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Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats

World Journal of Gastroenterology 2013年第34期19卷 5633-5644页

作者： Salim.S Al-Rejaie Hatem.m.Abuohash.sh.m.her m.Al-Enazi Abdullah H Al-Assaf m.hir Y Parm.r m.ham.ed m.Ahm.d Departm.nt of Pharm.cology andToxicology College of PharmacyKing Saud University Departm.nt of m.dical Laboratory Sciences College of Applied Medical SciencesSalman bin Abdulaziz University Departm.nt of Science and Nutrition College of Food and Agricultural SciencesKing Saud University

AIm.To evaluate the am.liorative effect of naringenin(NG)during ulcerative colitis(UC)in ***:Rats were treated with three different doses(25,50 and 100 m./kg per day)of NG and a single dose of m.salazine(m.S,300 m./kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal adm.nistration,anim.ls were scarified and the colonic tissues were *** m.cus content was estim.ted using Alcian blue dye binding *** colon tissues,levels of total glutathione sulphadryls(T-Gsh.,non-protein sulphadryls(NP-sh.and thiobarbituric acid reactive substances(TBARS)were *** activities of the antioxidant enzym.s,catalase(CAT)and superoxide dism.tase(SOD)were *** of nucleic acids(DNA and RNA)and total protein were also estim.ted in colon *** levels of tum.r necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were *** cross section of colitis tissue the histopathological changes were ***:Colonic m.cus content was decreased in AA com.ared to controls(587.09±65.59 m./kg vs941.78±68.41 m./kg,Pm.nistration m.rkedly reduced T-Gsh.5.25±0.37 nm.l/L vs 3.04±0.24 nm.l/L,Psh.3.16±0.04 nm.l/L vs 2.16±0.30 nm.l/L,Pm. vs 3.04±0.2 U/m.,Pm. vs 1.77±0.18 U/m.,Pm.l/L vs 59.90±16.34 nm.l/L,Pm. vs 134.24±4.77 pg/m.,Pm. vs 422.19±31.47 pg/m.,Pm. vs 638.58±115.9 pg/m.,Pm. vs 541.74±58.34 pg/m.,Pm.ol/g vs 101.90±10.73 m.ol/g,Pm.ared controls *** supplem.ntation,significantly and dose dependently increased the colonic m.cus *** elevated TBARS levels were significantly decreased(39.35±5.86nm.l/L,P<0

关键词： Naringenin Ulcerative colitis Inflam.atory bowel disease Oxidative stress

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老屋变新家

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2019年

作者： sh.化家庭编辑部

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A Com.arison between the m.chanical Behaviour of Steel Wires and Ultra High m.lecular Weight Poly Ethylene Cables for Sternum.Closure

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m.terials Sciences and Applications 2011年第10期2卷 1367-1374页

作者： Roelof m.rissen m.scha Nelis m.ldred Janssens m.chelle D. m. E. m.eks Jos G. m.essen 不详

Sternum.closure after open heart surgery is typically done with steel wires. Final approxim.tion of sternal parts and connection is achieved by twisting the ends of the wire and bending the twisted assem.ly towards the sternum.in order to m.nim.ze outward protrusion. Though this routine procedure is highly effective, som. failures do occur, e.g. due to wire fracture. Fatigue fracture of the wires, e.g. due to coughing im.lies a failure risk. An alternative developm.nt is to m.ke cables from.gel spun Ultra High m.lecular Weight Poly Ethylene (UHm.PE) fibres, such fibres are extrem.ly strong, yet flexible, and if m.de as a very pure grade, they are highly bio com.atible. The optim.l connection technique will be different from.that of steel. Connection will rather be with knotting than twisting. A new sternum.closure and fixation technique has been developed for the sternum. Additionally, a testing technique was developed, for a connection of sim.lated sternum.parts, using different m.terials according to their respective optim.l connection m.thod and subsequently testing the m.chanical properties of the connection. Substantial differences were observed. The m.chanical behaviour of twisted steel wire connection sh.wed m.re scatter than the knotted UHm.PE cables and som. initial slack was som.tim.s present in the twisted cables. The m.xim.m.attainable force in the steel wires was determ.ned by “untwisting” due to the external load. The m.xim.m.force in the UHm.PE cables was determ.ned by the knot strength, either slipping for sm.ll knots, or breaking of the cables at the knots for slip-im.roved knots. The m.xim.m.force on the knotted UHm.PE cables was substantially larger than the m.xim.m.force on the twisted steel wires. Fatigue tests were perform.d on both the steel solution and the UHm.PE cables solution. The perform.nce was about sim.lar, although the sim.lated sternum.opening was sm.ller for the UHm.PE cables at higher load levels. Sum.arizing, the UHm.PE cables sh

关键词： Heart Surgery Load Displacem.nt Fracture Deform.tion Twisting Knotting Slip Fatigue

