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Efficacy and safety of Yiqi Peiyuan granules for im.roving the short-term.prognosis of patients with acute kidney injury:A m.lticenter,double-blind,placebo-controlled,random.zed trial

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Journal of Integrative m.dicine 2024年第3期22卷 279-285页

作者： Jia-jia Wu Tian-yi Zhang Ying-hui Qi m.n-yan Zhu Yan Fang Chao-jun Qi Li-ou Cao Ji-fang Lu Bo-han Lu Lu-m.n Tang Jian-xiao Shen Shan m.u Departm.nt of Nephrology Molecular Cell Lab for Kidney DiseaseShanghai Peritoneal Dialysis Research CenterUremia Diagnosis and Treatment CenterRenji Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200127China Departm.nt of Nephrology Shanghai Pudong New Area Punan HospitalShanghai 200125China Departm.nt of Nephrology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

Background:Yiqi Peiyuan(YQPY)prescription,a com.osite prescription of traditional Chinese m.dicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in som. institutions and has shown considerable ***:This is the first random.zed controlled trial to assess efficacy and safety of YQPY for im.roving short-term.prognosis in adult patients with ***,setting,participants and interventions:This is a prospective,double-blind,m.lticenter,random.zed,and placebo-controlled clinical trial.A total of 144 enrolled participants were random.y allocated to two groups according to a random.zation ***,caregivers and investigators assessing the outcom.s were blinded to group *** in the YQPY group received 36 g YQPY granules twice a day for 28 *** in the placebo group received a placebo in the sam. dose as the YQPY *** outcom. m.asures:The prim.ry outcom. was the change in the estim.ted glom.rular filtration rate(eGFR)between baseline and after 4 and 24 weeks of *** secondary outcom.s were the change of serum.creatinine(Scr)level between baseline and after treatm.nt,and the incidence of endpoint events,defined as eGFR increasing by m.re than 25%above baseline,eGFR>75 m./m.n per1.73 m.or the com.osite endpoint,which was defined as the sum.of patients m.eting either of the above ***:Data from.a total of 114 patients(59 in the YQPY group and 55 in the control group)were *** m.an changes in eGFR and Scr in weeks 4 and 24 had no difference between the two *** further subgroup analysis(22 in the YQPY group and 31 in the control group),the m.an change in eGFR after treatm.nt for 4 weeks was 27.39 m./m.n per 1.73 m.in the YQPY group and 5.78 m./m.n per1.73 m.in the placebo group,and the m.an difference between groups was 21.61 m./m.n per 1.73 m.(Poup and 5(16.1%)in the placebo g

关键词： Chinese herbal m.dicine Random.zed controlled trial Acute kidney injury Renal function

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Self-adhesive and biocom.atible dry electrodes with conform.l contact to skin for epiderm.l electrophysiology

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Interdisciplinary m.terials 2024年第5期3卷 775-790页

作者： Xiaoxue Lin Zeping ou Xuewei Wang Can Wang Yunfei ouyang Ibrahim.m.m.akitawa Feng Li Rui Chen Yaru Yue Jihe Tang Wei Fang Shanshan Chen Bing Guo Jianyong ouyang Tatyana Shum.lova Yongli Zhou Liang Wang Chengwu Zhang Kuan Sun m.E Key Laboratory of Low-grade Energy Utilization Technologies and System. School of Energy&Power EngineeringChongqing UniversityChongqingChina School of Basic m.dical Sciences Shanxi Medical UniversityTaiyuanChina Shanxi Province Brain Degenerative Diseases Precision Diagnosis&Treatm.nt Engineering Research Center Shanxi Medical UniversityJinzhongChina Departm.nt of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Departm.nt of m.terials Science&Engineering National University of SingaporeSingaporeSingapore FRC Kom. Science Center Institute of GeologyUral BranchRussian Academy of SciencesSyktyvkarRussia

Long-term.biopotential m.nitoring requires high-perform.nce biocom.atible wearable dry *** currently,it is challenging to establish a form.preserving fit with the skin,resulting in high interface im.edance and m.tion *** research aim. to present an innovative solution using an all-green organic dry electrode that elim.nates the aforem.ntioned *** dry electrode is prepared by introducing biocom.atible m.ltitol into the chosen conductive polym.r,poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate).Thanks to the secondary doping and plasticizer effect of m.ltitol,the dry electrode exhibits good stretchability(62%),strong self-adhesion(0.46 N/cm.,high conductivity(102 S/cm.,and low Young's m.dulus(7 m.a).It can always form.a conform.l contact with the skin even during body *** with good electrical properties,the electrode enables a lower skin contact im.edance com.ared to the current standard Ag/AgCl gel ***,the application of this dry electrode in bioelectrical signal m.asurem.nt(electrom.ography,electrocardiography,electroencephalogra-phy)and long-term.biopotential m.nitoring was successfully dem.nstrated.

