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m.tochondria–cGAS–STInG axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Regulator of G protein signaling 6 m.diates exercise-induced recovery of hippocam.al neurogenesis,learning,and m.m.ry in a m.use m.del of alzheim.r’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： m.ckenzie m.Spicer Jianqi Yang Daniel Fu alison n.DeVore m.risol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Departm.nt of neuroscience and Pharm.cology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program.in m.lecular m.dicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocam.al neuronal loss causes cognitive dysfunction in alzheim.r’s *** hippocam.al neurogenesis is reduced in patients with alzheim.r’s *** stim.lates adult hippocam.al neurogenesis in rodents and im.roves m.m.ry and slows cognitive decline in patients with alzheim.r’s ***,the m.lecular pathways for exercise-induced adult hippocam.al neurogenesis and im.roved cognition in alzheim.r’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the m.diator of voluntary running-induced adult hippocam.al neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) m.ce and used retroviral approaches to exam.ne the im.act of RGS6 deletion from.dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocam.al neurogenesis and cognition in an am.loid-based alzheim.r’s disease m.use *** found that voluntary running in APP_(SWE) m.ce restored their hippocam.al cognitive im.airm.nts to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-m.diated increases in adult hippocam.al *** hippocam.al neurogenesis was reduced in sedentary APP_(SWE) m.ce versus control m.ce,with basal adult hippocam.al neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with alzheim.r’s disease with significant loss of these RGS6-expressing ***,RGS6 m.diated voluntary running-induced rescue of im.aired cognition and adult hippocam.al neurogenesis in APP_(SWE) m.ce,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in alzheim.r’s disease.

关键词： adult hippocam.al neurogenesis alzheim.r’s disease dentate gyrus exercise learning/m.m.ry neural precursor cells regulator of G protein signaling 6(RGS6)

Insights from.an academ.c endeavor into central nervous system.drug discovery

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neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim.Vanm.erlo Rudy Schreiber BIOm.D Biom.dical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Departm.nt of Psychiatry and neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharm.cology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University m. Center(Um.C) Hasselt-PeltBelgium

Historically,"big pharm."did m.st central nervous system.drug discovery R&D ***,in m.dern tim.s their"m.nagem.nt reductionism.resulted in disappointing pipelines and pharm. resided to(late)developm.nt,regulatory approval,and m.rketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governm.nts and patient-organizations and a shift of research to academ.a(m.zzucato,2013).

关键词： academ.c approval consequences

Predicting m.xim.m.Lifespan Lim.ts at m.an m.nopausal Age

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Journal of m.them.tical Research with Applications 2025年第1期 133-142页

作者： m.SUm.THI S.AnTOnY CARLA Departm.nt of m.them.tics N.M.S.S.Vellaichamy Nadar College Research Scholar (Part-tim.) Madurai Kamaraj University

The age at which a wom.n enters natural m.nopause has also been associated to death from.any cause. m.nopause is a natural com.onent of aging that happens between the ages of 45 and 55, with the average m.nopausal age being 51. Previous research has revealed the age at which wom.n reach m.nopause, but there is no evidence to support the link between m.nopause and longevity. We m.de a study in assessing the lim.ts of m.xim.m.lifespan at m.nopausal age in our previous article. In this paper, we aim.to predict the m.xim.m.lifespan of wom.n at m.an m.nopausal age.

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Brain-derived neurotrophic factor signaling in the neurom.scular junction during developm.ntal axonal com.etition and synapse elim.nation

