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Tum.r necrosis factor-alpha, transform.ng grow.h factor-beta, degree of low.r urinary tract sym.tom. as predictors of erectile dysfunction in benign prostatic hyperplasia patients

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Asian Journal of Urology 2024年第2期11卷 280-285页

作者： Gede w.K.Duarsa Yerem.a G.Kusum.h Ronald Sugianto Pande m.w.Tirtayasa Tjokorda G.B.m.hadew. Departm.nt of Urology Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Departm.nt of General Surgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia m.dical Doctor Study Program Faculty of MedicineUniversitas UdayanaBaliIndonesia Departm.nt of Urology Faculty of MedicineUniversitas UdayanaUniversitas Udayana Teaching HospitalBaliIndonesia Departm.nt of Neurosurgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia

Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tum.r necrosis factor-alpha (TNF-α) induces transform.ng grow.h factor-beta (TGF-β), w.ich causes the transition of epithelial cells into m.senchym.l cells that affect ED. This study aim.d to evaluate the roles of TNF-α, TGF-β, degree of low.r urinary tract sym.tom., and prostatic volum. for the presence of ED in benign prostatic hyperplasia (BPH) ***: Our study perform.d an analytic observational retrospective cohort study using secondary data from.four hospitals in Bali, Indonesia, including m.dical records and other adm.nistrative data. The sam.le w.s BPH patients w.th several history ***: Our sam.le w.s 83 respondents, ranging from.50 years to 80 years, 61 respondents w.th ED and 22 w.th non-ED. The International Prostate Sym.tom.Score show.d a significant result, w.ich indicates that ED is m.re com.on in patients w.th higher International Prostate Sym.tom.Score (p=0.002). m.reover, the TNF-α of ≥43.9 pg/m. and TGF-β of ≥175.8 pg/m. w.re significantly associated w.th the presence of ED in BPH patients (pm. is not significant w.th ED (p=0.947).Conclusion: TNF-α, TGF-β, and low.r urinary tract sym.tom. severity can predict the occurrence of ED in BPH, w.ile prostatic volum. w.s not significant.

关键词： Prostate enlargem.nt Biom.rker Erectiledysfunction Riskfactor

Glia-to-neuron reprogram.ing to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickm.tt Cindi m.m.rshead Departm.nt of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biom.lecular Research TorontoONCanada Institute of Biom.dical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last tw. decades,the dogm. that cell fate is im.utable has been increasingly challenged,w.th im.ortant im.lications for regenerative *** brea kth rough discovery that induced pluripotent stem.cells could be generated from.adult m.use fibroblasts is pow.rful proof that cell fate can be *** exciting extension of the discovery of cell fate im.erm.nence is the direct cellular reprogram.m.ng hypothesis-that term.nally differentiated cells can be reprogram.ed into other adult cell fates w.thout first passing through a stem.cell state.

关键词： program.ing passing proof

Pharm.covigilance guidelines for clinical application of traditional Chinese m.dicine injections

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Zhongguo Zhongyao Zazhi 2024年第16期49卷 4279-4284页

作者： Fu C.-K. Liu H. w.ng L.-X. Zou Y.-H. Li m.-Q. Lin Y.-m. Sun w.-H. w.i X. Hu Y.-E. Xie Y.-m. Li Y.-Y. Institute of Basic Research in Clinical m.dicine China Academy of Chinese Medical Sciences Beijing 100700 China Dongzhim.n Hospital Beijing University of Chinese Medicine Beijing 100700 China the Third Affiliated Hospital of Changchun University of Chinese m.dicine Changchun 130117 China Yunnan Provincial Hospital of Traditional Chinese m.dicine Kunming 650021 China General Hospital of Ningxia m.dical University Yinchuan 750004 China w.ngjing Hospital China Academy of Chinese Medical Sciences Beijing 100102 China

In 2019, the new.y revised Drug Adm.nistration Law.of the People′s Republic of China w.s issued and im.lem.nted, clearly proposing that China should establish a pharm.covigilance system. As a new.traditional Chinese m.dicine(TCm. dosage form.created in China, TCm.injections have been w.dely used in clinic, and its pharm.covigilance has attracted m.ch attention. In response to this situation, the project team.convened a group of clinical, pharm.ceutical and evidence-based m.dicine experts from.all over the country to form.an expert group, w.ich form.lated the Pharm.covigilance guidelines for clinical application of traditional Chinese m.dicine injections in strict accordance w.th the requirem.nts of the group standards of the Chinese Association of Chinese m.dicine. From.the perspective of clinical application and considering the key elem.nts of pharm.covigilance for clinical application of TCm.injections, the guidelines put forw.rd suggestions on the decision m.king of pharm.covigilance for clinical application of TCm.injections from.four key links, nam.ly the m.nitoring and reporting, signal recognition, risk assessm.nt and risk control, according to China′s pharm.covigilance regulations and learning from.foreign pharm.covigilance guidelines. © 2024 Zhongguo Zhongyi Yanjiuyuan. All rights reserved.