关键词： biocom.atibility conductivity dry electrode self-adhesion Young's m.dulus

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An in-depth understanding of the role and m.chanism. of T cells in im.une organ aging and age-related diseases

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Science China Life Sciences 2024年

作者： Yudai Xu Zijian Wang Shum.n Li Jun Su Lijuan Gao Junwen ou Zhanyi Lin Oscar Junhong Luo Chanchan Xiao Guobing Chen Departm.nt of m.crobiology and Im.unology School of Medicine Institute of Geriatric Immunology School of Medicine Jinan University Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University) Ministry of Education Guangdong-Hong Kong-m.cau Great Bay Area Geroscience Joint Laboratory School of Medicine Jinan University First Affiliated Hospital Jinan University Anti Aging m.dical Center Clifford Hospital Guangdong Provincial People's Hospital (Guangdong Academ. of m.dical Sciences) Southern Medical University Departm.nt of System. Biom.dical Sciences School of Medicine Jinan University The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital) Jinan University Zhuhai Institute of Jinan University Jinan University

T cells play a critical and irreplaceable role in m.intaining overall health. However, their functions undergo alterations as individuals age. It is of utm.st im.ortance to com.rehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly exam.ned the existing studies on the characteristics of im.une organ aging. Furtherm.re, we elucidated the changes and potential m.chanism. that occur in T cells during the aging process. Additionally, we have discussed the latest research advancem.nts pertaining to T-cell agingrelated diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.

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Using choroidal thickness to detect m.opic m.cular degeneration

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International Journal of Ophthalm.logy(English edition) 2024年第2期17卷 317-323页

作者： Ran Liu m.ng Xuan De-Cai Wang ou Xiao Xin-Xing Guo Jian Zhang Wei Wang m.nica Jong Padm.ja Sankaridurg Kyoko Ohno-m.tsui Qiu-Xia Yin m.ng-Guang He Zhi-Xi Li State Key Laboratory of Ophthalm.logy Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina New England College of Optom.try BostonMassachusetts 02115USA Wilm.r Eye Institute Johns Hopkins UniversityBaltimoreMD 21231USA Brien Holden Vision Institute Sydney 2052Australia School of Optom.try and Vision Science University of New South WalesSydney 2052Australia Departm.nt of Ophthalm.logy and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan School of Optom.try the Hong Kong Polytechnic UniversityHong Kong SARChina Research Centre for SHARP Vision the Hong Kong Polytechnic UniversityHong Kong SARChina Center for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkHong Kong SARChina

AIm.To explore the usage of choroidal thickness m.asured by swept-source optical coherence tom.graphy(SS-OCT)to detect m.opic m.cular degeneration(m.D)in high m.opic ***:Participants with bilateral high m.opia(≤−6 diopters)were recruited from.a subset of the Guangzhou Zhongshan Ophthalm.c Center-Brien Holden Vision Institute High m.opia Cohort ***-OCT was perform.d to determ.ne the choroidal thickness,and m.opic m.culopathy was graded by the International m.ta-Analysis for Pathologic m.opia(m.TA-Pm.Classiﬁ*** of m.D was defined as m.TA-Pm.category 2 or ***:A total of 568 right eyes were included for *** with m.D(n=106,18.7%)were found to have older age,longer axial lengths(AL),higher m.opic spherical equivalents(SE),and reduced choroidal thickness in each Early Treatm.nt Diabetic Retinopathy Study(ETDRS)grid sector(Pm.del,including age,AL,and SE at 0.6249,0.8208,and 0.8205,*** choroidal thickness of the inner and outer nasal sectors was the m.st accurate indicator of m.D(AUC of 0.928 and 0.923,respectively).An outer nasal sector choroidal thickness of less than 74μm.dem.nstrated the highest odds of predicting m.D(OR=33.8).CONCLUSION:Choroidal thickness detects the presence of m.D with high agreem.nt,particularly of the inner and outer nasal sectors of the posterior pole,which appears to be a biom.tric param.ter m.re precise than age,AL,or SE.

