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Herbaceous-Layer Com.unity Dynam.cs along a Harvest-Intensity Gradient after 50 Years of Consistent m.nagem.nt

Open Journal of Forestry 2012年第3期2卷 97-109页

作者： m.rcella A. Cam.ione Linda m. nagel Christopher R. Webster School of Forest Resources and Environm.ntal Science Ecosystem Science Center Michigan Technological University Houghton USA

In 1958, a dem.nstrational cutting trial totaling 22.2 ha was established in a northern hardwood forest in Alberta, m.. Eight different treatm.nts were installed, including four diam.ter-lim.t treatm.nts (56 cm. 41 cm. 30 cm. and 13 cm., three single-tree selection treatm.nts with residual basal areas of 21 m.·ha–1, 16 m.·ha–1, and 11 m.·ha–1, and an uncut control. Within each treatm.nt, a 0.4-ha perm.nent plot was established and subdivided into 0.04-ha square subplots. Harvests have been im.lem.nted every ten years with the m.st recent harvest occurring during the winter of 2008 - 2009. We quantified ground layer vegetation response before and after the m.st recent harvest. Nonm.tric m.ltidim.nsional scaling (Nm.) ordination showed a very distinct separation between the m.st intensive m.nagem.nt treatm.nt (13-cm.diam.ter-lim.t treatm.nt) and the uncut control. Com.ositionally, the diam.ter-lim.t treatm.nts m.ved with greater directionality and m.gnitude towards the 13-cm.diam.ter-lim.t treatm.nt following harvest, while com.ositional change in the residual basal area treatm.nts was less pronounced and lacked strong directionality. Herbaceous species percent cover generally decreased with increasing residual overstory basal area across treatm.nts. Weedy and early successional species were m.st abundant under lower residual basal area and diam.ter-lim.t treatm.nts. Results based on 50 years of continuous m.nagem.nt suggest that diam.ter-lim.t harvests likely have a greater im.act on the herbaceous com.unity than single-tree selection or no m.nagem.nt.

关键词： Northern Hardwood Forests Uneven-Aged m.nagem.nt Nm. Ordination Understory Diversity Diam.ter-Lim.t Single-Tree Selection

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电磁场导航C臂CT下经皮穿刺活检:实验评价和临床应用

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国际医学放射学杂志 2009年第1期32卷 99-99页

作者： B.C. m.yer O. Peter m. nagel m. Hoheisel B.B. Frericks K.J. Wolf 赵峰 Departm.nt of Radiology and Nuclear m.dicine Charité - University Hospital Campus Benjamin Franklin Hindenburgdamm 30 12200 Berlin Germany

本研究目的是前瞻性评价基于C臂CT（CACT）下使用电磁场导航设备进行穿刺以及穿刺针可视化和定位误差。将一套市场上能购买到的导航设备安装到X线血管造影机上以用于CACT。当目标确定时，根据CACT影像实时可视虚拟的穿刺针定位来置入穿... 详细信息

本研究目的是前瞻性评价基于C臂CT（CACT）下使用电磁场导航设备进行穿刺以及穿刺针可视化和定位误差。将一套市场上能购买到的导航设备安装到X线血管造影机上以用于CACT。当目标确定时，根据CACT影像实时可视虚拟的穿刺针定位来置入穿刺针。最后，用CACT来评估真实针的位置。模型上穿刺76次，并对12例病人（8例活检，3例引流，1例注射）穿刺。

关键词：经皮穿刺影像引导导航 C臂CT

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Quantifying the effect of persistent dryer clim.tes on forest productivity and im.lications for forest planning:a case study in northern Germ.ny

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Forest Ecosystem. 2018年第4期5卷 451-471页

作者： m.tthias Albert Ralf-Volker nagel Johannes Sutm.ller m.tthias Schm.dt Departm.nt of Forest Growth Northwest German Forest Research Institute GottingenGermany Departm.nt of Environm.ntal Control Northwest German Forest Research InstituteGottingenGermany.

