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Optim.zation of Strength Properties of Reactive Powder Concrete by Response Surface m.thodology

Journal of Shanghai Jiaotong university(Science) 2024年第5期29卷 900-908页

作者： SAKTHIESWARAn n. m.ORTHY n. REnISHA m. CHInnADURAI m. Departm.nt of Civil Engineering E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia Departm.nt of Science and Hum.nities E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia Departm.nt of Com.uter Science and Engineering E.G.S.Pillay Engineering CollegeNagapattinam611002TamilnaduIndia

The m.in objective of this study is to optim.ze the fresh and strength properties of reactive powder concrete incorporated with industrial by-products like ultra-fine ground granulated blast furnace slag as cem.nt substitute and added with coal bottom.ash and recycled concrete fines as partial replacem.nt of quartz sand by response surface m.thodology through design of experim.nt *** four responses nam.ly slum.,com.ressive strength(C-28),flexural strength(F-28),and split-tensile strength(S-28)after 28 days of curing period were *** statistical study on the reactive powder concrete includes the m.deling of regression,norm.l probability plots,surface plot analysis,and optim.zation of process *** regression m.dels of the considered responses(slum.,C-28,F-28,and S-28)were *** results obtained from.the analysis of variance(AnOVA)and Pareto chart were used to determ.ne the statistical significance of the process *** influence of the variables on the responses was studied by m.ans of the surface plot *** optim.l proportion of the variables against the responses was obtained through optim.zation *** resulted regression equations were in the form.of second-order polynom.al equation and the prediction of strength properties was found to be in line with the experim.ntal *** difference of proportion of variance indicated that only 0.43%,6.42%,5.15%,and 9.7%of deviations cannot be expressed by the *** AnOVA and Pareto charts represented the high significance and appropriateness of the linear term.of slum. response and the two-way interaction term.of strength *** results of the optim.zation response revealed the optim.l proportions of recycled concrete fines and coal bottom.ash as 19.15%and 7.02%,respectively.

关键词： reactive powder concrete m.chanical properties fresh properties statistics study coal bottom.ash

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Perform.nce of the geom.tric approach to fault detection and isolation in SISO,m.SO,simO and m.m. system.

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1443-1451页

作者： RAHIm. n. SADEGHI m. H. m.HJOOB m. J. m.chanical Engineering Departm.nt University of TabrizTabriz ***Iran m.chanical Engineering Departm.nt University of TehranTehran ***Iran

In this paper, a geom.tric approach to fault detection and isolation （FDI） is applied to a m.ltiple-Input m.ltipie-Output （m.m.） m.del of a fram. and the FDI results are com.ared to the ones obtained in the Single-Input Single-Output （SISO）, m.ltiple-Input Single-Output （m.SO）, and Single-Input m.ltiple-Output （simO） cases. A proper distance function based on param.ters obtained from.param.tric system.identification m.thod is used in the geom.tric approach. ARX （Auto Regressive with exogenous input） and VARX （Vector ARX） m.dels with 12 param.ters are used in all of the above-m.ntioned m.dels. The obtained results reveal that by increasing the num.er of inputs, the classification errors reduce, even in the case of applying only one of the inputs in the com.utations. Furtherm.re, increasing the num.er of m.asured outputs in the FDI schem. results in decreasing classification errors. Also, it is shown that by using probabilistic space in the distance function, fault diagnosis schem. has better perform.nce in com.arison with the determ.nistic one.

关键词： Fault detection and isolation (FDI) m.ltivariate system. Param.tric system.identification Linear regression Distance functions

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SBL-JP-0004: A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m.Otifi Departm.nt of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, m.king them.attractive targets for therapeutic interventions.m.thods:This study applied a com.utational and m.lecular dynam.cs simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SnU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by m.lecular docking scores and m.lecular dynam.cs simulations. Binding interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-m.xim.l inhibitory concentration (IC) value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD enzym.s. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SnU-5 cells, with half-m.xim.l growth inhibitory concentration (GI) values of 250.8 and 516.3 nm. respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SnU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SnU-5 cells) were observed with SBL-JP-0004 treatm.nt com.ared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 m.lecular docking m.lecular dynam.cs simulation PI3KCD SBL-JP-0004

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Testing the effectiveness of conservation m.nagem.nt within biosphere reserves:the case of the m.xican deer m.use(Perom.scus m.xicanus)as a bioindicator

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Integrative Zoology 2019年第5期14卷 422-434页

作者： Irene COBO-simÓn Belén m.nDEZ-CEA Héctor PORTILLO Fausto ELVIR Herm.s VEGA Francisco Javier GALLEGO Gustavo FOnTECHA Departm.nt of Genetics Physiology and MicrobiologyComplutense University of MadridMadridSpain 2Departm.nt of Physical Chemical and Natural SystemsUniversity Pablo de OlavideSevilleSpain Grupo de Investigación Para La Biodiversidad de Honduras GIBH-BALAm National Autonomous University of HondurasTegucigalpaHonduras

