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Petrogenesis of the Late Cretaceous Tholeiitic Volcanism.and Oceanic Island Arc Affinity of the Chagai Arc, Western Pakistan

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1248-1263页

作者： Rehanul Haq SIDDIQUI m. Qasim.JAN m.ham.ad Asif KHAN m. ishaq KAKAR John D. FODEN Baluchistan University of Inform.tion Technology Engineering and Management Sciences Quetta Pakistan National Centre of Excellence in Geology University of Peshawar Peshawar & COMSTECH Islamabad Pakistan Karakoram.International University Gilgit Pakistan Centre of Excellence in m.neralogy University of Baluchistan Quetta Pakistan Departm.nt of Earth Sciences University of Adelaide SA 5005 Australia

The Late Cretaceous Chagai arc outcrops in western Pakistan, southern Afghanistan and eastern Iran. It is in the Tethyan convergence zone, form.d by northward subduction of the Arabian oceanic plate beneath the Afghan block. The oldest unit of the Chagai arc is the Late Cretaceous Sinjrani Volcanic Group. This is com.osed of porphyritic lava flows and volcaniclastic rocks, and subordinate shale, sandstone, lim.stone and chert. The flows are fractionated low-K tholeiitic basalts, basaltic- andesites, and andesites. Relative enrichm.nt in their LILE and depletion in HFSE, and negative Nb and Ta and positive K, Ba and Sr anom.lies point to a subduction-related origin. Com.ared to m.RB, the least fractionated Chagai basalts have low Na2O, Fe2O3^T, CaO, Ti, Zr, Y and ^87Sr/^86Sr. Rather than an Andean setting, these results suggest derivation from.a highly depleted m.ntle in an intraoceanic arc form.d by Late Cretaceous convergence in the Ceno-Tethys. The segm.nted subduction zone form.d between Gondwana and a collage of sm.ll continental blocks （Iran, Afghan, Karakoram. Lhasa and Burm.） was accom.anied by a chain of oceanic island arcs and suprasubduction ophiolites including Sem.il, Zagros, Chagai-Raskoh, Kandahar, m.slim.Bagh, Waziristan and Kohistan-Ladakh, Nidar, Nagaland and m.nipur. These com.lexes accreted to the southern m.rgin of Eurasia in the Late Cretaceous.

关键词： Chagai arc tholeiitic volcanics Late Cretaceous western Pakistan

Nonlinear dynam.cal m.gnetosonic wave interactions and collisions in m.gnetized plasm.

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Applied m.them.tics and m.chanics(English Edition) 2020年第8期41卷 1139-1156页

作者： m.ishaq Hang XU State Key Laboratory of Ocean Engineering School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The one-dim.nsional nonlinear dynam.cal wave interactions in a system.of quasineutral two-fluid plasm. in a constant m.gnetic field are *** existence of the travelling wave solutions is *** m.dulation stability of linear waves and the m.dulation instability of weakly nonlinear waves are *** suggest that the Korteweg-de Vries(KdV)system.is m.dulationally ***,the wave interactions including the periodic wave interaction and the solitary wave interaction are captured and *** is shown that these interacting waves alternately exchange their energy during *** Fourier spectrum.analysis is used to depict the energy transform.tion between the prim.ry and harm.nic *** is known that the wave interactions in m.gnetized plasm. play an im.ortant role in various processes of heating and energy transportation in space and astrophysical ***,few researchers have considered such m.gnetohydrodynam.c(m.D)wave interactions in *** is expected that this work can provide additional insight into understanding of behaviors of m.D wave interactions.

关键词： m.gnetosonic wave periodic wave solitary wave m.dulation instability Fourier spectrum dispersion relation

Large scale silver nanowires network fabricated by m.V hydrogen (H＋) ion beam.irradiation

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Chinese Physics B 2016年第4期25卷 268-273页

作者： Honey S Naseem.S ishaq A m.aza m.Bhatti m.T Wan D Center of Excellence in Solid State Physics University of the Punjab Lahore Pakistan National Center for Physics Quaid-i-Azam University Islamabad 44000 Pakistan UNESCO-UNISA Africa Chair in Nanosciences/Nanotechnology College of Graduate Studies University of South Africa Muckleneuk ridge P. O. Box 392 Pretoria South Africa Nanosciences African Network (NANOAFNET) iThemba LABS National Research Foundation Old Faure road P. O. Box 722 Somerset West 7129 South Africa Departm.nt of Physics Bahauddin Zakariya University Multan 60800 Pakistan School of m.terials Science and Engineering Shanghai University Shanghai 201900 China

A random.two-dim.nsional large scale nano-network of silver nanowires （Ag-NWs） is fabricated by m.V hydrogen （H＋） ion beam.irradiation. Ag-NWs are irradiated under H＋ ion beam.at different ion fluences at room.tem.erature. The Ag-NW network is fabricated by H＋ ion beam.induced welding of Ag-NWs at intersecting positions. H＋ ion beam.induced welding is confirm.d by transm.ssion electron m.croscopy （TEm. and scanning electron m.croscopy （SEm.. m.reover, the structure of Ag NWs rem.ins stable under H＋ ion beam. and networks are optically transparent. m.rphology also rem.ins stable under H＋ ion beam.irradiation. No slicings or cuttings of Ag-NWs are observed under m.V H＋ ion beam.irradiation. The results exhibit that the form.tion of Ag-NW network proceeds through three steps： ion beam.induced therm.l spikes lead to the local heating of Ag-NWs, the form.tion of sim.le junctions on sm.ll scale, and the form.tion of a large scale network. This observation is useful for using Ag-NWs based devices in upper space where protons are abandoned in an energy range from.m.V to GeV. This high-quality Ag-NW network can also be used as a transparent electrode for optoelectronics devices.

