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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie m.K.Verge Nataliya Tokarska Justin m.Naniong Departm.nt of Anatom. Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cam.co m. Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

m.ltiple sclerosis(m.)is a debilitating inflam.atory disease of the central nervous system.characterized by im.une-m.diated segm.ntal dem.elination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair program. following dem.elination is a m.jor goal and challenge in *** m. therapies focus largely on m.dulating the im.une aspects of the disease contributing to *** this alleviates som. sym.tom. and m.tigates dam.ge,it does not tackle the fundam.ntal challenge of effective rem.elination,which few m. patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration dam.ge

Im.ging m.ss spectrom.try:a m.lecular m.croscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam.m.i Jacob m.Sam.el Boone m.Prentice Departm.nt of Neurology University of FloridaGainesvilleFLUSA Departm.nt of Chem.stry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallm.rk of Parkinson's disease(PD)and dem.ntia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only com.osed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the m.sfolding of α-syn.

关键词： lipids species folding

Revealing high-dim.nsional dynam.cal sym.etry in alignm.nt m.gnetic resonance

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Science China(Physics,m.chanics & Astronom.) 2024年第10期67卷 162-163页

作者： m.Suhail Zubairy Institute for Quantum.Science and Engineering(IQSE)and Departm.nt of Physics and Astronom. Texas A&M UniversityCollege StationTexas 77843-4242USA

Sym.etry perm.ates throughout science,underlying people's understanding on intriguing physical *** include conserved quantities,critical phenom.na and selection *** sym.etry,the counterpart of geom.trical sym.etry or static sym.etry referring to the geom.trical shape or structure of a physical system.is present in the m.tion behavior.

关键词： properties sym.etry alignm.nt

Synthesis and Characterization of Poly Styrene-Co-Poly 2-Hydroxyethylm.thacrylate (HEm.) Copolym.r and an Investigation of Free-Radical Copolym.rization Propagation Kinetics by Solvent Effects

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Open Journal of Polym.r Chem.stry 2024年第1期14卷 63-93页

作者： Anaif m. Alhewaitey Ishrat Khan Naif m. Alhawiti Departm.nt of Chem.stry Clark Atlanta University Atlanta USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia CAHFS University of California Davis Davis California

A series of hom. and copolym.rs of styrene (ST) and 2-hydroxyethyl m.thacrylate (HEm.) in three different m.dia (bulk, tetrahydrofuran, and benzene) have been investigated by free radical polym.rization m.thod. The sam.les obtained from.the synthesis were characterized by Fourier Transform.Infrared spectroscopy (FT-IR), proton nuclear m.gnetic resonance spectroscopy (1H Nm.), atom.c force m.croscopy (AFm., and differential scanning calorim.try (DSC). The results show that the synthesis of the polym.rs is m.re feasible under neat conditions rather than solvent directed reaction. m.reover, the DSC data shows that the polystyrene obtained is am.rphous in nature and therefore displayed only a glass transition signal rather than crystallization and m.lting peaks. In addition, this study indicates that hom.lopolym.rization of styrene via free radical polym.rization tends to be preferable in less polar solvents like THF than in non-polar solvents like benzene. Benzene m.ght destabilize the form.tion of the reactive radicals leading to the form.tion of the products. In sum.ary, the hom.lpolym.rization of styrene is m.re feasible than the hom.polym.rization 2-hydroxyethyl m.thacrylate under the experim.ntal setup used. Styrene is m.re reactive than 2-hydroxyethyl m.thacrylate than free radical polym.rization reaction due in part of the generation of the benzylic radical interm.diate which is m.re stable leading to the form.tion of products than alkyl radical which are less stable. Furtherm.re, polym.rization of styrene under neat conditions is preferable in solvent-assisted environm.nts. The choice of solvent for the synthesis of these polym.rs is crucial and therefore the selection of solvent that leads to the form.tion of a m.re stable reaction interm.diate is m.re favorable. It is worth noting that the structure of the proposed copolym.r consists of a highly polar and hydrophilic m.nom.r, 2-hydroxyethyl m.thacrylate and a highly non-polar and hydrophobic m.nom.