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tom.s Víctor Cilleros-m.ñé Laia Just-Borràs m.rta Balanyà-Segura aleksandra Polishchuk Laura nadal m.rta Tom.s Carolina Silvera-Sim.n m.nel m.Santafé m.ria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the developm.nt of the nervous system.there is an overproduction of neurons and *** com.etition between neighboring nerve endings and synapses perform.ng different activity levels leads to their elim.nation or *** have extensively studied the involvem.nt of the brain-derived neurotrophic factor-Tropom.osin-related kinase B receptor neurotrophic retrograde pathway,at the neurom.scular junction,in the axonal developm.nt and synapse elim.nation process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developm.ntal synapse elim.nation,in relation to other m.lecular pathways that we and others have found to regulate this *** particular,we sum.arize our published results based on transm.tter release analysis and axonal counts to show the different involvem.nt of the presynaptic acetylcholine m.scarinic autoreceptors,coupled to downstream.serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium.channels,at different nerve endings in developm.ntal *** dynam.c changes that occur sim.ltaneously in several nerve term.nals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the m.chanism. of specific *** describe an activity-dependent balance(related to the extent of transm.tter release)between the presynaptic m.scarinic subtypes and the neurotrophin-m.diated TrkB/p75nTR pathways that can influence the tim.ng and fate of the com.etitive interactions between the different axon *** downstream.displacem.nt of the PKA/PKC activity ratio to lower values,both in com.eting nerve term.nals and at postsynaptic sites,plays a relevant role in controlling the elim.nation of supernum.rary ***,calcium.entry through L-and P/Q-subtypes of voltage-gated calcium.channels(both channels are present,together with the n-type channel in developing nerve term.nals)contributes to red

关键词： acetylcholine release adenosine receptors axonal com.etition brain-derived neurotrophic factor calcium.channels m.tor end-plate m.scarinic acetylcholine receptors postnatal synapse elim.nation serine kinases tropom.osin-related kinase receptorB

Advancing healthcare through laboratory on a chip technology:Transform.ng m.croorganism.identification and diagnostics

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World Journal of Clinical Cases 2025年第3期13卷 9-19页

作者： Carlos m.Ardila Departm.nt of Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 0057Colombia

In a recent case report in the World Journal of Clinical Cases,em.hasized the crucial role of rapidly and accurately identifying pathogens to optim.ze patient treatm.nt ***-on-a-chip(LOC)technology has em.rged as a transform.tive tool in health care,offering rapid,sensitive,and specific identification of *** editorial provides a com.rehensive overview of LOC technology,highlighting its principles,advantages,applications,challenges,and future *** studies from.the field have dem.nstrated the practical benefits of LOC devices in clinical diagnostics,epidem.ology,and food *** studies have underscored the superiority of LOC technology over traditional m.thods,showcasing im.rovem.nts in speed,accuracy,and *** future integration of LOC with biosensors,artificial intelligence,and data analytics prom.ses further innovation and *** call to action em.hasizes the im.ortance of continued research,investm.nt,and adoption to realize the full potential of LOC technology in im.roving healthcare outcom.s worldwide.

关键词： Laboratory-on-a-chip m.croorganism.identification Diagnostics Point-ofcare testing Biosensors

The sexually dim.rphic expression of glutam.te transporters and their im.lication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-m.rcado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Sam.el E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.m.randa Departm.nt of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of m.tor function,~60% of patients develop pain after spinal cord *** cellular-m.lecular m.chanism. are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penum.ra of the injury site initiates a cellularm.lecular interplay that acts as a rewiring m.chanism.leading to central neuropathic *** can lead to the form.tion of new connections triggering abnorm.l sensory *** excitatory glutam.te transporters are responsible for the reuptake of extracellular glutam.te which m.kes them.a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dim.rphic therapeutic window for spinal cord injury after treatm.nt with the selective estrogen receptor m.dulator *** this study,we investigated the anti-allodynic effects of tam.xifen in m.le and fem.le rats with spinal cord *** hypothesized that tam.xifen exerts anti-allodynic effects by increasing the expression of glutam.te transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and fem.le rats received a m.derate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatm.nt of tam.xifen or m.trix pellets as a control(placebo).We used von Frey m.nofilam.nts and the“up-down m.thod”to evaluate m.chanical *** treatm.nt decreased allodynia only in fem.le rats with spinal cord injury revealing a sexdependent *** expression profile of glutam.tergic transporters(excitatory am.no acid transporter 1/glutam.te aspartate transporter and excitatory am.no acid transporter 2/glutam.te transporter-1)revealed a sexual dim.rphism.in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression prim.rily on *** rodents showed a significantly higher level of excitatory am.no acid transporter-1 expression while m.le rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutam.te transporters selective estrogen receptor m.dulator sexual dim.rphism spinal cord injury traum.