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2019年

作者： sh.化家庭编辑部

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补充蛋氨酸锌对荷斯坦奶牛乳中体细胞数和乳房炎的影响

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饲料与畜牧（新饲料） 2014年第5期 52-55页

作者： Gaafar H.m.A. m.I.Basiuoni m.F.E.Ali A.A.sh.tta A.sh.E.sh.m.s 吉隆达集团技术中心吉隆达集团技术中心

该研究选取240头不同泌乳阶段、1～8胎次的荷斯坦奶牛，探讨影响牛奶中体细胞数以及产奶量和乳成分的某些因素。同时，12头健康奶牛、15头亚临床乳房炎奶牛以及15头临床乳房炎奶牛分别分为3组，第1组不添加蛋氨酸锌，第2、5组分别添加... 详细信息

该研究选取240头不同泌乳阶段、1～8胎次的荷斯坦奶牛，探讨影响牛奶中体细胞数以及产奶量和乳成分的某些因素。同时，12头健康奶牛、15头亚临床乳房炎奶牛以及15头临床乳房炎奶牛分别分为3组，第1组不添加蛋氨酸锌，第2、5组分别添加蛋氨酸锌5g／d·头和10g／d·头。亚临床和临床性乳房炎奶牛乳房内注射抗生素（100m.），直到完全康复。研究结果显示，冬季乳中体细胞数最高（P〈0．05），接着是夏季，最低的是秋季。体细胞数的变化是随着泌乳开始产奶量上升到高峰期的过程中呈现下降趋势，之后显著升高（P〈0．05），并且随着泌乳期的增加也在升高。正常奶牛、亚临床乳房炎奶牛和临床乳房炎奶牛的比例分别为77．71％、15．82％以及6．46％。产奶量和乳成分以及产奶收入都随着体细胞数的增加而显著降低（P〈0．05）。补充蛋氨酸锌导致乳中体细胞数显著下降（P〈0．05）。亚临床和临床乳房炎补充蛋氨酸锌显著降低了乳中体细胞数、导电性、康复时间以及与未添加组奶牛相比消耗的费用（P〈0．05）。

关键词：荷斯坦奶牛蛋氨酸锌体细胞数乳房炎

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Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from.Feronia lim.onia Linn leaf

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Asian Pacific Journal of Tropical Biom.dicine 2011年第6期1卷 443-447页

作者： m.hendra Jain Rakhee Kapadia Ravirajsinh N Jadeja m.naka C Thounaojam.Ranjitsinh V Devkar sh.m.sh.a Herbal Drug Technology Laboratory Pharmacy DepartmentFaculty of Technology and EngineeringThe M.S.University of Baroda Novel Drug Delivery System.Laboratory Pharmacy DepartmentFaculty of Technology and EngineeringThe M.S.University of Baroda Division of Phytothrapeutics and m.tabolic Endocrinology Department of ZoologyThe M.S.University of Baroda

Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated com.ound from.the leaves of Feronia lim.nia(***).m.thods:Qualitative phytochem.cal analysis of extracts,fractions or com.ound was perform.d by m.ans of thin layer chrom.tography and spectroscopic ***%purity of com.ound was m.asured by analytical ***,fractions or com.ound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/m.).Based on the inhibitory concentration(IC_(50)) obtained from.the cell viability assay,graded concentrations of extracts,fractions or isolated com.ound were assessed(10,20,50,100,200 μg/m.) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by m.nitoring activity levels of serum.glutam.tic pyruvatic transam.nase(SGPT) and serum.glutam.c oxaloacetic transam.nase(SGOT).Results:Results indicated that the m.thanol extract of *** was non-toxic and hepatoprotective in nature as com.ared with the petroleum.ether *** acetone fraction of m.thanolic extract also sh.wed sim.lar properties but the subsequent two fractions were ***,the pure com.ound isolated from.the penultim.te fraction of m.thanolic extract was non-toxic and hepatoprotective in *** investigations(SCOT,SCPT) further corroborated these cytological ***:It can be concluded from.this study that *** m.thanol extract,som. fractions and pure isolated com.ound herein exhibit hepatoprotective ***,cytotoxicity recorded in the penultim.te fraction and investigation of structural details of pure com.ound warrants further study.

关键词： Feronia lim.nia leaf HepG2 Cytotoxicity Hepatoprotective Phytochem.cal analysis TLC HPLC Hepatoprotective activity SGPT SGOT Isolated com.ound Spectroscopic assay

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冲积谷sh.地震响应的快速计算

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世界地震译丛 1994年第3期25卷 53-57页

作者： R.Paolucci m.m.Suarez F.J.Sanchez-Sesm.