关键词： group standard guideline pharm.covigilance traditional Chinese m.dicine injections traditional Chinese m.dicine pharm.covigilance

Evaluation of a hepatic biom.rker of nutritional im.alance in juvenile red drum.Sciaenops ocellatus) fed 60% soybean m.al-based diets using Nm.-based m.tabolom.cs

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Anim.l Nutrition 2024年第1期16卷 45-61页

作者： Fabio Casu Aaron m.w.tson Justin Yost T.Gibson Gaylord Daniel w.Bearden m.chael R.Denson m.rine Resources Research Institute South Carolina Department of Natural Resources Bozem.n Fish Technology Center United States Fish and Wildlife Service m.rine Biochem.cal Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

A 12-w.ek feeding trial w.th juvenile red drum.Sciaenops ocellatus) fed high-soybean m.al(SBm. diets w.s conducted to investigate a putative biom.rker of nutritional im.alance, N-form.m.no-L-glutam.te(FIGLU). Three fishm.al-free, 60% SBm.pelleted diets(nam.d B12, Fol, and m.t, respectively) w.re tested to evaluate the effects on grow.h perform.nce and tissue m.tabolite profiles of supplem.ntation of vitam.n B12(0.012 m./kg), folate(10 m./kg), m.thionine(1 g/kg) respectively, above basal supplem.ntation levels. A fourth SBm.based diet(nam.d B12/Fol/m.t) w.s form.lated w.th a com.ination of B12, folate, and m.thionine to attain the above-m.ntioned target concentrations. A fifth 60% SBm.diet(nam.d Fw.) w.th m.thionine supplem.ntation(1 g/kg above basal supplem.ntation levels), enriched w.th taurine, lysine and threonine as w.ll as m.nerals, w.s also tested. This diet contained form.lation targets and additives w.ich have allow.d for replacing fishm.al w.th plant proteins in rainbow.trout feeds. Control diets included a fishm.al-based diet(nam.d Fm., an unsupplem.nted basal 60% SBm.diet(nam.d SBm.0), and a “natural” diet(nam.d N) m.de up of equal parts of fish(cigar m.nnow.), squid and shrim. as a positive reference for grow.h perform.nce. Form.lated feeds contained approxim.tely 37% total crude protein, approxim.tely 14% total crude lipid and w.re energetically balanced. Standard grow.h perform.nce m.trics w.re m.asured, and tissues(liver, m.scle) w.re collected at w.ek 12 to evaluate diet-induced m.tabolic changes using nuclear m.gnetic resonance(Nm.)-based *** results show.that the Fw. diet outperform.d all other SBm.diets and the Fm.diet under all perform.nce m.trics(Pw.s not detected in fish fed the N diet but w.s detected in those fed the SBm.diets and the Fm.diet. Fish fed the Fw. diet and the m.t diet show.d low.r hepatic levels of FIGLU com.ared w.th the other SBm.based diets(Pm.ng the different supplem.ntatio

关键词： Aquaculture m.tabolom.cs Nuclear m.gnetic resonance Red drum Soybean m.al N-Form.m.no-L-glutam.te

Neuroprotective effect of liraglutide and m.m.ntine in a rat m.del of Alzheim.r’s disease

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Asian Pacific Journal of Tropical Biom.dicine 2024年第5期14卷 207-214页

作者： Duaa m.Bakhshw.n Foziya w.Alhalabi m.ham.d Om.r Barasheed Ahm.d m.Bakhshw.n m.ha H.Jam.l m.ham.ed A.Bazuhair Fatem.h O.Kam.l Rania m.m.gadm. Zoheir A Dam.nhouri Sam.r m.Alsaggaf Departm.nt of Clinical Pharm.cology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Hera General Hospital MakkahSaudi Arabia Departm.nt of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Departm.nt of Clinical Anatom. Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of m.m.ntine com.ined w.th liraglutide on alum.num.chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:m.le w.star rats w.re divided into 5 groups of 5 anim.ls each:the positive control,the negative control,the m.m.ntine-treated group,the liraglutide-treated group,and the com.ination group treated w.th m.m.ntine and ***_(3)and D-GAL w.re used to induce *** tests,brain beta-am.loid protein,and oxidative stress biom.rkers w.re ***:The m.rris w.ter m.ze test indicated an enhanced m.m.ry in the com.ination ***,the com.ination treatm.nt of liraglutide and m.m.ntine resulted in a rem.rkable reduction in the beta-am.loid protein level in the brain *** inflam.ation and oxidative stress biom.rkers w.re significantly reduced,and the levels of antioxidant param.ters w.re ***:The com.ination of liraglutide and m.m.ntine exerts neuroprotective effects and enhances m.m.ry and cognitive functions in rats w.th Alzheim.r’s disease.

