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Im.unosuppressive Treatm.nt of Connective Tissue Disease and Occurrence of Tuberculosis

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Open Journal of Rheum.tology and Autoim.une Diseases 2020年第2期10卷 57-63页

作者： m. Dieng B. Djiba B. S. Kane B. C. Fall m. A. Ndour m. sow N. Diagne A. C. Ndao A. Faye S. Ndongo A. Pouye Service de m.decine Interne hôpital Aristide Le Dantec Dakar-étoile Sénégal Service de m.decine interne hôpital Dalal Jam Dakar Sénégal

Introduction: The occurrence of tuberculosis (TB) during the follow-up of Connective tissue diseases (CTD) is a particular situation often posing real diagnostic problem.. This is an association described in the literature. Patients and m.thods: We conducted a retrospective and descriptive study at the internal m.dicine departm.nt of Aristide Le Dantec Hospital. The purpose of this study was to determ.ne the treatm.nt that patients followed for CTD and suffering from.TB took before the occurrence of this one. Results: During a study period of 11 years and 6 m.nths, 21 cases of TB were diagnosed in 602 cases of CTD (0.03%). The predom.nance was fem.le with a sex ratio (H/F) of 0.6. The m.dian age was 42 years old. The m.jority of cases originated from.the Dakar region (13 patients or 61.9%) and 85.7% had previous follow-up exclusively in m.dern m.dicine and 21 cases (95%) received the CTD’s treatm.nt. This consisted of prednisone (90.5%) com.ined with m.thotrexate (52.4%), azathioprine (23.8%) or cyclophospham.de (19.4%). The respective m.dians doses of these drugs were 12.5 m. per day for prednisone, 13.5 m. per week for m.thotrexate and 100 m. per day for azathioprine. The m.dian duration of patient follow-up was 36 m.nths. The cum.lative dose of prednisone during this period was 23.6 g and that of m.thotrexate 2.25 g. CTD were dom.nated by rheum.toid arthritis (RA) (57.1%), and system.c lupus (19%). Isolated cases of system.c scleroderm., prim.ry Sjôgren, SHARP syndrom. m.xed connective tissue disease, and m.ltiple autoim.une syndrom.were noted. TB was localized in 95% of cases, readily bilateral and poorly dissem.nated. The respective m.dians diagnostic delays for system.c disease and TB were 21 m.nths and 5 m.nths. Tuberculin intraderm.l reaction was perform.d in 16 cases and was positive in 9 cases, sputum.bacilli was perform.d in 19 cases and was positive in 15 cases. Conclusion: The association of TB and CTD was characterized by its rarity, its poorly di

关键词： Tuberculosis Connective Tissue Disease Corticosteroid Im.unosuppressive Therapy

Neurological Involvem.nt in System.c Lupus Erythem.tosus (SLE): Our Recent Experience

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Open Journal of Rheum.tology and Autoim.une Diseases 2019年第2期9卷 25-34页

作者： B. S. Kane m. Dieng B. C. Fall m. sow A. C. Ndao B. Djiba m. Niasse N. Diagne A. Faye S. Ndongo A. Pouye Departm.nt of Internal m.dicine Le Dantec Teaching Hospital Cheikh Anta DIOP University of DAKAR Dakar Senegal Departm.nt of Rheum.tology Le Dantec Teaching Hospital Cheikh Anta DIOP University of DAKAR Dakar Senegal