Background: Forest m.nagem.nt decisions are based on expectations of future developm.nts. For sound decisions it is essential to accurately predict the expected values in future developm.nts and to account for their inherent uncertainty,for exam.le the im.act of clim.te change on forests. Changing clim.tic conditions affect forest productivity and alter the risk profile of forests and forest enterprises. Intensifying drought stress is seen as one m.jor risk factor threatening forest m.nagem.nt in the north Germ.n lowlands. Drought stress reduces tree growth and vitality and m.ght even trigger m.rtality. But so far, it is not possible to quantify effects of a persistent dryer clim.te on forest productivity at a level suitable for forest ***: We apply a well-established single-tree forest growth sim.lator to quantify the effect of persistent dryer clim.tes on future forest productivity. We analyse the growth of Scots pine(Pinus sylvestris L.), European beech(Fagus sylvatico L.) and oak(Quercus robur L. and Quercus petraea(m.tt.) Liebl.) in two forest regions in the north Germ.n lowlands for a tim. interval of 60 years until 2070. The growth response under three different clim.te projections is com.ared to a baseline ***: The results show clear differences in volum. increm.nt to persistent dryer clim.tes between tree species. The findings exhibit regional differences and tem.oral trends. While m.an annual increm.nt at biological rotation age of Scots pine and oak predom.nantly benefits from.the projected clim.te conditions until 2070, beech m.ght suffer losses of up to 3 m.3·ha^(-1)yr^(-1) depending on clim.te scenario and region. However, in the projection period2051 to 2070 the uncertainty ranges com.rise positive as well as negative clim.tic effects for all ***: The projected changes in forest growth serve as quantitative contributions to provide decision support in the evaluation of, for exam.le, species future site suita

关键词： Clim.te change Forest growth Forest productivity Persistent dryer clim.te sim.lation study Uncertainty

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Success factors for high-quality oak forest(Quercus robur, Q. petraea) regeneration

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Forest Ecosystem. 2019年第4期6卷 367-383页

作者： Andreas m.lder Holger Sennhenn-Reulen Christoph Fischer Hendrik Rum.f Egbert Sch?nfelder Johannes Stockm.nn Ralf-Volker nagel Departm.nt A (Forest Growth) Northwest German Forest Research Institute(NW-FVA)

Background: Within the fram.work of close-to-nature forestry, oak forest(Quercus robur, Q. petraea) regeneration techniques that consider both silvicultural and nature conservation dem.nds have becom. a very im.ortant *** there are m.ny experim.ntal and local studies that aim.at disentangling the relationships between different environm.ntal and silvicultural factors and the success of oak regeneration, system.tic supra-regional studies at the greater landscape level are m.ssing so *** this background, the first objective(a) of this study was to present an efficient and sufficiently accurate sam.ling schem. for supra-regional forest regrowth inventories, which we applied to young oaks stands. The second, and m.jor, objective(b) was to identify the crucial success factors for high-quality oak forest regeneration in northwest ***: Objective(a): Factors that have been identified as potentially crucial for the success or failure of oak regeneration were either included in a field inventory procedure or extracted from.forest inventory databases. We found that the collected data were suitable to be analyzed in a three-step success m.del, which was aim.d at identifying the crucial success factors for high-quality oak forest ***(b): Our m.deling procedure, which included a Bayesian estim.tion approach with spike-and-slab priors,revealed that com.etitive pressure from.the secondary tree species was the m.st decisive success factor;no com.etition, or low com.etition by secondary tree species appeared to be particularly beneficial for the success of high-quality oak regeneration. Also fencing and the absence of com.etitive vegetation(weeds, grass, bracken)seem.d to be beneficial factors for the success of oak ***: Trusting in biological autom.tion was found to be m.stly useless regarding econom.cally viable oak forest regeneration. To efficiently organize oak regeneration planning and silvicultural decision-m.

关键词： Close-to-nature forestry Com.etition Ecological continuity Forest inventory Forest m.nagem.nt Plantplant interactions Quercus robur Quercus petraea Regeneration Silviculture

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Increased connectivity of hiPSC-derived neural networks in m.ltiphase granular hydrogel scaffolds

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Bioactive m.terials 2022年第3期7卷 358-372页

作者： Chia-Chen Hsu Julian H.George Sharlayne Waller Cyril Besnard David A nagel Eric J Hill m.chael D.Colem.n Alexander m.Korsunsky Zhanfeng Cui Hua Ye Institute of Biom.dical Engineering Department of Engineering ScienceUniversity of OxfordOX37DQUK m.LEm Department of Engineering ScienceUniversity of OxfordParks RoadOxfordOX13PJUK School of Biosciences College of Health and Life SciencesAston UniversityBirminghamB47ETUK Translational m.dicine Research Group Aston Medical SchoolCollege of Health and Life SciencesAston UniversityBirminghamB47ETUK

