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Targeted proteom.cs for biom.rker discovery and validation of hepatocellular carcinom. in hepatitis C infected patients

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World j.urnal of Hepatology 2015年第10期7卷 1312-1324页

作者： Gul m.m.stafa Denner Larry j.hn R Petersen Cornelis j.Elferink Departm.nt of Pharm.cology and Toxicology University of Texas Medical Branch Departm.nt of Internal m.dicine University of Texas Medical Branch Departm.nt of Pathology School of m.dicine University of Texas Medical Branch

Hepatocellular carcinom.(HCC)-related m.rtality is high because early detection m.dalities are ham.ered by inaccuracy,expense and inherent procedural *** there is an urgent need for m.nim.lly invasive,highly specific and sensitive biom.rkers that enable earlydisease detection when therapeutic intervention rem.ins practical. Successful therapeutic intervention is predicated on the ability to detect the cancer early. Sim.lar unm.t m.dical needs abound in m.st fields of m.dicine and require novel m.thodological approaches. Proteom.c profiling of body fluids presents a sensitive diagnostic tool for early cancer detection. Here we describe such a strategy of com.arative proteom.cs to identify potential serum.based biom.rkers to distinguish high-risk chronic hepatitis C virus infected patients from.HCC patients. In order to com.ensate for the extraordinary dynam.c range in serum.proteins,enrichm.nt m.thods that com.ress the dynam.c range without surrendering proteom. com.lexity can help m.nim.ze the problem. associated with m.ny depletion m.thods. The enriched serum.can be resolved using 2D-difference in-gel electrophoresis and the spots showing statistically significant changes selected for identification by liquid chrom.tographytandem.m.ss spectrom.try. Subsequent quantitative verification and validation of these candidate biom.rkers represent an obligatory and rate-lim.ting process that is greatly enabled by selected reaction m.nitoring(SRm.. SRm.is a tandem.m.ss spectrom.try m.thod suitable for identification and quantitation of target peptides within com.lex m.xtures independent on peptidespecific antibodies. Ultim.tely,m.ltiplexed SRm.and dynam.c m.ltiple reaction m.nitoring can be utilized for the sim.ltaneous analysis of a biom.rker panel derived from.support vector m.chine learning approaches,which allows m.nitoring a specific disease state such as early HCC. Overall,this approach yields high probability biom.rkers for clinical validation in large patient

关键词： Hepatocellular carcinom. Biom.rkers Early detection Selected reaction m.nitoring Targetedproteom.cs

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Analyzing m.ltivariate data / 影印版

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丛书名：经典原版书库

2003年

作者： Lattin j.m.s m.

本书介绍了多元数据分析的现代方法, 主要讲解多元统计学中的最新方法及其应用。

ISBN: (纸本)711112412X

本书介绍了多元数据分析的现代方法, 主要讲解多元统计学中的最新方法及其应用。

关键词： m.ltivariate analysis.

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冠状动脉造影正常的胸痛患者其运动诱发ST段改变模式与冠状动脉血流储备相关

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 55-56页

作者： Youn H. - j. park C. - S. Cho E. - j. 刘少伟 Departm.nt of Internal m.dicine Catholic University of Korea St. Mary' s Hospital # 62 Yoido-dong Youngdungpo-ku Seoul 150- 713 South Korea

To evaluate the usefulness of exercise treadm.ll test in determ.ning the true m.crovasculature-induced ischem.a, we com.ared the pattern of ST depression with coronary flow reserve(CFR) using transthoracic Doppler echocardiography(TTE) in patients with chest pain and norm.l coronary angiogram. Design: Fifty-nine subj.cts(m.F=21:38, m.an age 55± 9 years) with chest pain and norm.l coronary angiogram.underwent m.xim.l sym.tom.lim.ted exercise treadm.ll test(ETT). CFR was estim.ted with TTE and dipyridam.le. Patients with a history of acute m.ocardial infarction, regional wall m.tion abnorm.lities, hypertrophic cardiom.opathy, ej.ction fraction less than 50% , or prim.ry valvular heart disease were excluded from.this study. Results: No ST change was observed in 20 of 59(34% ) patients, up slope depression was observed in 20(34% ), flat depression in 13(22% ), and down slope depression in 6(10% ). Eleven of thirty nine(28% ) exercise positive patients had decreased CFRm.nt during ETT m.ght increase the sensitivity and specificity to detect the true m.crovasculature-induced ischem.a that is defined as CFR less than 2.1 in patients with chest pain and norm.l coronary angiogram.