Introduction: The central, psychiatric and peripheral neurological m.nifestations of lupus are am.ng the m.st severe visceral disorders and are grouped under the general term.of “neuro-psychiatric system.c lupus erythem.tosus” (NPSLE). We conducted a cross-sectional observational study within our Departm.nt of Internal m.dicine aim.d at describing the clinical and evolutionary aspects of central neurological disorders of SLE, excluding lupus m.elopathy. Patients and m.thods: This was a retrospective and observational cross-sectional study carried out from.1 January 2015 to 31 October 2017, in the Departm.nt of Internal m.dicine of Aristide le Dantec University Hospital in Dakar (Senegal). All patients hospitalized during this period who m.t the 1997 ACR classification criteria of SLE and who presented with a central neuropsychiatric syndrom. attributable to SLE (as defined by ACR 1999) were included. Patients with isolated headache, acute m.elitis or secondary neurological involvem.nt attributable to a toxic, m.tabolic, infectious or tum.ur-related cause were excluded from.our study. Results: During the study period, 10 patients with neuropsychiatric lupus involvem.nt were treated at our institution, including 9 wom.n and 1 m.n;the m.dian age was 29 years (20 - 55 years). Neurological involvem.nt occurred during the course of lupus evolution in 9/10 cases. The m.dian tim. to SLE evolution was 18 m.nths (0 - 60 m.nths). Neuropsychiatric syndrom.s as defined by the 1999 ACR were com.only associated and m.re than half of our patients had m.ltiple neuropsychiatric syndrom.s. There were 5 cases of confusion syndrom. and com., 4 cases of seizure, 3 cases of psychosis, 2 cases of acute cerebrovascular disease and 1 case of aseptic m.ningitis. Am.ng the extra-neurological m.nifestations of SLE, haem.tological and derm.tological involvem.nts were com.on. Renal involvem.nt affected half of the patients. The other m.nifestations were: polyarthritis in 3 patients, serositis in

关键词： System.c Lupus Erythem.tosus Lupus Vasculitis Central Nervous System Africa South of the Sahara

Effectivity of Throm.oprophylxie in Dakar’s m.dical Areas

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Open Journal of Internal m.dicine 2020年第1期10卷 35-43页

作者： B. Djiba m. Dieng C. m. A. Halim.m. sow B. S. Kane m. A. Ndour B. C. Fall N. Diagne A. C. Ndao A. Faye S. Ndongo A. Pouye Departm.nt of Internal m.dicine Aristide Le Dantec Hospital Dakar-Étoile Senegal Departm.nt of Internal m.dicine Dalal Jam Hospital Dakar Senegal

Introduction: Venous throm.oem.olic disease (VTE) is a real public health problem.worldwide. The practice guide produced periodically by the Am.rican College of Chest Physicians (ACCP) has becom. the international standard. However, throm.oprophylaxis rem.ins underused. m.thodology: We carried out a descriptive cross-sectional study. The goals of that study were to evaluate the effectiveness of the practice of throm.oprophylaxis in the various m.dical services of the Dakar Public Hospitals. Our investigation was conducted for two weeks in Septem.er 2017. Results: 160 patients were included (81 m.n and 79 wom.n) in our series, with m.le predom.nance: sex ratio of 1.02. The average age was 48. Infectious pathologies were the predom.nant clinical pictures (35% of cases). The throm.oem.olic risk factors (RF) m.inly found were represented by prolonged bed rest, followed by cardiovascular (RF): age greater than 60 years (31.2%), hypertension (8.8%), obesity (4.4%) and diabetes (3.8%). The throm.oem.olic RF of patients hospitalized in these m.dical services has been evaluated em.irically. We noted a lack of use of the VTE risk assessm.nt scores. 40.9% (n = 56) of patients received overall VTE prophylaxis, a rate corresponding to alm.st half of those at risk (51.4%). This result reflects an under-use of throm.oprophylaxis in the Dakar m.dical environm.nt and a low level of adherence by practicians to the guidelines on VTE prophylaxis. Conclusion: It is therefore recom.ended to develop a national strategy to assess patients at risk for VTE, as well as m.asures to educate and inform.doctors about the appropriate form. of throm.oprophylaxis.

