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An.ioxidan. an. Cytotoxicity Poten.ial of Six Syn.hesized Chalcon.s

Pharm.cology & Pharm.cy 2018年第12期9卷 536-546页

作者： S. L. Kouakou m. Ouattara J. P. n.Guessan.S. Coulibaly A. G. Irié-n.Guessan.G. Kouakou-Siran.y Laboratoire de Pharm.cologie UFR Sciences Pharmaceutiques Université FHB Abidjan Cote d’Ivoire Departem.n. Chim.e Therapeutique et de Chim.e Organ.que UFR Sciences Pharmaceutiques Universite FHB Abidjan Cote d’Ivoire

Backgroun.: Chalcon.s are open.chain.flavon.ids which display a large n.m.er of pharm.cological activities such as cytotoxic, an.i-in.lam.atory in.ludin. an.ioxidan.. The objective of this study was to assess an.ioxidan. an. cytotoxic activity of six syn.hesized chalcon.s. m.thodology: For the curren. experim.n.s, 1,3-diphen.lpropen.n. (com.oun. R) was used as m.lecular m.del to syn.hetize six com.oun.s, n.m.ly three ben.yl-ben.im.dazolyl-chalcon.s (U1, U2, WAC1) an. three im.dazopyridin.l-chalcon.s (V1, V2, V3). All the com.oun.s were evaluated for their ability to scaven.e the stable free ABTS.+ radical cation. accordin. to the m.thod develop by Choon. et al. In.addition. the cytotoxicity test described by Price et al., was perform.d usin. healthy hum.n.cell lin., then.in.hum.n.m.lign.n. cell lin.s (HEP-2, A549). Results: All syn.hesized chalcon.s reduced the ABTS.+ radical cation. In.eed, ben.yl ben.im.dazolyl com.oun.s WAC1, U1, U2, by developin. respectively 39.61%, 66.09%, an. 84.20% percen.ages of reduction. showed an.an.ioxidan. effect 6, 11 an. 14 tim.s greater than.the com.oun. R (6.14%). As a result, im.dazopyridin.l-chalcon.s com.oun.s, n.m.ly V1, V2 an. V3 reduced the ABTS.+ radical cation.at 91.62%, 99.84% an. 97.45% respectively, bein. 15 an. 16 tim.s m.re active than.the com.oun. R. About cytotoxicity, V2 in.ibited n.t sign.fican.ly HEP-2 m.lign.n. cells growth at 48.64%, com.ared to the stan.ard product, i.e. doxorubicin.that in.ibited the growth of the sam. cells at 42.37%. WAC1 in.ibited sign.fican.ly the growth of A549 m.lign.n. cells at 89.53%, m.re than.doxorubicin.which percen.age of growth in.ibition.was 71.58%. Con.lusion. The presen.e of the α, β-un.aturated carbon.l system.(or 1,3-diphen.lpropen.n.) alon. with a ben.im.dazole or im.dazopyridin. heterocyclic rin. is likely to con.ribute to both cytotoxic an. an.ioxidan. activities of these com.oun.s.

关键词： Chalcon.s An.ioxidan. Cytotoxic HEP-2 A549 ABTS

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Jeffrey流体流过有限长圆柱管时磁流体动力学的蠕动流

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应用数学和力学 2011年第10期32卷 1148-1160页

作者： D.特里帕蒂 n.阿里 T.哈亚特 m.K.焅比 A.A.佷迪吴承平海得拉巴大学印度博拉理工学院国际伊斯兰大学数学与统计系巴基斯坦真纳大学数学系沙特国王大学科学学院物理系印度大学技术学院应用数学系

研究Jeffrey流体流过有限长管道时的蠕动流.在外加磁场作用时,流体呈导电性.分析是在长波长和低Reyn.lds数近似假设下完成.得到了压力梯度、体积流量、平均体积流量和局部壁面剪应力的表达式.研究了松弛时间、延迟时间和Hartm.n.,对压... 详细信息

研究Jeffrey流体流过有限长管道时的蠕动流.在外加磁场作用时,流体呈导电性.分析是在长波长和低Reyn.lds数近似假设下完成.得到了压力梯度、体积流量、平均体积流量和局部壁面剪应力的表达式.研究了松弛时间、延迟时间和Hartm.n.,对压力、局部壁面剪应力以及蠕动泵机械效率的影响.还研究了回流现象,调查了沿管道壁波数非整倍数时的传播情况,研究有限长管道传播的内在特性.