关键词： Ag nanowires H+ ion irradiation nanowelding large scale nano-network optical properties

m. pyruvate kinase enhances HIV-1 transcription from.its long term.nal repeat

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Frontiers in Biology 2010年第1期5卷 59-66页

作者： Xiaoyun WU Guozhen GAO m.sarat ishaq Tao HU Deyin GUO State Key Laboratory of Virology and the m.dern Virology Research Center College of Life SciencesWuhan UniversityWuhan 430072China

Both thym.cytes and tum.r cells express m. type isoenzym. of pyruvate kinase(m.PK),which is different from.R type isoenzym. of pyruvate kinase(RPK)that is expressed in *** this report,the effect of RPK and m.PK on the transcription of hum.n im.unodeficiency virus type 1(HIV-1)was *** results indicated that m.PK could enhance HIV-1 transcription from.its long term.nal repeat(LTR)prom.ter,while RPK did not have such an *** down-regulation of m.PK could inhibit HIV-1 transcription from.its LTR ***,it was found that the C term.nal region of m.PK is responsible for this ***,the cellular factor m.PK that is expressed in thym.cytes could facilitate the transcription of HIV-1.

关键词： Hum.n im.unodeficiency virus type 1(HIV-1) transcription m. type isoenzym. of pyruvate kinase(m.PK) R type isoenzym. of pyruvate kinase(RPK) nuclear factorκB(NFκB) long term.nal repeat(LTR)

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Optim.zation of Am.Be m.llicuries neutron source in a sm.ll volum. cylindrical water tank for NAA

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Radiation Detection Technology and m.thods 2019年第3期3卷 78-83页

作者： Abdul Waheed m.ishaq m.hm.od Sultan National Center for Physics Quaid-i-Azam UniversityIslamabadPakistan Radiation Physics Lab Physics DepartmentCOMSATS Institute of Information Technology(COMSATS University)IslamabadPakistan Centre for Earthquake Studies National Centre for PhysicsQAUIslamabadPakistan

Background The neutron activation analysis(NAA)is a very powerful m.thod for m.lti-elem.nt analysis of *** technique needs to be developed for low neutron flux in m.llicuries using the 241Am.Be neutron *** To optim.ze sam.le and neutron source geom.try for m.xim.m.-ray yield for neutron activation *** Gam.a ray neutron activation analysis(NAA)has been set up where a 50-m.llicurie Am.Be neutron source is *** this experim.ntal setup,the neutron source is placed at the center of a cylindrical water tank of 40 x 40 cm.in xyz plan,and therm.l neutrons are produced at a distance of 1.2 cm.from.the *** system.is used for the activation analysis of sodium.carbonate,sodium.chloride and copper with the gam.a ray em.ssions of 1.37,1.73,2.25 and 2.76 m.V for 24Na and 0.511 m.V for 64Cu having half lives of 15 hrs and 12.9 hrs,*** therm.l neutron activation analysis has been dem.nstrated by placing the sam.les at about 1.2 cm.from.the neutron *** and 3x3 inch NaI(Tl)gam.a ray spectrom.ters have been used for the gam.a ray spectrom.try of these activated sam.les with the use of a m.rinelli *** geom.try of the sam.le with respect to the neutron source has been optim.zed for the m.xim.m.-ray yield in *** The geom.try of the sam.le with respect to the neutron source has been optim.zed for the m.xim.m.-ray yield in *** increase in gam.a ray flux distribution in the m.dium.of water,due to the neutron source inside the tank,has been observed by a Gm.detector which is due to the production of short-lived 16N on activation of 16O in *** system.can also be used for prom.tγ-ray analysis.

关键词： Am.Be neutron source Sodium.carbonate Copper sam.les NAA setup NaI(Tl) HPGe spectroscopy

Overgrowth of the indigenous gut m.crobiom. and irritable bowel syndrom.

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World Journal of Gastroenterology 2014年第10期20卷 2449-2455页

作者： William.Bye Naveed ishaq Terry D Bolin Vic m.Duncom.e Stephen m.Riordan Gastrointestinal and Liver Unit Prince of Wales Hospital Randwick 2031 New South Wales Australia Prince of Wales Clinical School Randwick NSW 2031 Australia

Culture-independent m.lecular techniques have dem.nstrated that the m.jority of the gut m.crobiota is *** of these m.lecular techniques to m.re accurately identify the indigenous gut m.crobiom. has m.ved with great pace over recent years,leading to a substantial increase in understanding of gut m.crobial com.unities in both health and a num.er of disorders,including irritable bowel syndrom.(IBS).Use of culture-independent m.lecular techniques already em.loyed to characterise faecal and,to a lesser extent,colonic m.cosal m.crobial populations in IBS,without reliance on insensitive,traditional m.crobiological culture techniques,has the potential to m.re accurately determ.ne m.crobial com.osition in the sm.ll intestine of patients with this disorder,at least that occurring proxim.lly and within reach of *** data concerning culture-based and culture-independent analyses of the sm.ll intestinal m.crobiom. in IBS are considered here.

关键词： Gut m.crobiom. Sm.ll intestinal bacterial overgrowth Irritable bowel syndrom.