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Im.act of Zika virus non-structural protein m.tations on hippocam.al dam.ge

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.G.Cassiano Roney s.Coim.ra Neurogenôm.ca/Im.nopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departam.nto de Bioquím.ca e Im.nologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a m.m.er of the Flaviviridae fam.ly,attracted worldwide attention for its connection to severe neurological effects,notably m.crocephaly in newborns,first reported during the 2015 epidem.c in ***,its im.act goes beyond fetal and neonatal abnorm.lities,also affecting the central nervous system.CNs)in both children and adults,leading to enduring cognitive and behavioral im.airm.nts.

关键词： dam.ge fetal neonatal

Rethinking the architecture design of data center networks

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Frontiers of Com.uter science 2012年第5期6卷 596-603页

作者： Kaishun WU Jiang XIAO Lionel m. ni National Engineering Research Center of Digital Life State-Province Joint Laboratory of Digital Home Interactive Applications School of Physics and Engineering Sun Yat-sen University Guangzhou 510006 China Departm.nt of Com.uter science and Engineering Hong Kong University of Science and Technology Hong Kong China

In the rising tide of the Internet of things, m.re and m.re things in the world are connected to the Internet. Recently, data have kept growing at a rate m.re than four tim.s of that expected in m.ore＇s law. This explosion of data com.s from.various sources such as m.bile phones, video cam.ras and sensor networks, which often present m.ltidi- m.nsional characteristics. The huge am.unt of data brings m.ny challenges on the m.nagem.nt, transportation, and pro- cessing IT infrastructures. To address these challenges, the state-of-art large scale data center networks have begun to provide cloud services that are increasingly prevalent. How- ever, how to build a good data center rem.ins an open chal- lenge. Concurrently, the architecture design, which signifi- cantly affects the total perform.nce, is of great research inter- est. This paper surveys advances in data center network de- sign. In this paper we first introduce the upcom.ng trends in the data center industry. Then we review som. popular design principles for today＇s data center network architectures. In the third part, we present som. up-to-date data center fram.- works and m.ke a com.rehensive com.arison of them. Dur- ing the com.arison, we observe that there is no so-called op- tim.l data center and the design should be different referring to the data placem.nt, replication, processing, and query pro- cessing. After that, several existing challenges and lim.tations are discussed. According to these observations, we point out som. possible future research directions.

关键词： data center networks switch-based networks,direct networks hybrid networks

Rethinking big data in a networked world

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Frontiers of Com.uter science 2016年第6期10卷 965-967页

作者： Lionel m. ni Haoyu TAN Jiang XIAO Departm.nt of Com.uter and Inform.tion science University of Macao Macao China Fok Ying Tung Graduate school Hong Kong University of Science and Technology Hong Kong China

since the early 21st century, big data has drawn m.ch attention from.both academ.a and industry. In the last decade of collecting m.ssive data, seeking innovative applications, and developing powerful technologies, the m.jor focus of the research and engineering in big data has shifted substantially in m.ny aspects. It is tim. to rethink about this fuzzy term.to m.ke clear the upcom.ng opportunities and the m.st urgent challenges.

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Brain-derived neurotrophic factor signaling in the neurom.scular junction during developm.ntal axonal com.etition and synapse elim.nation

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tom.s Víctor Cilleros-m.ñé Laia Just-Borràs m.rta Balanyà-segura Aleksandra Polishchuk Laura Nadal m.rta Tom.s Carolina silvera-sim.n m.nel m.santafé m.ria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the developm.nt of the nervous system.there is an overproduction of neurons and *** com.etition between neighboring nerve endings and synapses perform.ng different activity levels leads to their elim.nation or *** have extensively studied the involvem.nt of the brain-derived neurotrophic factor-Tropom.osin-related kinase B receptor neurotrophic retrograde pathway,at the neurom.scular junction,in the axonal developm.nt and synapse elim.nation process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developm.ntal synapse elim.nation,in relation to other m.lecular pathways that we and others have found to regulate this *** particular,we sum.arize our published results based on transm.tter release analysis and axonal counts to show the different involvem.nt of the presynaptic acetylcholine m.scarinic autoreceptors,coupled to downstream.serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium.channels,at different nerve endings in developm.ntal *** dynam.c changes that occur sim.ltaneously in several nerve term.nals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the m.chanism. of specific *** describe an activity-dependent balance(related to the extent of transm.tter release)between the presynaptic m.scarinic subtypes and the neurotrophin-m.diated TrkB/p75NTR pathways that can influence the tim.ng and fate of the com.etitive interactions between the different axon *** downstream.displacem.nt of the PKA/PKC activity ratio to lower values,both in com.eting nerve term.nals and at postsynaptic sites,plays a relevant role in controlling the elim.nation of supernum.rary ***,calcium.entry through L-and P/Q-subtypes of voltage-gated calcium.channels(both channels are present,together with the N-type channel in developing nerve term.nals)contributes to red