关键词：蠕动流磁流体动力学 Jeffrey流有限长管道机械效率回流

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沙土在孔隙水注入实验中渗透剪切破坏(英文)

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西北地震学报 2005年第3期27卷 212-219页

作者： Kazam. m.Uzuoka R Sen.o n.Un.o T 东北大学土木工程系仙台980-8579日本

前人曾指出液化后伴随着超孔隙水压重新分配的渗透会引起流体破坏的可能性。为了研究这一现象,利用实验室三轴试验将孔隙水注入土壤检测了土壤的渗透剪切破坏。该实验是在各项异性的固结作用后保持差应力,使用孔隙水控制装置在体积不变... 详细信息

前人曾指出液化后伴随着超孔隙水压重新分配的渗透会引起流体破坏的可能性。为了研究这一现象,利用实验室三轴试验将孔隙水注入土壤检测了土壤的渗透剪切破坏。该实验是在各项异性的固结作用后保持差应力,使用孔隙水控制装置在体积不变的应变控制条件下将孔隙水注入。实验中所用的材料是在1995年神户地震时被液化的常规洁净细砂和风化的花岗岩土壤。本文以实验结果为基础,讨论了由孔隙水注入引起的渗透剪切破坏判据和导致后液化行为的剪切应变发展特征。

关键词：渗透剪切破坏风化花岗岩土壤后液化作用孔隙水注入

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热传导

热传导

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作者： m.n.·奥齐西克(m.n. Ozisik)

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Crystallographic an. Low Frequen.y Con.uctivity Studies of the Spin.l System. CuFe_2O_4 an. Cu_(1-x)Zn.xGa_(0.1)Fe_(1.9)O_4

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沈阳理工大学学报 2010年第3期29卷 87-94页

作者： A.m. Hashhash n.n. n.kiten.ov I.P. Chern.v Yu.I. Tyurin Tom.k polytechn.c un.versity

Spin.l solid solution. of CuFe2O4 an. Cu1-xZn.Ga0.1Fe1.9O4 with (0.0≤x≤0.5) are syn.hesized. Crystallographic phase tran.form.tion.from.tetragon.l-to-cubic occurred at x=0.2. The derived structural param.ters m.n.fest that Zn.occupies the tetrahedral A-site while Cu an. Ga occupy the octahedral B-site an. Fe distributes am.n. A-an. B-sites. Electrical con.uctivity m.asurem.n.s of these m.terials as a fun.tion.of tem.erature an. frequen.y revealed sem.con.uctin. behavior except CuFe2O4 sam.le,which has a m.tallic behavior at low frequen.y an. at high frequen.y,m.tallic-to-sem.con.uctor tran.ition.occurred as tem.erature in.reases. The m.tallic behavior in.this sam.le is attributed to cation.cation.in.eraction. at B-site while,the sem.con.uctor behavior in.Cu1-xZn.Ga0.1Fe1.9O4 com.oun.s is due to the cation.an.on.cation.in.eraction. at the sam. site in.the spin.l lattice. All com.osition. exhibit tran.ition.with chan.e in.the slope of con.uctivity versus tem.erature curve. This tran.ition.tem.erature (Tc) decreases lin.arly with in.reasin. Zn.con.en. x. The relation.of the un.versal expon.n. s with tem.erature gives eviden.e that over large polaron.OLP an. correlated barrier hoppin. CBH con.uction.m.chan.sm. are presen.ed in.CuFe2O4 an. Cu1-xZn.Ga0.1Fe1.9O4 com.oun.s respectively.

关键词：尖晶石固溶体铁酸铜电导率

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Com.in.tion.of Paracetam.l an. the Glutathion. Depletin. Agen. Buthion.n. Sulfoxim.n. Show Differen.ial Effect on.Liver Can.er Cells an. n.rm.l Hepatocytes

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Pharm.cology & Pharm.cy 2016年第11期7卷 443-458页

作者： m.rwa E. Sayour Ran.a m. Abd El Salam.m.ham.d F. Elyam.n. Abeer m. El Sayed Raafat A. El-Awady n.tion.l Can.er In.titute Cairo University Cairo Egypt Departm.n. of Pharm.cology & Toxicology Faculty of Pharmacy Cairo University Cairo Egypt Departm.n. of Pathology National Cancer Institute Cairo University Cairo Egypt Sharjah In.titute for m.dical Research an. College of Pharm.cy University of Sharjah Sharjah UAE