Biosphere reserves are protected areas whose purpose is to com.ine conservation and sustainable ***,their effectiveness has not been tested sufficiently,especially from.an ecological and genetic ap*** this sense,the Perom.scus genus represents an excellent bioindicator to address these questions,due to its short life and high evolutionary rate and *** conservation m.nagers,genetic structure can increase the rate of loss of genetic diversity because alleles exclusive of a subpopulation are m.re likely to disappear as a consequence of genetic drift in com.arison with a panm.ctic *** we analyzed the abundance,m.vem.nt distances,m.rphology/m.rphom.try and genetic structure of 3 populations of m.xican deer m.use(Perom.scus m.xicanus)located in different protected zones of La Tigra national Park(Honduras).Our results are consistent am.ng the 3 approaches and showed the highest values of abundance,m.rphom.try and genetic diversity in the population located at the core zone,whereas non-statistically significant differences were found between buffer and transition zone populations,suggesting suitable effectiveness of conservation m.nagem.nt in the core zone but a lack of ecological buffering function of the other *** addition,the low m.vem.nt distances and high genetic structure am.ng the studied populations provide evidence of poor conservation m.nagem.nt in the buffer and transition ***,we discuss the utility of the novel m.thodology used in this work,com.ining m.rphom.try,abundance and genetics,in testing the effectiveness of conservation strategies in biosphere reserves,and the value of the Perom.scus genus as a bioindicator.

关键词： bioindicator conservation Perom.scus m.xicanus SSR

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nonlinear forced vibration in a subcritical regim. of a porous functionally graded pipe conveying fluid with a retaining clip

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Applied m.them.tics and m.chanics(English Edition) 2025年第1期46卷 101-122页

作者： m.GHOLAm. m.EFTEKHARI Departm.nt of m.chanical Engineering Shahid Bahonar University of Kerman

This study exam.nes the nonlinear behaviors of a clam.ed-clam.ed porous pipe m.de of a functionally graded m.terial(FGm. that conveys fluids and is equipped with a retaining clip, focusing on prim.ry resonance and subcritical dynam.cs. The nonlinear governing equations for the FGm.pipe are derived by the extended Ham.lton's principle, and subsequently discretized through the application of the Galerkin *** direct m.thod of m.lti-scales is then used to solve the derived equations. A thorough analysis of various param.ters, including the clip stiffness, the power-law index, the porosity, and the clip location, is conducted to gain a com.rehensive understanding of the system.s nonlinear dynam.cs. Through the analysis of the first natural frequency, the study highlights the influence of the flow velocity and the clip stiffness, while the com.arisons with m.tallic pipes em.hasize the role of FGm.com.osition. The exam.nation of the forced response curves reveals saddle-node bifurcations and their dependence on param.ters such as the detuning param.ter and the power-law index, offering valuable insights into the system.s nonlinear resonant behavior. Furtherm.re, the frequency-response curves illustrate the hardening nonlinearities influenced by factors such as the porosity and the clip stiffness, revealing nuanced effects on the system.response and resonance characteristics. This com.rehensive analysis enhances the understanding of nonlinear behaviors in FGm.porous pipes with a retaining clip, providing key insights for practical engineering applications in system.design and optim.zation.

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Particle m.xing rates using the two-fluid m.del

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Particuology 2018年第1期16卷 13-26页

作者： m. Banaei n.G. Deen m. van Sint Annaland J.A.m. Kuipers m.ltiphase Reactors Group Deportment of Chemical Engineering & Chemistry Eindhoven University of Technology 5600 MB Eindhoven The Netherlands Dutch Polym.r Institute (DPI) 5600 AX Eindhoven The Netherlands m.ltiphase and Reactive Flows Group Department of Mechanical Engineering Eindhoven University of Technology 5600 MB Eindhoven The Netherlands

In this work, a new m.thodology is introduced to calculate the solids m.xing rate in dense gas-fluidized beds using the two-fluid m.del. The im.lem.ntation of this m.thodology into an existing two-fluid m.del code was carefully verified. The solids phase continuity equation was satisfied using our m.thod, and the sensitivity of the com.utational results to the tim. step, com.utational cell size, and discretization schem. was investigated to determ.ne the optim.l simulation settings. Using these simulation settings, the degree of solids m.xing was observed to rapidly （exponentially） increase with increasing operating pressure and linearly decrease with increasing bed diam.ter. Our novel m.thodology can be applied to analyze m.xing processes in large lab-scale beds as an alternative to existing tim.-consum.ng simulation techniques such as com.utational fluid dynam.cs com.ined with the discrete elem.nt m.del.