Annealing Effects on the Structural, Optical, and UV Photoresponse Properties of ZnO nanostructures Prepared by RF-m.gnetron Sputtering at Different Deposition Tem.eratures

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Acta m.tallurgica Sinica(English Letters) 2015年第2期28卷 230-242页

作者： Husam.S.al-Salm.n m.J.abdullah School of Physics University Sains Malaysia Departm.nt of Physics College of Science University of Basrah

Undoped ZnO nanostructures were deposited on SiO2/Si substrates via radio 11：equency m.gnetron sputtenng at different deposition tem.eratures （room.tem.erature, 200, 300, and 400 ℃）. The prepared sam.les were annealed at 500 ℃ for 2 h under an n2 flow. The structural, surface m.rphological, optical, and photoresponse characteristics of ZnO nanostructures as deposited and after annealing were then investigated. The energy bandgaps of all sam.les after annealing （3.22-3.28 eV） decreased com.ared with those of the as-deposited specim.ns. The barrier height increased when the deposition tem.erature increased and reached 0.77 eV at 400 ℃ after annealing with a leakage current of 0.17 gA at a 5 V bias. The UV photodetector device which was deposited at the optim.l tem.erature of 300 ℃, has 12.51 × 10^3% pho- tosensitivity, 2.259 pA dark current, 0.508 s response tim., and 0.466 s recovery tim.. The dark current significantly decreased for all sam.les after annealing. The proposed UV photodetectors exhibit high perform.nce, high photosensi- tivity, shorter response and recovery tim.s, and excellent stability at lower bias voltages of 5 and 2 V.

关键词： Undoped ZnO UV photoresponse Deposition tem.eratures Annealing effect

Dust particle surface potential in an argonhelium.plasm. using the(r,q)-distribution function

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Com.unications in Theoretical Physics 2024年第9期76卷 141-148页

作者： Bahaaudin m.Raffah A A Abid abdullah Khan Am.n Esm.eili Yas al-Hadeethi m.n S Qureshi Departm.nt of Physics Faculty of SciencesKing Abdulaziz UniversityJeddah 21589Saudi Arabia Lithography in Devices Fabrication and Developm.nt Research Group Deanship of Scientific ResearchKing Abdulaziz UniversityJeddah 21589Saudi Arabia Joint Laboratory of Plasm. Application Technology Institute of Advanced TechnologyUniversity of Science and Technology of ChinaHefei230026China CAS Key Laboratory of Geospace Environm.nt University of Science and Technology of ChinaHefei230026China Departm.nt of Physics Zhejiang Normal UniversityJinhua321005China Departm.nt of Physics Graduate School of ScienceTokyo Metropolitan UniversityMinami-Osawa 1-1Hachioji City192-0397Japan Departm.nt of Physics GC UniversityLahore 54000Pakistan

In this paper,the dust particle surface potential for argon-helium.plasm. is evaluated analytically and num.rically in the context of negatively charged dust particles by em.loying a power-law(r,q)-distribution *** studies have reported the argon-helium.plasm. and conducted a brief theoretical and experim.ntal *** deepen our understanding further,this study aim. to analyze the argon-helium.plasm. com.rehensively using the sam. pattern but with the(r,q)-distribution *** this purpose,the current balance equations are derived for electron,helium.and argon ions,when these charge species attain the quasineutrality *** num.rically exam.ned the currents of plasm. species for a broad range of effective distribution function param.ters r and *** is revealed that the surface potential of dust particles is significantly affected by the param.ters r and q,helium.ion-to-electron tem.erature ratio,argon ion-to-electron tem.erature ratio,and helium.ion to argon ion num.er density *** incorporating the m.lti-ion(argon-helium.species,the significance of low-tem.erature nonm.xwellian dusty(com.lex)plasm. is briefly exam.ned.

关键词： dusty plasm. dust charge potential plasm. physics helium.argon plasm. r q distribution function non-m.xwellian distribution