Backgroun.: Paracetam.l exerts toxic effects on.liver cells through its m.tabolism.in.o n.acetyl-p-ben.oquin.n. im.n. (n.PQI), which is detoxified by con.ugation.with cellular glutathion. (GSH). On.e GSH is depleted, n.PQI stim.lates a ran.e of oxidative reaction. that result in.cell n.crosis. The aim.of the presen. in.estigation.is to fin. a n.w strategy that would selectively protect n.rm.l hepatic tissues an. sen.itize liver can.er cells to the toxic effects of paracetam.l or its m.tabolite. This m.y lead to the developm.n. of a targeted therapy for liver can.er. m.thods: The an.i-proliferative effects of paracetam.l an. buthion.n. sulfoxim.n. BSO (a glutathion. depletin. agen.) alon. an. in.com.in.tion.on.the liver can.er cells HepG2 an. n.rm.l rat hepatocytes were in.estigated by sulphorhodam.n.-B assay. Effects on.cell cycle regulation.an. in.uction.of apoptosis were tested by flow cytom.try. The level of prostaglan.in.expression.was m.asured by ELISA. Results: The presen. study showed that both agen.s alon. or in.com.in.tion.have an.i-proliferative effects on.both cell types. Surprisin.ly, BSO showed a cytoprotective effects on.n.rm.l hepatocytes treated with high con.en.ration. (1.75 an. 2 m.) of paracetam.l. This was con.irm.d by cell cycle an.lysis that recorded decreased fraction.of sub-G1 cells in.icatin. reduction.of apoptosis in.n.rm.l hepatocytes. An.lysis of prostaglan.in.E2 revealed differen.ial effects of paracetam.l on.n.rm.l an. liver can.er cells. A sign.fican. in.rease in.PGE2 level over the con.rol was observed in.n.rm.l hepatocytes whereas a sign.fican. decrease was seen.in.HepG2 cells after treatm.n. with paracetam.l. Con.lusion. These results in.icate that com.in.tion.of paracetam.l/BSO has differen.ial effects on.liver can.er cells an. n.rm.l hepatocytes, which open. the aven.e for a n.w effective an. selective com.in.tion.for m.n.gem.n. of liver can.er.

关键词： Paracetam.l Buthion.n. Sufoxim.n. (BSO) Selective GSH Depletion HepG2 Prostaglan.in.E2 (PGE2)

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一种测量胫骨平台骨折中胫股轴向旋转的简单工具的3D验证

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国际医学放射学杂志 2024年第1期 130-130页

作者： H.Tsen. H.Bartels n.n.ppe S.Van.leef m.Herteleer H.Hoekstra 刘爽

摘要目的旋转性胫骨平台骨折（TPF）经常涉及多个运动平面，但目前的术前评估方法没有考虑到胫股轴向旋转。介绍并验证一种简单的工具来测量旋转性Gerdy结节-胫骨

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Effect of the Substitution.of San. by Rubber of Waste Tires on.the m.chan.cal Properties of Hydraulic Con.rete an. Exposure to Gam.a Radiation

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Journ.l of m.n.rals an. m.terials Characterization.an. En.in.erin. 2021年第3期9卷 245-256页

作者： Jesús m. Colín.de la Cruz Carm.n.Gabriela Guzm.n.Ferm.n.Castillo m.jía Ben.am.n.Leal Acevedo Osvaldo Flores Cedillo Isabel Gam.oa de Buen.Arturo m.lin. Ocam.o Horacio m.rtín.z Valen.ia Facultad de Cien.ias Quím.cas e In.en.ería Universidad Autónoma del Estado de Morelos Cuernavaca México Laboratorio de Espectroscopia Instituto de Ciencias Físicas Universidad Nacional Autónoma de México Cuernavaca México In.tituto de Cien.ias n.cleares Universidad Nacional Autónoma de México México City México Cen.ro de In.estigación.en.In.en.ería y Cien.ias Aplicadas UAEM Cuernavaca México

For a lon. tim. an. un.il n.w, rubber is the m.st used m.terial for the m.n.facture of tires for m.tor vehicles. Un.ortun.tely, on.e the tire m.ets its life cycle, the rem.in.n. rubber can.ot be recycled, so the tires are discarded in.collection.cen.ers an. often.in.clan.estin. dum.s. This represen.s a serious en.iron.0}n.al problem.because, in.on. case, these waste tires becom. breedin. groun.s for in.ects an. wildlife that is harm.ul to hum.n.. In.the secon. case, the tires are burn.d, releasin. highly dam.gin. gases in.o the atm.sphere. On.the other han., con.rete is worldwide the con.truction.m.terial par excellen.e. It is basically com.osed of cem.n., gravel an. san.. m.xin. these three com.on.n.s in.differen. proportion., their m.chan.cal stren.th in.com.ression.can.be in.reased. However, due to its fragile n.ture, con.rete, on.e a crack is form.d, it rapidly advan.es by fragm.n.in. the m.terial an. producin. its rapid collapse. In.the presen. work, in.order con.ribute to the care of the en.iron.0}n. as well as to m.dify the fracture m.de of the con.rete, rubber particles obtain.d from.waste tires were used as san. substitute in.hydraulic con.rete. In.addition. rubber m.dified sam.les con.rete were lately exposed to 70 kGy of gam.a radiation.in.order to study the effects of this radiation.on.the m.chan.cal deform.tion.of con.rete. The results showed a decrease in.the m.chan.cal properties of the con.rete with rubber particles with respect to the tradition.l con.rete itself. However, such decreases were offset by the fact that sam.les with rubber addition.do n.t collapses as fast as the free rubber sam.les. The acquired data pave the way for research with great ben.fits, such as the use of recycled tires in.con.rete for its fracture m.de m.dification.in.a ben.ficial way, as well as a possible decrease in.the cost of con.rete.

关键词： Hydraulic Con.rete Scrap Tire Rubber Stren.th Gam.a Radiation m.chan.cal Properties

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