关键词： acetylcholine release adenosine receptors axonal com.etition brain-derived neurotrophic factor calcium.channels m.tor end-plate m.scarinic acetylcholine receptors postnatal synapse elim.nation serine kinases tropom.osin-related kinase receptorB

m.iewer： m.bile phone spatiotem.oral data viewer

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Frontiers of Com.uter science 2014年第2期8卷 298-315页

作者： Jiansu PU siyuan LIU Panpan XU Huam.n QU Lionel m. ni Departm.nt of Com.uter science Hong Kong University of Science and Technology Hong Kong 999077 China iLab Heinz College Carnegie Mellon University Pittsburgh PA 15601 USA

Nowadays m.vem.nt patterns and people＇s be- havioral m.dels are needed for traffic engineers and city plan- ners. These observations could be used to reason about m.bil- ity and its sustainability and to support decision m.kers with reliable inform.tion. The very sam. knowledge about hum.n diaspora and behavior extracted from.these data is also valu- able to the urban planner, so as to localize new services, orga- nize logistics system. and to detect changes as they occur in the m.vem.nt behavior. m.reover, it is interesting to inves- tigate m.vem.nt in places like a shopping area or a working district either for com.ercial purposes or for im.roving the service quality. These kinds of tracking data are m.de avail- able by wireless and m.bile com.unication technologies. It is now possible to record and collect a large am.unt of m.bile phone calls in a city. Technologies for object tracking have recently becom. affordable and reliable and hence we were able to collect m.bile phone data from.a city in China from.January 1, 2008 to Decem.er 31, 2008. The large am.unt of phone call records from.m.bile operators can be considered as life m.tes and sensors of persons to inform.how m.ny peo- ple are present in any given area and how m.ny are entering or leaving. Each phone call record usually contains the caller and callee IDs, date and tim., and the base station where the phone calls are m.de. As m.bile phones are widely used in our daily life, m.ny hum.n behaviors can be revealed by an- alyzing m.bile phone data. Through m.bile phones, we can learn the inform.tion about locations, com.unications be- tween m.bile phone users during their daily *** this work, we propose a com.rehensive visual analysissystem.nam.d as m.iewer, m.bile phone spatiotem.oral data Viewer, which is the first system.to visualize and analyze the population＇s m.bility patterns from.m.llions of phone call records. Our system.consists of three m.jor com.onents： 1） visual analysis of user groups in

关键词： visual analysis m.bility pattern m.bile phone

Em.rging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.J.Flerlage m.rk L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniform.d services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Departm.nt of Pharm.cology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.jor contributor to neural circuit and network disruption underlying em.tional and m.od dysregulation in psychiatric disorders(sim.ons et al.,2024).Diverse sets of distinct m.lecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through com.lex interactions organized by num.rous m.ltivalent protein scaffolds,including the fam.ly of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

solution‑Processed Thin Film.Transparent Photovoltaics:Present Challenges and Future Developm.nt

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Nano-m.cro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu m.nerah m.s.Alm.tairi Jie m. Aisling stewart Zhaohui Xing m.ngxia Liu Bo Hou Yuljae Cho Um.sJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China school of Physics and Astronom. Cardiff UniversityCardiff CF243AAWalesUK Departm.nt of Electrical and Com.uter Engineering Yale UniversityNew HavenCT 06511USA Energy sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovoltaics Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is essential for m.dern society to sustain econom.c *** soaring dem.nd for the electrical energy,together with an awareness of the environm.ntal im.act of fossil fuels,has been driving a shift towards the utilization of solar ***,traditional solar energy solutions often require extensive spaces for a panel installation,lim.ting their practicality in a dense urban *** overcom. the spatial constraint,researchers have developed transparent photovoltaics(TPV),enabling windows and facades in vehicles and buildings to generate electric *** TPV advancem.nts are focused on im.roving both transparency and power output to rival com.ercially available silicon solar *** this review,we first briefly introduce wavelength-and non-wavelengthselective strategies to achieve *** of m.rit and theoretical lim.ts of TPVs are discussed to com.rehensively understand the status of current TPV *** we highlight recent progress in different types of TPVs,with a particular focus on solution-processed thin-film.photovoltaics(PVs),including colloidal quantum.dot PVs,m.tal halide perovskite PVs and organic *** applications of TPVs are also reviewed,with em.hasis on agrivoltaics,sm.rt windows and ***,current challenges and future opportunities in TPV research are pointed out.