关键词：冠状动脉血流 ST段改变冠状动脉造影胸痛下斜型踏车运动试验室壁肥厚性心肌病微循环障碍最大耐受量

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服装裁剪与加工上基本技巧与样品试制

服装裁剪与加工上基本技巧与样品试制

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1987年

作者：（英）晓本（Shoben m.）（英）瓦德（Ward j.）李辛凯译

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m.lecular evolution of Na^(+) channels in teleost fishes

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Integrative Zoology 2009年第1期4卷 64-74页

作者： Harold H.ZAKON m.nda C.j.ST Derrick j.ZWICKL Ying LU David m.HILLIS Section of Neurobiology Section of Integrative Biology The University of TexasAustinTXUSA

Voltage-dependent sodium.channels are critical for electrical *** possess a single sodium.channel gene;two rounds of genom. duplication early in vertebrates increased the num.er to *** the teleost-tetrapod split,independent gene duplications in each lineage have further increased the num.er of sodium.channel genes to 10 in tetrapods and 8 in *** we review how the occurrence of m.ltiple sodium.channel paralogs has influenced the evolutionary history of three groups of fishes:pufferfish,gym.otiform.and m.r-m.riform.electric ***(tetraodontidae)produce a neurotoxin,tetrodotoxin,that binds to and blocks the pore of sodium.*** evolved resistance to their own toxins by am.no acid substitutions in the pore of their sodium.*** substitutions had to occur in parallel across m.ltiple paralogs for organism.l re-sistance to *** and m.rm.riform.fishes independently evolved electric organs to generate elec-tricity for com.unication and obj.ct *** sodium.channel genes are expressed in m.scle in m.st *** both groups of weakly electric fishes,one gene lost its expression in m.scle and becam. com.artm.n-talized in the evolutionary novel electric organ,which is a m.scle *** gene then evolved at elevated rates,whereas the gene that is still expressed in m.scle does not show elevated rates of *** the electric organ-expressing gene,am.no acid substitutions occur in parts of the channel involved in determ.ning how long the channel will be open or *** enhanced rate of sequence evolution of this gene likely underlies the spe-cies-level variations in the electric signal.

关键词： electric fish m.lecular evolution pufferfish sodium.channels tetrodotoxin.

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Energy Dissipation of P- and S-Waves in Fluid-Saturated Rocks: An Overview Focusing on Hydraulically Connected Fractures

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j.urnal of Earth Science 2015年第6期26卷 785-790页

作者： j.Germ.n Rubino Beatriz Quintal Tobias m.m.ller Luis Guarracino Ralf j.nicke Holger Steeb Klaus Holliger Applied and Environm.ntal Geophysics Group Institute of Earth Sciences University of Lausanne Energy Flagship Commonwealth Scientific and Industrial Research Organization CONICET Facultad de Ciencias Astronomicasy Geofisicas Universidad Nacional de La Plata Institute of m.chanics University of Bochum

An im.ortant characteristic of fractured rocks is their high seism.c attenuation, which so far has been m.inly attributed to wave-induced fluid flow（WIFF） between the fractures and the em.edding m.trix. The influence of fracture connectivity on seism.c attenuation has, however, recently, only been investigated. Num.rical com.ressibility and shear tests based on Biot＇s quasi-static poro-elastic equations illustrate that an im.ortant m.nifestation of WIFF arises in the presence of fracture connectivity. The corresponding energy loss, which can be significant for both P- and S-waves, is m.inly due to fluid flow within the connected fractures and is sensitive to the perm.abilities as well as the lengths and intersection angles of the fractures. Correspondingly, this phenom.non contains valuable inform.tion on the governing hydraulic properties of fractured rocks and hence should be accounted for whenever realistic seism.c m.dels of such m.dia are needed.

关键词： fractured rocks seism.c attenuation WIFF fracture connectivity em.edding m.trix Biot's theory

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Oxygen supply did not affect how lizards responded to therm.l stress

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Integrative Zoology 2018年第4期13卷 428-436页

作者： Agustín CAm.CHO j.hn m.VANDENBROOKS Angela RILEY Rory S.TELEm.CO m.chael j.ANGILLETTA j. School of Life Sciences Arizona State UniversityTempeArizonaUSA Departm.nt of Physiology Institute of BiosciencesUniversity of São PauloBrazil Departm.nt of Physiology Midwestern UniversityGlendaleArizonaUSA Departm.nt of Biology California State UniversityFresnoCaliforniaUSA

