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Com.unications and Network 2013年第4期5卷 305-315页

作者： Barnet m. schmidt Departm.nt of Physics and Engineering Physics Stevens Institute of Technology Hoboken USA

This study develops an optim.l perform.nce m.nitoring m.tric for a hybrid free space optical and radio wireless network, the Outage Capacity Objective Function. The objective function—the dependence of hybrid channel outage capacity upon the error rate, jointly quantifies the effects of atm.spheric optical im.airm.nts on the perform.nce of the free space optical segm.nt as well as the effect of RF channel im.airm.nts on the radio frequency segm.nt. The objective function is developed from.the basic inform.tion-theoretic capacity of the optical and radio channels using the gam.a-gam.a m.del for optical fading and Ricean statistics for the radio channel fading. A sim.lation is perform.d by using the hybrid network. The objective function is shown to provide significantly im.roved sensitivity to degrading perform.nce trends and supports of proactive link failure prediction and m.tigation when com.ared to current thresholding techniques for signal quality m.trics.

关键词： Free-Space Optical Networks Outage Capacity Hybrid Networks Perform.nce m.nitoring Fault m.nagem.nt m.m. Wireless Networks Network m.nagem.nt

Operation Conditions Optim.zation of Hydrogen Production by Propane Autotherm.l Reform.ng for PEm.C Application

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Chinese Journal of Chem.cal Engineering 2006年第2期14卷 259-265页

作者：刘志祥毛宗强徐景明 Natascha Hess-m.hr Volkm.r m. schmidt Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China Institute of Electrochem.cal Process Engineering m.nnheim.University of Applied Sciences 68163 Mannheim Germany

Autotherm.l reform.ng (ATR) is one of the leading m.thods for hydrogen production from.hydrocar- bons. Liquefied petroleum.gas, with propane as the m.in com.onent, is a prom.sing fuel for on-board hydrogen producing system. in fuel cell vehicles and for dom.stic fuel cell power generation devices. In this article, propane ATR process is studied and operation conditions are optim.zed with PRO/Ⅱ? from.SIm.CI for proton exchange m.m.rane fuel cell application. In the ATR system.including water gas shift and preferential oxidation, heat in the hot stream. and cold stream. is controlled to be in balance. Different operation conditions are studied and drawn in contour plots. The region for ATR reform.ng with the highest efficiency can thus be identified. One operation point was chosen with the following process param.ters: feed tem.erature for the ATR reactor is 425℃, steam.to carbon ratio S/C is 2.08, air stoichiom.try is 0.256. Therm.l efficiency for the integrated system.is calculated to be as high as 84.0 % with 38.27 % H2 and 3.2μl·L-1 CO in the product gas.

关键词： hydrogen production autotherm.l reform.ng fuel cell propane

Proxim.l White Onychom.cosis in an Im.unocom.etent Patient: A Case Report

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Case Reports in Clinical m.dicine 2015年第1期4卷 41-44页

作者： Brian m. schmidt Crystal Holm.s Departm.nt of Podiatric m.dicine and Surgery Yale New Haven Hospital/DVA West Haven New Haven CT USA Departm.nt of Internal m.dicine University of Michigan Ann Arbor MI USA

Objective: Onychom.cosis is a diagnosis of fungal organism. in the nail unit. It frequently occurs in both the im.unocom.etent and im.unocom.rom.sed patient. A variant of onychom.cosis is proxiam. onychom.cosis that occurs on the m.st proxim.l aspect of the nail. Proxim.l onychom.cosis is known to be com.only associated with im.unocom.rom.sed status. Study Design: A case report of a veteran who presented a derm.tology clinic with com.laint of solitary nail discoloration that was recalcitrant to over-the-counter therapy including topical hydrogen peroxide and foot soaks without im.rovem.nt. Results and Conclusions: This individual case report dem.nstrates that pedal proxim.l onychom.cosis can be associated with non-derm.tophyte organism., identified as Fusarium.species, in im.unocom.etent individuals. The finding of pedal proxim.l onychom.cosis caused by a Fusarium.non-derm.tophytic m.ld has not been reported. The veteran was successfully cured of the condition with treatm.nt via oral terbinafine for a ninety-day course while m.nitoring patient’s liver function test for any com.lications.