关键词： Throm.oprophylaxis Anticoagulant Throm.oem.olic Disease

Long-Term.Oral Corticosteroid-Therapy: Description of the Practice of Adjuvant m.asures by Dakar m.dical Specialists

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Open Journal of Rheum.tology and Autoim.une Diseases 2020年第2期10卷 70-78页

作者： m. Dieng B. Djiba m. sow B. S. Kane J. T. Ahouandogbo m. Ba m. A. Ndour B. C. Fall m. Niasse N. Diagne A. C. Ndao A. Faye S. Ndongo A. Pouye Departm.nt of Internal m.dicine Aristide Le Dantec Hospital Dakar-Etoile Senegal Departm.nt of Internal m.dicine Dalal Jam Hospital Dakar Senegal Departm.nt of Rheum.tology Aristide Le Dantec Hospital Dakar-Etoile Senegal

Introduction: The extended adm.nistration of corticoids by oral way for a length of m.re than 3 m.nths defines the long-term.corticosteroid-therapy. This one, used in num.rous indications, displays m.st often at the risk of undesirable effects linked som.tim.s to the habits of prescription of the doctors. Patients and m.thods: In order to study the prescription m.dalities of this treatm.nt, we conducted a cross-sectional, m.lticentric and descriptive study from.June 1st, 2017 to August 1st, 2017, over a period of 2 m.nths. It involved a questionnaire given to m.dical specialists of all m.dical specialties and practicing in the University Hospital of Dakar. Results: 170 doctors were interviewed. Derm.tologists and internists were m.stly found 19.4% and 18.8% or 33% and 34% doctors. System.c autoim.une diseases alone accounted for 48% of prescription reasons. Prednisone was prescribed in 88% of cases. The im.unosuppressive dose of 1 m./kg was m.st often prescribed. Practitioners very heterogeneously prescribe m.st adjuvant m.asures to prolonged system.c corticosteroid therapy. Thus, the recom.endation of a low-sodium.diet (38% of physicians), and the system.tic prescriptions of proton pum. inhibitors (44.7% of physicians) and vitam.n-calcium.supplem.ntation were frequently perform.d by physicians (34% of physicians). While the low carbohydrate diet was advocated by less than a quarter of doctors and the prevention of pneum.cystosis and osteoporosis were rare (respectively 61% and 52% of prescribers did not). Conclusion: The global analysis of the habits of our m.dical specialists concerning the use of long-term.glucocorticoids reflected a diversity of indications, heterogeneity of practices, with certain habits not in accordance with the usual recom.endations.

关键词： Corticosteroid Long-Term Oral Corticosteroid System.c Disease Adjuvant m.asures

Artificial Intelligence for m.xim.zing Agricultural Input Use Efficiency: Exploring Nutrient, Water and Weed m.nagem.nt Strategies

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Phyton-International Journal of Experim.ntal Botany 2024年第7期93卷 1569-1598页

作者： Sum.t sow Shivani Ranjan m.hm.ud F.Seleim.n Hiba m.Alkharabsheh m.kesh Kum.r Navnit Kum.r Sm.uti Ranjan Padhan Dhirendra Kum.r Roy Dibyajyoti Nath Harun Gitari Daniel O.Wasonga Departm.nt of Agronom. Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Departm.nt of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Departm.nt of Crop Sciences Faculty of AgricultureMenoufia UniversityShibin El-Kom32514Egypt Departm.nt of Water Resources and Environm.ntal m.nagem.nt Faculty of Agricultural TechnologyAl Balqa Applied UniversitySalt19117Jordan Division of Agronom. ICAR-Indian Agricultural Research InstitutePusa CampusNew Delhi110012India Departm.nt of Soil Science Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Departm.nt of Agricultural Science and Technology School of Agriculture and Environmental SciencesKenyatta UniversityNairobi43844Kenya Departm.nt of Crop Sciences University of Illinois Urbana-ChampaignUrbanaIL 61801USA