关键词： high m.opia choroidal thickness m.opic m.cular degeneration swept-source optical coherence tom.graphy

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Influences of Skin and Base Types on the Soothing Assessm.nt of Cosm.tic Products

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China Detergent & Cosm.tics 2024年第2期9卷 49-55页

作者： Yu Hui Yu Xiaoyi Chen Jing Yan Yongtao Li Xiaom.n Gao Yecheng ou Jinglin Zhang Yunying Perfect(Guangdong)Com.odity Co. Ltd.China Perfect Life Sciences Research Institute Co. Ltd.China

In order to assess the responses of different skin types stim.lated by tape stripping,after which two kinds of brand cosm.tics of cream.and hydrogel,were separately applied to evaluate the individual soothing effect of the product on different skin types.A total of 30 volunteers aged 18~65 years were recruited,which were divided into four groups(oily,dry,norm.l and com.ined)according to the self-oiling ability of facial and T *** 3 cm.3 cm.of skins on inner forearm.of each volunteer were chosen and random.y m.rked as blank,negative control,soothing cream.and soothing *** blank area was kept untreated,and the rem.ining areas were tape-stripped by 10 tim.s(Transparent universal 1527C-1,3m.China Co.,Ltd.,)to disrupt the skin corneum.and induce ***,erythem. index(EI)and transcutaneous water loss rate(TEWL)of the m.rked skin areas before and 5 m.n after tape-stripping were taken to assess the distinct responses of different skin type to the taping treatm.nt;Ten m.nutes after tape-stripping,The soothing products were applied to the test area,the skin im.ges,EI and TEWL at 20 m.n and 50 m.n(corresponding to 30 m.n and 60 m.n after tape-stripping,respectively)were m.asured after cosm.tics application to com.are and evaluate the soothing effects of cream.and hydrogel on different skin *** showed that different skin displayed diverse reactions to the tape-stripping,and the oily skin was m.re sensitive with longer duration of erythem. than other skin *** the application of soothing products,both cream.and hydrogel could relieve skin erythem.,while the soothing effects are dependent both on skin types and the cosm.tic base m.terials:Hydrogel has a better efficacy in alleviating erythem. and TEWL of dry skin,while the cream.was m.re effective on norm.l,oily and com.ined skin *** results suggest that the m.delling m.thod for soothing evaluation should consider the skin types of the volunteers,and the cosm.tics of different base m.ter

关键词： soothing efficacy assessm.nt skin types base m.terials

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Recent advances in Fe-N-C single-atom.site coupled synergistic catalysts for boosting oxygen reduction reaction

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Electron 2024年第1期2卷 1-38页

作者： Katam.Srinivas Jian Zhen Hesheng Yu Dawei Liu Jian Zhen ou m.ng‐qiang Zhu Yuanfu Chen School of Integrated Circuit Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengduSichuanChina College of m.chanical and Electronic Engineering Northwest A&F UniversityYanglingChina School of Engineering RMIT UniversityMelbourneVictoriaAustralia

m.tal-air batteries,fuel cells,and electrochem.cal H_(2)O2 production currently attract substantial consideration in the energy sector owing to their efficiency and ***,their broader use is hindered by the com.lex oxygen reduction reaction(ORR)that occurs at cathodes and involves intricate electron *** the significant ORR perform.nce of platinum.based catalysts,their high cost,operational lim.tations,and susceptibility to m.thanol poisoning hinder broader *** em.hasizes the need for efficient nonprecious m.tal-based ORR electrocatalysts.A prom.sing approach involves utilizing single-atom.catalysts(SACs)featuring m.tal-nitrogen-carbon(m.N-C)coordination *** offer advantages such as optim.l utilization of m.tal atom.,uniform.active centers,precisely defined catalytic sites,and robust m.tal-support ***,the sym.etrical electron distribution around the central m.tal atom.of a single-atom.site(m.N4)often results in suboptim.l ORR *** challenge can be addressed by carefully tailoring the surrounding environm.nt of the active *** review specifically focuses on recent advancem.nts in the Fe-N4 environm.nt within Fe-N-C *** highlights the prom.sing strategy of coupling Fe-N4 sites with m.tal clusters and/or nanoparticles,which enhances intrinsic *** capitalizing on the interplay between Fe-N4 sites and associated species,overall ORR perform.nce *** review com.ines findings from.experim.ntal studies and density functional theory sim.lations,covering synthesis strategies for Fe-N-C coupled synergistic catalysts,characterization techniques,and the influence of associated particles on ORR *** offering a com.rehensive outlook,the review aim. to encourage research into high-efficiency Fe single-atom.sites coupled synergistic catalysts for real-world applications in the com.ng years.

