interacting quantum.field in m.nkowski spacetim. (λφ 4) has been achieved through the consideration of the nega- tive-norm.states defined in Krein space. It has been shown that the com.ination of quantum.field theory in Krein space together with consideration of quantum.m.tric fluctuation, results in quantum.field the- ory without any divergences. Pursuing this approach, we express Wick’s theorem.and calculate m.ller scattering in the one-loop approxim.tion in generalized Krein space. The m.them.tical consequence of this m.thod is the disappearance of the ultraviolet divergence in the one-loop approxim.tion.

关键词： quantum field theory Krein space negative energy states