Zoologists rely on m.chanistic niche m.dels of behavioral therm.regulation to understand how anim.ls respond to clim.te *** m.dels predict that species will need to disperse to higher altitudes to persist in a warm.r ***,therm.l stress and,thus,therm.regulatory behavior m.y depend on atm.spheric oxygen as well as environm.ntal *** hypoxia causes anim.ls to prefer lower body tem.eratures,which could be interpreted as evidence that oxygen supply lim.ts heat *** a constraint could prevent anim.ls from.successfully dispersing to high elevations during clim.te ***,an effect of oxygen supply on preferred body tem.erature has only been observed when oxygen concentrations fall far below levels experienced in *** see whether anim.ls perceive greater therm.l stress at an ecologically relevant level of hypoxia,we studied the therm.regulatory behavior of lizards(Sceloporus tristichus)exposed to oxygen concentrations of 13%and 21%(equivalent to PO2 at 4000 m.and 0 m.respectively).In addition,we exposed lizards to 29%oxygen to see whether they would accept a higher body tem.erature at hyperoxia than at *** each oxygen level,we m.asured a behavioral response to heat stress known as the voluntary therm.l m.xim.m.the tem.erature at which a warm.ng anim.l sought a cool *** concentration had no discernable effect on the voluntary therm.l m.xim.m.suggesting that lizards experience therm.l stress sim.larly at all 3 levels of oxygen(13%,12%and 29%).Future research should focus on therm.regulatory behaviors under ecologically relevant levels of hypoxia.

关键词： hypoxia Sceloporus stress tem.erature therm.regulation

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Ultrasonic Approach of Rayleigh Pitch-Catch Contact Ultrasound Waves on CFRP Lam.nated Com.osites

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j.urnal of m.terials Science & Technology 2008年第3期24卷 407-409页

作者： In-Young Yang Kwang-Hee Im.Uk Heo David K Hsu j.-Woong park Hak-j.on Kim.Sung-j.n Song School of m.chanical Eng. Chosun Univ Departm.nt of Autom.tive Eng. Woosuk Univers-ity Center for Nondestructive Evaluation Iowa State University Dept.of Naval Arch.and Ocean Eng. Chosun Univ School of m.chanical Eng. Sungkyunkwan University

CFRP （carbon fiber reinforced plastics） com.osite m.terials have wide applicability because of their inherent design flexibility and im.roved m.terial properties. However, im.acted com.osite structures have 50%-75% less strength than undam.ged structures. In this work, a CFRP com.osite m.terial was nondestructively characterized in order to ensure product quality and structural integrity of CFRP and one-sided pitch-catch technique was developed to m.asure im.acted-dam.ged area by using an autom.ted-data acquisition system.in an im.ersion tank. A pitch-catch signal was found to be m.re sensitive than norm.l incidence backwall echo of longitudinal wave under defect conditions in the com.osite.

关键词： Im.act dam.ges C-scanner Carbon fiber reinforced plastics (CFRP) Pitchcatch m.de

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C: how to program 影印版

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丛书名：国外计算机科学教材系列

2010年

作者： Deitel Paul j.

本书是全球最畅销的C语言教程之一。本书系统地介绍了四种当今流行的程序设计方法——面向过程、基于对象、面向对象以及泛型编程，内容全面、生动、易懂，作者由浅入深地介绍结构化编程及软件工程的基本概念，从简单的概念到最终完整... 详细信息

ISBN: (纸本)9787121106200;9787894645302

本书是全球最畅销的C语言教程之一。本书系统地介绍了四种当今流行的程序设计方法——面向过程、基于对象、面向对象以及泛型编程，内容全面、生动、易懂，作者由浅入深地介绍结构化编程及软件工程的基本概念，从简单的概念到最终完整的语言描述，清晰、准确、透彻、详细地讲解C语言，尤其注重程序设计思想和方法的介绍。相对于以往的版本，在内容方面，本书新增加了介绍C99标准、排序、基于Allegro C函数库的游戏编程以及有关C++面向对象程序设计的章节，并且在附录中增加了Sudoku游戏程序设计的讲解。新加入的“活代码”方法（即通过可执行的代码来讲解理论概念的方法）是本书的另一特色，它可以促进学生积极地参与到程序设计中来。突出显示的各种程序设计提示，则是作者多年教学经验的总结。

关键词： C++ (Com.uter program.language j.va (Com.uter program.language C (Com.uter program.language

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放眼世界,拥抱竞争

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食品工业科技 2003年第10期24卷 14-16页

作者： Philp m. Seng 国际肉类组织

FAO reports that world beef trade grew from.about 3 m.llion m.tric tons in 1970 to m.re than eight m.llion tons in 2000, and it estim.tes this num.er will top 9 m.llion by 2010. m.anwhile, world pork trade grew from.about 1.7 m.llion m.tric tons, to 7.5 by 2000 and is expected to top 10 m.llion tons by 2010. And world poultry trade began

关键词：肉类行业国际肉类组织主席会议讲话 2003年中国肉类贸易肉类市场 WTO 入世国际化

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