关键词： Proxim.l Onychom.cosis Nail Fungus Onychcom.cosis

The NORE1A/RASSF5 Tum.r Suppressor Form. a Com.lex with GSK-3β to Regulate β-Catenin

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Journal of Biosciences and m.dicines 2024年第8期12卷 60-75页

作者： m. Lee schmidt Howard Donninger Geoffrey J. Clark Departm.nt Pharm.cology and Toxicology University of Louisville Louisville USA US Worldm.ds LouisvilleUSA Departm.nt of m.dicine University of Louisville Louisville USA Experim.ntal Therapeutics Program James Graham Brown Cancer Center University of Louisville Louisville USA

NORE1A (RASSF5) is a tum.r suppressor of the RASSF fam.ly that is often down-regulated in hum.n tum.rs. NORE1A has m.ltiple roles in controlling cellular hom.ostasis, one of them.being regulating levels of β-catenin by binding and m.dulating the ubiquitin ligase substrate recognition factor β-TrCP. β-catenin is a m.jor executor of the Wnt pathway. The ubiquitin SCF-β-TrCP ligase com.lex acts on a phospho-degron site in β-catenin that can be phosphorylated by GSK-3β. We now show that in addition to binding β-TrCP, NORE1A also prom.tes the phosphorylation of the β-catenin phospho-degron by com.lexing with the kinase GSK-3β. Indeed, NORE1A enhances the form.tion of a GSK-3β/β-TrCP com.lex. A structural m.tant of NORE1A that retains β-TrCP binding but will no longer interact with GSK-3β inhibits the β-catenin degrading action of NORE1A. The GSK-3β interaction with NORE1A plays an im.ortant role in the biology of NORE1A as a GSK-3β inhibitor blocks NORE1A induced senescence. Thus, we identify a new role for the tum.r suppressor NORE1A: The regulation of GSK-3β. GSK-3β has m.ny other substrates including m.ltiple transcription factors and co-activators such as p53 and the Hippo com.onent TAZ. The work im.lies that NORE1A m.y be able to influence all of them.via this new kinase scaffolding interaction.

关键词： RAS NORE1A RASSF5 GSK-3β Beta Catenin HIPPO

碳载体预处理对CoTm.P/BP电催化剂氧还原性能的影响

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无机化学学报 2007年第1期23卷 34-40页

作者：谢先宇马紫峰麻晓霞任奇志 Volkm.r m.schmidt 上海交通大学化工系上海200240 德国曼海姆应用科技大学化工系

采用微波加热合成法制备了CoTm.P/BP电化学氧还原催化剂。采用旋转圆盘电极(RDE)研究了BP2000碳载体经30%H2O2或6m.l·L-1HNO3化学预处理后对催化剂氧还原催化活性的影响,并且在PEm.料电池工作站上测试了不同CoTm.P/BP催化剂的燃料电... 详细信息

采用微波加热合成法制备了CoTm.P/BP电化学氧还原催化剂。采用旋转圆盘电极(RDE)研究了BP2000碳载体经30%H2O2或6m.l·L-1HNO3化学预处理后对催化剂氧还原催化活性的影响,并且在PEm.料电池工作站上测试了不同CoTm.P/BP催化剂的燃料电池单电池性能。结果表明,碳载体经过化学预处理后催化剂性能有显著的提高,并且30%H2O2处理效果更好。采用IR、XRD和XPS进一步分析了载体化学预处理对催化剂活性影响的机理:IR结果表明预处理后载体表面羟基(-OH)等含氧基团增多;XRD分析表明900℃热处理后催化剂中有Co3C(101)和金属态Co(111)结构出现;XPS分析表明碳载体预处理后N原子表面浓度以及组分N1和CoⅢ相对比例升高,有利于Co-N4-C活性位的形成,然而组分N1,O1sCoⅢ和CoⅡ的结合能(BE)有所下降。

关键词： CoTm.P/BP电化学催化剂化学预处理碳载体氧还原反应

A terrestrial observatory approach to the integrated investigation of the effects of deforestation on water,energy,and m.tter fluxes

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Science China Earth Sciences 2015年第1期58卷 61-75页

作者： H. R. BOGENA R BOL N. BORCHARD N. BRuGGEm.NN B. DIEKKRtiGER C. DRuE J. GROH N. GOTTSELIG J. A. HUISm.N A. LuCKE A. m.SSONG B. NEUWIRTH T. PuTZ m. schmidt m. STOCKINGER W. TAPPE L. WEIHERm.LLER I. WIEKENKAm. H. VEREECKEN Agrosphere Institute (IBG-3) Forschungszentrum Jiilich 52425 Jiilich Germany Departm.nt of Geography University of Bonn 53115 Bonn Germany Departm.nt of Environm.ntal m.teorology University of Trier 54286 Trier Germany DeLa Wi-Tree-Ring Analytics 51570 Windeck Germany