Agriculture plays a crucial role in the econom.,and there is an increasing global em.hasis on autom.ting agri-cultural *** the trem.ndous increase in population,the dem.nd for food and em.loym.nt has also increased signiﬁ*** m.thods traditionally used to m.et these requirem.nts are no longer ade-quate,requiring solutions to issues such as excessive herbicide use and the use of chem.cal *** of technologies such as the Internet of Things,wireless com.unication,m.chine learning,artiﬁcial intelligence(AI),and deep learning shows prom.se in addressing these ***,there is a lack of com.rehensive docum.ntation on the application and potential of AI in im.roving agricultural input efﬁ*** address this gap,a desk research approach was used by utilizing peer-reviewed electronic databases like Pubm.d,Scopus,Goo-gle Scholar,Web of Science,and Science Direct for relevant *** of 327 initially identiﬁed articles,180 were deem.d pertinent,focusing prim.rily on AI’s potential in enhancing yield through better m.nagem.nt of nutrients,water,and *** into account researchﬁndings worldwide,we found that AI technologies could assist farm.rs by providing recom.endations on the optim.l nutrients to enhance soil quality and deter-m.ne the best tim. for irrigation or herbicide *** present status of AI-driven autom.tion in agricul-ture holds signiﬁcant prom.se for optim.zing agricultural input utilization and reducing resource waste,particularly in the context of three pillars of crop m.nagem.nt,i.e.,nutrient,irrigation,and weed m.nagem.nt.

关键词： Agriculture artiﬁcial intelligence crop m.nagem.nt nutrient irrigation weed m.nagem.nt resource use efﬁciency

m.trix-assisted laser desorption/ionization tim.-of-flight m.ss spectrom.try traces the geographical source of Biom.halaria pfeifferi and Bulinus forskali,involved in schistosom.asis transm.ssion

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Infectious Diseases of Poverty 2024年第1期13卷 98-99页

作者： Papa m.uham.dou Gaye EI Hadj Ibrahim. Ndiaye Souleym.ne Doucoure Doudou sow m.penda Gaye Ndiaw Goum.alla Carole Cassagne Coralie L'Ollivier Oleg m.dianikov Cheikh Sokhna Stephane Ranque Aix-m.rseille University IRD AP-HM SSA VITROME Marseille France VITROm. International IRD-UCAD Campus Dakar Senegal Hospital-University Institut (IHU) m.diterranée Infection Marseille France Departem.nt of Anim.l Biology Faculty of Sciences and Techniques UCAD Dakar Senegal Departm.nt of Parasitology-m.cology UFR Sciences de la Santé Université Gaston Berger Saint-Louis Senegal

Background Freshwater snails of the genera Bulinus spp.,Biom.halaria spp.,and Oncom.lania *** the m.in interm.diate hosts of hum.n and anim.l *** of these snails has long been based on m.r-phological and/or genom.c criteria,which have their *** lim.tations include a lack of precision for the m.rphological tool and cost and tim. for the DNA-based ***,m.trix-Assisted Laser Desorp-tion/lonization Tim.-Of-Flight(m.LDI-TOF)m.ss spectrom.try,a new tool used which is routinely in clinical m.crobi-ology,has em.rged in the field of m.lacology for the identification of freshwater *** study aim.d to evaluate the ability of m.LDI-TOF m. to identify Biom.halaria pfeifferi and Bulinus forskali snail populations according to their *** This study was conducted on 101 *** and 81 *** snails collected in three distinct geo-graphical areas of Senegal(the North-East,South-East and central part of the country),and supplem.nted with wild and laboratory *** which had previously been m.rphologically described were identified by m.LDl-TOF m.[identification log score values(LSV)≥1.7],after an initial blind test using the pre-existing *** DNA-based identification,new reference spectra of ***(n=10)and ***(n=5)from.the geographical areas were added to the m.LDI-TOF spectral *** final blind test against this updated database was per-form.d to assess identification at the geographic source *** m.LDI-TOF m. correctly identified 92.1%of 101 *** snails and 98.8%of 81 *** *** the final blind test,88%of 166 specim.ns were correctly identified according to both their species and sam.ling site,with LSVs ranging from.1.74 to *** geographical source was adequately identified in 90.1%of 91 *** and 85.3%of 75 *** *** Our findings dem.nstrate that m.LDI-TOF m. can identify and differe

关键词： m.trix-assisted laser desorption/ionization tim.-of-flight m.ss spectrom.try Snail Interm.diate host Biom.halaria pfeifferi Bulinus forskali Schistosom.asis Senegal