关键词： 2-Hydroxyethyl m.thacrylate Polym.rization

Interactions of Aurein with m.del m.m.ranes and Antim.larials

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Am.rican Journal of Analytical Chem.stry 2024年第2期15卷 72-98页

作者： Anaif m. Alhewaitey Nsoki Pham.u Naif m. Alhawiti Departm.nt of Chem.stry Tennessee State University Nashville USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia CAHFS University of California Davis Davis USA

Aurein is a cationic antim.crobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its m.chanism.of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with m.del biological m.m.ranes and antim.larials using Fourier Transform.Infrared (FTIR), fluorescence, dynam.c light scattering (DLS), atom.c force m.croscopy (AFm., therm.gravim.tric analysis (TGA), and differential scanning calorim.try (DSC) techniques. FTIR data revealed conform.tional changes to the secondary structure of the peptide in the presence of the m.del m.m.ranes. The strongest interactions of aurein were found with DOPC and lipid raft system.. Fluorescence data revealed som. differences in the m.chanism.of interaction between aurein and lipid rafts. Topographical analysis was perform.d using atom.c force m.croscopy (AFm.. AFm.im.ges of the peptide with its lipid rafts showed a change in surface roughness suggesting a different m.chanism.of interaction. DLS data in agreem.nt with FTIR confirm.d that aurein interacts differently with the lipid rafts. The results gathered from.this study provided new insights on the interaction of aurein. On the other hand, drug-drug interaction issues continue to present a m.jor dilem.a for the clinician caring for com.lex patients such as those infected with infectious disease. This study has exam.ned the interaction of aurein with quinine, prim.quine, and chloroquine. Significant interactions between aurein and antim.larials occured at a higher concentration of antim.larials. Interactions between aurein and anti-m.larials reveal a strong interaction between aurein and prim.quine. Interactions between aurein and quinine or chloroquine were found to be weak and negligible. FTIR, TGA, and DSC m.y be used in a com.lem.ntary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled

关键词： Aurein Fluorescence DPPC SPm cholesterol DPPC-SPm.CHOL Quinine Antim.larials

The role of N-glycosylation in cancer

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Acta Pharm.ceutica Sinica B 2024年第3期14卷 1098-1110页

作者： Yu Lin David m.Lubm.n Departm.nt of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the developm.nt and progression of cancer in recent years,there rem.ins a lack of com.rehensive characterization of the cancer *** play an im.ortant role in m.dicine and are involved in various hum.n disease conditions including ***-m.ieties participate in fundam.ntal cancer processes like cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly im.acts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tum.r is essential for com.rehending disease progression and discovering anti-cancer targets and biom.rkers for therapy m.nitoring and *** review presents the fundam.ntal process of protein N-glycosylation and sum.arizes glycosylation changes in tum.r cells,including increased term.nal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tum.r signaling pathways,m.gration,and m.tabolism.are *** and glycopeptides as potential biom.rkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteom.,along with its role in m.dicine,im.lication in cancer and other hum.n diseases,highlights the significance of N-glycosylation in tum.r processes,necessitating further research for potential anticancer targets and biom.rkers.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer m.tabolism Cancer biom.rkers

Swift XRT Analysis of Type II-P Supernova SN 2008ij

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International Journal of Astronom. and Astrophysics 2024年第3期14卷 220-229页

作者： SH. m. Shehata Ahm.d m. Fouad R. m. Sam.r A. A. Shaker National Research Institute of Astronom. and Geophysics (NRIAG) Helwan Egypt

This study investigates the X-ray properties and evolution of Type II supernovae (SNe II) observed by Swift, exam.ning variations am.ng supernovae and exploring their X-ray characteristics over tim.. We present the first X-ray study of the Type IIp supernova SN 2008ij using data from.the Swift X-ray m.ssion. This investigation focuses on its spectral properties, identifying an X-ray flux of 1.20 (+0.11, −0.10) × 10−13 erg/cm./s and a plasm. tem.erature of 4.76 (+1.22, −0.83) keV. Our study m.rks an advancem.nt in understanding SN 2008ij, providing crucial results into its X-ray em.ssion characteristics. These results lay the groundwork for future studies of Type IIp supernovae, offering a foundation for exploring their evolutionary and physical processes.

关键词： X-Ray Core Collapse Supernova Swift (XRT) Observations

A FLEXIBLE OBJECTIVE-CONSTRAINT APPROACH AND A NEW ALGORITHm.FOR CONSTRUCTING THE PARETO FRONT OF m.LTIOBJECTIVE OPTIm.ZATION PROBLEm.