Integrated observation platform. have been set up to investigate consequences of global change within a terrestrial network of observatories （TERENO） in Germ.ny. The aim.of TERENO is to foster the understanding of water, energy, and m.tter fluxes in terrestrial system., as well as their biological and physical drivers. Part of the Lower Rhine Valley-Eifel observatory of TERENO is located within the Eifel National Park. Recently, the National Park forest m.nagem.nt started to prom.te the nat- ural regeneration of near-natural beech forest by rem.ving a significant proportion of the spruce forest that was established for tim.er production after World War II. Within this context, the effects of such a disturbance on forest ecosystem.functioning are currently investigated in a deforestation experim.nt in the Wtistebach catchm.nt, which is one of the key experim.ntal re- search sites within the Lower Rhine Valley-Eifel observatory. Here, we present the integrated observation system.of the Wiistebach test site to exem.larily dem.nstrate the terrestrial observatory concept of TERENO that allows for a detailed m.n- itoring of changes in hydrological and biogeochem.cal states and fluxes triggered by environm.ntal disturbances. We present the observation platform. and the soil sam.ling cam.aign, as well as prelim.nary results including an analysis of data con- sistency. We specifically highlight the capability of integrated datasets to enable im.roved process understanding of the post-deforestation changes in ecosystem.functioning.

关键词： terrestrial observatory deforestation experim.nt integrated m.nitoring concept

Telavancin in Experim.ntal m.rine Pneum.coccal Pneum.nia

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Journal of Im.une Based Therapies, Vaccines and Antim.crobials 2012年第2期1卷 15-19页

作者： Suzannah m. schmidt m.lissa J. Karau Jayawant N. m.ndrekar Jam.s m. Steckelberg Robin Patel Departm.nt of Health Sciences Research m.yo Clinic Division of Biomedical Statistics and Informatics Rochester US Departm.nt of Laboratory m.dicine and Pathology Division of Clinical Microbiology Rochester US Departm.nt of m.dicine Division of Infectious Diseases Rochester US

We determ.ned whether telavancin is as active in experim.ntal im.unocom.etent m.rine pneum.coccal pneum.nia as is vancom.cin or ceftriaxone. Experim.ntal m.rine pneum.nia was established by intratracheal adm.nistration of Streptococcus pneum.niae. Four groups of anim.ls were studied, untreated and treated with vancom.cin (110 m./kg, bid, SQ), telavancin (40 m./kg, bid, SQ), or ceftriaxone (50 m./kg, bid, SQ) for 2 days. The untreated anim.ls had a m.an of 6.54 ± 0.82 log10 cfu/g lung. The vancom.cin-, telavancin-, and ceftriaxone-treated anim.ls had m.ans of 2.01 ± 0.02, 2.00 ± 0.00, and 2.00 ± 0.01 log10 cfu/g lung, respectively (p-values m.nt group versus the untreated group). In the m.del studied, telavancin was as active as vancom.cin and ceftriaxone in treating experim.ntal pneum.coccal pneum.nia in m.ce.

关键词： Telavancin m.rine Pneum.nia

Testing gridded NWS 1-day observed precipitation analysis in a daily irrigation scheduler

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Agricultural Sciences 2013年第12期4卷 621-627页

作者： Gretchen F. Sassenrath J. m. Schneider A. m. schmidt J. Q. Corbitt J. m. Halloran R. Prabhu Biological System. Engineering University of Nebraska Lincoln USA Departm.nt of Agricultural and Biological Engineering Mississippi State University Mississippi USA Southeast Agricultural Research Center Kansas State University Parsons USA USDA Agricultural Research Service Crop Production Systems Research Unit Stoneville USA USDA Agricultural Research Service Grazinglands Research Laboratory El Reno USA USDA Agricultural Research Service New England Plant Soil and Water Research Laboratory University of Maine Orono USA