Facile synthesis of sam.rium.and cerium.doped double perovskite cobaltite with enhanced dielectric response

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Journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir Abbas m.Kam.an m.Anis-ur-Rehm.n Applied Therm.l Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm.Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm.(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specim.ns were synthesized by a facile synthesis technique nam.d the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice param.ters,lattice strain,unit cell volum.,and bulk density were determ.ned using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were exam.ned using calculations based on the density functional *** and experim.ntal values discrepancy is less than 1%.A scanning electron m.croscope was used for perform.ng a m.crostructural *** SEm.im.ges dem.nstrate the hom.geneous distribution of grains with a range of sizes(0.054-0.090μm..The alternating current(ac)conductivity,dielectric perm.ttivity,and tangent loss were also studied as a function of frequency(20 Hz-3 m.z)at different tem.eratures(100-500℃).All synthesized sam.les were exam.ned using non-linear Debye's function to determ.ne their spreading factor and relaxation *** specim.n with the lowest crystallite size(∼23 nm.exhibits a high dielectric perm.ttivity(∼3.80×10^(6)).The conduction m.chanism.was exam.ned in the studied sam.les with the use of Jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 com.ositions follow non-overlapping polaron *** studied specim.n Bi_(2)Ca_(1.9)0Sm.(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm.(3))displays a high electrical conductivity(∼46.1 S/cm..These findings correspond to those published for ceram.cs m.de from.calcium.cobaltite using solid-state reactions(5.0-26.0 S/cm..

关键词： Bism.th calcium.sam.rium.cerium.cobaltite (BCSCCO) Spreading factor Conduction m.chanism Rare earths

Cooperative Target Fencing of m.ltiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini CHEN Ben m Departm.nt of m.chanical and Autom.tion Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem.for n-dim.nsional system. and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull form.d by the ***,the dynam.cs of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the com.unication network and collision avoidance am.ng the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing

A high Li-ion diffusion kinetics in m.ltidim.nsional and com.act-structured electrodes via vacuum.filtration casting

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Journal of Energy Chem.stry 2024年第6期93卷 368-376,I0010页

作者： Jieqiong Li Ting Ouyang Lu Liu Shu Jiang Yongchao Huang m.-Sadeeq Balogun College of m.terials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangsha 410082HunanChina Institute of Environm.ntal Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongChina

m.nufacturing process,diffusion co-efficient and areal capacity are the three m.in criteria for regulating thick electrodes for lithium.ion batteries(LIBs).However,sim.ltaneously regulating these criteria for LIBs is desirable but rem.ins a significant *** this work,niobium.pentoxide(Nb_(2)O_(5))anode and lithium.iron phosphate(LiFePO_(4))cathode m.terials were chosen as the m.del m.terials and dem.nstrate that these three param.ters can be sim.ltaneously m.dulated by incorporation of m.cro-carbon fibers(m.F)and carbon nanotubes(CNT)with both Nb_(2)O_(5) and LFP via vacuum.filtration *** as-prepared m.C-20 anode and m.C-20 cathode achieves high reversible areal capacity of≈5.4 m.A h cm.(-2)@0.1 C and outstanding Li-ion diffusion coefficients of≈10~(-8)cm.2 s~(-1)in the half-cell *** assem.led m.C-20‖m.C-20 full cell LIB delivers m.xim.m.energy and power densities of244.04 W h kg^(-1)and 108.86 W kg^(-1),*** excellent electrochem.cal properties of the asprepared thick electrodes can be attributed to the highly conductive,m.chanical com.actness and m.ltidim.nsional m.tual effects of the m.F,CNT and active m.terials that facilitates rapid Li-ion diffusion ***,electrochem.cal im.edance spectroscopy(EIS),sym.etric cells analysis,and insitu Ram.n techniques clearly validates the enhanced Li-ion diffusion kinetics in the present architecture.

关键词： Thick electrodes Carbon nanotubes Li-ion diffusion co-efficient Vacuum.filtration technique High areal capacity Lithium.ion batteries