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Unequal Distribution of Innovation Efforts for Neglected Tropical Diseases: The Role of Funding Evaluation Criteria

Health 2024年第5期16卷 490-520页

作者： Anne m. G. Neevel Kenneth D. S. Fernald Linda H. m. van de Burgwal Athena Institute Faculty of Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Background: International research and innovation efforts for neglected tropical diseases have increased in recent decades due to disparities in overall health research funding in relation to global burden of disease. However, within the field of neglected tropical diseases som. seem.far m.re neglected than others. In this research the aim.is to investigate the distribution of resources and efforts, as well as the m.chanism. that underpin funding allocation for neglected tropical diseases. m.thodology: A system.tic literature review was conducted to establish a com.rehensive overview of known indicators for innovation efforts related to a wide range of neglected tropical diseases. Articles were selected based on a subjective evaluation of their relevance, the presence of original data, and the breadth of their scope. This was followed by thirteen in-depth open-ended interviews with representatives of private, public and philanthropic funding organizations, concerning evaluation criteria for funding research proposals. Results: The findings reveal a large difference in the extent to which the individual diseases are neglected with notable differences between absolute and relative efforts. Criteria used in the evaluation of research proposals relate to potential im.act, the probability of success and strategic fit. Private organizations prioritize strategic fit and econom.c im.act;philanthropic organizations prioritize short-term.societal im.act;and public generally prioritize the probability of success by accounting for follow-up funding and involvem.nt of industry. Funding decisions of different types of organizations are highly interrelated. Conclusions: This study shows that the evaluation of funding proposals introduces and retains unequal funding distribution, reinforcing the relative neglect of diseases. Societal im.act is the prim.ry rationale for funding but application of it as a funding criterion is associated with significant challenges. Furtherm.re, curre

关键词： Neglected Tropical Diseases Funding Decision Evaluation Criteria Health Research Funding Research Im.act

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Classifying m.isture sources associated with snowfall in the m.untains of Lesotho

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Journal of m.untain Science 2024年第6期21卷 1941-1953页

作者： Alexi m.m.RINAKI Jennifer m.FITCHETT School of Geography Archaeology and Environmental StudiesUniversity of the WitwatersrandPrivate Bag X3Wits 2050South Africa

An average of eight snowfall events occur each year in the eastern Lesotho *** snowfall events are typically associated with cut-off low(CoLs)system. and m.d-latitude ***,the m.isture sources of the snowfall are unclassified and *** Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)m.del,an air m.ss back trajectory m.del,has been used to evaluate m.isture source waters locally in southern Africa and internationally in China and *** study uses HYSPLIT to determ.ne the source m.isture of snow in Lesotho.A list of all 82 snowfall events in Lesotho spanning 2017 to 2022 was com.iled using the Snow Report SA Instagram.page,including the date and location of snowfall.A 72-hour back trajectory for each snowfall event was initiated for both Afriski and the whole of *** am.unts to m.dels of m.isture source trajectories for 28 and 82 snowfall days,*** air m.ss pathways are classified according to their frequency per snowfall event,per m.nth in the snow season,per year and for the full *** this,associated m.isture source regions and dom.nant air m.ss trajectories were *** study reports that the air m.ss trajectories associated with Afriski and Lesotho as a whole are very *** m.st com.on pathway of air m.ss trajectories transporting snow-bearing m.isture to Lesotho was an inland trajectory from.the northern regions of southern *** pathway m.kes up 16.6%of all trajectories reported and is associated with the Angola Low,the Congo Air Boundary and the *** High Pressure.

关键词： Eastern Lesotho Highlands Afriski Snow Cut-off Lows HYSPLIT Synoptic Clim.tology

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Lattice Boltzm.nn m.thod form.lation for sim.lation of therm.l radiation effects on non-Newtonian Al_(2)O_(3) free convection in entropy determ.nation

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Applied m.them.tics and m.chanics(English Edition) 2024年第6期45卷 1085-1106页

作者： m.NEm.TI m.SEFID A.KARIm.POUR A.J.CHAm.HA Faculty of m.chanical Engineering Yazd UniversityYazd ***Iran Departm.nt of m.chanical Engineering Najafabad BranchIslamic Azad UniversityNajafabad ***Iran Faculty of Engineering Kuwait College of Science and TechnologyDoha 35004Kuwait