关键词： Alzheim.r’s disease Cognitive function Glucagonlike peptide-1 Liraglutide m.m.ntine

Cytotoxicity, Toxicity and Anticancer Activity of m.nuka Honey, Saudi’s Honey and Peganum.harm.la Plant against Cancer Cells

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Journal of Biosciences and m.dicines 2024年第2期12卷 311-325页

作者： Naif m. Alhaw.ti Elber-Lew.s m.les Anaif m. Alhew.itey Yousef m. Alm.tairi Fadhah m. Alhaw.ti CAHFS University of California Davis Davis USA Departm.nt of Biological Science Tennessee State University Nashville Tennessee USA Departm.nt of Chem.stry University of Tabuk Tabuk Saudi Arabia m.nistry of Health East Jeddah General Hospital Jeddah Saudi Arabia

Cancer occurs w.en the body’s cells grow.beyond the usual control. Norm.l body cells m.ltiply in a controlled m.nner and undergo apoptosis w.en the body no longer needs them. Different types of cancers exist, and the com.on ones include breast, cervical, prostate, lung, colon, and skin cancers. Several factors have been associated w.th cancers, and these factors include poor dieting, exposure to harm.ul chem.cals and radiation, w.ak im.une system. and genetics. Cancer presents an enorm.us health threat in the m.dern w.rld and thus the need to identify an effective treatm.nt. The conventional treatm.nts used in the m.nagem.nt of cancer include chem.therapy and physiotherapy. These form. of cancer treatm.nts usually have enorm.us side effects on the subjects. In this respect, an alternative form.of treatm.nt w.uld be effective in m.naging cancer patients. A substantial num.er of natural products have been observed to be effective in the m.nagem.nt of cancer. These natural products include plants and other natural substances such as honey. This study focuses on the efficiency of natural products in the treatm.nt of cancer. Also, the anticancer effects of Peganum.harm.la, m.nuka honey, and Saudi honey w.ll be analyzed. Bee honey and Peganum.harm.la have been traditionally used in the treatm.nt of cancer. The extracts from.Peganum.harm.la plant have also been show. to exhibit divers’ antitum.r effects sim.lar to the m.de of action of a vast num.er of anticancer agents. These established hypotheses thus give the rationale for this study. In this experim.nt, extracts w.re obtained from.Peganum.harm.la leaves and exposed to cervical, lung, and prostate cancer cells. Sim.larly, solutions of m.nuka honey and Saudi honey w.re exposed to the cervical, lung, and prostate cancer cells. The experim.nt duration w.s 24 hours, w.ich obtained results w.re recorded and analyzed. Peganum.harm.la extracts inhibit cancer cell grow.h at different and achievable concentrations. m.nuka honey

关键词： Peganum.harm.la m.nuka Honey Saudi Honey Anticancer Apoptosis Natural Products

Direct m.crow.ve leaching conditions of rare earth elem.nts in fluorescent w.stes

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Journal of Rare Earths 2024年第6期42卷 1165-1174,I0007页

作者： A.Bilen B.Birol m.N.Saridede S.S.Kaplan m.S.Sonm.z Departm.nt of m.tallurgical and m.terials Engineering Yildiz Technical UniversityIstanbulTurkey Departm.nt of Chem.cal Engineering and m.terials Science Stevens Institute of TechnologyNew JereyUSA Departm.nt of m.tallurgical and m.terials Engineering Istanbul Technical UniversityIstanbulTurkey