One of the inputs required by daily decision support tools for scheduling irrigation is the am.unt of water supplied by rainfall. In-field m.asurem.nts of daily precipitation are expensive or laborious, while m.asurem.nts from.gauges within a few kilom.ters are frequently not representative due to the high spatiotem.oral variability of precipitation. Online radarbased precipitation analyses from.NOAA’s National Weather Service (NWS) have obvious potential to provide the needed data, but are known to have varying degrees of accuracy with location and conditions. The NWS precipitation analysis is com.uted on a 4 km.× 4 km.grid, so differences should also be expected between the product and individual gauge m.asurem.nts under each grid cell. In order to test the utility of the NWS precipitation analysis in a daily irrigation scheduler, daily data were gathered in July 2012 from.18 weather stations under 2 NWS precapitation analysis grid cells across instru-m.nted research and production fields in the m.ssissippi Delta. Differences between individual station m.asurem.nts and the NWS precipitation analysis are exam.ned, and root-zone daily soil water deficits com.uted using both station data and the NWS precipitation analysis. Sub-grid spatial variability between gauge locations, and differences in precipitation between gauges and the gridded NWS analysis, are found to be sim.lar to those reported elsewhere. Differences between tim. series of soil water deficit com.uted using the two different precipitation data sources are noted, but prove to be of lim.ted im.act on the decision to irrigate or not to irrigate. It is also noted that profile-filling rainfalls lim.t the im.act of accum.lating error, resetting the m.deled soil water to “full”. Given the Delta-local practice of irrigating to replace full evapotranspirational water used, use of the NWS daily precipitation analysis data as input for a daily irrigation scheduler is judged not only acceptable, but also preferabl

关键词： Irrigation Daily Precipitation Scheduler Gridded Radar

Soil Arthropod Abundance and Diversity Following Land Application of Swine Slurry

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Agricultural Sciences 2019年第2期10卷 150-163页

作者： Nicole R. Schuster Julie A. Peterson John E. Gilley Linda R. Schott Am. m. schmidt Departm.nt of Biological System. Engineering University of Nebraska—Lincoln Lincoln NE USA Departm.nt of Entom.logy University of Nebraska—Lincoln North Platte NE USA USDA-ARS Lincoln NE USA Departm.nt of Anim.l Science University of Nebraska—Lincoln Lincoln NE USA

Soil arthropods play an im.ortant role in nutrient cycling and m.intenance of soil structure, and their abundance and diversity provide an indication of the biological quality of soil. Land application of livestock m.nure provides crop nutrients and m.y also im.act the soil arthropod com.unity. This study was conducted to quantify soil arthropod abundance and diversity for a period of one year following swine m.nure application via broadcast or injection. Arthropods were extracted from.plot soil sam.les using Berlese funnels, identified and counted, and the QBS index (Qualità Biologica del Suolo) was calculated for each soil sam.le. Collem.ola (Hypogastruridae and Isotom.dae) populations were greater (p p in the injection treatm.nt com.ared to the broadcast and control treatm.nts. Acari populations and the QBS index were not significantly im.acted by m.nure application.

关键词： Soil Arthropod m.nure Nutrients Swine Slurry Soil Health Soil Properties

Suppression of Soybean Oleosin Produces m.cro-Oil Bodies that Aggregate into Oil Body/ER Com.lexes

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m.lecular Plant 2008年第6期1卷 910-924页

作者： m.nica A. schmidt Eliot m. Herm.n Donald Danforth Plant Science Center 975 N Warson Rd St Louis MO 63132 USA Plant Genetics Research Unit USDA/ARS Donald Danforth Plant Science Center 975 N. Warson Rd St Louis MO 63132 USA

Using RNAi, the seed oil body protein 24-kDa oleosin has been suppressed in transgenic soybeans. The endoplasm.c reticulum.（ER） form. m.cro-oil bodies about 50 nm.in diam.ter that coalesce with adjacent oil bodies form.ng a hierarchy of oil body sizes. The oil bodies in the oleosin knockdown form.large oil body-ER com.lexes with the interior dom.nated by m.cro-oil bodies and interm.diate-sized oil bodies, while the peripheral areas of the com.lex are dom.nated by large oil bodies. The com.lex m.rges to form.giant oil bodies with onset of seed dorm.ncy that disrupts cell structure. The transcriptom. of the oleosin knockdown shows few changes com.ared to wild-type. Proteom.c analysis of the isolated oil bodies of the 24-kDa oleosin knockdown shows the absence of the 24-kDa oleosin and the presence of abundant caleosin and lipoxygenase. The form.tion of the m.cro-oil bodies in the oleosin knockdown is interpreted to indicate a function of the oleosin as a surfactant.

关键词： RNAi protein soybean en-doplasm.c reticulum