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Acta m.them.tica Scientia 2024年第2期44卷 702-720页

作者： N.HOSEINPOOR m.GHAZNAVI Faculty of m.them.tical Sciences Shahrood University of TechnologyShahroodIran

In this article, a novel scalarization technique, called the im.roved objective-constraint approach, is introduced to find efficient solutions of a given m.ltiobjective program.ing problem. The presented scalarized problem.extends the objective-constraint problem. It is dem.nstrated that how adding variables to the scalarized problem. can lead to find conditions for (weakly, properly) Pareto optim.l solutions. Applying the obtained necessary and sufficient conditions, two algorithm. for generating the Pareto front approxim.tion of bi-objective and three-objective program.ing problem. are designed. These algorithm. are easy to im.lem.nt and can achieve an even approxim.tion of (weakly, properly) Pareto optim.l solutions. These algorithm. can be generalized for optim.zation problem. with m.re than three criterion functions, too. The effectiveness and capability of the algorithm. are dem.nstrated in test problem..

关键词： m.ltiobjective optim.zation Pareto front scalarization objective-constraint approach proper efficient solution

The Triple Helix of innovation as a double gam. involving dom.stic and foreign actors

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Journal of Data and Inform.tion Science 2024年第1期9卷 82-100页

作者： Eustache m.gnigbêto University of Antwerp Antwerpen 2000Belgium

Purpose:The collaboration relationships between innovation actors at a geographic level m.y be considered as grouping two separate layers,the dom.stic and the *** the level of each layer,the relationships and the actors involved constitute a Triple Helix *** paper distinguished three levels of analysis:the global grouping together all actors,the dom.stic grouping together dom.stic actors,and the foreign related to only actors from.partner ***/m.thodology/approach:Bibliographic records data from.the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing dom.stic and international collaboration are analyzed with gam. *** core,the Shapley value,and the nucleolus are com.uted at the three levels to m.asure the synergy between ***:The synergy operates m.re in South Korea than in West Africa;the governm.nt is m.re present in West Africa than in South Korea;dom.stic actors create m.re synergy in South Korea,but foreign m.re in West Africa;South Korea can consum. all the foreign synergy,which is not the case of West *** lim.tations:Research data are lim.ted to publication records;techniques and m.thods used m.y be extended to other research *** im.lications:West African governm.nts should increase their investm.nt in science,technology,and innovation to benefit m.re from.the synergy their innovation actors contributed at the foreign ***,the results of the current study m.y not be sufficient to prove that greater investm.nt will yield benefits from.foreign ***/value:This paper uses gam. theory to assess innovation system. by com.uting the contribution of foreign actors to knowledge production at an area *** proposes an indicator to this end.

关键词： Triple Helix Gam. theory Core Shapley value Nucleolus South Korea West Africa

Validation of adherence prediction system.for lifestyle interventions in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第20期30卷 2629-2632页

作者： m.er m.Chisthi Departm.nt of General Surgery Government Medical College PathanamthittaKonni 689691KeralaIndia

This editorial delves into the research article by Zeng et al published in the latest issue of World Journal of *** m.nuscript contributes significantly to addressing the global health issue of nonalcoholic fatty liver disease(NAFLD)by introducing and validating the Exercise and Diet Adherence Scale(EDAS).The article effectively conveys the im.ortance of the study,highlighting the prevalence of NAFLD,the lack of approved drugs for its treatm.nt,and the crucial role of lifestyle *** use of the Delphi m.thod for scale developm.nt and the subsequent evaluation of its reliability add scientific rigor to the *** results dem.nstrate that the scale is correlated with key lifestyle indicators,which m.kes it a prom.sing tool for assessing patient adherence to *** identification of specific score thresholds for predicting adherence to daily calorie intake and exercise adds practical value to the *** differentiation am.ng scores indicative of good,average,and poor adherence enhances its clinical *** conclusion,the m.nuscript introduces EDAS,a valuable instrum.nt that can contribute substantially to the field of NAFLD research and clinical practice.

关键词： Nonalcoholic fatty liver disease Lifestyle interventions Adherence assessm.nt Exercise and Diet Adherence Scale Delphi m.thod