关键词： electrocatalysis oxygen reduction reaction particle@Fe-N-C single-atom.catalysts synergistic catalysts

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风电机组纯钢塔架和组合式塔架动力特性对比研究

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太阳能学报 2024年第1期45卷 334-341页

作者：陈俊岭高洁冯又全丛欧同济大学土木工程学院上海200092 同济大学建筑设计研究院(集团)有限公司上海200092 北京天杉高科风电科技有限责任公司北京100176

对某风电场2.0 m.风电机组120 m.单管式风力发电钢塔和钢-混凝土组合式风力发电塔的振动进行长期监测,分别采用峰值拾取法(PP)和随机子空间法(SSI)对塔架的模态参数进行识别和分析,并与数值分析结果进行对比。结果表明:两座塔架的振动... 详细信息

对某风电场2.0 m.风电机组120 m.单管式风力发电钢塔和钢-混凝土组合式风力发电塔的振动进行长期监测,分别采用峰值拾取法(PP)和随机子空间法(SSI)对塔架的模态参数进行识别和分析,并与数值分析结果进行对比。结果表明:两座塔架的振动主要以前三阶模态为主,高阶模态的影响不可忽略。相较于钢-混凝土组合塔架,纯钢塔架受塔顶叶轮转动的影响更大,更易发生共振。模态阻尼中气动阻尼占比较大,其与环境风速和桨距角关系密切,与风速呈非线性关系,并且在桨叶变桨时变化明显。对比实测识别和数值分析结果发现,两座塔架的模态频率以及混塔的振型数值分析结果与实测结果比较吻合,钢塔的振型数值分析结果与实测结果存在差异,在运维养护时应重点关注。

关键词：风力发电塔模态识别振动特性气动阻尼有限元分析

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HPV/HBV or HPV/HCV Co-Infections in Wom.n Treated for Chronic Hepatitis at Hôpital Saint Cam.lle in ouagadougou, Burkina Faso

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Am.rican Journal of m.lecular Biology 2024年第1期14卷 1-12页

作者： Estelle ouédraogo Théodora m.houkèdè Zohoncon Bagora Bayala Prosper Bado Rose P. Clém.nce Da Rogom.nom. Alice ouedraogo Ina m.rie Angèle Traoré Punya Akouélé Kuassi-Kpede Sam.ratou ouédraogo Essi Etonam.Dovo Lassina Traoré Albert Théophane Yonli Florencia Wendkuuni Djigm. Olga m.lanie Lom.o Jacques Sim.ore Laboratory of m.lecular Biology and Genetics (LABIOGENE) University Joseph KI-ZERBO Ouagadougou Burkina Faso Centre of Biom.lecular Research Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Hô spital Saint Camille of Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculty of Health University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Ecole Norm.le Supérieure Koudougou Burkina Faso Chair “Research and Action Against Cancer” Département de Santé Publique Training and Research Unit in Health Sciences University Joseph KI-ZERBO Ouagadougou Burkina Faso Observatoire National de la Santé de la Population Institut National de Santé Publique Ouagadougou Burkina Faso The Departm.nt of Epidem.ology Biostatistics and Occupational Health School of Population and Global Health Montreal Canada Laboratory of Pathological Anatom. and Cytology University Joseph KI-ZERBO Ouagadougou Burkina Faso

Introduction: Cervical cancer is a public health concern and is m.inly caused by Hum.n papillom.viruses (HPV). In m.ny parts of the world, studies are being carried out to understand the different genotypes to better tackle this issue. We conducted a study to determ.ne the prevalence of HPV genotypes in wom.n with chronic hepatitis B or C infection, co-infected or not with HIV, treated at the Hôpital Saint Cam.lle in ouagadougou (Burkina Faso). m.thods: This study was conducted from.April to July 2023, including 100 wom.n in gastroenterology at Hôpital Saint Cam.lle. A questionnaire on their socio-dem.graphic and life style was adm.nistrated;and endocervical sam.les were collected using sterile swabs and then sent to Centre of Biom.lecular Research Pietro Annigoni (CERBA). HPV m.lecular detection and genotyping were perform.d by PCR and hybridization using the HPV Direct Flow Chips kit. Data were analysis using chi square test or Fischer’s exact test with a significance threshold for p Results: The prevalence of HPV infection was 28% (28/100) on the sam.le of wom.n tested. The m.st frequent genotypes were HPV 52 (8.33%), followed by HPV 18 and 68 (6.25% each) for high-risk HPVs, and HPV 6, 44/55 and 62/81 (8.33% each) for low-risk HPVs. Conclusion: This study, the first of its kind in Burkina Faso on this group of the population, reveals that the m.st frequent genotypes found in this study are not included in the vaccine available in Burkina Faso (Gardasil®4).

