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Erlotinib com.ination with a m.tochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram.Pui-Kei Wu susan Tsai Jong-In Park Departm.nt of Biochem.stry Medical College of WisconsinMilwaukeeWI 53226United States Departm.nt of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epiderm.l growth factor receptor(EGFR)is often observed in pancreatic cancer,and the sm.ll m.lecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be com.ined with other drugs to im.rove therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase m.tochondrial m.m.rane potential(Δψm.,facilitate tum.r cell uptake ofΔψm.sensitive agents,disrupt m.tochondrial hom.ostasis,and subsequently trigger tum.r cell *** has not been tested for this *** To determ.ne whether erlotinib can elevateΔψm.and increase tum.r cell uptake ofΔψm.sensitive agents,subsequently triggering tum.r cell ***Δψm.sensitive fluorescent dye was used to determ.ne how erlotinib affectsΔψm.in pancreatic adenocarcinom.(PDAC)cell *** viability of conventional and patient-derived prim.ry PDAC cell lines in 2D-and 3D cultures was m.asured after treating cells sequentially with erlotinib and m.tochondria-targeted ubiquinone(m.toQ),aΔψm.sensitive *** synergy between erlotinib and m.toQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug com.ination was determ.ned using im.une-com.rom.sed nude m.ce bearing PDAC cell line *** Erlotinib elevatedΔψm.in PDAC cells,facilitating tum.r cell uptake and m.tochondrial enrichm.nt ofΔψm.sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatm.nt potentiated low doses of *** suggested that these drugs synergistically induced tum.r cell *** with in vitro data,erlotinib and m.toQ com.ination suppressed hum.n PDAC cell line xenografts in m.ce m.re effectively than single treatm.nts of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib m.tochondria-targeted ubiquinone m.tochondria Com.ination therapy

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaem.c lesions at 1 m.nth: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam.Longting Lin Christina Lam.Carlos Garcia-Esperon Yash Gawarikar Ronak Patel m.tthew Lee-Archer Andrew Wong m.chael Roizm.n Am.nda Gilligan Andrew Lee Kee m.ng Tan susan Day Christopher Levi Stephen m.Davis m.rk Parsons Bernard Yan m.lbourne Brain Centre at Royal m.lbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Departm.nt of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Departm.nt of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Departm.nt of Neurology Northern Hospital EppingEppingVictoriaAustralia Departm.nt of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of m.dicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Departm.nt of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of m.dicine and Public Health AdelaideSouth AustraliaAustralia Departm.nt of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Departm.nt of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optim.l tim. to com.ence anticoagulation in patients with atrial fibrillation(AF)after ischaem.c stroke or transient ischaem.c attack(TIA)is unclear,with guidelines differing in recom.endations.A lim.tation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted im.ging ischaem.c *** aim.d to quantify silent ischaem.c lesions and haem.rrhages on m.I at 1m.nth in patients com.enced on early(m.c lesions and m.re haem.rrhages in the early anticoagulant group at 1-m.nth *** A prospective m.lticentre,observational cohort study was perform.d at 11 Australian stroke *** and m.I data were collected at baseline and follow-up,with blinded im.ging assessm.nt perform.d by two *** of com.encem.nt of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom.208 m.t the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).m.dian baseline ischaem.c lesion volum. was 5m.(IQR 2–17).There were a greater num.er of new ischaem.c lesions on follow-up m.I in patients com.enced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haem.rrhage rates(22%vs 32%,p=0.10).Baseline ischaem.c lesion volum. of≤5m. was less likely to have a new haem.rrhage at 1m.nth(p=0.02).There was no difference in haem.rrhage rates in patients with an initial ischaem.c lesion volum. of>5m.,regardless of anticoagulation *** Com.encing anticoagulationm.c lesions at 1m.nth in AF *** is no increased rate of haem.rrhage with early *** results suggest that early anticoagulation after m.ld-to-m.derate acute ischaem.c stroke associated w

关键词： patients lesions ischaem.c

Form. and bioavailability of phosphorus associated with natural organic m.tter

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Acta Geochim.ca 2006年第S1期 259-259页

作者： Tsutom. Ohno Barbara J. Cade-m.nun m. susan erich C. Wayne Honeycutt Dept. of Plant Soil and Environmental Sciences Univ. of Maine Orono ME 04469 USA Geol. & Environ. Sci. Dept. Stanford University Stanford CA 94305 USA

Form. and bioavailability of phosphorus associated with natural organic m.tter

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Chinese Journal Of Geochem.stry 2006年第B8期25卷 259-259页