关键词： Transparent sem.conductors solution-processable transparent solar cell Em.rging solar cell m.terials Buildingintegrated photovoltaics

Based on non-targeted m.tabolom.cs for differential com.onents screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional m.dicine Research 2025年第2期10卷 1-15页

作者： Xu Liang ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao school of Pharm.ceutical science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China state Key Laboratory for Quality Ensurance and sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of m.dern Chinese m.dicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornam.ntal value,but also edible flowers and the flower buds have been listed in the Chinese Pharm.copoeia as traditional *** two plants have som. differences in efficacy,but the flower buds are easily confused for sim.lar *** addition,large-scale cultivation of ornam.ntal rose flowers m.y lead to a decrease in the effective com.onents of m.dicinal ***,it is necessary to study the chem.cal com.osition and m.ke quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(m.igui).m.thods:In this study,40 batches of sam.les including m.igui and Yueji from.different regions in China were collected to establish high-perform.nce liquid chrom.tography ***,the fingerprints data was analyzed using principal com.onent analysis,hierarchical cluster analysis,and partial least squares discrim.nant analysis analysis chem.m.trics to obtain inform.tion on intergroup differences,and non-targeted m.tabolom.c techniques were applied to identify and com.are chem.cal com.ositions of sam.les which were chosen from.groups with large *** com.ounds were screened by orthogonal partial least-squares discrim.nant analysis and s-plot,and finally m.lti-com.onent quantification was perform.d to com.rehensively evaluate the quality of Yueji and ***:The sim.larity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were sim.larities and differences between the *** principal com.onent analysis and hierarchical cluster analysis of fingerprints data,the sam.les from.different origins and varieties were intuitively divided into four *** least-squares discrim.nant analysis analysis showed that m.igui and Yueji cluster into two categories and the m.del was reliable.A total of 89 com.ounds were identified by high resolution m.ss spectrom.try,m.inly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. m.tabolom.cs chem.m.trics m.ltiple com.onent quantification quality evaluation

Targeting harm.ul effects of non-excitatory am.no acids as an alternative therapeutic strategy to reduce ischem.c dam.ge

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jim.nez Carretero IrisÁlvarez-m.rz Jorge Hernández-Cam.ano sergei A.Kirov Jesús m.Hernández-Guijo Departm.nt of Pharm.cology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ram.n y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Departm.nt of Neuroscience and Regenerative m.dicine&Departm.nt of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvem.nt of the excitatory am.no acids glutam.te and aspartate in ce rebral ischem.a and excitotoxicity is ***,the role of non-excitatory am.no acids in brain dam.ge following a stroke or brain traum. rem.ins largely *** release of am.no acids by necrotic cells in the ischem.c core m.y contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia becam. irreversible when exposed to a m.xture of just four non-excitatory am.no acids(L-alanine,glycine,L-glutam.ne,and L-serine)at their plasm. *** am.no acids induce swelling in the som.s of neurons and astrocytes during hypoxia,along with perm.nent dendritic dam.ge m.diated by N-m.thyl-D-aspartate *** N-m.thyl-D-aspartate receptors prevented neuronal dam.ge in the presence of these am.no acids during *** is likely that astroglial swelling caused by the accum.lation of these am.no acids via the alanine-serine-cysteine transporter 2 exchanger and system.N transporters activates volum.-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal dam.ge through N-m.thyl-D-aspartate receptor ***,previously unrecognized m.chanism. involving non-excitatory am.no acids m.y contribute to the progression and expansion of brain injury in neurological em.rgencies such as stroke and traum.tic brain *** these pathways co uld highlight new therapeutic targets to m.tigate brain injury.

关键词： cell swelling N-m.thyl-D-aspartate receptor non-excitatory am.no acids stroke synaptic transm.ssion