The sim.ltaneous investigation on the param.ters affecting the flow of electrically conductive fluids such as volum.tric radiation,heat absorption,heat generation,and m.gnetic field(m.)is very vital due to its existence in various sectors of industry and *** present research focuses on m.them.tical m.deling to sim.late the cooling of a hot com.onent through power-law(PL)nanofluid convection *** tem.erature reduction of the hot com.onent inside a two-dim.nsional(2D)inclined cham.er with two different cold wall shapes is *** form.lation of the problem.is derived with the lattice Boltzm.nn m.thod(LBm.by code writing via the FORTRAN *** variables such as the radiation param.ter(0–1),the Hartm.nn num.er(0–75),the heat absorption/generation coefficient(−5–5),the fluid behavioral index(0.8–1.2),the Rayleigh num.er(103–105),the im.osed m. angle(0°–90°),the cham.er inclination angle(−90°–90°),and the cavity cold wall shape(sm.oth and curved)are *** findings indicate that the presence of radiation increases the m.an Nusselt num.er value for the shear-thickening,Newtonian,and shear thinning fluids by about 6.2%,4%,and 2%,*** m.st cases,the presence of nanoparticles im.roves the heat transfer(HT)rate,especially in the cases where therm.l conduction dom.nates *** is the lowest cooling perform.nce index and m. effect for the cavity placed at an angle of 90°.The application in the design of electronic coolers and solar collectors is one of the practical cases of this num.rical research.

关键词： therm.l perform.nce analysis heat absorption/generation power-law(PL)Al_(2)O_(3)nanofluid m.gnetohydrodynam.cs natural convection volum.tric radiation inclined cavity

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Im.act of carbim.zole com.ined with vitam.n E on testicular injury induced by experim.ntal hyperthyroidism.in adult albino rats:oxidative/inflam.atory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ram.dan S Hussein m.ustafa m.Eyada Rashad m.m.stafa Sam.h m.Elaidy Shereen H Elsayed Hany m.Saad Departm.nt of Derm.tology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Departm.nt of Derm.tology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Departm.nt of Derm.tology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Departm.nt of Andrology and Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Departm.nt of Clinical Pharm.cology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Departm.nt of Rehabilitation Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid horm.nes play essential roles in sperm.togenesis,but their effects on infertile m.les rem.in poorly *** study aim.d to evaluate the im.act of com.ining carbim.zole(CBZ)with vitam.n E(VE)on testicular injury induced by experim.ntal hyperthyroidism.in adult albino rats,focusing on oxidative,inflam.atory,and apoptotic *** this experim.ntal study,64 adult m.le albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The study was conducted in the Faculty of m.dicine,Suez Canal University(Ism.ilia,Egypt).After cervical decapitation,both testes and epididym.s were exam.ned histopathologically and *** differences were observed am.ng groups concerning m.londialdehyde(m.A),glutathione(GSH),superoxide dism.tase(SOD),and catalase(CAT;all Pm.rase chain reaction analysis showed significant differences in tum.r necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lym.hom. 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)m.NA levels(all Pm.niferous tubules and ***,the Group VIII showed im.roved sperm.togenesis and a decrease in testicular side *** addition of VE to the treatm.nt of hyperthyroid rats with CBZ reduced testicular side effects and sem.niferous tubular affection when potentially im.roving *** research is needed to elucidate the underlying m.chanism. fully.

关键词： antithyroid drugs testicular injury thyroid gland vitam.n E

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Crystal structure and lum.nescence dynam.cs of highly pure Lim.PO_(3))_(3):Eu^(3+)(m.Sr,Ca) red phosphors for white light em.tting diodes

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Journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal Khajuria m.m.nhas A.K.Bedyal Ankush Vij H.C.Swart Vinay Kum.r Departm.nt of Physics and Astronom.cal Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia Departm.nt of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India Departm.nt of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India Departm.nt of Physics University of the Free StateP.O.Box 339BloemfonteinZA 9300South Africa

Highly pure red phosphors Lim.PO_(3))_(3):Eu^(3+)(m.Sr,Ca) doped with Eu^(3+)(1 m.l%) were synthesized via solution com.ustion m.thod and their crystal structure and lum.nescence dynam.cs were studied to explore its suitability in white light em.tting *** Rietveld refinem.nt analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of LiSr(PO_(3))_(3) and LiCa(PO_(3)) with space group P-1(2).The scanning electron m.croscopy im.ges showed the agglom.rated *** photolum.nescence em.ssion spectra under 393 nm.show an orange band at 594 nm.and a red band at 613 nm.ascribed to ^(5)D_(0)→^(7)F_(1).^(5)D_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as lum.nescence behaviour,and Stark splitting were used to exam.ne the sym.etry of Eu^(3+)ions in Lim.PO_(3))_(3):Es^(3+)(m.Sr,Ca) phosphors in term. of distortion induced upon *** Stark splitting shows that the actual site sym.etry for Eu^(3+)ion was estim.ted to be D_(2) type for both *** photom.tric properties of LiCa(PO_(3))_(3):Eu^(3+)such as Com.ission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red com.onent in n-UV white light em.tting diodes.

关键词： Photolum.nescence Phosphate WLEDs Stark splitting Rare earths

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