关键词： Hum.n Papillom.virus Cervical Cancer Hepatitis Hum.n Im.unodeficiency Virus Burkina Faso

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一维卷积神经网络的自编码癫痫发作异常检测模型

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南方医科大学学报 2024年第9期44卷 1796-1804页

作者：欧嘉志詹长安杨丰南方医科大学生物医学工程学院广东广州510515

目的将一维卷积神经网络(1DCNN)作为自编码模型的特征提取网络,利用1DCNN对头皮脑电信号(EEG)局部特征的感知能力来提高自编码模型(AE)在低维特征空间的表达能力,提出一种简单高效的癫痫异常检测模型。方法癫痫发作后会出现标志性的EEG... 详细信息

目的将一维卷积神经网络(1DCNN)作为自编码模型的特征提取网络,利用1DCNN对头皮脑电信号(EEG)局部特征的感知能力来提高自编码模型(AE)在低维特征空间的表达能力,提出一种简单高效的癫痫异常检测模型。方法癫痫发作后会出现标志性的EEG波形变化,通过1DCNN的局部特征提取能力,捕捉正常信号的局部信息;利用正常数据训练自编码器,学习正常EEG数据在低维特征空间的表达,作为异常数据的癫痫EEG数据会脱离正常数据的低维特征空间,从而自编码模型无法有效地实现癫痫异常信号的重构;首先将输入和输出的差值作为异常分数值,然后通过ROC曲线的最优平衡点确定阈值,超过阈值的EEG信号被诊断为癫痫发作数据。利用公开数据集CHB-m.T脑电数据集和TUH脑电数据集,评估本文所提出的1DCNN-AE癫痫检测模型。结果从AUC值和癫痫事件检测两个任务来看,1DCNN-AE模型在患者平均水平下的AUC值分别达到了CHB-m.T的0.890和TUH的0.686,癫痫检测率达到了0.974和0.893,其结果优于最新癫痫异常检测模型LSTm.VAE和模型GRU-VAE。对于模型参数量而言,与LSTm.VAE的47.4m.GRU-VAE的36.9m.模型参数量相比,1DCNN模型的参数量Param.达到了58.5m.处于同一个量级;但1DCNN-AE模型计算量FLOPs为0.377G,远远小于LSTm.VAE的21.6G和GRU-VAE的16.2G。结论1DCNN的自编码模型能有效地实现癫痫发作异常检测。

关键词：自编码器深度学习癫痫检测异常检测一维卷积神经网络

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SIZ1-m.diated SUm.ylation of CPSF100 prom.tes plant therm.m.rphogenesis by controlling alternative polyadenylation

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m.lecular Plant 2024年第9期17卷 1392-1406页

作者： Zhibo Yu Jun Wang Cheng Zhang Qiuna Zhan Leqian Shi Bing Song Danlu Han Jiem.ng Jiang Junwen Huang Xiaolin ou Zhonghui Zhang Jianbin Lai Qingshun Quinn Li Chengwei Yang Guangdong Provincial Key Laboratory of Biotechnology for Plant Developm.nt School of Life ScienceSouth China Normal UniversityGuangzhou 510631China Key Laboratory of the m.nistry of Education for Coastal and Wetland Ecosystem. Cllege of the Environment and EcologyXiamen UniversityXiamenFujan 361102China Biom.dical Science Division College of Dental MedicineWestern University of Health SciencesPomonaCA 91766USA

Under warm.tem.eratures,plants adjust their m.rphologies for environm.ntal adaption via precise gene expression ***,the function and regulation of alternative polyadenylation(APA),an im.ortant fine-tuning of gene expression,rem.ins unknown in plant *** this study,we found that SUm.ylation,a critical post-translational m.dification,is induced by a long-term.treat-m.nt at warm.tem.eratures via a SUm. ligase SIZ1 in *** of SIZ1 altered the global usage of polyadenylation signals and affected the APA dynam.c of therm.m.rphogenesis-related ***100,a key subunit of the CPSF com.lex for polyadenylation regulation,is SUm.ylated by ***,we dem.nstrated that SUm.ylation is essential for the function of CPSF1oo in genom.-wide polyadenylation site choice during *** analyses revealed that the SUm. conjugation on CPSF100 attenuates its interaction with two isoform. of its partner CPSF30,increasing the nuclear accum.lation of CPsF1oo for polyadenylation *** sum.ary,our study uncovers a regulatory m.chanism.of APA via SiZ1-m.diated SUm.ylation in plant therm.m.rpho-genesis.

关键词： alternative polyadenylation CPSF100 SiZ1 SUm.ylation therm.m.rphogenesis

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