作者： Zhongqi HE Tsutom. Ohno Barbara J. Cade-m.nun m. susan erich C. Wayne Honeycutt USDA-ARS New England Plant Soil and Water Laboratory Orono ME 04469 USA Dept. of Plant Soil and Environmental Sciences Univ. of Maine Orono ME 04469 USA Geol. ＆ Environ. Sci. Dept. Stanford University Stanford CA 94305 USA

“When you’re down, stay down”:A lesson for all com.etitive alpine skiers supported by an ACL rupture m.asured in vivo

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Journal of Sport and Health Science 2022年第1期11卷 14-20页

作者： Jörg Spöorri erich m.ller Josef Kröoll Sports m.dical Research Group Department of OrthopaedicsBalgrist University HospitalUniversity of ZurichZurich 8008Switzerland University Centre for Prevention and Sports m.dicine Department of OrthopaedicsBalgrist University HospitalUniversity of ZurichZurich 8008Switzerland Departm.nt of Sport Science and Kinesiology University of SalzburgHallein-Ri 5400Austria

Background:During an experim.nt,a ski racer equipped with various m.asurem.nt devices suffered an anterior cruciate ligam.nt(ACL)rupture in his right *** aim.of this study was to describe the underlying injury m.chanism.from.a functional ***:Eight giant slalom.turns(i.e.,4 left turns),followed by 1 left turn at which the ACL injury occurred,were recorded by 2 video cam.ras,electrom.ography of 4 relevant m.scle groups,inertial m.asurem.nt units to m.asure knee and hip angles,and pressure insoles to determ.ne ground reaction ***:Due to a loss of balance,the ski racer began to slide sideways at the apex of a left *** sliding,his right(outside)leg was actively abducted upward without touching the *** ski racer then attem.ted to stand up again by dropping his leg back towards the snow *** end of this dropping was accom.anied by a decrease in electrom.ographic activity in the knee stabilizing *** the inside edge of the outer ski caught the snow surface,a rapidly increasing peak force,knee flexion,and an aggressive sudden activation of the vastus m.dialis m.scle were observed,while biceps fem.ris and rectus fem.ris further decreased their activation *** likely resulted in excessive anterior translation of the tibia relative to the fem.r,causing dam.ge to the ***:Our exam.le em.hasizes that ski racers should not get up until they stop ***:“When you’re down,stay down.”

关键词： Alpine skiing Athletes Injury m.chanism Injury prevention Knee injuries

Beijing 2022 Winter Olym.ic Gam.s:Com.itm.nts to science and public health

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Journal of Sport and Health Science 2022年第1期11卷 1-2页

作者： Yu Liu Barbara E.Ainsworth erich m.ller Key Laboratory of Exercise and Health Science of m.nistry of Education Shanghai University of SportShanghai 200438China Barbara E.Ainsworth Guest Editor School of KinesiologyShanghai University of SportShanghai 200438China Departm.nt of Sport Science and Kinesiology University of SalzburgSalzburg5400Austria

The Beijing 24th 2022 Winter Olym.ic Gam.s present a unique opportunity to prom.te the spirit and values of the Olym.ic Gam.s in relation to their im.act on physical activity and global health,sports m.dicine,and sports *** 2022 Winter Olym.ic Gam.s m.rk the 98th year since the first Winter Gam.s were held in Cham.nix,France,in *** inaugural Winter Olym.ic Gam.s sponsored 16 events,and 250 athletes from.16 nations participated.1 In contrast,the Beijing 2022 Winter Olym.ic Gam.s will sponsor 109 events.

关键词： Winter Gam.s sports

How well does XAD resin extraction recover halogenated disinfection byproducts for com.rehensive identification and toxicity testing?

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Journal of Environm.ntal Sciences 2022年第7期34卷 264-275页

作者： Xiaobin Liao Joshua m.Allen Caroline O.Granger susan D.Richardson Departm.nt of Chem.stry and Biochem.stry University of South CarolinaColumbiaSouth Carolina 29208USA Institute of m.nicipal and Environm.ntal Engineering College of Civil EngineeringHuaqiao UniversityFujian 361021China Currently at LanzaTech 535 Commerce DriveSopertonGeorgia 30457USA