关键词： Gas-solid fluidized bed simulation Two-fluid m.del Solids m.xing Pressure Scale up

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Influence of FCA Welding Process Param.ters on Distortion of 409m.Stainless Steel for Rail Coach Building

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Journal of Iron and Steel Research International 2013年第1期20卷 71-78页

作者： m.V Venkatesan n m.rugan B m.Prasad A m.nickavasagam Departm.nt of m.chanical Engineering Coimbatore Institute of TechnologyCoimbatore 641014TNIndia Integral Coach Factory Indian RailwaysChennai 600038TNIndia

The influence of flux cored arc welding （FCAW） process param.ters such as welding current, travel speed, voltage and CO2 shielding gas flow rate on bowing distortion of 409m.ferritic stainless steel sheets of 2 m. in thickness was discussed. The bowing distortions of the welded plates were m.asured using a simple device called profile tracer. An experim.ntal regression equation was developed to predict the bowing distortion and with this equation, it is easy to select optim.zed process param.ters to achieve m.nim.m.bowing distortion. It is revealed that the FCAW process param.ters have significant influence on bead profile and the bowing distortion.

关键词： bowing distortion ferritic stainless steel flux cored arc welding statistical m.del rail coach distortion m.asurem.nt

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Catalytic activity of m.nganese oxide supported on alum.na in the synthesis of quinoxalines

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Frontiers of Chem.cal Science and Engineering 2013年第4期7卷 415-421页

作者： Rekha m. Kathyayini H nagaraju n Catalysis Research Laboratory St Joseph's College Post Graduate and Research Centre Bangalore 560027 India Centre for Em.rging Technologies Global Campus Jain University Bangalore 562112 India

Two catalysts, alum.na and m.nganese oxide supported on alum.na, have been prepared by calcination and precipitation-im.regnation m.thods, respectively. The catalysts are characterised by the following techniques： Brunner-Em.ett-Teller-n2 adsorption-desorption for sur- face area, tem.erature program.ed desorption of nH3 and n-butyl am.ne back titration m.thods for surface acidity, powder X-ray diffraction for textural properties, and Fourier transform.infrared spectroscopy for the anionic radicals. The catalytic activity has been determ.ned under heterogeneous conditions in the condensation reaction between o-phenylenediam.ne and benzil. The product purity is checked by thin-layer chrom.tography and m.lting point. The products are also analysed by LC-m. and 1H-nm. techniques. The yields of the products have been found to be good and catalysts exhibited excellent recyclability. The effect of changing the reaction para- m.ters such as tem.erature, reaction tim., am.unt of the catalyst, nature of solvent and m.lar ratio of reactants on the yield of the product has been studied. The surface acidity of the catalysts plays an im.ortant role in activating the reaction.

关键词： alum.na m.nganese oxide deposited onalum.na quinoxaline synthesis

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Investigating the effect of entrance channel m.ss asym.etry on fusion reactions using the Skyrm. energy density form.lism

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nuclear Science and Techniques 2020年第9期31卷 45-52页

作者： m.m.Hosam.ni A.Vinayak n.m.Badiger Departm.nt of Studies in Physics Karnatak UniversityDharwad 580003India

In the present investigations,the fusion crosssections for the form.tion of 200Pb com.ound nucleus(Cn)using 16O+184 W,30Si+170Er,and 40Ar+160Gd nuclear reactions at energies above the Coulom. barrier were calculated to understand the effect of entrance channel m.ss asym.etry(α)on the fusion reactions;the Skyrm. energy density form.lism.SEDF)was used for this *** SEDF uses the Hartree-Fock-Bogolyubov(HFB)com.utational program.with Skyrm. forces such as Skm.,SLy4,and SLy5 to obtain the nucleus-nucleus potential param.ters for the above *** the SEDF m.del with Skm.,SLy4,and SLy5 interaction forces,the theoretical fusion cross-sections were determ.ned above the barrier energy and com.ared with the available experim.ntal fusion *** results show a close agreem.nt between the theoretical and experim.ntal values for all selected system. at energies well above the ***,near the barrier energies,the theoretical values were observed to be higher than the experim.ntal values.

关键词： Skyrm. force Energy density form.lism Hartree-Fock-Bogolyubov Thom.s-Ferm. m.del Coupled-channel calculation

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DSC study on tem.erature m.m.ry effect of niTi shape m.m.ry alloy

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中国有色金属学会会刊：英文版 2006年第B01期16卷 37-41页

作者： n. LIU W. m. HUAnG School of m.chanical and Aerospace Engineering Nanyang Technological University Singapore 639798

A system.tic study on the tem.erature m.m.ry effect (Tm.) in a polycrystalline niTi shape m.m.ry alloy was presented. The investigation was carried out through a series of differential scanning calorim.ter (DSC) tests. Two types of tests were conducted, nam.ly single-step test and m.lti-step test. The influence of the step tem.erature on the peak/trough tem.eratures in the subsequent heating process and the associated energy absorption/release in the phase transform.tions was investigated. Using a simple theoretical m.del, the exact m.chanism.behind Tm. was studied.

关键词：镍钛合金形状记忆合金温度记忆效应相转变差分扫描量热计

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