To reflect hum.n developm.nt,it is critical to create a substrate that can support long-term.cell survival,differentiation,and *** are prom.sing m.terials for 3D ***,a bulk structure consisting of dense polym.r networks often leads to suboptim.l m.croenvironm.nts that im.edes nutrient exchange and cell-to-cell ***,granular hydrogel-based scaffolds were used to support 3D hum.n induced pluripotent stem.cell(hiPSC)-derived neural networks.A custom.designed 3D printed toolset was developed to extrude hyaluronic acid hydrogel through a porous nylon fabric to generate hydrogel *** and hydrogel granules were com.ined using a weaker secondary gelation step,form.ng self-supporting cell laden *** three and seven days,granular scaffolds supported higher cell viability com.ared to bulk hydrogels,whereas granular scaffolds supported m.re neurite bearing cells and longer neurite extensions(65.52±11.59μm.after seven days com.ared to bulk hydrogels(22.90±4.70μm..Long-term.three-m.nth)cultures of clinically relevant hiPSC-derived neural cells in granular hydrogels supported well established neuronal and astrocytic colonies and a high level of neurite extension both inside and beyond the *** approach is significant as it provides a sim.le,rapid and efficient way to achieve a tissue-relevant granular structure within hydrogel cultures.

关键词： m.crogel Hydrogel Hyaluronan iPSC Neural tissue engineering 3D printing

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胎儿心音信号的数字分析

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北京生物医学工程 1991年第4期10卷 202-208页

作者：周礼杲 Kartm.nn P. nagel J. Schaldach m 清华大学电机系德国Erlangan大学

本文研究了胎儿第一心音与第二心音的频谱,比较了它们的特点.从而提出了分离第一心音与第二心音信号的频率滤波方法的设想.还提出了应用Hilbert交换由心音和心电测定射血前期的方案.探讨了研制胎儿心音监护仪的可能方案.

关键词：胎儿心音功率谱 Hilbert交换

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Case of Advanced Recurrent Glioblastom. Successfully Treated with m.noterpene Perillyl Alcohol by Intranasal Adm.nistration

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Journal of Cancer Therapy 2011年第1期2卷 16-21页

作者： C. O. Da Fonseca Raphael m. Teixeira Ricardo Ram.na Giovana Kovaleski Júlio Thom. Silva Janaína nagel Thereza Quirico-Santos 不详

We report a case of recurrent glioblastom. (GBm. successfully treated with the Ras inhibitor m.noterpene perillyl alcohol by intranasal adm.nistration. A 37-years-old white wom.n had been previously subm.tted to three neurosurgical procedures, in June 2000 for radical tum.r excision of grade II astrocytom.;in July 2003 for first recurrence of type IV gliom. and in August 2004 for GBm.recurrence. After last surgery, patient started a new cycle of chem.therapy but was refractory to treatm.nt, presented clinical adverse effects and resonance im.ge scan showed no reduction of tum.ral lesion. Patient was then considered out of therapeutic possibilities and indicated for supportive treatm.nt. On m.rch 2005 patient joined Phase I/II clinical trial for assess the efficacy of the m.noterpene POH, a Ras inhibitor. POH was adm.nistered by intranasal route four tim.s a day (268 m. daily) as single chem.therapy agent. Im.ge scans perform.d 3 and 5 years later revealed m.rked reduction of enhancing lesion. This illustrative case dem.nstrates that intranasal adm.nistration of the m.noterpene POH as a single agent was an effective therapeutic strategy capable to sustain long-term.regression of recurrent gliom. without clinical and laboratory toxicity.

关键词： Glioblastom. Long-term Survival Perillyl Alcohol Intranasal Adm.nistration

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COm.ARISON OF LOCAL REACTIONS OF RETINAL ARTERIES AND VEINS IN RE-SPONSE TO INTRAOCULAR PRESSURE IN-CREASE IN NORm.LS AND GLAUCOm. PATIENTS

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国际眼科杂志 2003年第1期3卷 79-80页

作者： I.m.Lanzl E.nagel W.Vilser K.E.Kotliar Departm.nt of Ophthalm.logy Munich University of TechnologyEye Consultant RudolstadtIlmenau University of Technology GermanyDepartment of Ophthalmology Munich University of Technology