Halogenated disinfection byproducts(DBPs) are an unintended consequence of drinking water disinfection, and can have significant toxicity. XAD resins are com.only used to extract and enrich trace levels of DBPs for com.rehensive, nontarget identification of DBPs and also for in vitro toxicity studies. However, XAD resin recoveries for com.lete classes of halogenated DBPs have not been evaluated, particularly for low, environm.ntally relevant levels(ng/L to low μg/L). Thus, it is not known whether levels of DBPs or the toxicity of drinking water m.ght be underestim.ted. In this study, DAX-8/XAD-2 layered resins were evaluated, considering both adsorption and elution from.the resins, for extracting 66 DBPs from.water. Results dem.nstrate that am.ng the 7 classes of DBPs investigated, trihalom.thanes(THm.), including iodo-THm., were the m.st efficiently adsorbed, with recovery of m.st THm. ranging from.50%-96%, followed by halonitrom.thanes(40%-90%). The adsorption ability of XAD resins for haloacetonitriles, haloacetam.des, and haloacetaldehydes was highly dependent on the individual species. The adsorption capacity of XAD resins for haloacetic acids was lower(5%-48%), even after adjusting to p H 1 before extraction. Recovery efficiency for m.st DBPs was com.arable with their adsorption, as m.st were eluted effectively from.XAD resins by ethyl acetate. DBP polarity and m.lecular weight were the two m.st im.ortant factors that determ.ne their recovery. Recovery of trichlorom.thane, iodoacetic acid, chloro-and iodo-acetonitrile, and chloroacetam.de were am.ng the lowest, which could lead to underestim.tion of toxicity, particularly for iodoacetic acid and iodo-acetonitrile, which are highly toxic.

关键词： XAD resins Disinfection byproducts DBPs Recovery Toxicity

Local tips, global im.act: com.unity-driven m.asures as avenues of prom.ting inclusion in the control of neglected tropical diseases: a case study in Kenya

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Infectious Diseases of Poverty 2022年第4期11卷 81-90页

作者： Elizabeth A.Ochola Diana m.S.Karanja susan J.Elliott Departm.nt of Geography and Environm.ntal m.nagem.nt University ofWaterlooWaterlooONCanada

Background:Neglected tropical diseases(NTDs)affect poor populations with little or no’’political voice’to influence control *** m.st NTDs have interventions that work,the biggest challenge rem.ins in delivering targeted interventions to affected populations residing in areas experiencing weak health *** the upward developm.nt trends in m.st countries of sub-Saharan Africa(SSA),the healthcare worker to population ratio rem.ins exceptionally low,with som. areas not served at all;thus,there is a need to involve other personnel for school and com.unity-based healthcare ***,the current com.unity-based program. suffer from.inconsistent com.unity participation due to a lack of coordinated response,and an expanded intervention agenda that lacks context-specific solutions applicable to rural,urban,and m.rginalized ***:This research investigated the capacity of local com.unities to address the burden of *** by the social theory of hum.n capability,the research collected prim.ry qualitative data by conducting key inform.nt interviews and focus group discussions of people infected or affected by *** interview data were collected and transcribed verbatim.for them.tic analysis using Nvivo version ***:Our findings reveal,first,a need for intersectoral collaboration between governm.nts and affected populations for inclusive and sustainable NTD ***,a’’bottom.up’approach that enhances capacity building,sensitization,and behaviour change for im.roved uptake of NTD ***,the enforcem.nt of Public Health Legislative Acts that m.ndates the reporting and treatm.nt of NTDs such as ***,the establishm.nt of support groups and counseling services to assist persons suffering from.debilitating and perm.nent effects of ***:Our research dem.nstrates the im.ortance of hum.n agency in encouraging new form. of participation leading to the co-production of inclusive and susta

关键词： Neglected tropical diseases Control Com.unity-driven m.asure Local solution Global im.act Inclusion Kenya

Perceptions of trust and power are associated with tax com.liance:A cross-cultural study

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Econom.c and Political Studies 2023年第3期11卷 365-381页

作者： Christoph Kogler Jerom. Olsen erich Kirchler Larissa m.Batrancea Anca Nichita Departm.nt of Social Psychology School of Social and Behavioural SciencesTilburg UniversityTilburgThe Netherlands m.x Planck Institute for Research on Collective Goods BonnGermany Departm.nt of Occupational Economic and Social PsychologyFaculty of PsychologyUniversity of ViennaViennaAustria Institute for Advanced Studies(IHS) ViennaAustria Departm.nt of Business Babes¸-Bolyai UniversityCluj-NapocaRomania Departm.nt of Business Adm.nistration and m.rketing Faculty of EconomicsUniversity of Alba IuliaAlba IuliaRomania

The slippery slope fram.work(SSF)of tax com.liance postulates that taxpayers’com.liance behaviour depends on the two dim.nsions:trust in authorities and power of *** an attem.t to overcom. com.on-m.thod biases,the present study tests the m.in assum.tions of the SSF with a sam.le of 44 countries/***/region-level trust and power indices are calculated based on experim.ntal data involving 14,509 participants and related to shadow econom. estim.tes and–as an alternative indicator of non-com.liance–corruption *** results indicate that both trust and power are negatively related to the size of the shadow econom. and the extent of *** results em.hasise the im.ortance of both SSF dim.nsions in com.ating tax evasion and counterproductive behaviour within a society in general.

关键词： Trust power shadow econom. corruption tax com.liance tax evasion