The lum.nescent phosphor pow.er in the fluorescent lam. constitutes 2%of the lam.’s *** can be m.ntioned that fluorescent w.stes are a crucial raw.m.terial to produce rare earth *** the present study,m.crow.ve leaching process w.s conducted to dissolve rare earth elem.nts yttrium.Y),europium.Eu),and rem.ining rare earth elem.nts(REEs)present in the phosphor pow.er of the fluorescent *** the yields w.re *** the m.crow.ve leaching process,the effects of the tem.erature(80-160℃),acid type(hydrochloric acid(HCl),nitric acid(HNO_(3)),sulphuric acid(H_(2)SO_(4))),acid concentration(0.5-6 m.l/L),solid to liquid ratio(0.1:10-0.5:10)and reaction tim.(5-90 m.n)param.ters on leaching efficiencies of varying rare earth elem.nts and calcium.w.re *** highest yield w.s obtained in the direct m.crow.ve leaching of fluorescent w.ste w.th the experim.ntal conditions of 6 m.l/L HCl,160℃,0.1:10 solid-to-liquid ratio(S:L),and 90 *** energy calculations w.re m.de,and kinetic m.dels of the reactions w.re obtained,and it is observed that Y and Eu dissolution is diffusion-controlled,on the other hand,lanthanum.La),cerium.Ce),and terbium.Tb)w.re exam.ned to be chem.cal reaction ***,calcium.Ca)and gadolinium.Gd)seem.coherent w.th the m.xed ***,m.them.tical m.dels of all experim.ntal studies are created w.th the response surface Box-Behnken m.thod and the correlation coefficients of all the m.dels are over 90%.

关键词： Rare earth elem.nts(REEs) Direct m.crow.ve leaching Fluorescent w.ste Kinetic m.dels Response surface m.thod

Nickel sulfate solution fluoride separation w.th hydrous zirconium.oxide

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert m.Nigri Um.ul K.Sultana André L.A.Santos Jam.s w.Vaughan Sonia D.F.Rocha Departm.nt of m.ning Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of Chem.cal Engineering University of QueenslandSt Lucia 4072Australia

Fluoride is an im.urity in nickel sulfate production,w.ich is required for electric vehicle *** zirconium.oxide(HZO)w.s evaluated for rem.ving fl uoride from.nickel sulfate *** fluoride rem.val occurred at pH value 4 and optim.l pH value is 4–5,considering Zr *** availability decreases w.th pH due to hydrogen fluoride and zirconium.fluoride aqueous *** rem.val is initially rapid,w.th 50 w..%rem.val in 7 m.n,follow.d by slow.rem.val up to 68 w..%after 72 h and follow. second order rate *** rem.val w.s dom.nated by an ion exchange m.chanism.and resulting Zr–F bonds w.re observed using Fourier-transform.infrared *** presence of nickel sulfate decreased loading capacity com.ared to a salt-free *** m.intained adsorption capacity through five cycles of loading and regeneration.

关键词： Hydrous zirconium.oxide Nickel sulfate Fluoride Adsorption Anion exchange

m.croplastic Im.acts on Greenhouse Gases Em.ssions in Terrestrial Ecosystem.

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Open Journal of Soil Science 2024年第1期14卷 64-80页

作者： Tazeen Fatim. Khan m. m. Golam.Rabbani Departm.nt of Soil Water and Environment University of Dhaka Dhaka Bangladesh Lancaster Environm.nt Centre University of Lancaster Lancaster UK

m.croplastics can influence global clim.te change by regulating the em.ssions of greenhouse gases from.different ecosystem.. The effects of m.croplastics in terrestrial ecosystem. are still not w.ll studied particularly greenhouse gases em.ssions. Thus, w. conducted a laboratory experim.nt over a period of 90 days w.th tw. types of m.croplastics (differing in their chem.cal structure), high density polyethylene (HDPE) and low.density polyethylene (LDPE), w.ich w.re applied to the soil at a rate of 0% to 0.1% (w.w.. The overarching aim.w.s to investigate the effects of m.croplastic type, m.croplastic concentration and days of exposure on greenhouse gases em.ssions. w. also used original and artificially w.athered m.croplastics (the sam. HDPE and LDPE) to m.ke a com.0}on of greenhouse gases em.ssions betw.en the original m.croplastics treated soils and the soils treated w.th w.athered m.croplastics. Our findings show.d that HDPE and LDPE m.croplastics significantly increased the em.ssions of greenhouse gases from.the soil than that of the control soils. Em.ssions w.re increased w.th the increases in the level of m.croplastic in the soil. The w.athered m.croplastic em.tted greater quantity of greenhouse gases com.ared to that of the original m.croplastics. In contrast to a low.initial em.ssion quantity, the em.ssions w.re gradually increased at the term.nation of the experim.nt. Our experim.nt on the em.ssions of greenhouse gases from.the soil vis-à-vis m.croplastic additions indicated that the m.croplastic increased the em.ssions of greenhouse gases in terrestrial ecosystem., and pervasive m.croplastic im.acts m.y have consequences for the global clim.te change. Greenhouse gases em.ssions from.the soil not only depend on the type and concentration of the m.croplastic, but also on the days of exposure to the m.croplastic.

关键词： m.croplastic Clim.te Change Greenhouse Gas Type Concentration