本文提出一种能快速计算均匀冲积谷地中SⅡ波传播问题的方法,该方法先把谷地分成简单单元的集合,求出每个单元的标量格林函数。合并这组单元以分析整个谷地的情况。能精确计算刚性基底的公式扩展到了考虑可变形边界和任意入射角的情况... 详细信息

本文提出一种能快速计算均匀冲积谷地中SⅡ波传播问题的方法,该方法先把谷地分成简单单元的集合,求出每个单元的标量格林函数。合并这组单元以分析整个谷地的情况。能精确计算刚性基底的公式扩展到了考虑可变形边界和任意入射角的情况。对于三角形谷地,此种既用解析解又用数值解的方法成功地通过了检验,表明该方法能节约大量的计算时间。

关键词：冲积谷 sh. 地震响应计算法

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聚氨酯泡沫塑料薄层直接分光光度法测定痕量汞(Ⅱ)和苯基汞

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环境科学与管理 1991年第1期23卷 71-73页

作者： m.N.Abbas N.B.EL-Assy sh.Abdel-m.niem.邹运香

本文介绍了用聚氨酯泡沫塑料(PUF)薄层分光光度法测定 ppb 浓度范围内的汞和苯基汞。汞和苯基汞被吸收在担载二苯基硫卡巴腙(双硫腙)的泡沫塑料平行六面体上,这使有色物质富集了约140倍,因而使其吸光度值大大提高。本法可以得到满意的结... 详细信息

本文介绍了用聚氨酯泡沫塑料(PUF)薄层分光光度法测定 ppb 浓度范围内的汞和苯基汞。汞和苯基汞被吸收在担载二苯基硫卡巴腙(双硫腙)的泡沫塑料平行六面体上,这使有色物质富集了约140倍,因而使其吸光度值大大提高。本法可以得到满意的结果;当试样体积为100m.时,汞和苯基汞的检测极限分别为每升5μg 和10μg。从自来水中,汞和苯基汞的回收率分别为100%和96.6%。

关键词：分光光度法测定痕量汞聚氨酯泡沫塑料吸光度有色物质预富集双硫腙检测极限天然水工作曲线

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Reducing problem.of m.ltiplication operators on Bergm.n space

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Chinese Science Bulletin 1997年第1期42卷 83-83页

作者： Yu, DH Sun, sh Departm.nt of m.them.tics Sichuan University Chengdu China

THE L_a^2(D) refers to Bergm.n space on D, where D is the unit disk on the com.lex plane. Using the super-isom.tric dilation technique, we obtain the following results. Proposition 1. The m.ltiplication operator m.φ on Bergm.n space L_a^2 (D) is unitarily equivalent to the com.ression of the direct sum.of 2N-1 copies of Bergm.n sh.ft, where φ is a Blaschke product of order N (<∞).

关键词： Reducing problem.of m.ltiplication operators on Bergm.n space

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Supplem.ntation of m.lk form.la with galacto-oligosaccharides im.roves intestinal m.cro-flora and ferm.ntation in term.infants

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Chinese m.dical Journal 2004年第6期117卷 927-931页

作者：贲晓明周晓玉赵卫华喻文亮潘伟张伟利吴圣楣 Christien m. Van Beusekom.Anne Schaafsm. Departm.nt of Newborn Infants Nanjing Children's HospitalNanjing University Departm.nt of Pediatrics Affiliated Hospital of South East University Paediatric Research Institute Xinhua HospitalShanghai Second Medical University Friesland Research Institute

Background Oligosaccharides in hum.n m.lk m.y protect infants by im.roving the intestinal m.cro-flora and ferm.ntation. This study was to investigate effects of infant form.la m.lk consisting of galacto-oligosaccharide (GOS) on intestinal m.crobial populations and the ferm.ntation characteristics in term.infants in com.arison with that of hum.n m.lk. m.thods The test form.la (Frisolac H,Friesland,Netherland) was supplem.nted with GOS at a concentration of 0.24 g/dl. Hum.n m.lk and another form.la without oligosaccharides (Frisolac H,Friesland,Netherland) were used as positive and negative control respectively. Growth,stool characteristics,and side effects of the recruited infants were recorded after 3 and 6 m.nths’ follow-up,and the fecal species were collected for the analysis of intestinal m.cro-flora,sh.rt chain fatty acid (SCFA) and *** At the end of 3- and 6-m.nth feeding period,intestinal Bifidobacteria and Lactobacilli were significantly increased in infants fed with GOS supplem.nted form.la and hum.n m.lk when com.ared with infants fed with negative control form.la; however,there was no statistically significant difference between GOS supplem.nted form.la and hum.n m.lk groups. Stool characteristics were influenced by the supplem.nt and m.in fecal SCFA (acetic),and stool frequency were significantly increased in infants fed with GOS supplem.nted form.la and hum.n m.lk,while the fecal pH was significantly decreased as com.ared with that of negative control ( P m.ntation had no influence on incidence of side effects (including crying,regurgitation and vom.ting). Conclusions Supplem.nting infant form.la with GOS at a concentration of 0.24 g/dl stim.lates the growth of Bifidobacteria and Lactobacilli in the intestine and stool characteristics are sim.lar to in term.infants fed with hum.n m.lk.

关键词： galacto-oligosaccharides·intestinal m.cro-flora·ferm.ntation·infant

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