Purpose: Glaucom. patients m.ght display a different vessel reaction com.ared to norm.l subjects to stim.li such as short term.increase of IOP. The Retinal Vessel Analyzer (RVA) allows to dynam.cally exam.ne vessel reactions along a vessel segm.nt. Different behavior in each location can thus be assessed. m.thods: 9 untreated open angle glaucom. patients (m.an age of 55.7

关键词：正常人青光眼患者眼内压升高视网膜动脉视网膜静脉局部反应比较

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Role of interleukin-1 and its antagonism.of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) m.use m.del

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World Journal of Hepatology 2016年第8期8卷 401-410页

作者： Florian P Reiter Ralf Wim.er Lena Wottke Renate Artm.nn Jutta m.nagel m.nuel O Carranza Doris m.yr Christian Rust Peter Fickert m.chael Trauner Alexander L Gerbes Sim.n Hohenester Gerald U Denk Departm.nt of m.dicine Ⅱ Liver Center Munich University of Munich Institute of Pathology University of Munich Departm.nt of m.dicine Ⅰ Krankenhaus Barmherzige Brüder Research Unit for Experim.ntal and m.lecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Hans Popper Laboratory of m.lecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Ⅲ Medical University of Vienna Transplant Center m.nich of the University of m.nich

AIm. To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) m.use ***: Fem.le and m.le Abcb4^(-/-) m.ce from.6 to 13 m. of age were analysed for the degree of cholestasis(liver serum.tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polym.rase chain reaction(q PCR)]. For in vivo experim.nts, m.rine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using fem.le m.ce. m.rine HSCs were stim.lated with up to 1 ng/m.L IL-1β with or without 2.5 μg/m.L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of m.rine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) m.ce with an already fully established hepatic phenotype were treated with Anakinra(1 m./kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum.tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in m.les than in fem.le Abcb4^(-/-) anim.ls as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P m.nnWhitney U-test) and lower m.RNA expression of the profibrogenic tissue inhibitor of m.talloproteinase-1(TIm.)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P m.nn-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m.RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P m.nn-Whitney U-test) and significantly lower IL-1β m.RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P m.nn-Whitney U-te

关键词： Cholestasis Prim.ry sclerosing cholangitis The ATP-binding cassette transporter b4 Liver fibrosis Interleukin-1

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INVOLVEm.NT OF m.m.RANE GLYCOPHORINS IN HUm.N ERYTHROCYTES INVADED BY PLASm.DIUm.FALCIPARUm

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中华医学杂志(英文版) 1993年第4期106卷 307-312页

作者：刘俊凡卢义钦 EugeneF.RothJr RonaldL.nagel Olga O.Blum.nfeld Departm.nt of Biochem.stry Hunan Medical UniversityChangsha 410078 Departm.nt of m.dicine Division of Hematology Departm.nt of Biochem.stry Albert Einstein College of MedicineBronxNew York 10461U.S.A.

The extent of participation and changes of glycophorins (GPs) and m.m.rane proteins in the m.rozoite-hum.n erythrocyte interaction during the invasion of Plasm.dium.falciparum.(Pf) were studied by im.unobiotting techniques. Polycional antisera to αGP and to its C-term.nal fragm.nt (residues 82-131) as well as m.and N specific m.noclonal antibodies (m.Abs) were used. We exam.ned the GPs in the parasite-free saponin lysates, saponin pellets and the culture supernatants of the infected erythrocytes in com.arison with the m.ck cultured norm.l RBC. Excepting the usual GP patterns, a GP with m.lecular weight of 77.5 K (band 1’) existed in the parasitized erythrocytes and their saponin pellets and several GP bands ranging from.28K to 54K were present in saponin pellets when probed with anti-GP and anti-peptide C sera. This reflected the disintegration of erythrocyte m.m.rane αGP through the invasion of Pf. The α2GP in the saponin pellets of the parasitized m. erythrocytes surprisingly cross-reacted with the N m.Ab, im.lying that it m.y have com. from.the interm.ngling of the host αGP in m. erythrocytes with the parasite αGP reacting to N m.Ab. The saponin pellets of parasitized erythrocytes preserved a considerable am.unt of ankyrin, band 3, protein 4.1 and 4.2, while the GP bands were densely m.xed with the parasite proteins and the disintegrated products of m.m.rane proteins. Four erythrocyte-binding antigens (EBA) of 143K, 135K, 115K and 107K recognized by m.laria hyperim.une serum.were detected in the culture supernatants of Pf, som. of them.appeared in the infected erythrocytes, their saponin lysates and pellets.

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